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Cutaneous Adverse Drug Reactions in Pediatric Population

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Book cover Advances in Diagnosis and Management of Cutaneous Adverse Drug Reactions

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Abstract

Cutaneous adverse drug reactions (CADR) are the most common drug reactions in the pediatric population. Several aspects of CADR and other rashes are more unique to children and impact the diagnosis and management of CADRs in this population. Such factors include different age groups, each with unique features, concurrent viral/bacterial illnesses which could be associated with an exanthem and age-specific pharmacokinetics. The proportional dominance of offending drug classes is different than in adults—anti-infectives make the majority, followed by antipyretics and antiepileptics. In this chapter, unique CADR features in the pediatric population are discussed, and a morphologic approach, based on simple and complex/severe eruptions, is suggested.

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Abbreviations

ADR:

Adverse drug reactions

AGEP:

Acute generalized exanthematous pustulosis

cADR:

Cutaneous adverse drug reactions

CPNDS:

Canadian pharmacogenomics network for drug safety

DIHS:

Drug-induced hypersensitivity syndrome

DRESS:

Drug reaction with eosinophilia and systemic symptoms

EM:

Erythema multiforme

GI:

Gastrointestinal

JIA:

Juvenile idiopathic arthritis

MIRM:

Mycoplasma-induced rash and mucositis

NICUs:

Neonatal intensive care units

NSAIDs:

Nonsteroidal anti-inflammatory drugs

SJS/TEN:

Stevens–Johnson syndrome/toxic epidermal necrolysis

SSLR:

Serum sickness-like reactions

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Author information

Authors and Affiliations

  1. Paediatric Dermatology, The Hospital of Sick Children, Toronto, ON, Canada

    Ilan Fridental

  2. Emergency Medicine, Clinical Pharmacology and Toxicology, The Hospital of Sick Children, Toronto, ON, Canada

    Yaron Finkelstein

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  1. Ilan Fridental
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  2. Yaron Finkelstein
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Correspondence to Yaron Finkelstein .

Editor information

Editors and Affiliations

  1. University of Toronto Medical School, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

    Neil H. Shear

  2. Department of Dermatology, Emek Medical Center, Afula, Israel

    Roni P. Dodiuk-Gad

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Fridental, I., Finkelstein, Y. (2019). Cutaneous Adverse Drug Reactions in Pediatric Population. In: Shear, N., Dodiuk-Gad, R. (eds) Advances in Diagnosis and Management of Cutaneous Adverse Drug Reactions. Adis, Singapore. https://doi.org/10.1007/978-981-13-1489-6_11

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  • DOI: https://doi.org/10.1007/978-981-13-1489-6_11

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  • Online ISBN: 978-981-13-1489-6

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