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Diabetic Neuropathy and Clinical Practice pp 121–138Cite as

Sudomotor Dysfunction and Histopathology in Diabetic Neuropathy

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Abstract

Sudomotor dysfunction means the dysfunction of the sweat glands. It is often randomly patchy; sometimes the patches are really extensive. Diabetes is one of the frequent causes. Sweating is an important homeostatic mechanism for thermoregulation of the body. Internal visceral and superficial peripheral thermoreceptors form the two sensory inputs to determine sudomotor activity and vascular response of vasodilation or constriction of the arterial tree to achieve this. Up to 3.5 L of sweat can be produced per day depending on humidity, ambient temperature, age, inter- and intra-subject variability, sweat gland density, and gender.

Histopathological information provided here will help by giving a visual and quantitative idea of the structural components of the nerves, the intra-epidermal nerve fiber density, and the functional abnormalities much better. Corneal confocal microscopy (CCM) is also discussed in this chapter.

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Notes

  1. 1.

    It detects changes in electrodermal conductance following emotional responses in highly sensitive ways and is used as lie detector as well.

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  1. Independent Health Researcher, Pune, Maharashtra, India

    Sanjeev Kelkar

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Kelkar, S. (2020). Sudomotor Dysfunction and Histopathology in Diabetic Neuropathy. In: Diabetic Neuropathy and Clinical Practice. Springer, Singapore. https://doi.org/10.1007/978-981-15-2417-2_7

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