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The consequences of eccentric contractions and their relationship to delayed onset muscle pain

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Summary

Exercise can cause muscle pain for a number of reasons. Usually the pain is experienced during the exercise and recovers rapidly afterwards. There is one type of muscle pain that has a very different and characteristic time course. In this situation the exercise itself, and the immediate post-exercise period are painfree. The pain is not felt for about eight hours and is maximal 1 or 2 days later. Delayed onset muscle pain occurs after unaccustomed, high force contractions and is particularly associated with eccentric contractions. The concensus of opinion is that the pain is caused by some form of damage, but the mechanism for the pain is not known. This review summarises the literature on the consequences of eccentric contractions and relates them to delayed onset muscle pain. There is clear evidence of damage to the muscle fibres themselves, their membranes and, at a later stage, mononuclear cell infiltration, but all these have very different time courses and none are the same as the pain. Intramuscular pressures are raised in some, but not all, painful compartments and even when raised follow a different time course to the pain. Anti-inflammatory agents do not affect the pain, but due to the incomplete understanding of the action of these drugs, the role of inflammation in delayed onset muscle pain is uncertain.

Despite the considerable evidence of damage after eccentric contractions, the cause of delayed onset muscle pain is still unknown.

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References

  • Abbott BC, Bigland B, Ritchie JM (1952) The physiological cost of negative work. J Physiol 117:380–390

    Google Scholar 

  • Abraham WM (1977) Factors in delayed muscle soreness. Med Sci Sports 9:11–26

    Google Scholar 

  • Armstrong RB (1984) Mechanisms of exercise-induced delayed onset muscular soreness: a brief review. Med Sci Sport Exerc 16:529–538

    Google Scholar 

  • Armstrong RB, Oglivie RW, Schwane JA (1983) Eccentric exercise induced injury in rat skeletal muscle. J Appl Physiol 54:80–93

    Google Scholar 

  • Asmussen E (1953) Positive and negative muscular work. Acta Physiol Scand 28:364–382

    Google Scholar 

  • Asmussen E (1956) Observations on experimental muscular soreness. Acta Rheum Scand 2:109–16

    Google Scholar 

  • Bellina CR, Bianchi R, Bombardieri S, Feni C, Mariani G, Muratoria A, Rossi B, Picchi L (1978) Quantitative evaluation of 99m TC pyrophosphate muscle uptake in patients with inflammatory and non-inflammatory muscle diseases. J Nucl Med 22:89–96

    Google Scholar 

  • Berg A, Haralambie G (1978) Changes in serum creatine kinase and hexose phosphate isomerase activity with exercise duration. Eur J Appl Physiol 39:191–201

    Google Scholar 

  • Brendstrup P (1962) Late edema after muscular exercise. Arch Physiol Med Rehab 43:401–405

    Google Scholar 

  • Brill DR (1981) Radionuclide imaging of non-neoplastic soft tissue disorders. Semin Nucl Med 11:277

    Google Scholar 

  • Brooke MH, Caroll JE, Davis JE, Hagberg JM (1979) The prolonged exercise test. Neurology 29:636–643

    Google Scholar 

  • Bulke JAL, Baert AC (1982) Clinical and radiological aspects of myopathies. Springer, Heidelberg Berlin New York

    Google Scholar 

  • Davies CTM, Barnes C (1972) Negative (eccentric) work. II. Physiological responses to walking uphill and downhill on a motor-driven treadmill. Ergonomics 15:121–131

    Google Scholar 

  • Davies CTM, White MJ (1981) Muscle weakness following eccentric work in man. Pflügers Arch 392:168–171

    Google Scholar 

  • Dubovitz V, Roy S (1970) Central core disease of muscle: Clinical, histochemical and electron microscopic studies of an affected mother and child. Brain 93:133–146

    Google Scholar 

  • Fischman DA, Meltzer HY, Poppei RW (1973) The ultrastructure of human skeletal muscle: variations from archetypal morphology. In: Pearson CM, Mostofi EK (eds) The striated muscle. Williams and Wilkins, Baltimore, pp 58–79

    Google Scholar 

  • Friden J (1983) Exercise induced muscle soreness. PhD thesis. Umea University Medical Dissertations, New Series 105, Sweden

