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The influence of partial gastrectomy on biochemical parameters of bone metabolism and bone density

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Summary

Since it has been suggested that gastric resections are followed by changes in bone metabolism, the aim of our study was to determine the biochemical parameters of bone metabolism and radial and lumbar bone density in 15 male ulcus patients treated by partial gastrectomy (Billroth II). Comparing the data with those of a corresponding control group, the lumbar bone density measured by quantitative computed tomography was statistically significantly lower (P < 0.04) in the patient group, whereas the peripheral bone mass of the distal part of the nondominant forearm measured by single-photon absorptiometry showed no statistically significant difference. In addition, a marked increase in alkaline phosphatase (P < 0.002) and urinary excretion of hydroxyproline (P < 0.003) was found in the gastrectomy group, whereas the 25-hydroxy-vitamin D levels were found to be significantly decreased (P < 0.04). Osteocalcin, a biochemical marker for osteoblast activity, and the carboxy-terminal propeptide of type I procollagen (PICP), a marker of collagen formation, were slightly but not significantly higher in gastrectomy-treated patients. The serum parathyroid hormone levels were similar in both groups. As none of the patients had any radiologic evidence of osteopenia, the changes in biochemical parameters of bone metabolism and bone mass in patients who had undergone partial gastrectomy could be a marker of latent bone loss.

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Abbreviations

DPA/SPA:

dual/single-photon absorptiometry

BMD:

bone mineral density

QCT:

quantitative computed tomography

PICP:

carboxy-terminal propeptide of type I procollagen

250HD3 :

25-hydroxy-vitamin D

iPTH:

parathyroid hormone

OC:

osteocalcin

BMC:

bone mineral content

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Authors and Affiliations

  1. Medizinische Abteilung Krankenhaus der Barmherzigen Brüder, Große Mohrengasse 9, A-1020, Wien, Austria

    H. Resch, B. Pernecker, E. Krexner & R. Willvonseder

  2. Ludwig Boltzmann Institut für Altersforschung, Wien

    H. Resch & R. Willvonseder

  3. II. Medizinische Universitätsklinik, Wien

    P. Pietschmann

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  1. H. Resch
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  2. P. Pietschmann
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  3. B. Pernecker
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  4. E. Krexner
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  5. R. Willvonseder
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Resch, H., Pietschmann, P., Pernecker, B. et al. The influence of partial gastrectomy on biochemical parameters of bone metabolism and bone density. Clin Investig 70, 426–429 (1992). https://doi.org/10.1007/BF00235526

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  • DOI: https://doi.org/10.1007/BF00235526

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