Skip to main content

Plant-Derived Extracts and Compounds: An Alternative Therapy Against Breast Cancer

  • Chapter
  • First Online:

Abstract

Breast cancer is among the second overall cause for death in women. In 2012, 1.7 million new cases of breast cancer have been reported worldwide. Emerging modern cancer therapy advocates the usage of alternative natural sources for cure and prevention of breast cancer. Plant sources are most widely used for naturally derived anticancer agents. Plant crude extracts, plant-derived compounds, and secondary metabolites have shown anticancer healing or protective property. Thus, the aim of this chapter is to summarize the various plant sources having the potential to be used as an anti-breast cancer agent.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • ACS (2016) What is breast cancer. https://www.cancer.org/cancer/breast-cancer/about/what-is-breast-cancer.html. Accessed 20 Aug 2017

  • Arpornsuwan T, Punjanon T (2006) Tumor cell selective antiproliferative effect of the extract from Morinda citrifolia fruits. Phytother Res 20:515–517

    Article  PubMed  Google Scholar 

  • Baker VA, Hepburn PA, Kennedy SJ, Jones PA, Lea LJ, Sumpter JP, Ashby J (1999) Safety evaluation of phytosterol esters. Part 1. Assessment of oestrogenicity using a combination of in vivo and in vitro assays. Food Chem Toxicol 37:13–22

    Article  CAS  PubMed  Google Scholar 

  • Begg L, Kuller LH, Gutai JP, Caggiula AG, Wolmark N, Watson CG (1987) Endogenous sex hormone levels and breast cancer risk. Genet Epidemiol 4:233–247

    Article  CAS  PubMed  Google Scholar 

  • Boggs DA, Palmer JR, Stampfer MJ, Spiegelman D, Adams-Campbell LL, Rosenberg L (2010) Tea and coffee intake in relation to risk of breast cancer in the Black Women’s Health Study. Cancer Causes Control 21:1941–1948

    Article  PubMed  PubMed Central  Google Scholar 

  • Bora M, Lokhandwala A (2016) Mycorrhizal association: a safeguard for plant pathogen. In: Hakeem KR, Akhtar MS (eds) Plant, soil and microbes: volume 2: mechanisms and molecular interactions. Springer International Publishing, Cham, pp 253–275

    Google Scholar 

  • Brandi G, Schiavano GF, Zaffaroni N, De Marco C, Paiardini M, Cervasi B, Magnani M (2005) Mechanisms of action and antiproliferative properties of Brassica oleracea juice in human breast cancer cell lines. J Nutr 135:1503–1509

    Article  CAS  PubMed  Google Scholar 

  • Brusselbach S, Nettelbeck DM, Sedlacek HH, Muller R (1998) Cell cycle independent induction of apoptosis by the anti-tumor drug Flavopiridol in endothelial cells. Int J Cancer 77:146–152

    Article  CAS  PubMed  Google Scholar 

  • Carlson BA, Dubay MM, Sausville EA, Brizuela L, Worland PJ (1996) Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase CDK2 and CDK4 in human breast carcinoma cells. Cancer Res 56:2973–2978

    PubMed  CAS  Google Scholar 

  • Chang X, Firestone GL, Bjeldanes LF (2006) Inhibition of growth factor-induced Ras signaling in vascular endothelial cells and angiogenesis by 3,3′-diindolylmethane. Carcinogenesis 27:541–550

    Article  CAS  PubMed  Google Scholar 

  • Choi JA, Kim JY, Lee JY, Kang CM, Kwon HJ, Yoo YD, Kim TW, Lee YS, Lee SJ (2001) Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin. Int J Oncol 19:837–844

    PubMed  CAS  Google Scholar 

  • Correia JJ, Lobert S (2001) Physiochemical aspects of tubulin-interacting antimitotic drugs. Curr Pharm Des 7:1213–1228

    Article  CAS  PubMed  Google Scholar 

  • Cover CM, Hsieh SJ, Tran SH, Hallden G, Kim GS, Bjeldanes LF, Firestone GL (1998) Indole-3-carbinol inhibits the expression of cyclin-dependent kinase-6 and induces a G1 cell cycle arrest of human breast cancer cells independent of estrogen receptor signaling. J Biol Chem 273:3838–3847

    Article  CAS  PubMed  Google Scholar 

  • Cover CM, Hsieh SJ, Cram EJ, Hong C, Riby JE, Bjeldanes LF, Firestone GL (1999) Indole-3-carbinol and tamoxifen cooperate to arrest the cell cycle of MCF-7 human breast cancer cells. Cancer Res 59:1244–1251

