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Oxidative Stress in Lung Diseases pp 177–211Cite as

Role of Oxidative Stress Induced by Cigarette Smoke in the Pathogenicity of Chronic Obstructive Pulmonary Disease

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Abstract

Cigarette smoke (CS) exposes lungs to oxidative stress and inflammation and is a major risk factor for the development of chronic obstructive pulmonary disease (COPD). COPD is a complex lung disease characterized by chronic inflammation with limited airflow and chronic bronchitis associated with mucus hypersecretion, thickened small airway walls, and emphysema. CS-induced oxidative stress is responsible for altered cellular metabolism, including increased infiltrating immune cells, pro-inflammatory cytokine production, protease–antiprotease imbalance, lipid peroxidation, apoptosis, upregulation of unfolded protein response (UPR), and protein misfolding. This chapter reviews the current knowledge on different mechanisms through which both direct and secondhand CS-induced oxidative stress in lungs plays a significant role in the pathogenesis of COPD. Despite the presence of considerable reports recognizing the harmful effects of CS-generated oxidative stress, effective treatment for COPD is lacking. Extensive research on the immune and pathogenetic mechanisms of COPD will help in developing new treatment strategies. Clinical trials leveraging multiple antioxidants, anti-inflammatory processes, and UPR inhibitors are urgently needed to advance COPD therapies.

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Acknowledgments

The work is supported by grants from Fuji Oil Company, Osaka, Japan, and NIH (MeTRC5U5AMD007593). The Meharry Office for Scientific Editing and Publications provided language editing support.

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Author notes

  1. Anuradha Ratna

    Present address: Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA

Authors and Affiliations

  1. Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College, Nashville, TN, USA

    Anuradha Ratna & Salil K. Das

  2. Department of Professional Medical Education, Meharry Medical College, Nashville, TN, USA

    Shyamali Mukherjee

Authors
  1. Anuradha Ratna
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  2. Shyamali Mukherjee
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  3. Salil K. Das
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Correspondence to Salil K. Das .

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Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Department of Internal Medicine, The Ohio State University, Columbus, OH, USA

    Narasimham L. Parinandi

  3. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Rita Ghosh

  4. Apollo Hospitals Educational & Research Foundation (AHERF), Indraprastha Apollo Hospitals, New Delhi, Delhi, India

    Nirmal K. Ganguly

  5. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Tapati Chakraborti

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Ratna, A., Mukherjee, S., Das, S.K. (2020). Role of Oxidative Stress Induced by Cigarette Smoke in the Pathogenicity of Chronic Obstructive Pulmonary Disease. In: Chakraborti, S., Parinandi, N., Ghosh, R., Ganguly, N., Chakraborti, T. (eds) Oxidative Stress in Lung Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-32-9366-3_8

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