Abstract
In a retrospective analysis of 64 patients stimulated with human menopausal gonadotropin (hMG) and/or pure follicle stimulating hormone (FSH); 35 cycles with spontaneous luteinizing hormone (LH) surges were compared with 29 control cycles with respect to serum FSH and estradiol (E2) levels drawn on the day prior to and the day of human chorionic gonadotropin (hCG), approximately 16 hr after gonadotropin stimulation. FSH decreased significantly (P<0.05) in control cycles where two or more preovulatory oocytes (preovs) were obtained, in contrast to cycles with a spontaneous LH surge, where FSH increased irrespective of the number of preovs. The E2 increase in the LH surge cycles was significantly higher (P<0.05) than in the control cycles. However, the increase in E2 did not correlate with the change in FSH levels or with the number of preovs.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Sopelak JM, Hodgen GD: Blockade of the estrogen-induced luteinizing hormone surge in monkeys: A non-steroidal, antigenic factor in porcine follicular fluid. Fertil Steril 1984;41:108
Schenken RS, Hodgen GD: Follicle stimulating hormone induced ovarian hyperstimulation in monkeys: Blockade of the luteinizing hormone surge. JCEM 1983;57:50
Ferraretti AP, Garcia JE, Acosta AA, Jones GS: Serum luteinizing hormone during ovulation induction with human menopausal gonadotropin for in vitro fertilization in normal menstruating women. Fertil Steril 1983;40:742
Eibschitz I, Belaisch-Allart JL, Frydman R: In vitro fertilization management and results in stimulated cycles with spontaneous luteinizing hormone discharge. Fertil Steril 1986;45:231
Rossavik IK, Gibbons WE: Growth curve analyses of follicular growth in the in vitro fertilization program. Fertil Steril 1986;45:834
Jones SL, Dorfmann A, Patton L, Pitt C, Joyce B, Schulman JD: The importance of the premature LH surge in IVF cycles with low dose pergonal follicle stimulation. Society for Gynecologic Investigation, 33rd Annual Meeting, Toronto, Ontario, Canada, March 19–22, 1986, abstr 47
Droesch K, Muasher SJ, Kreiner D, Jones GS, Rosenwaks Z: Timing of oocyte retrieval in cycles with a spontaneous luteinizing hormone (LH) surge in a large in vitro fertilization (IVF) program. American Fertility Society, 43rd Annual Meeting, Reno, Nevada, Sept 29–Oct 1, 1987, abstr 57
Sandow BA: Characteristics of human oocytes aspirated for in vitro fertilization. Infertility 1983;6:143
McLachlan RI, Healy DL, Robertson DM, DeKretser DM, Burger HG: Plasma inhibin levels during gonadotropin induced ovarian hyperstimulation for IVF: A new index of follicular function. Lancet 1986;8942:1233
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kreiner, D., Droesch, K., Itskovitz, J. et al. Spontaneous luteinizing hormone (LH) surges are associated with more rapidly increasing estradiol (E2) and follicle stimulating hormone (FSH) in in vitro fertilization and embryo transfer. J Assist Reprod Genet 5, 265–267 (1988). https://doi.org/10.1007/BF01132175
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01132175