    PubMed  CAS  Google Scholar 

  • Cragg GM, Newman DJ (2005) Plants as a source of anti-cancer agents. J Ethnopharmacol 100:72–79

    Article  CAS  PubMed  Google Scholar 

  • Das DK (1994) Naturally occurring flavonoids: structure, chemistry, and high-performance liquid chromatography methods for separation and characterization. Methods Enzymol 234:410–420

    Article  CAS  PubMed  Google Scholar 

  • Diaby V, Tawk R, Sanogo V, Xiao H, Montero AJ (2015) A review of systematic reviews of the cost-effectiveness of hormone therapy, chemotherapy, and targeted therapy for breast cancer. Breast Cancer Res Treat 151:27–40

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Disis ML, Park KH (2009) Immunomodulation of breast cancer via tumor antigen specific Th1. Cancer Res Treat 41:117–121

    Article  PubMed  PubMed Central  Google Scholar 

  • El-Sayed A, Cordell GA (1981) Catharanthus alkaloids. XXXIV. Catharanthamine, a new antitumor bisindole alkaloid from Catharanthus roseus. J Nat Prod 44:289–293

    Article  CAS  PubMed  Google Scholar 

  • El-Sayed A, Handy GA, Cordell GA (1983) Catharanthus alkaloids, XXXVIII. Confirming structural evidence and antineoplastic activity of the bisindole alkaloids leurosine-N′b-oxide (pleurosine), roseadine and vindolicine from Catharanthus roseus. J Nat Prod 46:517–527

    Article  CAS  PubMed  Google Scholar 

  • Fagherazzi G, Touillaud MS, Boutron-Ruault MC, Clavel-Chapelon F, Romieu I (2011) No association between coffee, tea or caffeine consumption and breast cancer risk in a prospective cohort study. Public Health Nutr 14:1315–1320

    Article  PubMed  Google Scholar 

  • Ferlini C, Ojima I, Distefano M, Gallo D, Riva A, Morazzoni P, Bombardelli E, Mancuso S, Scambia G (2003) Second generation taxanes: from the natural framework to the challenge of drug resistance. Curr Med Chem Anticancer Agents 3:133–138

    Article  CAS  PubMed  Google Scholar 

  • Finlay-Schultz J, Sartorius CA (2015) Steroid hormones, steroid receptors, and breast cancer stem cells. J Mammary Gland Biol Neoplasia 20:39–50

    Article  PubMed  PubMed Central  Google Scholar 

  • Fouche GEK, Kolesnikova N, Maharaj VJ, Nthambeleni R, van der Merwe M (2006) Investigation of South African plants for anticancer properties. Pharmacol Online 3:494–500

    Google Scholar 

  • Fouche G, Cragg GM, Pillay P, Kolesnikova N, Maharaj VJ, Senabe J (2008) In vitro anticancer screening of South African plants. J Ethnopharmacol 119:455–461

    Article  CAS  PubMed  Google Scholar 

  • Fuchs DA, Johnson RK (1978) Cytologic evidence that taxol, an antineoplastic agent from Taxus brevifolia, acts as a mitotic spindle poison. Cancer Treat Rep 62:1219–1222

    PubMed  CAS  Google Scholar 

  • Gallus S, Talamini R, Giacosa A, Montella M, Ramazzotti V, Franceschi S, Negri E, La Vecchia C (2005) Does an apple a day keep the oncologist away. Ann Oncol 16:1841–1844

    Article  CAS  PubMed  Google Scholar 

  • Ganmaa D, Willett WC, Li TY, Feskanich D, van Dam RM, Lopez-Garcia E, Hunter DJ, Holmes MD (2008) Coffee, tea, caffeine and risk of breast cancer: a 22-year follow-up. Int J Cancer 122:2071–2076

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gibellini L, Pinti M, Nasi M, Montagna JP, De Biasi S, Roat E, Bertoncelli L, Cooper EL, Cossarizza A (2011) Quercetin and cancer chemoprevention. Evid Based Complement Alternat Med 2011:591356. https://doi.org/10.1093/ecam/neq053

    Article  Google Scholar 

  • Grattan BJ Jr (2013) Plant sterols as anticancer nutrients: evidence for their role in breast cancer. Nutrients 5:359–387

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Grover S, Gudi S, Gandhi AK, Puri PM, Olson AC, Rodin D, Balogun O, Dhillon PK, Sharma DN, Rath GK, Shrivastava SK, Viswanathan AN, Mahantshetty U (2017) Radiation oncology in India: challenges and opportunities. Semin Radiat Oncol 27:158–163

