Summary
Prednisolone, a water-soluble glucocorticoid hormone, suppressed the secretion of interleukin-1 beta from human peripheral blood mononuclear cells in culture. The prednisolone-induced suppression of the monokine release was doserelated and the half maximal response was observed at 0.1 nM.
References
McEwen, B., and Liebeskind, J., in: The Neuro-Immune-Endocrine Connection, p. 71. Eds C. W. Cotman, R. E. Brinton, A. Galaburda and B. McEwen. New York 1988.
Grossmann, C. J., Endocr. Rev.5 (1984) 435.
Uehara, A., Gillis, S., and Arimura, A., Neuroendocrinology45 (1987) 343.
Uehara, A., and Arimura, A., Clin. Res.35 (1987) 37A.
Uehara, A., Gottschall,P. E., Dahl, R. R., and Arimura, A., Endocrinology121 (1987) 1580.
Sapolsky, R., Rivier, C., Yamamoto, G., Plotsky, P., and Vale, W., Science238 (1987) 522.
Berkenbosch, F., van Oers, J., del Rey, A., Tilders, F., and Besedovsky, H., Science238 (1987) 524.
Berczi, I., in: Pituitary Function and Immunity, p. 49. Ed. I. Berczi. Florida 1986.
Besedovsky, H., del Rey, A., Sorkin, E., and Dinarello, C. A., Science233 (1986) 652.
Stôsić-Grujič, S., and Simić, M. H., Cell. Immun.69 (1982) 235.
Synder, S. S., and Unanue, E. R., J. Immun.129 (1982) 1803.
Gearing, A. J. H., Bird, C. R., Bristow, A., Poole, S., and Thorpe, R., J. immun. Meth.99 (1987) 7.
Falk, W., Krammer, P. H., and Männel, D. N., J. immun. Meth.99 (1987) 47.
Uede, T., Kohda, H., Ibayashi, Y., Osawa, H., Diamantstein, T., and Kikuchi, K., J. Immun.135 (1985) 3243.
March, C. J., Mosley, B., Larsen, A., Cerretti, D. P., Braedt, G., Price, V., Gillis, S., Hennex, C. S., Kronheim, S. R., Grabstein, K., Conlon, P. J., Hopp, T. P., and Cosman, D., Nature315 (1985) 641.
Uehara, A., Gottschall, P. E., Dahl, R. R., and Arimura, A., Biochem. biophys. Res. Commun.146 (1987) 1286.
Besedovsky, H., Sorkin, E., Kellere, M., and Muller, J., Proc. Soc. exp. Biol. Med.150 (1975) 466.
Beisel, W. R., Am. J. clin. Nutr.30 (1977) 1236.
Kroemer, G., Brezinschek, H.-P., Faessler, R., Schauenstein, K., and Wick, G., Immun. Today9 (1988) 163.
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Uehara, A., Kohda, H., Sekiya, C. et al. Inhibition of interleukin-1 beta release from cultured human peripheral blood mononuclear cells by prednisolone. Experientia 45, 166–167 (1989). https://doi.org/10.1007/BF01954861
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DOI: https://doi.org/10.1007/BF01954861