Abstract
Stomach, intestinal, and colonic transit were measured in males with insulin-requiring diabetes of greater than 10 years' duration to compare with symptoms and to estimate the medical significance. For all diabetics only the symptom constipation correlated with the appropriate regional delayed transit. Diabetics with delayed transit in any region, however, had more overall gastrointestinal symptoms. Diabetics with delayed transit had disease of significantly longer duration than those without delay. Delayed transit was common in the diabetics selected for study with 21 of 54 stomachs, 10 of 20 small intestines, and 14 of 20 colons showing impairment. Of 35 diabetics with impaired transit at one or more locations, only seven were judged of medical importance and five of these responded to treatment. In this study, delayed transit was frequent; in the one fifth requiring management, the symptoms related closely to the region impaired.
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Guy RJC, Dawson JL, Garrett JR, Laws JW, Thomas PK, Sharma AK, Watkins PJ: Diabetic gastroparesis from autonomic neuropathy: Surgical considerations and changes in vagus nerve morphology. J Neurol Neurosurg Psychiatry 47:686–691, 1984
Ahn Y-H, Maturu P, Steinheber FU, Goldman JM: Association of diabetes mellitus with gastric bezoar formation. Arch Intern Med 147:527–528, 1987
Dudl RJ, Anderson DS, Forsythe AB, Ziegler MG, O'Dorisio TM: Treatment of diabetic diarrhea and orthostatic hypotension with somatostatin analogue. Am J Med 83:584–588, 1987
Berenyi MR, Schwarz GS: Megasigmoid syndrome in diabetes and neurologic disease. Am J Gastroenterol 47:311–320, 1967
Schiller LR, Santa Ana CA, Schmulen AC, Hendler RS, Harford WV, Fordtran JS: Pathogenesis of fecal incontinence in diabetes mellitus: Evidence for internal-analsphincter dysfunction. N Engl J Med 307:1666–1671, 1982
Yang R, Arem R, Chan L: Gastrointestinal tract complications of diabetes mellitus: Pathophysiology and management. Arch Intern Med 144:1251–1256, 1984
Ogbonnaya KI: Diabetic diarrhea: Pathophysiology, diagnosis and management. Arch Intern Med 150:262–267, 1990
Camilleri M, Malagelada JR, Abell TL, Brown ML, Hench V, Zinsmeister AR: Effect of six weeks of treatment with cisapride in gastroparesis and intestinal pseudoobstruction. Gastroenterology 96:704–712, 1989
Dudl RJ, Anderson DS, Forsythe AB, Ziegler MG, O'Dorisio TM: Treatment of diabetic diarrhea and orthostatic hypotension with somatostatin analogue. Am J Med 83:584–588, 1987
Fedorak RN, Field M, Chang EB: Treatment of diabetic diarrhea with clonidine. Ann Intern Med 102:197–199, 1985
Kageyama S, Taniguchi I, Tanaka S, Tajima N, Saito N, Ikeda Y, Abe M: A critical level of diabetic autonomic neuropathy. Tohoku J Exp Med 141(suppl):479–483, 1983
Clouse RE, Alpers DH: The relationship of psychiatric disorder to gastrointestinal illness. Annu Rev Med 37:283–295, 1986
Wegener M, Borsch G, Schaffstein J, Luerweg C, Leverkus F: Gastrointestinal transit disorders in patients with insulin treated diabetes mellitus. Dig Dis Sci 8:23–26, 1990
Keshavarzian A, Iber FL: Gastrointestinal involvement in insulin-requiring diabetes mellitus. J Clin Gastroenterol 9:685–692, 1987
Wilcoxon F: Individual comparisons by ranking methods. Biometrics 1:80–83, 1945
Ladas SD, Latoufis C, Giannopoulou H, Hatziioannou J, Raptis SA: Reproducible lactulose hydrogen breath test as a measure of mouth-to-cecum transit time. Dig Dis Sci 34:919–924, 1989
Feldman M, Schiller L: Disorders of gastrointestinal motility associated with diabetes mellitus. Ann Intern Med 98:378–384, 1983
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Iber, F.L., Parveen, S., Vandrunen, M. et al. Relation of symptoms to impaired stomach, small bowel, and colon motility in long-standing diabetes. Digest Dis Sci 38, 45–50 (1993). https://doi.org/10.1007/BF01296772
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DOI: https://doi.org/10.1007/BF01296772