    Article  PubMed  Google Scholar 

  • Guo Q, Cheng L, Liu Z (2010) Study on influence of arbuscular mycorrhizal fungi Pinellia ternata yield and chemical composition. Zhongguo Zhong Yao Za Zhi 35:333–338

    PubMed  Google Scholar 

  • Gutendorf B, Westendorf J (2001) Comparison of an array of in vitro assays for the assessment of the estrogenic potential of natural and synthetic estrogens, phytoestrogens and xenoestrogens. Toxicology 166:79–89

    Article  CAS  PubMed  Google Scholar 

  • Guthrie N, Carroll KK (1998) Inhibition of mammary cancer by citrus flavonoids. Adv Exp Med Biol 439:227–236

    Article  CAS  PubMed  Google Scholar 

  • Hakimuddin F, Paliyath G, Meckling K (2004) Selective cytotoxicity of a red grape wine flavonoid fraction against MCF-7 cells. Breast Cancer Res Treat 85:65–79

    Article  CAS  PubMed  Google Scholar 

  • Hakimuddin F, Paliyath G, Meckling K (2006) Treatment of mcf-7 breast cancer cells with a red grape wine polyphenol fraction results in disruption of calcium homeostasis and cell cycle arrest causing selective cytotoxicity. J Agric Food Chem 54:7912–7923

    Article  CAS  PubMed  Google Scholar 

  • Hankinson SE, Colditz GA, Willett WC (2004) Towards an integrated model for breast cancer etiology: the lifelong interplay of genes, lifestyle, and hormones. Breast Cancer Res 6:213–218

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • He X, Liu RH (2008) Phytochemicals of apple peels: isolation, structure elucidation, and their antiproliferative and antioxidant activities. J Agric Food Chem 56:9905–9910

    Article  CAS  PubMed  Google Scholar 

  • Heller W, Forkman G (1995) The flavonoids: advances in research since 1986. J Chem Educ 72:A73. https://doi.org/10.1021/ed072pA73.11

    Article  Google Scholar 

  • Himes RH (1991) Interactions of the Catharanthus (Vinca) alkaloids with tubulin and microtubules. Pharmacol Ther 51:257–267

    Article  CAS  PubMed  Google Scholar 

  • Hollman PC, van Trijp JM, Buysman MN, van der Gaag MS, Mengelers MJ, de Vries JH, Katan MB (1997) Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man. FEBS Lett 418:152–156

    Article  CAS  PubMed  Google Scholar 

  • Hong C, Firestone GL, Bjeldanes LF (2002a) Bcl-2 family-mediated apoptotic effects of 3,3′-diindolylmethane (DIM) in human breast cancer cells. Biochem Pharmacol 63:1085–1097

    Article  CAS  PubMed  Google Scholar 

  • Hong C, Kim HA, Firestone GL, Bjeldanes LF (2002b) 3,3′-Diindolylmethane (DIM) induces a G(1) cell cycle arrest in human breast cancer cells that is accompanied by Sp1-mediated activation of p21(WAF1/CIP1) expression. Carcinogenesis 23:1297–1305

    Article  CAS  PubMed  Google Scholar 

  • Ismail IS, Nagakura Y, Hirasawa Y, Hosoya T, Lazim MI, Lajis NH, Shiro M, Morita H (2009) Chrotacumines A-D, chromone alkaloids from Dysoxylum acutangulum. J Nat Prod 72:1879–1883

    Article  CAS  PubMed  Google Scholar 

  • Jeong JH, An JY, Kwon YT, Rhee JG, Lee YJ (2009) Effects of low dose quercetin: cancer cell-specific inhibition of cell cycle progression. J Cell Biochem 106:73–82

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jordan VC (2000) Progress in the prevention of breast cancer: concept to reality. J Steroid Biochem Mol Biol 74:269–277

    Article  CAS  PubMed  Google Scholar 

  • Jordan MA, Thrower D, Wilson L (1992) Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles. Implications for the role of microtubule dynamics in mitosis. J Cell Sci 102:401–416

    PubMed  CAS  Google Scholar 

  • Ju YH, Carlson KE, Sun J, Pathak D, Katzenellenbogen BS, Katzenellenbogen JA, Helferich WG (2000) Estrogenic effects of extracts from cabbage, fermented cabbage, and acidified brussels sprouts on growth and gene expression of estrogen-dependent human breast cancer (MCF-7) cells. J Agric Food Chem 48:4628–4634

