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Stem Cell Transplantation Therapy for Retinal Degenerative Diseases

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Stem Cell-based Therapy for Neurodegenerative Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1266))

Abstract

In the past decade, progress in the research on human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) has provided the solid basis to derive retinal pigment epithelium, photoreceptors, and ganglion cells from hESCs/iPSCs for transplantation therapy of retinal degenerative diseases (RDD). Recently, the iPSC-derived retinal pigment epithelium cells have achieved efficacy in treating patients with age-related macular degeneration (AMD). However, there is still much work to be done about the differentiation of hESCs/iPSCs into clinically required retinal cells and improvement in the methods to deliver the cells into the retina of patients. Here we will review the research advances in stem cell transplantation in animal studies and clinical trials as well as propose the challenges for improving the clinical efficacy and safety of hESCs/iPSCs-derived retinal neural cells in treating retinal degenerative diseases.

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Acknowledgments

This work was supported by National Natural Science Foundation of China (NSFC 81571241). We also thank Wei Wang, and Yanming Liu in our lab for technically editing the references and preparing figures of the manuscript.

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Authors and Affiliations

  1. The Institute for Translational Medicine, Shandong University/Affiliated Second Hospital, Jinan, Shandong, China

    Fabin Han

  2. The Institute for Tissue Engineering and Regenerative Medicine, Liaocheng University/Liaocheng People’s Hospital, Liaocheng, Shandong, China

    Fabin Han

  3. School of Medicine/Department of Ophthalmology, Tongji University, Shanghai, China

    Guotong Xu

  4. East China Stem Cell Bank/Tongji Stem Cell Bank, Tongji University School of Medicine, Shanghai, China

    Guotong Xu

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  1. Fabin Han
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Correspondence to Fabin Han .

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Editors and Affiliations

  1. The Second Affiliated Hospital, Shandong University, Jinan, Shandong, China

    Fabin Han

  2. School of Medicine, University of California at San Diego, La Jolla, CA, USA

    Pengzhe (Paul) Lu

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Han, F., Xu, G. (2020). Stem Cell Transplantation Therapy for Retinal Degenerative Diseases. In: Han, F., Lu, P.(. (eds) Stem Cell-based Therapy for Neurodegenerative Diseases. Advances in Experimental Medicine and Biology, vol 1266. Springer, Singapore. https://doi.org/10.1007/978-981-15-4370-8_9

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