Zusammenfassung
Die radioimmunologisch gemessenen Plasmaspiegel von Parathormon, die renale Ausscheidung von zyklischem Adenosin 3′,5′-Monophosphat (cAMP) und die Stimulierbarkeit der renalen Tubuli nach einer Infusion von Kalzium und von Parathormonextrakt wurden untersucht bei einem Patienten mit nichtfamiliärer hypophosphatämischer Osteomalazie. Die Plasmakonzentration von Parathormon war normal, und die basale renale Ausscheidung von cAMP erhöht. Nach Verabfolgung von Parathormonextrakt war die renale kortikale Adenylzyklase, gemessen als renale Ausscheidung von cAMP, sicher so empfindlich wie bei normalen Personen. Nach einer vorhergehenden Kalziuminfusion war in den Nieren eine größere Parathormon-empfindliche Komponente von Phosphortransport vorhanden als bei zwei Kontrollpersonen. Unsere Ergebnisse zeigen, daß bei nichtfamiliärer hypophosphatämischer Osteomalazie die Stimulierbarkeit der renalen Tubuszellen durch Parathormon erhöht sein könnte.
Summary
Plasma immunoreactive parathyroid hormone level, urinary excretion of adenosine cyclic 3′,5′-monophosphate (cyclic AMP) and the sensitivity of the renal tubule to calcium infusion and to parathyroid extract were investigated in a patient with nonfamilial hypophosphatemic osteomalacia. Plasma immunoreactive parathyroid hormone concentration was normal and basal urinary excretion of cyclic AMP was increased. Renal cortical adenylate cyclase, as measured by urinary cyclic AMP excretion, was certainly as sensitive to exogenous parathyroid extract as in normal subjects. After a previous calcium infusion, a greater parathyroid-hormone-sensitive component of phosphorus transport in the kidney was present than in two control subjects. Our results indicate that in nonfamilial hypophosphatemic osteomalacia the renal tubule could be hyperresponsive to parathyroid hormone.
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This work was supported by a grant (no 20,463) from the Belgian Nationaal Fonds voor Geneeskundig Wetenschappelijk Onderzoek
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de Backer, M., de Nutte, N., Verbeelen, D. et al. Renal responsiveness to parathyroid hormone in a case of nonfamilial hypophosphatemic osteomalacia. Klin Wochenschr 58, 689–694 (1980). https://doi.org/10.1007/BF01478606
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DOI: https://doi.org/10.1007/BF01478606