Abbreviations
- ABU:
-
asymptomatic bacteriuria
- K-AG:
-
K antigen
- KDO:
-
2-keto-3-deoxyoctanoic acid
- LPS:
-
lipopoly-saccharides
- MR pili:
-
mannose resistant pili
- MS pili:
-
mannose sensitive pili
- O AG:
-
O-antigen
- PHA:
-
phytohaemagglutinin-A
- UTI:
-
urinary tract infection
References
Abraham SN, Babu JP, Giampapa CS, Hasty DL, Simpson WA, Beachey EH (1985) Protection against Escherichia coli-induced urinary tract infection with hybridoma antibodies directed against type 1 fimbriae of complementary d-mannose receptors. Infect Immun 48:625–628
Ahlstedt S, Hagberg M, Jodal U, Marild S (1983) Cell-mediated immune parameters in children with pyelonephritis caused by Escherichia coli. Prog Allergy 33:289–297
Angel JR, Smith TW, Roberts JA (1979) The hydrodynamics of pyelorenal reflux. J Urol 122:20–25
Bachmann HJ, Schmeck J, Brunier E, Olbing H (1980) Hypertonie bei Kindern mit Harnwegsinfektionen und Nierenparenchymnarben. In: Olbing H (ed) Rezidivierende, nicht-obstruktive Harnwegsinfektionen bei Kindern. Springer Verlag, Berlin Heidelberg New York, pp 33–40
Bahna SL (1980) Initialbefunde und Verlauf — Vergleich von Jungen und Mädchen mit Harnwegsinfektionen. In: Olbing H (ed) Rezidivierende, nicht-obstruktive Harnwegsinfektionen bei Kindern. Springer Verlag, Berlin Heidelberg New York, pp 3–9
Bollgren I, Winberg J (1976) The periurethral aerobic flora in girls highly susceptible to urinary tract infections. Acta Paediatr Scand 65:81–87
Bredt W (1985) Das Erregersoektrum und seine Erkennung. In: Bichler KH, Altwein JE (eds) Der Harnwegsinfekt: Pathogenese, Diagnostik, Therapie. Springer Verlag, Berlin Heidelberg New York Tokyo, pp 18–23
Cox CE, Hinman F (1961) Experiments with induced bacteriuria, vesical emptying and bacterial growth on the mechanism of bladder defense to infection. J Urol 86:739–743
Fasth A, Jodal U (1983) Analysis of autoantibodies to Tamm-Horsfall kidney glycoprotein to detect patients with urinary tract infection at risk to develop renal scarring. Prog Allergy 33:247–258
Ginsburg CM, McCracken GH (1982) Urinary tract infections in young infants. Pediatrics 69:409–412
Girardet P (1979) Twenty years on research on urinary tract infections in children: progress and problems. Ergeb Inn Med Kinderheilkd 42:90–133
Hagberg L, Jodal U, Korhonen TK, Lidin-Janson G, Lindberg U, Svanborg Eden C (1981) Adhesion, hemagglutination, and virulence of Escherichia coli causing urinary tract infections. Infect Immun 31:564–570
Hagberg L, Engberg I, Freter R, Lam J, Olling S, Svanborg Eden C (1983) Ascending, unobstructed urinary tract infection in mice caused by pyelonephritogenic Escherichia coli of human origin. Infect Immun 40:273–283
Hagberg L, Hull R, Falkow S, Freter R, Svanborg Eden C (1983) Contribution of adhesion to bacterial persistance in the mouse urinary tract. Infect Immun 40:265–272
Hanley J, Salit JE, Hofmann T (1985) Immunochemical characterization of P pili from invasive Escherichia coli. Infect Immun 49:581–586
Hanson LA, Ahlstedt S, Jodal U, Kaijser B, Larsson P, Lidin-Janson G, Lincoln K, Lindberg U, Mattsby I, Olling S, Peterson H, Shol A (1975) The host-parasite relationship in urinary tract infections. Kidney Int 8:28–34
Hjelm EM (1984) Local cellular immune response in ascending urinary tract infection: occurrence of T-cells, immunoglobulin-producing cells, and Ia-expressing cells in rat urinary tract tissue. Infect Immun 44:627–632
Hofmann K, Marget W, Belohradsky B (1981) Veränderte bakterielle Periurethralflora bei jungen Mädchen mit chronisch rekurrierenden Harnwegsinfektionen? Infection 9:252–254
Hoyer JR (1980) Tubulointerstitial immune complex nephritis in rats immunized with Tamm-Horsefall protein. Kidney Int 17:284
Huland H, Busch R (1985) Ätiologie von Harnwegsinfekten. In: Bichler KH, Altwein JE (eds) Der Harnwegsinfekt: Pathogenese, Diagnostik, Therapie. Springer Verlag, Berlin Heidelberg New York Tokyo, pp 9–17
Jann K (1982) Bacterial structures involved in urinary tract infections. In: Schulte-Wissermann H (ed) Clinical, bacteriological and immunological aspects of urinary tract infections in children. Thieme Verlag, Stuttgart New York, pp 73–82
