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Atrophic Gastritis and Intestinal Metaplasia

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Helicobacter pylori

Abstract

Currently, many international guidelines recommend Helicobacter pylori (H. pylori) eradication in patients with precancerous lesions such as atrophic gastritis (AG) and intestinal metaplasia (IM). However, there are still many controversies in whether H. pylori eradication improves AG and IM. Taking the results of related studies together, it seems likely that H. pylori eradication improves AG to some extent. However, a dominant opinion is that IM which progressed to a certain level is already an irreversible status (point of no return). Therefore, in order to obtain an optimal effect for gastric cancer prevention, eradication of H. pylori in the earlier and reversible stage of AG and IM is recommended.

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References

  1. Sung JJ, Lin SR, Ching JY, Zhou LY, To KF, Wang RT, et al. Atrophy and intestinal metaplasia one year after cure of H. pylori infection: a prospective, randomized study. Gastroenterology. 2000;119:7–14.

    Article  CAS  PubMed  Google Scholar 

  2. Kim N, Lim SH, Lee KH, Choi SE, Jung HC, Song IS, et al. Long-term effects of Helicobacter pylori eradication on intestinal metaplasia in patients with duodenal and benign gastric ulcers. Dig Dis Sci. 2000;45:1754–62.

    Article  CAS  PubMed  Google Scholar 

  3. Annibale B, Aprile MR, D’Ambra G, Caruana P, Bordi C, Delle Fave G. Cure of Helicobacter pylori infection in atrophic body gastritis patients does not improve mucosal atrophy but reduces hypergastrinemia and its related effects on body ECL-cell hyperplasia. Aliment Pharmacol Ther. 2000;14:625–34.

    Article  CAS  PubMed  Google Scholar 

  4. Ohkusa T, Fujiki K, Takashimizu I, Kumagai J, Tanizawa T, Eishi Y, et al. Improvement in atrophic gastritis and intestinal metaplasia in patients in whom Helicobacter pylori was eradicated. Ann Intern Med. 2001;134:380–6.

    Article  CAS  PubMed  Google Scholar 

  5. Ruiz B, Garay J, Correa P, Fontham ET, Bravo JC, Bravo LE, et al. Morphometric evaluation of gastric antral atrophy: improvement after cure of Helicobacter pylori infection. Am J Gastroenterol. 2001;96:3281–7.

    Article  CAS  PubMed  Google Scholar 

  6. Ito M, Haruma K, Kamada T, Mihara M, Kim S, Kitadai Y, et al. Helicobacter pylori eradication therapy improves atrophic gastritis and intestinal metaplasia: a 5-year prospective study of patients with atrophic gastritis. Aliment Pharmacol Ther. 2002;16:1449–56.

    Article  CAS  PubMed  Google Scholar 

  7. Annibale B, Di Giulio E, Caruana P, Lahner E, Capurso G, Bordi C, et al. The long-term effects of cure of Helicobacter pylori infection on patients with atrophic body gastritis. Aliment Pharmacol Ther. 2002;16:1723–31.

    Article  CAS  PubMed  Google Scholar 

  8. Yamada T, Miwa H, Fujino T, Hirai S, Yokoyama T, Sato N. Improvement of gastric atrophy after Helicobacter pylori eradication therapy. J Clin Gastroenterol. 2003;36:405–10.

    Article  PubMed  Google Scholar 

  9. Iacopini F, Consolazio A, Bosco D, Marcheggiano A, Bella A, Pica R, et al. Oxidative damage of the gastric mucosa in Helicobacter pylori positive chronic atrophic and nonatrophic gastritis, before and after eradication. Helicobacter. 2003;8:503–12.

    Article  CAS  PubMed  Google Scholar 

  10. Kamada T, Haruma K, Hata J, Kusunoki H, Sasaki A, Ito M, et al. The long-term effect of Helicobacter pylori eradication therapy on symptoms in dyspeptic patients with fundic atrophic gastritis. Aliment Pharmacol Ther. 2003;18:245–52.

    Article  CAS  PubMed  Google Scholar 

  11. Wambura C, Aoyama N, Shirasaka D, Kuroda K, Maekawa S, Ebara S, et al. Influence of gastritis on cyclooxygenase-2 expression before and after eradication of Helicobacter pylori infection. Eur J Gastroenterol Hepatol. 2004;16:969–79.

