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Increased iron content in the putamen of patients with striatonigral degeneration

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Summary

We measured the total content of iron, cooper, zinc and manganese in the putamen of four patients with striatonigral degeneration (SND) and age-and gender-matched normal controls. The iron content in the SND patients was five times greater than in the controls. Electron microscopic histochemistry revealed the iron reaction products in the pigments showing a triphasic pattern of coarse, electron-dense globules, fine granular and fibrillary materials, and lamellated structures. These findings suggest that increased iron deposition may be related to pigment formation in the putament of SND.

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Authors and Affiliations

  1. Bluestone Laboratory, Division of Neuropathology, Montefiore Medical Center, 111 East 210th Street, 10467, Bronx, NY, USA

    S. Kato, J. F. Llena & A. Hirano

  2. Department of Public Health, Tottori University School of Medicine, 683, Yonago, Japan

    S. Meshitsuka

  3. Division of Neuropathology, Tottori University School of Medicine, 683, Yonago, Japan

    S. Kato & E. Ohama

  4. Division of Neuropathology, Jikei University School of Medicine, 105, Tokyo, Japan

    J. Tanaka

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  1. S. Kato
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  2. S. Meshitsuka
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  3. E. Ohama
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  4. J. Tanaka
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  5. J. F. Llena
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  6. A. Hirano
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Kato, S., Meshitsuka, S., Ohama, E. et al. Increased iron content in the putamen of patients with striatonigral degeneration. Acta Neuropathol 84, 328–330 (1992). https://doi.org/10.1007/BF00227827

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  • DOI: https://doi.org/10.1007/BF00227827

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