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Implantation Failure 1: Intrauterine Circumstances and Embryo–Endometrium Synchrony at Implantation

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Treatment Strategy for Unexplained Infertility and Recurrent Miscarriage

Abstract

The causes of recurrent implantation failure (RIF) include chronic endometritis, cesarean scar syndrome, and embryo–endometrial asynchrony at implantation such as impaired decidualization of the uterine endometrium. The gold standard treatments for chronic endometritis and cesarean scar syndrome are broad-spectrum antibiotics and hysteroscopic surgery, respectively. The optimal window of implantation (WOI) can be identified with an endometrial receptivity array or nucleolar channel system test. If optimal WOI is detected, the best strategy for patients with a history of RIF is frozen-warmed single-blastocyst transfer.

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References

  1. Johnston-MacAnanny EB, Hartnett J, Engmann LL, Nulsen JC, Sanders MM, Benadiva CA. Chronic endometritis is a frequent finding in women with recurrent implantation failure after in vitro fertilization. Fertil Steril. 2010;93:437–41.

    Article  PubMed  Google Scholar 

  2. Kitaya K, Tada Y, Taguchi S, Funabiki M, Hayashi T, Nakamura Y. Local mononuclear cell infiltrates in infertile patients with endometrial macropolyps versus micropolyps. Hum Reprod. 2012;27:3474–80.

    Article  CAS  PubMed  Google Scholar 

  3. Kitaya K, Matsubayashi H, Yamaguchi K, Nishiyama R, Takaya Y, Ishikawa T, Yasuo T, Yamada H. Chronic endometritis: potential cause of infertility and obstetric and neonatal complications. Am J Reprod Immunol. 2016;75:13–22.

    Article  PubMed  Google Scholar 

  4. Kushnir VA, Solouki S, Sarig-Meth T, Vega MG, Albertini DF, Darmon SK, Deligdisch L, Barad DH, Gleicher N. Systemic inflammation and autoimmunity in women with chronic endometritis. Am J Reprod Immunol. 2016;75:672–7.

    Article  CAS  PubMed  Google Scholar 

  5. McQueen DB, Perfetto CO, Hazard FK, Lathi RB. Pregnancy outcomes in women with chronic endometritis and recurrent pregnancy loss. Fertil Steril. 2015;104:927–31.

    Article  PubMed  Google Scholar 

  6. Cicinelli E, De Ziegler D, Nicoletti R, Colafiglio G, Saliani N, Resta L, Rizzi D, De Vito D. Chronic endometritis: correlation among hysteroscopic, histologic, and bacteriologic findings in a prospective trial with 2190 consecutive office hysteroscopies. Fertil Steril. 2008;89:677–84.

    Article  PubMed  Google Scholar 

  7. Cicinelli E, Resta L, Nicoletti R, Tartagni M, Marinaccio M, Bulletti C, Colafiglio G. Detection of chronic endometritis at fluid hysteroscopy. J Minim Invasive Gynecol. 2005;12:514–8.

    Article  PubMed  Google Scholar 

  8. Bouet PE, El Hachem H, Monceau E, Gariepy G, Kadoch IJ, Sylvestre C. Chronic endometritis in women with recurrent pregnancy loss and recurrent implantation failure: prevalence and role of office hysteroscopy and immunohistochemistry in diagnosis. Fertil Steril. 2016;105:106–10.

    Article  PubMed  Google Scholar 

  9. Kitaya K, Matsubayashi H, Takaya Y, Nishiyama R, Yamaguchi K, Takeuchi T, Ishikawa T. Live birth rate following oral antibiotic treatment for chronic endometritis in infertile women with repeated implantation failure. Am J Reprod Immunol. 2017;78(5). https://doi.org/10.1111/aji.12719.

    Article  CAS  Google Scholar 

  10. Cicinelli E, Matteo M, Tinelli R, Lepera A, Alfonso R, Indraccolo U, Marrocchella S, Greco P, Resta L. Prevalence of chronic endometritis in repeated unexplained implantation failure and the IVF success rate after antibiotic therapy. Hum Reprod. 2015;30:323–30.

    Article  PubMed  Google Scholar 

  11. Khan KN, Kitajima M, Hiraki K, Yamaguchi N, Katamine S, Matsuyama T, Nakashima M, Fujishita A, Ishimaru T, Masuzaki H. Escherichia coli contamination of menstrual blood and effect of bacterial endotoxin on endometriosis. Fertil Steril 2010;94:2860–3.e1–3.

    Article  CAS  Google Scholar 

  12. Khan KN, Fujishita A, Kitajima M, Hiraki K, Nakashima M, Masuzaki H. Intra-uterine microbial colonization and occurrence of endometritis in women with endometriosisdagger. Hum Reprod. 2014;29:2446–56.