    Article  CAS  PubMed  Google Scholar 

  12. Lahner E, Bordi C, Cattaruzza MS, Iannoni C, Milione M, Delle Fave G, et al. Long-term follow-up in atrophic body gastritis patients: atrophy and intestinal metaplasia are persistent lesions irrespective of Helicobacter pylori infection. Aliment Pharmacol Ther. 2005;22:471–81.

    Article  CAS  PubMed  Google Scholar 

  13. Lu B, Chen MT, Fan YH, Liu Y, Meng LN. Effects of Helicobacter pylori eradication on atrophic gastritis and intestinal metaplasia: a 3-year follow-up study. World J Gastroenterol. 2005;11:6518–20.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Kamada T, Hata J, Sugiu K, Kusunoki H, Ito M, Tanaka S, et al. Clinical features of gastric cancer discovered after successful eradication of Helicobacter pylori: results from a 9-year prospective follow-up study in Japan. Aliment Pharmacol Ther. 2005;21:1121–6.

    Article  CAS  PubMed  Google Scholar 

  15. Toyokawa T, Suwaki K, Miyake Y, Nakatsu M, Ando M. Eradication of Helicobacter pylori infection improved gastric mucosal atrophy and prevented progression of intestinal metaplasia, especially in the elderly population: a long-term prospective cohort study. J Gastroenterol Hepatol. 2010;25:544–7.

    Article  PubMed  Google Scholar 

  16. Park YH, Kim N. Review of atrophic gastritis and intestinal metaplasia as a premalignant lesion of gastric cancer. J Cancer Prev. 2015;20:25–40.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Mera R, Fontham ET, Bravo LE, Bravo JC, Piazuelo MB, Camargo MC, et al. Long term follow up of patients treated for Helicobacter pylori infection. Gut. 2005;54:1536–40.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Correa P, Fontham ET, Bravo JC, Bravo LE, Ruiz B, Zarama G, et al. Chemoprevention of gastric dysplasia: randomized trial of antioxidant supplements and anti-helicobacter pylori therapy. J Natl Cancer Inst. 2000;92:1881–8.

    Article  CAS  PubMed  Google Scholar 

  19. You WC, Brown LM, Zhang L, Li JY, Jin ML, Chang YS, et al. Randomized double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions. J Natl Cancer Inst. 2006;98:974–83.

    Article  PubMed  Google Scholar 

  20. Leung WK, Lin SR, Ching JY, To KF, Ng EK, Chan FK, et al. Factors predicting progression of gastric intestinal metaplasia: results of a randomised trial on Helicobacter pylori eradication. Gut. 2004;53:1244–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Lee YC, Chen TH, Chiu HM, Shun CT, Chiang H, Liu TY, et al. The benefit of mass eradication of Helicobacter pylori infection: a community-based study of gastric cancer prevention. Gut. 2013;62:676–82.

    Article  PubMed  Google Scholar 

  22. Wong BC, Lam SK, Wong WM, Chen JS, Zheng TT, Feng RE, et al. Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial. JAMA. 2004;291:187–94.

    Article  CAS  PubMed  Google Scholar 

  23. Shiotani A, Haruma K, Graham DY. Metachronous gastric cancer after successful Helicobacter pylori eradication. World J Gastroenterol. 2014;20:11552–9.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Asaka M. A new approach for elimination of gastric cancer deaths in Japan. Int J Cancer. 2013;132:1272–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Uemura N, Mukai T, Okamoto S, Yamaguchi S, Mashiba H, Taniyama K, et al. Effect of Helicobacter pylori eradication on subsequent development of cancer after endoscopic resection of early gastric cancer. Cancer Epidemiol Biomarkers Prev. 1997;6:639–42.

    CAS  PubMed  Google Scholar 

  26. Fukase K, Kato M, Kikuchi S, Inoue K, Uemura N, Okamoto S, et al. Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial. Lancet. 2008;372:392–7.

    Article  PubMed  Google Scholar 

  27. Maehata Y, Nakamura S, Fujisawa K, Esaki M, Moriyama T, Asano K, et al. Long-term effect of Helicobacter pylori eradication on the development of metachronous gastric cancer after endoscopic resection of early gastric cancer. Gastrointest Endosc. 2012;75:39–46.

    Article  PubMed  Google Scholar 

  28. Choi J, Kim SG, Yoon H, Im JP, Kim JS, Kim WH, et al. Eradication of Helicobacter pylori after endoscopic resection of gastric tumors does not reduce incidence of metachronous gastric carcinoma. Clin Gastroenterol Hepatol. 2014;12:793–800.