    Article  CAS  PubMed  Google Scholar 

  • Kaileh M, Vanden Berghe W, Boone E, Essawi T, Haegeman G (2007) Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity. J Ethnopharmacol 113:510–516

    Article  PubMed  Google Scholar 

  • Kaur G, Stetler-Stevenson M, Sebers S, Worland P, Sedlacek H, Myers C, Czech J, Naik R, Sausville E (1992) Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275. J Natl Cancer Inst 84:1736–1740

    Article  CAS  PubMed  Google Scholar 

  • Kumar S, Pandey AK (2013) Chemistry and biological activities of flavonoids: an overview. Sci World J 2013:162750. https://doi.org/10.1155/2013/162750

    Article  CAS  Google Scholar 

  • Kuzumaki T, Kobayashi T, Ishikawa K (1998) Genistein induces p21(Cip1/WAF1) expression and blocks the G1 to S phase transition in mouse fibroblast and melanoma cells. Biochem Biophys Res Commun 251:291–295

    Article  CAS  PubMed  Google Scholar 

  • Larsson SC, Bergkvist L, Wolk A (2009) Coffee and black tea consumption and risk of breast cancer by estrogen and progesterone receptor status in a Swedish cohort. Cancer Causes Control 20:2039–2044

    Article  PubMed  Google Scholar 

  • Leveque D, Jehl F (1996) Clinical pharmacokinetics of vinorelbine. Clin Pharmacokinet 31:184–197

    Article  CAS  PubMed  Google Scholar 

  • Levitsky DO, Dembitsky VM (2014) Anti-breast cancer agents derived from plants. Nat Prod Bioprospect 5:1–16

    Article  CAS  PubMed Central  Google Scholar 

  • Li J, Seibold P, Chang-Claude J, Flesch-Janys D, Liu J, Czene K, Humphreys K, Hall P (2011) Coffee consumption modifies risk of estrogen-receptor negative breast cancer. Breast Cancer Res 13:R49. https://doi.org/10.1186/bcr2879

    Article  PubMed  PubMed Central  Google Scholar 

  • Li XJ, Ren ZJ, Qin JW, Zhao JH, Tang JH, Ji MH, JZ W (2013) Coffee consumption and risk of breast cancer: an up-to-date meta-analysis. PLoS One 8:e52681. https://doi.org/10.1371/journal.pone.0052681

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lingua G, Bona E, Manassero P, Marsano F, Todeschini V, Cantamessa S, Copetta A, D’Agostino G, Gamalero E, Berta G (2013) Arbuscular mycorrhizal fungi and plant growth-promoting pseudomonads increases anthocyanin concentration in strawberry fruits (Fragaria × ananassa var. Selva) in conditions of reduced fertilization. Int J Mol Sci 14:16207–16225

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liu RH, Liu J, Chen B (2005) Apples prevent mammary tumors in rats. J Agric Food Chem 53:2341–2343

    Article  CAS  PubMed  Google Scholar 

  • Lv X, Zhao S, Ning Z, Zeng H, Shu Y, Tao O, Xiao C, Lu C, Liu Y (2015) Citrus fruits as a treasure trove of active natural metabolites that potentially provide benefits for human health. Chem Cent J 9:68. https://doi.org/10.1186/s13065-015-0145-9

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Miliauskas G, Venskutonis PR, van Beek TA (2004) Screening of radical scavenging activity of some medicinal and aromatic plant extracts. Food Chem 85:231–237

    Article  CAS  Google Scholar 

  • Nakachi K, Suemasu K, Suga K, Takeo T, Imai K, Higashi Y (1998) Influence of drinking green tea on breast cancer malignancy among Japanese patients. Jpn J Cancer Res 89:254–261

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nakagawa H, Kiyozuka Y, Uemura Y, Senzaki H, Shikata N, Hioki K, Tsubura A (2001) Resveratrol inhibits human breast cancer cell growth and may mitigate the effect of linoleic acid, a potent breast cancer cell stimulator. J Cancer Res Clin Oncol 127:258–264

    Article  CAS  PubMed  Google Scholar 

  • Nifli AP, Kampa M, Alexaki VI, Notas G, Castanas E (2005) Polyphenol interaction with the T47D human breast cancer cell line. J Dairy Res 72:44–50

    Article  CAS  PubMed  Google Scholar 

  • Ogunleye AA, Xue F, Michels KB (2010) Green tea consumption and breast cancer risk or recurrence: a meta-analysis. Breast Cancer Res Treat 119:477–484