  • Friden J (1984) Changes in human skeletal muscle induced by long-term eccentric exercise. Cell Tiss Res 236:365–372

    Google Scholar 

  • Friden J, Sfakianos PN, Hargens AR (1986) Delayed muscle soreness and intramuscular fluid pressure: comparison between eccentric and concentric load. J Appl Physiol 61:2175–2179

    Google Scholar 

  • Friden, J, Sjostrom M, Ekblom B (1981) A morphological study of delayed muscle soreness. Experientia 37:506–7

    Google Scholar 

  • Friden J, Sjostrom M, Ekblom B (1983) Myofibrillar damage following intense eccentric exercise in man. Int J Sports Med 4:170–76

    Google Scholar 

  • Giraldi C, Mariani G, Molea N, Rossi B (1979) 99m TC-pyrophosphate muscle uptake in four subjects with Becker's disease. J Nucl Med Allied Sci 23:45–47

    Google Scholar 

  • Graves J, Clarkson PM, Kirwan J, Litchfield P (1984) Serum creatine kinase levels following three different isometric exercise regimes. Med Sci Sports Exerc 16:186–187

    Google Scholar 

  • Hill AV (1951) Mechanics of voluntary muscle. Lancet 2:947–951

    Google Scholar 

  • Headley SA, Newham DJ, Jones DA (1986) The effect of prednisolone on exercise induced muscle pain and damage. Clin Sci 70:85P

    Google Scholar 

  • Hough T (1902) Ergographic studies in muscular soreness. Am J Physiol 7:76–92

    Google Scholar 

  • Janssen E, Kuipers H, Verstappen F, Costill D (1983) Influence of an anti-inflammatory drug on muscle soreness. Med Sci Sports Exerc 15:165

    Google Scholar 

  • Jones DA, Newham SD, Clarkson PM (1987) Skeletal muscle stiffness and pain following eccentric exercise of the elbow flexors. Pain 30:233–242

    Google Scholar 

  • Jones DA, Newham DJ, Round JM, Tolfree SEJ (1986) Experimental human muscle damage: morphological changes in relation to other indices of damage. J Physiol 375:435–448

    Google Scholar 

  • Knuttgen HG, Bonde-Peterson F, Klausen K (1971) O2 uptake and heart rate responses to exercise performed with concentric and eccentric muscle contractions. Med Sci Sports 3:1–5

    Google Scholar 

  • Komi PV (1973) Relationship between muscle tension, EMG and velocity of contraction under concentric and eccentric conditions. In: Desmedt J (ed.) New developments in electromyography and clinical neurophysiol, vol I. Karger, Basel, pp 596–606

    Google Scholar 

  • Komi PV, Buskirk ER (1972) Effect of eccentric and concentric muscle conditioning on tension and electrical activity of human muscle. Ergonomics 15:417–34

    Google Scholar 

  • Komi PV, Rusko O (1974) Quantitative evaluation of mechanical and electrical changes during fatigue loading of eccentric and concentric work. Scand J Rehab Med [Suppl] 3:121–126

    Google Scholar 

  • Kuipers H, Keizer HA, Verstappen FTJ, Costill DL (1983) Influence of a prostaglandin inhibiting drug on muscle soreness after eccentric work. Int J Sports Med 6:336–339

    Google Scholar 

  • Lentle BC, Percy JS, Regal WM (1978) Localisation of TC-99m pyrophosphate in muscle after exercise. J. Nucl Med 19:223–224

    Google Scholar 

  • Lewis T (1942) Pain. Macmillan, London

    Google Scholar 

  • Margaria R (1968) Positive and negative work performance and their efficiencies in human locomotion. Int Z Angew Physiol 25:339–351

    Google Scholar 

  • Matin P, Lang G, Garetta R, Simon G (1983) Scintographic evaluation of muscle damage following extreme exercise. J Nucl Med 24:308–311

    Google Scholar 

  • Maxwell JH, Bloor CM (1981) Effects of conditioning on exertional rhabdomyolysis and serum creatine kinase after severe exercise. Enzyme 26:177–181

    Google Scholar 

  • Meltzer HY, Kund RW, Click J, Yang V (1976) Incidence of Z band streaming and myofibrillar disruptions in skeletal muscle from healthy young people. Neurology 26:853–857

