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An improved method for the determination of phenol in the urine of workers exposed to benzene or phenol

  • Occupational Chronic Exposure to Organic Solvents
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Summary

Interlaboratory comparison of phenol in urine analyses shows large variability, much larger than is normally associated with gas chromatographic analysis which suggest sample preparation problems are to blame. This paper describes a simple method of analysis which has been in use for four years in our laboratory. 2-Ethyl phenol is added to the urine as an internal standard; the sample is distilled and the distillate directly analysed by gas chromatography on a column packed with Tenax-GC using FID detectors. The detection limit is 0.1 mg/l and the coefficient of variation at 5.9 mg/l is 4.1 % (n = 8).

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References

  1. Angerer J, Lehnert G (1979) Phenolic compounds-Metabolites of alkylbenzenes in man. Int Arch Occup Environ Health 43:145–150

    Google Scholar 

  2. Buchwald H (1966) The colourimetric determination of phenol in air and urine with a stabilized diazonium salt. Ann Occup Hyg 9:7–14

    Google Scholar 

  3. Dirmikis SM, Darber A (1974) Gas-liquid chromatography of simple phenols for urinalysis. J Chromatog 94:169–187

    Google Scholar 

  4. Elkins HB, Pagnotto LD (1965) Is the 24-hour urine sample a fallacy? Am Ind Hyg Assoc J 26:456–460

    Google Scholar 

  5. Roush GJ, Ott MG (1977) A study of benzene exposure versus urinary phenol levels. Am Ind Hyg Assoc J 38:67–75

    Google Scholar 

  6. Van Haaften AB, Sic ST (1965) The measurement of phenol in urine by gas chromatography as a check on benzene exposure. Ind Hyg J 26:52–58

    Google Scholar 

  7. Van Roosmalen PB, Klein AL, Drummond I (1980) Simultaneous determination by gas chromatography of phenol, 2-chlorophenol, 2,4- and 2,6-dichlorophenol, 2,4,6-trichlorophenol, and 2,3,5,6-tetrachlorophenol in the urine of industrially exposed workers. Int Arch Occup Environ Health 45:57–62

    Google Scholar 

  8. (Unpublished study) Co-ordinated by Dr J-P Weber, Toxicology Laboratory, Le Centre Hospitalier de l'Université Laval, 2705, boul Laurier, Québec, Qué, GIV 4G2, Canada

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Authors and Affiliations

  1. Workers' Health, Safety, and Compensation, Occupational Health and Safety Division, 103 St., 10158, Edmonton, Alberta, T5J 0X6, Canada

    P. B. Van Roosmalen, J. Purdham & I. Drummond

Authors
  1. P. B. Van Roosmalen
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  2. J. Purdham
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  3. I. Drummond
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Van Roosmalen, P.B., Purdham, J. & Drummond, I. An improved method for the determination of phenol in the urine of workers exposed to benzene or phenol. Int. Arch Occup Environ Heath 48, 159–163 (1981). https://doi.org/10.1007/BF00378436

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  • DOI: https://doi.org/10.1007/BF00378436

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