    Article  PubMed  Google Scholar 

  • Oh JK, Sandin S, Strom P, Lof M, Adami HO, Weiderpass E (2015) Prospective study of breast cancer in relation to coffee, tea and caffeine in Sweden. Int J Cancer 137:1979–1989

    Article  CAS  PubMed  Google Scholar 

  • Orhan H, Marol S, Hepsen IF, Sahin G (1999) Effects of some probable antioxidants on selenite-induced cataract formation and oxidative stress-related parameters in rats. Toxicology 139:219–232

    Article  CAS  PubMed  Google Scholar 

  • Osborne C, Wilson P, Tripathy D (2004) Oncogenes and tumor suppressor genes in breast cancer: potential diagnostic and therapeutic applications. Oncologist 9:361–377

    Article  CAS  PubMed  Google Scholar 

  • Oskoueian E, Abdullah N, Ahmad S, Saad WZ, Omar AR, Ho YW (2011) Bioactive compounds and biological activities of Jatropha curcas L. kernel meal extract. Int J Mol Sci 12:5955–5970

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Otaegui-Arrazola A, Menendez-Carreno M, Ansorena D, Astiasaran I (2010) Oxysterols: a world to explore. Food Chem Toxicol 48:3289–3303

    Article  CAS  PubMed  Google Scholar 

  • Parker BW, Kaur G, Nieves-Neira W, Taimi M, Kohlhagen G, Shimizu T, Losiewicz MD, Pommier Y, Sausville EA, Senderowicz AM (1998) Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol. Blood 91:458–465

    PubMed  CAS  Google Scholar 

  • Pezzuto JM (2008) Grapes and human health: a perspective. J Agric Food Chem 56:6777–6784

    Article  CAS  PubMed  Google Scholar 

  • Prasad DMR, Izam A, Khan MM (2012) Jatropha curcas: plant of medical benefits. J Med Plant Res 6:2691–2699

    Google Scholar 

  • Rice S, Whitehead SA (2006) Phytoestrogens and breast cancer-promoters or protectors. Endocr Relat Cancer 13:995–1015

    Article  CAS  PubMed  Google Scholar 

  • Roche Y, Gerbeau-Pissot P, Buhot B, Thomas D, Bonneau L, Gresti J, Mongrand S, Perrier-Cornet JM, Simon-Plas F (2008) Depletion of phytosterols from the plant plasma membrane provides evidence for disruption of lipid rafts. FASEB J 22:3980–3991

    Article  CAS  PubMed  Google Scholar 

  • Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC, Kotchen JM, Ockene J (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women’s health initiative randomized controlled trial. JAMA 288:321–333

    Article  CAS  PubMed  Google Scholar 

  • Russo M, Russo GL, Daglia M, Kasi PD, Ravi S, Nabavi SF, Nabavi SM (2016) Understanding genistein in cancer: the good and the bad effects: a review. Food Chem 196:589–600

    Article  CAS  PubMed  Google Scholar 

  • Safia KM, Jadiya P, Sheikh S, Haque E, Nazir A, Lakshmi V, Mir SS (2015) The chromone alkaloid, rohitukine, affords anticancer activity via modulating apoptosis pathways in A549 cell line and yeast mitogen activated protein kinase (MAPK) pathway. PLoS One 10:e0137991. https://doi.org/10.1371/journal.pone.0137991

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sartippour MR, Pietras R, Marquez-Garban DC, Chen HW, Heber D, Henning SM, Sartippour G, Zhang L, Lu M, Weinberg O, Rao JY, Brooks MN (2006) The combination of green tea and tamoxifen is effective against breast cancer. Carcinogenesis 27:2424–2433

    Article  CAS  PubMed  Google Scholar 

  • Schrump DS, Matthews W, Chen GA, Mixon A, Altorki NK (1998) Flavopiridol mediates cell cycle arrest and apoptosis in esophageal cancer cells. Clin Cancer Res 4:2885–2890

    PubMed  CAS  Google Scholar 

  • Sharma GN, Dave R, Sanadya J, Sharma P, Sharma KK (2010) Various types and management of breast cancer: an overview. J Adv Pharm Technol Res 1:109–126

    PubMed  PubMed Central  Google Scholar 

  • Sharma S, Dhamija HK, Parashar B (2012) Jatropha curcas: a review. Asian J Res Pharm Sci 2:107–111

