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Insulin and Diabetic Peripheral Nerve Pathologies

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Abstract

Brain and all other neural tissue consume glucose without assistance from insulin. Till about 2 decades ago, it was therefore assumed that insulin has little to do with cerebral/neural pathologies. However, there is a large body of highly beneficial evidence both in animal and human experiments of intricate nature and evidence from large trials. It is certain that for the preservation of the structure and for the preservation of its functions in an uninterrupted optimal manner of all neural tissues adequacy of insulin is an extremely important factor. This chapter highlights this importance in considerable detail, with reference to diabetic neuropathic afflictions in particular. This will or should increase the use of insulin as early, adequately and with understanding of the doctor and for the patients about the valuable positive impact of this wonderful drug on their neuropathic and overall well-being.

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Further Reading

  • He is also referred to the chapter on Physiology of Insulin in the author’s volume on – ‘Towards Optimal Management of Diabetes in Surgery,’ also published by SpringerNature.

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  • National Guidelines for Management of Diabetic Foot Diabetic Foot Society of India in November 2017.

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  • The reader is referred to this paper [66.Oki Thomas et al., see ref. below for an excellent expose of the physiology of insulin in normal and its changes after the development of diabetes.

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  • Towards ‘Optimal Management of Diabetes in Surgery’ published by Springer in August 2019.

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  • Van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R. Intensive Insulin Therapy in Critically Ill Patients. N Engl J Med. 2001;345:1359–67. https://doi.org/10.1056/NEJMoa011300.

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  1. Independent Health Researcher, Pune, Maharashtra, India

    Sanjeev Kelkar

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Kelkar, S. (2020). Insulin and Diabetic Peripheral Nerve Pathologies. In: Diabetic Neuropathy and Clinical Practice. Springer, Singapore. https://doi.org/10.1007/978-981-15-2417-2_13

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