Kaijser B (1973) Immunology of Escherichia coli: K antigen and its relation to urinary tract infection. J Infect Dis 127:670
Kaijser B, Larson P, Mattsby-Baltzer I, Söderström T (1982) Immune response to E. coli antigens and prophylactic immunization against acute pyelonephritis. In: Schulte-Wissermann H (ed) Clinical, bacteriological and immunological aspects of urinary tract infections in children. Thieme Verlag, Stuttgart New York, pp 83–87
Kusecek B, Wloch H, Mercer A, Vaisänen V, Pluschke G, Korhonen T, Achtman M (1984) Lipopolysaccharide, capsule, and fimbriae as virulence factors among O1, O7, O16, O18, or O75 and K1, K5, or K100 Escherichia coli. Infect Immun 43:368–379
Leffler H, Svanborg Eden C (1981) Glycolipid receptors for uropathogenic Escherichia coli on human erythrocytes and uroepithelial cells. Infect Immun 34:920–929
Lomberg H, Hanson LA, Jacobsson B, Jodal U, Leffler H, Svanborg Eden C (1983) Correlation of P blood group, vesicoureteral reflux, and bacterial attachment in patients with recurrent pyelonephritis. New Engl J Med 308, 20:1189–1192
Marrie TJM, Lam J, Costerton JW (1980) Bacterial adhesion to uroepithelial cells: a morphologic study. J Infect Dis 142:239–246
Miller T, Marshall E (1982) Cell-mediated immune mechanisms in renal infection. In: Schulte-Wissermann H (ed) Clinical, bacteriological and immunological aspects of urinary tract infections in children. Thieme Verlag, Stuttgart New York, pp 163–171
Miller T, Phillips S, Stewart E (1980) Immunologie der Pyelonephritis-Beziehung der Immunantwort zur Pathogenese. In: Olbing H (ed) Rezidivierende, nicht-obstruktive Harnwegsinfektionen bei Kindern. Springer Verlag, Berlin Heidelberg New York, pp 135–143
Normark S, Lark D, Hull R, Norgren M, Baga M, O'Hanley P, Schoolink G, Falkow S (1983) Genetics of digalactoside-binding adhesin from a uropathogenic Escherichia coli. Infect Immun 41:942–949
Olbing H (1985) Kinder mit Harnwegsinfektionen: Risikogerechte Diagnostik und Therapie. Dtsch Ärzteblatt 82/34:2404–2414
Olling S, Mattsby-Balzer I (1982) Histopathology and anti-lipid A antibodies in experimental pyelonephritis in rats. In: Schulte-Wissermann H (ed) Clinical, bacteriological and immunological aspects of urinary tract infections in children. Thieme Verlag Stuttgart, New York, pp 55–58
Orskov I, Ference A, Orskov F (1980) Tamm Horsefall Protein or uromucoid is the normal urinary slime that traps type I fimbriated Escherichia coli. Lancet I:887
Parry SH, Boonchai S, Abraham SN, Salter JM, Rooke DM, Simpson JM, Bint AJ, Sussman M (1983) A comparative study of the mannose-resistant and mannose-sensitive haemagglutinins of Escherichia coli isolated from urinary tract infections. Infection 11:123–128
Perry A, Ofek I, Silverblatt FJ (1983) Enhancement of mannose-mediated stimulation of human granulocytes by type 1 fimbriae aggregated with antibodies on Escherichia coli. Infect Immun 39:1334–1345
Ratner JJ, Thomas VL, Sanford BA, Forland M (1983) Antibody to kidney antigen in the urine of patients with urinary tract infections. J Infect Dis 147:434–444
Roberts JA (1975) Experimental pyelonephritis in the monkey. III. Pathophysiology of ureteral malfunction induced by bacteria. Invest Urol 13:117
Shand GH, Anwar H, Kadurugamuwa J, Brown MRW, Silverman SH, Melling J (1985) In vivo evidence that bacteria in urinary tract infection grow under iron-restricted conditions. Infect Immun 48:35–39
Smellie JM, Edwards D, Hunter N, Normand ICS, Prescod N (1975) Vesico-ureteric reflux and renal scarring. Kidney Int 8:65–72
Smellie JM, Normand ICS (1975) Bacteriuria, reflux and renal scarring. Arch Dis Child 50:581–585
Smith JW (1982) The immune response in urinary tract infection. Requirements in a non-immunological organ or “after adhesion, what then?” In: Schulte-Wissermann H (ed) Clinical bacteriological and immunological aspects of urinary tract infections in children. Thieme Verlag, Stuttgart New York, pp 135–142