    Google Scholar 

  • Shrubsole MJ, Lu W, Chen Z, Shu XO, Zheng Y, Dai Q, Cai Q, Gu K, Ruan ZX, Gao YT, Zheng W (2009) Drinking green tea modestly reduces breast cancer risk. J Nutr 139:310–316

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • So FV, Guthrie N, Chambers AF, Moussa M, Carroll KK (1996) Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices. Nutr Cancer 26:167–181

    Article  CAS  PubMed  Google Scholar 

  • Soares ACF, Martins MA, Mathias L, Freitas MSM (2005) Arbuscular mycorrhizal fungi and the occurrence of flavonoids in roots of passion fruit seedlings. Sci Agric 62:331–336

    Article  CAS  Google Scholar 

  • Srivastava S, Somasagara RR, Hegde M, Nishana M, Tadi SK, Srivastava M, Choudhary B, Raghavan SC (2016) Quercetin, a natural flavonoid interacts with DNA, arrests cell cycle and causes tumor regression by activating mitochondrial pathway of apoptosis. Sci Rep 6:24049. https://doi.org/10.1038/srep24049

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Sun CL, Yuan JM, Koh WP, Yu MC (2006) Green tea, black tea and breast cancer risk: a meta-analysis of epidemiological studies. Carcinogenesis 27:1310–1315

    Article  CAS  PubMed  Google Scholar 

  • Takada Y, Aggarwal BB (2004) Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9. J Biol Chem 279:4750–4759

    Article  CAS  PubMed  Google Scholar 

  • Tan AR, Swain SM (2002) Review of flavopiridol, a cyclin-dependent kinase inhibitor, as breast cancer therapy. Semin Oncol 29:77–85

    Article  CAS  PubMed  Google Scholar 

  • Tanaka T, Decuzzi P, Cristofanilli M, Sakamoto JH, Tasciotti E, Robertson FM, Ferrari M (2009) Nanotechnology for breast cancer therapy. Biomed Microdevices 11:49–63

    Article  CAS  PubMed  Google Scholar 

  • Touillaud MS, Pillow PC, Jakovljevic J, Bondy ML, Singletary SE, Li D, Chang S (2005) Effect of dietary intake of phytoestrogens on estrogen receptor status in premenopausal women with breast cancer. Nutr Cancer 51:162–169

    Article  CAS  PubMed  Google Scholar 

  • Treml J, Šmejkal K (2016) Flavonoids as potent scavengers of hydroxyl radicals. Comp Rev Food Sci Food Saf 15:720–738

    Article  CAS  Google Scholar 

  • Uche FI, Aprioku JS (2008) The Phytochemical constituents, analgesic and anti-inflammatory effects of methanol extract of Jatropha curcas leaves in mice and wister albino rats. J Appl Sci Environ Manag 12:22–102

    Google Scholar 

  • Vacca A, Iurlaro M, Ribatti D, Minischetti M, Nico B, Ria R, Pellegrino A, Dammacco F (1999) Antiangiogenesis is produced by nontoxic doses of vinblastine. Blood 94:4143–4155

    PubMed  CAS  Google Scholar 

  • Wall ME, Wani MC (1995) Camptothecin and taxol: discovery to clinic. Cancer Res 55:753–760

    PubMed  CAS  Google Scholar 

  • Wang JH, Liu XY (2003) Targeting strategies in cancer gene therapy. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 35:311–316

    PubMed  CAS  Google Scholar 

  • Wang MY, Jensen C, Su C (2005) Preventative effects of Morinda citrifolia on mammary breast cancer. Patents No. US20050037101 A1

    Google Scholar 

  • Wani MC, Taylor HL, Wall ME, Coggon P, McPhail AT (1971) Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc 93:2325–2327

    Google Scholar 

  • Weaver BA (2014) How Taxol/paclitaxel kills cancer cells. Mol Biol Cell 25:2677–2681

    Article  PubMed  PubMed Central  Google Scholar 

  • Yang J, Liu RH (2009) Synergistic effect of apple extracts and quercetin 3-beta-d-glucoside combination on antiproliferative activity in MCF-7 human breast cancer cells in vitro. J Agric Food Chem 57:8581–8586

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ami Lokhandwala .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Lokhandwala, A., Jain, J. (2018). Plant-Derived Extracts and Compounds: An Alternative Therapy Against Breast Cancer. In: Akhtar, M., Swamy, M. (eds) Anticancer Plants: Natural Products and Biotechnological Implements. Springer, Singapore. https://doi.org/10.1007/978-981-10-8064-7_19

Download citation

Publish with us

Policies and ethics