Summary
Male Wistar rats were injected intraperitoneally (i.p.) with toluene alone, m-xylene alone, and in combination with both of them. Urinary excretion of hippuric acid or m-methylhippuric acid of rats injected with solvents of various concentrations was investigated from the end of the injections up to 48 h later, at appropriate intervals. The amounts of increased excretion of HA and m-MHA in 0–24h urine samples of the rats given simultaneous injections of toluene and m-xylene were not lower than those of the rats given single injections of toluene alone or m-xylene alone, in the same amount. Data indicated that simultaneous administration of toluene and m-xylene did not significantly interfere with the metabolism of toluene or m-xylene.
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Read before the 50th Annual Meeting of Japan Industrial Health Association, Kurume, April 5, 1977
The work was supported in part by grant No. 357188 of the Ministry of Education Agency
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Ogata, M., Fujii, T. Urinary excretion of hippuric acid and m-methylhippuric acid after administration of toluene and m-xylene mixture to rats. Int. Arch Occup Environ Heath 43, 45–51 (1979). https://doi.org/10.1007/BF00454279
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DOI: https://doi.org/10.1007/BF00454279