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Alcoholic Liver Disease and Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis

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Book cover Diagnosis of Liver Disease

Abstract

Alcoholic liver disease (ALD) has been reported worldwide with a prevalence of 0–20% and remains one of the major causes of liver disease. The spectrum of ALD includes fatty liver, alcoholic hepatitis, alcoholic fibrosis, and cirrhosis. Hepatocellular carcinoma may also develop, especially in patients with cirrhosis. Histologically, ALD shows simple steatosis and steatohepatitis and eventually progresses to cirrhosis. These clinical and histological features overlap.

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References

  1. O’Shea RS, Dasarathy S, McCullough AJ, et al. AASLD practice Guildelines; alcoholic liver disease. Hepatology. 2010;51:307–28.

    Article  Google Scholar 

  2. Singal AK, Bataller R, Ahn J, et al. ACG clinical guideline: alcoholic liver disease. Am J Gastroenterol. 2018;113:175–94.

    Article  Google Scholar 

  3. European Association for the Study of the Liver. EASL clinical practical guidelines: management of alcoholic liver disease. J Hepatol. 2012;57:399–420.

    Article  Google Scholar 

  4. Nakano M, Worner TM, Lieber CS. Perivenular fibrosis in alcoholic liver injury: ultrastructural and histologic progression. Gastroenterology. 1982;83:777–85.

    CAS  PubMed  Google Scholar 

  5. Goodman ZD, Ishak KG. Occlusive venous lesions in alcoholic liver disease. A study of 200 cases. Gastroenterology. 1982;83:786–96.

    CAS  PubMed  Google Scholar 

  6. Jensen K, Gluud C. The Mallory body: morphological, clinical and experimental studies (part 1 of a literature survey). Hepatology. 1994;20:1061–77.

    Article  CAS  Google Scholar 

  7. Younossi ZM, Koenig AB, Abdelatif D, et al. Global epidemiology of nonalcoholic fatty liver disease—meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology. 2016;64:73–84.

    Article  Google Scholar 

  8. Sookoian S, Pirola CJ. Meta-analysis of the influence of I148M variant of Patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease. Hepatology. 2011;53:1883–94.

    Article  CAS  Google Scholar 

  9. Watanabe S, Hashimoto E, Ikejima K, et al. Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. J Gastroenterol. 2015;50:364–77.

    Article  Google Scholar 

  10. easloffice@easloffice.eu EAftSotLEEa, (EASD) EAftSoD, (EASO) EAftSoO. EASL-EASD-EASO clinical practice guidelines for the management of non-alcoholic fatty liver disease. J Hepatol. 2016;64:1388–402.

    Google Scholar 

  11. Wong VW, Chan WK, Hashimoto E, et al. The Asia-Pacific working party on nonalcoholic fatty liver disease guidelines 2017 part 1: definition, risk factors and assessment. J Gastroenterol Hepatol. 2018;33(1):70–85.

    Article  Google Scholar 

  12. Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and Management of Nonalcoholic Fatty Liver Disease: practice guidance from the American Association for the Study of Liver Diseases. Hepatology. 2017;67:328. https://doi.org/10.1002/hep.29367.

    Article  PubMed  Google Scholar 

  13. McPherson S, Hardy T, Henderson E, et al. Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: implications for prognosis and clinical management. J Hepatol. 2015;62:1148–55.

    Article  Google Scholar 

  14. Dufour JF. Time to abandon NASH? Hepatology. 2016;63:9–10.

    Article  Google Scholar 

  15. Ludwig J, Viggiano TR, McGill DB, et al. Nonalcoholic steatohepatitis. Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clinic proc. 1980;55:434–8.

    CAS  Google Scholar 

  16. Hashimoto E, Tokushige K, Ludwig J. Diagnosis and classification of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis: current concepts and remaining challenges. Hepatol Res. 2014:1–9.

    Google Scholar 

  17. Matteoni CA, Younossi ZM, Gramlich T, et al. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology. 1999;116:1413–9.

    Article  CAS  Google Scholar 

  18. Brunt EM, Janney CG, DiBisceglie AM, et al. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol. 1999;94:2467–74.

    Article  CAS  Google Scholar 

  19. Kleiner DE, Brunt EM, Van Natta M, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 2005;41:1313–21.

    Article  Google Scholar 

  20. Bedossa P, Poitou C, Veyrie N, et al. Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients. Hepatology. 2012;56:1751–9.