    Article  PubMed  Google Scholar 

  29. Rokkas T, Pistiolas D, Sechopoulos P, Robotis I, Margantinis G. The long-term impact of Helicobacter pylori eradication on gastric histology: a systematic review and meta-analysis. Helicobacter. 2007;12 Suppl 2:32–8.

    Article  PubMed  Google Scholar 

  30. Wang J, Xu L, Shi R, Huang X, Li SW, Huang Z, et al. Gastric atrophy and intestinal metaplasia before and after Helicobacter pylori eradication: a meta-analysis. Digestion. 2011;83:253–60.

    Article  PubMed  Google Scholar 

  31. Kong YJ, Yi HG, Dai JC, Wei MX. Histological changes of gastric mucosa after Helicobacter pylori eradication: a systematic review and meta-analysis. World J Gastroenterol. 2014;20:5903–11.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Dinis-Ribeiro M, Areia M, de Vries AC, Marcos-Pinto R, Monteiro-Soares M, O’Connor A, et al. Management of precancerous conditions and lesions in the stomach (MAPS): guideline from the European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter Study Group (EHSG), European Society of Pathology (ESP), and the Sociedade Portuguesa de Endoscopia Digestiva (SPED). Endoscopy. 2012;44:74–94.

    Article  CAS  PubMed  Google Scholar 

  33. Malfertheiner P, Megraud F, O’Morain CA, Atherton J, Axon AT, Bazzoli F, et al. Management of Helicobacter pylori infection – the Maastricht IV/Florence consensus report. Gut. 2012;61:646–64.

    Article  CAS  PubMed  Google Scholar 

  34. Kim SG, Jung H-K, Lee HL, Jang JY, Lee H, Kim CG, et al. Guidelines for the diagnosis and treatment of Helicobacter pylori infection in Korea, 2013 revised edition. Korean J Gastroenterol. 2013;62:3–26.

    Article  PubMed  Google Scholar 

  35. Chinese Society of Gastroenterology, Chinese Study Group on Helicobacter pylori, Liu WZ, Xie Y, Cheng H, Lu NH, Hu FL, et al. Fourth Chinese National Consensus Report on the management of Helicobacter pylori infection. J Dig Dis. 2013;14:211–21.

    Article  Google Scholar 

  36. Kuipers EJ. Review article: relationship between Helicobacter pylori, atrophic gastritis and gastric cancer. Aliment Pharmacol Ther. 1998;12 Suppl 1:25–36.

    Article  PubMed  Google Scholar 

  37. Lim JH, Kim N, Lee HS, Choe G, Jo SY, Chon I, et al. Correlation between endoscopic and histological diagnoses of gastric intestinal metaplasia. Gut Liver. 2013;7:41–50.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Lee SY. Current progress toward eradicating Helicobacter pylori in East Asian countries: differences in the 2013 revised guidelines between China, Japan, and South Korea. World J Gastroenterol. 2014;20:1493–502.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Take S, Mizuno M, Ishiki K, Yoshida T, Ohara N, Yokota K, et al. The long-term risk of gastric cancer after the successful eradication of Helicobacter pylori. J Gastroenterol. 2011;46:318–24.

    Article  PubMed  Google Scholar 

  40. Lee SY. Future candidates for indications of Helicobacter pylori eradication: do the indications need to be revised? J Gastroenterol Hepatol. 2012;27:200–11.

    Article  CAS  PubMed  Google Scholar 

  41. Lee SY. New guidelines for Helicobacter pylori treatment: comparisons between Korea and Japan. Korean J Gastroenterol. 2014;63:151–7.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro 173 beon-gil, Bundang-gu, Seongnam, Gyeonggi-do, 13620, South Korea

    Hyuk Yoon MD

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  1. Hyuk Yoon MD
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Correspondence to Hyuk Yoon MD .

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Editors and Affiliations

  1. Seoul National University, Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea (Republic of)

    Nayoung Kim

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© 2016 Springer Science+Business Media Singapore

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Yoon, H. (2016). Atrophic Gastritis and Intestinal Metaplasia. In: Kim, N. (eds) Helicobacter pylori. Springer, Singapore. https://doi.org/10.1007/978-981-287-706-2_52

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  • DOI: https://doi.org/10.1007/978-981-287-706-2_52

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-287-705-5

  • Online ISBN: 978-981-287-706-2

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