    Article  CAS  PubMed  Google Scholar 

  13. Terao M, Koga K, Fujimoto A, Wada-Hiraike O, Osuga Y, Yano T, Kozuma S. Factors that predict poor clinical course among patients hospitalized with pelvic inflammatory disease. J Obstet Gynaecol Res. 2014;40:495–500.

    Article  CAS  PubMed  Google Scholar 

  14. Moreno I, Codoner FM, Vilella F, Valbuena D, Martinez-Blanch JF, Jimenez-Almazan J, Alonso R, Alama P, Remohi J, Pellicer A, Ramon D, Simon C. Evidence that the endometrial microbiota has an effect on implantation success or failure. Am J Obstet Gynecol. 2016;215:684–703.

    Article  PubMed  Google Scholar 

  15. LaSala AP, Berkeley AS. Primary cesarean section and subsequent fertility. Am J Obstet Gynecol. 1987;157:379–83.

    Article  CAS  PubMed  Google Scholar 

  16. Gubbini G, Centini G, Nascetti D, Marra E, Moncini I, Bruni L, Petraglia F, Florio P. Surgical hysteroscopic treatment of cesarean-induced isthmocele in restoring fertility: prospective study. J Minim Invasive Gynecol. 2011;18:234–7.

    Article  PubMed  Google Scholar 

  17. Tulandi T, Cohen A. Emerging manifestations of cesarean scar defect in reproductive-aged women. J Minim Invasive Gynecol. 2016;23:893–902.

    Article  PubMed  Google Scholar 

  18. Morris H. Surgical pathology of the lower uterine segment caesarean section scar: is the scar a source of clinical symptoms? Int J Gynecol Pathol. 1995;14:16–20.

    Article  CAS  PubMed  Google Scholar 

  19. Morris H. Caesarean scar syndrome. S Afr Med J. 1996;86:1558.

    PubMed  CAS  Google Scholar 

  20. Tower AM, Frishman GN. Cesarean scar defects: an underrecognized cause of abnormal uterine bleeding and other gynecologic complications. J Minim Invasive Gynecol. 2013;20:562–72.

    Article  PubMed  Google Scholar 

  21. Armstrong V, Hansen WF, Van Voorhis BJ, Syrop CH. Detection of cesarean scars by transvaginal ultrasound. Obstet Gynecol. 2003;101:61–5.

    PubMed  Google Scholar 

  22. Tanimura S, Funamoto H, Hosono T, Shitano Y, Nakashima M, Ametani Y, Nakano T. New diagnostic criteria and operative strategy for cesarean scar syndrome: endoscopic repair for secondary infertility caused by cesarean scar defect. J Obstet Gynaecol Res. 2015;41:1363–9.

    Article  PubMed  Google Scholar 

  23. Noyes RW, Haman JO. Accuracy of endometrial dating; correlation of endometrial dating with basal body temperature and menses. Fertil Steril. 1953;4:504–17.

    Article  CAS  PubMed  Google Scholar 

  24. Noyes RW, Hertig AT, Rock J. Dating the endometrial biopsy. Am J Obstet Gynecol. 1975;122:262–3.

    Article  CAS  PubMed  Google Scholar 

  25. Diaz-Gimeno P, Horcajadas JA, Martinez-Conejero JA, Esteban FJ, Alama P, Pellicer A, Simon C. A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature. Fertil Steril. 2011;95:50–60.

    Article  CAS  PubMed  Google Scholar 

  26. Garrido-Gomez T, Ruiz-Alonso M, Blesa D, Diaz-Gimeno P, Vilella F, Simon C. Profiling the gene signature of endometrial receptivity: clinical results. Fertil Steril. 2013;99:1078–85.

    Article  CAS  PubMed  Google Scholar 

  27. Guffanti E, Kittur N, Brodt ZN, Polotsky AJ, Kuokkanen SM, Heller DS, Young SL, Santoro N, Meier UT. Nuclear pore complex proteins mark the implantation window in human endometrium. J Cell Sci. 2008;121:2037–45.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Rybak EA, Szmyga MJ, Zapantis G, Rausch M, Beshay VE, Polotsky AJ, Coutifaris C, Carr BR, Santoro N, Meier UT. The nucleolar channel system reliably marks the midluteal endometrium regardless of fertility status: a fresh look at an old organelle. Fertil Steril. 2011;95:1385–9.e1.

    Article  CAS  PubMed  Google Scholar 

  29. Nejat EJ, Ruiz-Alonso M, Simon C, Meier UT. Timing the window of implantation by nucleolar channel system prevalence matches the accuracy of the endometrial receptivity array. Fertil Steril. 2014;102:1477–81.

    Article  PubMed  Google Scholar 

  30. Wu D, Kimura F, Zheng L, Ishida M, Niwa Y, Hirata K, Takebayashi A, Takashima A, Takahashi K, Kushima R, Zhang G, Murakami T. Chronic endometritis modifies decidualization in human endometrial stromal cells. Reprod Biol Endocrinol. 2017;15:16.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Roque M, Lattes K, Serra S, Sola I, Geber S, Carreras R, Checa MA. Fresh embryo transfer versus frozen embryo transfer in in vitro fertilization cycles: a systematic review and meta-analysis. Fertil Steril. 2013;99:156–62.