    Article  Google Scholar 

  21. Bedossa P. FLIP pathology consortium. Utility and appropriateness of the fatty liver inhibition of progression (FLIP) algorithm and steatosis, activity, and fibrosis (SAF) score in the evaluation of biopsies of nonalcoholic fatty liver disease. Hepatology. 2014;60:565–75.

    Article  CAS  Google Scholar 

  22. Angulo P, Kleiner DE, Dam-Larsen S, et al. Liver fibrosis, but no other histologic features is associated with long-term outcomes of patients with nonalcoholic fatty liver disease. Gastroenterology. 2015;149:389–97.

    Article  Google Scholar 

  23. Yatsuji S, Hashimoto E, Tobari M, Taniai M, Tokushige K, Shiratori K. Clinical features and outcomes of cirrhosis due to non-alcoholic steatohepatitis compared with cirrhosis caused by chronic hepatitis C. J Gastroenterol Hepatol. 2009;24:248–54.

    Article  CAS  Google Scholar 

  24. Ascha MS, Hanouneh IA, Lopez R, Tamimi TA, Feldstein AF, Zein NN. The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis. Hepatology. 2010;51:1972–8.

    Article  Google Scholar 

  25. Hashimoto E, Tokushige K. Hepatocellular carcinoma in non-alcoholic steatohepatitis: growing evidence of an epidemic? Hepatol Res. 2012;42:1–14.

    Article  Google Scholar 

  26. Hannah WN, Harrison SA. Noninvasive imaging methods to determine severity of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Hepatology. 2016;64:2234–43.

    Article  CAS  Google Scholar 

  27. Yoshioka Y, Hashimoto E, Yatsuji S, et al. Nonalcoholic steatohepatitis: cirrhosis, hepatocellular carcinoma, and burnt-out NASH. J Gastroenterol. 2004;39(12):1215–8.

    Article  Google Scholar 

  28. Suzuki D, Hashimoto E, Kaneda H, et al. Liver failure caused by non-alcoholic steatohepatitis in an obese young male. J Gastroenterol Hepatol. 2005;20:327–9.

    Article  Google Scholar 

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Acknowledgments

Prof. Paul Y. Kwo is acknowledged for his contribution in editing this chapter.

Author information

Authors and Affiliations

  1. Tokyo, Japan

    Etsuko Hashimoto MD, PhD

  2. Kyoto, Japan

    Masaki Iwai MD, PhD

  3. New Hampshire, USA

    Arief A. Suriawinata MD

Authors
  1. Etsuko Hashimoto MD, PhD
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  2. Masaki Iwai MD, PhD
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  3. Arief A. Suriawinata MD
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Corresponding author

Correspondence to Etsuko Hashimoto MD, PhD .

Editor information

Editors and Affiliations

  1. Department of Gastroenterology & Hepatology, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, Japan

    Etsuko Hashimoto

  2. Department of Gastroenterology/Hepatology, Stanford University School of Medicine, Palo Alto, CA, USA

    Paul Y. Kwo

  3. Department of Pathology and Laboratory Medicine, Dartmouth–Hitchcock Medical Center, Lebanon, NH, USA

    Arief A. Suriawinata

  4. Department of Pathology, Caritas Medical Center, Kowloon, Hong Kong, China

    Wilson M.S. Tsui

  5. Division of Gastroenterology, Hepatology & Internal Medicine, Iwai Clinic, Kamigyo-ku, Kyoto, Japan

    Masaki Iwai

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© 2019 Springer Nature Singapore Pte Ltd.

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Hashimoto, E., Iwai, M., Suriawinata, A.A. (2019). Alcoholic Liver Disease and Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis. In: Hashimoto, E., Kwo, P., Suriawinata, A., Tsui, W., Iwai, M. (eds) Diagnosis of Liver Disease. Springer, Singapore. https://doi.org/10.1007/978-981-13-6806-6_7

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  • DOI: https://doi.org/10.1007/978-981-13-6806-6_7

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-6805-9

  • Online ISBN: 978-981-13-6806-6

  • eBook Packages: MedicineMedicine (R0)

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