Smith JW (1982) Role of suppressor cells in experimental pyelonephritis. In: Schulte-Wissermann H (ed) Clinical, bacteriological and immunological aspects of urinary tract infections in children. Thieme Verlag, Stuttgart New York, pp 172–177
Stamey TA, Mihara G (1976) Studies of introital colonization in women with recurrent urinary tract infection. VI. Analysis of segmented leukocytes in the vaginal vestibule in relation to enterobacterial colonization. J Urol 116:72–73
Straub E, Gardilcic S, Schofer O, Schulte-Wissermann H (1982) Urine and kidney factors influencing UTI. In: Schulte-Wissermann H (ed) Clinical, bacteriological and immunological aspects of urinary tract infections in children. Thieme Verlag, Stuttgart New York, pp 59–65
Schulte-Wissermann H, Mannhardt W (1985) Immunpathogenese der Pyelonephritis. In: Bichler KH, Altwein JE (eds) Der Harnwegsinfekt: Pathogenese, Diagnostik, Therapie. Springer Verlag, Berlin Heidelberg New York Tokyo, pp 1–8
Schulte-Wissermann H, Beetz R, Ludwig K-H, Mannhardt W, Schofer O, Tröger J, Riedmiller H, Hohenfellner R (1985) Klinischer Verlauf und Narbenentwicklung beim operierten vesicorenalen Reflux in einer Langzeitbeobachtung. Klin Wochenschr 63:920–926
Schulte-Wissermann H, Mannhardt W, Schwarz J, Zepp F, Bitter-Suermann D (1985) Comparison of antibacterial effect of uroepithelial cells from healthy donors and children with asymptomatic bacteriuria. Eur J Pediatr 144:230–233
Schulte-Wissermann H, Ludwig KH, Mannhardt W, Beetz R, Schofer O, Zepp F (1986) Antibacterial capacity of buccal epithelial cells from healthy donors and children with recurrent urinary tract incections. Eur J Pediatr, submitted
Sussman M, Rooke DM, Parry SH (1985) Bacterial adhesion and urinary tract infection. In: Floth A, Porpaczy P, Schmidbauer P, Schramek P (eds) Bacterial adherence in urinary tract infection. Proceedings, Wiener Medizinische Akademie, Wien, pp 19–26
Svanborg Eden C, Jodal U, Hanson LA, Lindberg U, Sohl Akerlund A (1976) Variable adherence to normal human urinary-tract epithelial cells of Escherichia coli strains associated with various forms of urinary-tract infection. Lancet 4:490–492
Svanborg Eden C, Jodal U (1979) Attachment of Escherichia coli to urinary sediment epithelial cells from urinary tract infection-prone and healthy children. Infect Immun 26:837–840
Svanborg Eden C, Hagberg L, Leffler H, Lomberg H (1982) Recent progress in the understanding of the role of bacterial adhesion in the pathogenesis of urinary tract infection. Infection 10:327–332
Svanborg Eden C, Gotschlich EC, Korhonen TK, Leffler H, Schoolnik G (1983) Aspects on structure and function of pili on uropathogenic Escherichia coli. Prog Allergy 33:189–202
Svanborg Eden C, Hagberg L, Hanson LA, Hull S, Hull R, Jodal U, Leffler H, Lomberg H, Straube E (1983) Bacterial adherence — a pathogenic mechanism in urinary tract infections caused by Escherichia coli. Prog Allergy 33:175–188
Svanborg Eden C, Bjursten L-M, Hull R, Magnusson K-E, Moldovano Z, Leffler H (1984) Influence of adhesins on the Escherichia coli with human phagocytes. Infect Immun 44:672–680
Väisänen-Rhen V, Elo J, Väisänen E, Siitonen A, Orskov I, Orskov F, Svenson SB, Mäkelä PH, Korhonen TK (1984) Pfimbrated clones among uropathogenic Escherichia coli strains. Infect Immun 43:149–155
Verweij-van Vught AMJJ, van den Bosch JF, Namavar F, Sparrius M, MacLaren DM (1983) K antigens of Eschrichia coli and virulence in urinary-tract infection: studies in a mouse model. J Med Microbiol 16:147–155
Winberg J (1982) Determinants of renal damage in childhood UTI (1982) In: Schulte-Wissermann H (ed) Clinical, bacteriological and immunological aspects of urinary tract infections in children. Thieme Verlag, Stuttgart New York, pp 3–10
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Mannhardt, W., Schofer, O. & Schulte-Wissermann, H. Pathogenic factors in recurrent urinary tract infections and renal scar formation in children. Eur J Pediatr 145, 330–336 (1986). https://doi.org/10.1007/BF00439233
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DOI: https://doi.org/10.1007/BF00439233