    Article  PubMed  Google Scholar 

  32. Horcajadas JA, Pellicer A, Simon C. Wide genomic analysis of human endometrial receptivity: new times, new opportunities. Hum Reprod Update. 2007;13:77–86.

    Article  CAS  PubMed  Google Scholar 

  33. Kolibianakis E, Bourgain C, Albano C, Osmanagaoglu K, Smitz J, Van Steirteghem A, Devroey P. Effect of ovarian stimulation with recombinant follicle-stimulating hormone, gonadotropin releasing hormone antagonists, and human chorionic gonadotropin on endometrial maturation on the day of oocyte pick-up. Fertil Steril. 2002;78:1025–9.

    Article  PubMed  Google Scholar 

  34. Dieamant FC, Petersen CG, Mauri AL, Comar V, Mattila M, Vagnini LD, Renzi A, Petersen B, Nicoletti A, Oliveira JBA, Baruffi RL, Franco JG Jr. Fresh embryos versus freeze-all embryos – transfer strategies: nuances of a meta-analysis. JBRA Assist Reprod. 2017;21:260–72.

    PubMed  PubMed Central  Google Scholar 

  35. Coates A, Kung A, Mounts E, Hesla J, Bankowski B, Barbieri E, Ata B, Cohen J, Munne S. Optimal euploid embryo transfer strategy, fresh versus frozen, after preimplantation genetic screening with next generation sequencing: a randomized controlled trial. Fertil Steril. 2017;107:723–30.e3.

    Article  PubMed  Google Scholar 

  36. Brosens JJ, Salker MS, Teklenburg G, Nautiyal J, Salter S, Lucas ES, Steel JH, Christian M, Chan Y-W, Boomsma CM, Moore JD, Hartshorne GM, Sucurovic S, Mulac-Jericevic B, Heijnen CJ, Quenby S, Koerkamp MJG, Holstege FCP, Shmygol A, Macklon NS. Uterine selection of human embryos at implantation. Sci Rep. 2014;4:3894.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Teklenburg G, Salker M, Molokhia M, Lavery S, Trew G, Aojanepong T, Mardon HJ, Lokugamage AU, Rai R, Landles C, Roelen BAJ, Quenby S, Kuijk EW, Kavelaars A, Heijnen CJ, Regan L, Brosens JJ, Macklon NS. Natural selection of human embryos: decidualizing endometrial stromal cells serve as sensors of embryo quality upon implantation. PLoS One. 2010;5:e10258.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Wintner EM, Hershko-Klement A, Tzadikevitch K, Ghetler Y, Gonen O, Wintner O, Shulman A, Wiser A. Does the transfer of a poor quality embryo together with a good quality embryo affect the In Vitro Fertilization (IVF) outcome? J Ovarian Res. 2017;10:2.

    Article  PubMed  PubMed Central  Google Scholar 

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Author information

Authors and Affiliations

  1. Center for Reproductive Medicine and Implantation Research, Sugiyama Clinic Shinjuku, Tokyo, Japan

    Keiji Kuroda

  2. Department of Obstetrics and Gynaecology, Faculty of Medicine, Juntendo University, Tokyo, Japan

    Keiji Kuroda & Satoko Yamashita

  3. Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Yufu-shi, Oita, Japan

    Satoko Yamashita

Authors
  1. Keiji Kuroda
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  2. Satoko Yamashita
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Corresponding author

Correspondence to Keiji Kuroda .

Editor information

Editors and Affiliations

  1. Center for Reproductive Medicine and Implantation Research, Sugiyama Clinic Shinjuku, Tokyo, Japan

    Keiji Kuroda

  2. Department of Obstetrics and Gynaecology, Faculty of Medicine, Juntendo University, Tokyo, Japan

    Jan J. Brosens

  3. The Division of Biomedical Sciences, Clinical Science Research Laboratories Warwick Medical School, Coventry, United Kingdom

    Siobhan Quenby

  4. Department of Obstetrics and Gynaecology, Juntendo University, Tokyo, Japan

    Satoru Takeda

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Kuroda, K., Yamashita, S. (2018). Implantation Failure 1: Intrauterine Circumstances and Embryo–Endometrium Synchrony at Implantation. In: Kuroda, K., Brosens, J., Quenby, S., Takeda, S. (eds) Treatment Strategy for Unexplained Infertility and Recurrent Miscarriage. Springer, Singapore. https://doi.org/10.1007/978-981-10-8690-8_4

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  • DOI: https://doi.org/10.1007/978-981-10-8690-8_4

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-8689-2

  • Online ISBN: 978-981-10-8690-8

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