Summary
Accumulation of aromatic nitroxide radicals in microsomal membranes of rabbit liver has been observed by ESR-spectroscopy in the course of biotransformation of 2-acetylaminofluorene, 2-aminofluorene, 2-aminonaphthalene, 4-aminostilbene, 4,4′-diamincstilbene, 4-nitroquinoline-1-oxide.
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References
Bartsch, H., Traut, M., Hecker, E.: On the metabolic activation of N-hydroxy-N-2-acetylaminofluorene II. Simultaneous formation of 2-nitrosofluorene and N-acetoxy-N-2-acetylamino fluorene from N-hydroxy-N-2-acetylaminofluorene via a free radical intermediate. Biochim. biophys. Acta (Amst.) 237, 556–566 (1971).
Fouts, J. R.: Liver smooth endoplasmic reticulum “microsomal” drug-metabolizing enzyme systems. In: A. Schwartz, ed.: Methods in Pharmacology, Vol. 2, pp. 287–325. New York: Appleton Century Crofts 1971.
McConnell, H. M., McFarland, B. G.: Physics and chemistry of spin labels. Quart. Rev. Biophys. 3, 91–136 (1970).
Miller, J. A., Miller, E. C.: The metabolic activation of aromatic amines and amides. Progr. exp. Tumor Res. 11, 273–301 (1969).
Stier, A., Reitz, I.: Radical production in amine oxidation by liver microsomes. Xenobiotical 1, 499–500 (1971).
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Stier, A., Reitz, I. & Sackmann, E. Radical accumulation in liver microsomal membranes during biotransformation of aromatic amines and nitro compounds. Naunyn-Schmiedeberg's Arch. Pharmacol. 274, 189–191 (1972). https://doi.org/10.1007/BF00501853
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DOI: https://doi.org/10.1007/BF00501853