    Google Scholar 

  • Messina C, Bonanno N, Vita G (1978) Radio isotope scanning with TC 99m labelled phosphate complex in neuromuscular disease. Boll Soc Ital Sper 54:2457–2461

    Google Scholar 

  • Mills KR, Newham DJ, Edwards RHT (1982) Force, contraction frequency and energy metabolism as determinants of ischaemic muscle pain. Pain 14:149–164

    Google Scholar 

  • Mubarak SJ (1981) Exertional compartment syndromes. In: Mubarak SJ, Hargen's (eds) AR Compartment syndromes and Volkman's contracture. WB Saunders London, pp 209–226

    Google Scholar 

  • McGlynn GH, Laughlin NT, Rowe V (1979) Effect of electromyographic feedback and static stretching on artificially induced muscular soreness. Am J Physiol Med 58:139–148

    Google Scholar 

  • Mclean AEM (1977) Abnormal localisation of Gallium 67 citrate in pseudohyperthrophic muscular dystrophy. Lancet II:180

    Google Scholar 

  • Newham DJ, Jones DA (1985) Intra-muscular pressure in the painful human biceps. Clin Sci 69:27P

    Google Scholar 

  • Newham DJ, Jones DA, Edwards RHT (1983c) Large delayed plasma creatine kinase changes after stepping exercise. Muscle Nerve 6:380–385

    Google Scholar 

  • Newham DJ, Jones DA, Edwards RHT (1986a) Plasma creatine kinase changes after eccentric and concentric contractions. Muscle Nerve 9:59–63

    Google Scholar 

  • Newham DJ, Jones DA, Edwards RHT (1986b) Plasma creatine kinase changes after eccentric and concentric contractions. Muscle Nerve 9:59–63

    Google Scholar 

  • Newham DJ, Jones DA, Tolfree SEJ, Edwards RHT (1986) Skeletal muscle damage: a study of isotope uptake, enzyme efflux and pain after stepping. Eur J Appl Physiol 55:106–112

    Google Scholar 

  • Newham DJ, Mills KR, Quigley BM, Edwards RHT (1983a) Pain and fatigue following concentric and eccentric muscle contractions. Clin Sci 64:55–62

    Google Scholar 

  • Newham DJ, McPhail G, Mills KR, Edwards RHT (1983b) Ultrastructural changes after concentric and eccentric contractions. J Neurol Sci 61:109–122

    Google Scholar 

  • Pennington RJT (1981) biochemical aspects of muscle disease. In: Walton JN (ed.) Disorders of voluntary muscle. 4th Edition. Churchill Livingstone, Edinburgh, pp 417–444

    Google Scholar 

  • Robinson GP, Battaglia DJ (1975) Technetium-99m-tetracycline-preparation, biological dynamics and uptake in damaged and normal skeletal muscle. Int J Appl Rad Isotop 26:147–152

    Google Scholar 

  • Rodbard S, Pragay EB (1968) Contraction frequency, blood supply and muscle pain. J Appl Physiol 24:142–145

    Google Scholar 

  • Spies SM, Swift TR, Brown M (1975) Increased 99m TC polyphosphonate muscle uptake in a patient with polymyositis. J Nucl Med 16:1125–1127

    Google Scholar 

  • Swift TR, Brown M (1978) TC 99m pyrophosphate muscle labelling in McArdles Syndrome. J Nucl Med 19:295–297

    Google Scholar 

  • Valk P (1984) Muscle localisation of TC-99m MDP after exertion. Clin Nucl Med 9:493–494

    Google Scholar 

  • Vita G, Harris JB (1981) The uptake of 99m Technetium diphosphonate into degenerating and regenerating muscle. J Neurol Sci 51:339–354

    Google Scholar 

  • Vries de HA (1966) Quantitative EMG investigation of the spasm theory of muscle pain. Am J Physiol Med 45:119–134

    Google Scholar 

Download references

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  1. Department of Medicine, The Rayne Institute, University College, University Street, WCIE 6JJ, London

    D. J. Newham

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Newham, D.J. The consequences of eccentric contractions and their relationship to delayed onset muscle pain. Europ. J. Appl. Physiol. 57, 353–359 (1988). https://doi.org/10.1007/BF00635995

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