Abstract
Purpose. Evaluation of choroidal alterations associated with idiopathic choroidal neovascularization (ICNV) and the possible relation between this affection and Multifocal Choroidopathies (MC). Methods. The authors analysed, using high definition videoangiography, the choroidal findings in 21 consecutive patients affected by ICNV (7 males and 14 females; 19–46 years; mean age: 31.8 years); with a follow-up at 5–30 months (mean 13 months). Moreover, a retrospective study of 20 cases of ICNV (11 males and 9 females; age: 17–39 years; mean age: 29.3 years), with a follow-up at 6–11 years (mean 8.9), was performed. Results. In 7 eyes, the indocyanine green angiography (ICGA) showed choroidal hypofluorescent spots similar to those observed in MC (in 3 cases even in the fellow unaffected eye), in 2 of them the regression of the spots was observed after steroid therapy. In 2 eyes, the ICGA revealed hyperfluorescent spots; in one of them the complete regression of the spots after oral cyprofloxacine was observed. In 6 patients (10 eyes), choroidal permeability alterations could be visualized (in 4 cases even in the unaffected eye). Conclusions. The indocyanine green angiographic findings (hypo and hyperfluorescent spots, choroidal permeability alterations) could support the theory of Gass which considers that ICNV is not idiopathic but secondary to a widespread choroidal inflammatory disease. The similarity of the ICGA alterations in ICNV and MC, the observation that cases of ICNV would become MC in the follow-up, could allow the hypothesis of a close connection between these two affections.
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References
Junius P. Erscheinungsformen und Ablauf juvenilen Retinitis exsudativa macularis. Z Augenheilk 1930; 70: 129–48.
Davis WT, Sheppard E. Juvenile macular exudative retinitis (Junius). Arch Ophthalmol 1935; 13: 960.
Verhoeff FM, Grossman HP. Pathogenesis of disciform detachment of the macula. Arch Ophthalmol 1937; 18: 561–85.
Maumenee AE. Serous and hemorrhagic disciform detachment of the macula. Tr Pac Coast Ophthalmol Soc 1959; 40: 139–60.
Francois J, De Laey JJ, Dakir M. Choroidopathie maculaire hémorragique chez les sujets jeunes. Bull Soc Belge Ophtalmol 1974; 167: 664–78.
Cleasby GW. Idiopathic focal subretinal neovascularization. Am J Ophthalmol 1976; 81: 590–6.
Soubrane G, Koenig F, Coscas G. Choroidopathie maculaire hémorragique du sujet jeune. J Fr Ophtalmol 1983; 6: 25–34.
Bottoni FG, Deutman AF. Idiopathic sub-retinal neovascular membranes in the macula (hemorrhagic macular choroidopathy of young adults). Clinical report and effectiveness of laser treatment. Doc Ophthalmol 1987; 64: 311–43.
Ho AC, Yannuzzi LA, Pisicano K, De Rosa J. The natural history of idiopathic choroidal neovascularization. Ophthalmology 1995; 102: 782–9.
Giovannini A, Scassellati-Sforzolini B, D'Altobrando E, Tittarelli R. Idiopathic choroidal neovascularization and indocyanine green angiography. Update of Indocyanine green angiography. Proceedings of the second International Symposium on Indocyanine Green Angiography}. Nara 1995, 95-7.
Giovannini A, Tittarelli R. L'angiografia al verde indocianina in oftalmologia. Monografie della Società Oftalmologica Italiana. I.N.C., Roma, 1994.
Slakter JS, Giovannini A, Yannuzzi LA, Scassellati Sforzolini B, Guyer DR, Orlock DA. Indocyanine green videoangiography of multifocal choroiditis and the presumed ocular histoplasmosis syndrome. The Macula Society, Rancho Mirage 1994, 110.
Gass JDM. Pathogenesis of disciform detachment of the neuroepithelium. See: disciform macular degeneration secondary to focal choroiditis. Am J Ophthalmol 1967; 63: 661–87.
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Giovannini, A., Scassellati-Sforzolini, B., Mariotti, C. et al. Indocyanine green angiographic findings in idiopathic choroidal neovascularization. Int Ophthalmol 20, 171–179 (1996). https://doi.org/10.1007/BF00175256
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DOI: https://doi.org/10.1007/BF00175256