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PrP amyloid plaques in Creutzfeldt-Jakob disease of short duration: immunohistochemical studies of 5 cases from Poland.

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Abstract

We report here PrP-immunohistochemistry performed on brains from CJD cases from Poland. Only one of five definitive CJD cases exhibited typical PrP-immunoreactive kuru-like plaques and this was case of a short duration. We thus confirm the low frequency of PrP plaques in CJD of Eastern and Central European origin.

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Authors and Affiliations

  1. Electron Microscopic Laboratory, Dept. Oncology, Medical Academy Lodz, Lodz , Gagarina, 4 Poland

    P. P. Liberski & B. Mirecka

  2. Dept. Neurology, Medical Academy Warsaw, Warsaw, Poland

    H. Kwiecinski & M. Barcikowska

  3. 1st Dept. Neurol gy, Inst. of Psychiatry and Neurology, Warsaw, Poland

    M. Barcikowska & J. Kulczycki

  4. Dept. Neuropathology, the Center of Clinical and Experimental Medicine Polish Academy of Sciences, Warsaw, Poland

    E. Kida

  5. Laboratory of Central Nervous System Studies, the National Institutes of Health, Bethesda, Md, USA

    P. Brown & D. C. Gajdusek

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  1. P. P. Liberski
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  2. H. Kwiecinski
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  3. M. Barcikowska
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Liberski, P.P., Kwiecinski, H., Barcikowska, M. et al. PrP amyloid plaques in Creutzfeldt-Jakob disease of short duration: immunohistochemical studies of 5 cases from Poland.. Eur J Epidemiol 7, 505–510 (1991). https://doi.org/10.1007/BF00143130

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