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Male Factor in Recurrent Pregnancy Loss

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Abstract

Recurrent pregnancy loss (RPL) is defined as two or more consecutive pregnancy losses. Evaluation of the female factors implicated in RPL is well established, but the significance of male factor contributing to RPL is an area less explored. Abnormal conventional semen analysis, abnormal sperm function tests, genetic aspects, sperm DNA damage, oxidative stress, and some other factors are thought to be contributory to RPL. This chapter aims to summarize various factors in the male partner of couples with RPL, their investigation and management. These factors still require validation, and as of now no guidelines have been established in this context.

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References

  1. Stirrat GM. Recurrent miscarriage. Lancet. 1990;336:673–5.

    Article  CAS  Google Scholar 

  2. American Society for Reproductive Medicine (ASRM). Recurrent pregnancy loss: patient fact sheet. 2008. http://www.asrm.org/Guidelines/.

  3. Alberman E. The epidemiology of repeated abortion. In: Beard RW, Sharp F, editors. Early pregnancy loss: mechanisms and treatment. New York: Springer; 1988. p. 9–17.

    Chapter  Google Scholar 

  4. Stephenson MD. Frequency of factors associated with habitual abortion in 197 couples. Fertil Steril. 1966;66:24–9.

    Google Scholar 

  5. Hill JA, Abbott AF, Politch JA. Sperm morphology and recurrent abortion. Fertil Steril. 1994;61(4):776–8.

    Article  CAS  Google Scholar 

  6. Wang R, Zhou H, Zhang Z, et al. The impact of semen quality, occupational exposure to environmental factors and lifestyle on recurrent pregnancy loss. J Assist Reprod Genet. 2013;30:1513–8.

    Article  Google Scholar 

  7. Saxena P, Misro MM, Roy S, Chopra K, Sinha D, Nandan D, Trivedi S. Possible role of male factors in recurrent pregnancy loss. Indian J Physiol Pharmacol. 2008;52(3):274–82.

    PubMed  Google Scholar 

  8. Buckett WM, Luckas MJ, Aird IA, et al. The hypo-osmotic swelling test in recurrent miscarriage. Fertil Steril. 1997;68:506–9.

    Article  CAS  Google Scholar 

  9. Gopalkrishnan K, Padwal V, Meherji PK. Poor quality of sperm as it affects repeated early pregnancy loss. Arch Androl. 2000;45(1):111–7.

    Article  CAS  Google Scholar 

  10. Vigodner M, Shrivastava V, Gutstein LE, Schneider J, Nieves E, Goldstein M, Feliciano M, Callaway M. Localization and identification of sumoylated proteins in human sperm: excessive sumoylation is a marker of defective spermatozoa. Hum Reprod. 2013;28(1):210–23.

    Article  CAS  Google Scholar 

  11. De Braekeler M, Dao TN. Cytogenetic studies in couples experiencing repeated pregnancy losses. Hum Reprod. 1990;5:519–28.

    Article  Google Scholar 

  12. Morel F, Roux C, Bresson JL. FISH analysis of chromosomal status of spermatozoa from three men with 45,XY,der(13;14)(9q10;q10) karyotype. Mol Hum Reprod. 2001;7:483–8.

    Article  CAS  Google Scholar 

  13. Fauth C, Bartels I, Haaf T, Speicher MR. Additional dark G-band in the p-arm of chromosome 19 due to a paracentric inversion with a breakpoint in the pericentromeric heterochromatin. Am J Med Genet. 2001;103:160–2.

    Article  CAS  Google Scholar 

  14. Kochhar PK, Ghosh P. Reproductive outcome of couples with recurrent miscarriage and balanced chromosomal abnormalities. J Obstet Gynaecol Res. 2013;39:113–20.

    Article  Google Scholar 

  15. Gonçalves RO, Santos WV, Sarno M, Cerqueira BA, et al. Chromosomal abnormalities in couples with recurrent first trimester abortions. Rev Bras Ginecol Obstet. 2014;36:113–7.

    Article  Google Scholar 

  16. Sugiura-Ogasawara M, Ozaki Y, Sato T, et al. Poor prognosis of recurrent aborters with either maternal or paternal reciprocal translocations. Fertil Steril. 2004;81:367–73.

    Article  Google Scholar 

  17. Carrell DT, Wilcox AL, Lowy L, et al. Elevated sperm aneuploidy and apoptosis in patients with unexplained recurrent pregnancy loss. Obstet Gynecol. 2003;101:1229–35.

    PubMed  Google Scholar 

  18. Aldrich CL, Stephenson MD, Karrison T, et al. HLA-G genotypes and pregnancy outcome in couples with unexplained recurrent miscarriage. Mol Hum Reprod. 2001;7:1167–72.

    Article  CAS  Google Scholar 

  19. Jivraj S, Rai R, Underwood J, Regan L. Genetic thrombophilic mutations among couples with recurrent miscarriage. Hum Reprod. 2006;21:1161–5.

    Article  CAS  Google Scholar 

  20. Ferlin A, Arredi B, Speltra E, Cazzadore C, Selice R, Garolla A, et al. Molecular and clinical characterization of Y chromosome microdeletions in infertile men: a 10-year experience in Italy. J Clin Endocrinol Metab. 2007;92:762–70.

    Article  CAS  Google Scholar 

  21. Agarwal S, Agarwal A, Khanna A, Singh K. Microdeletion of Y chromosome as a cause of recurrent pregnancy loss. J Hum Reprod Sci. 2015;8(3):159–64.

    Article  CAS  Google Scholar 

  22. Dewan S, Puscheck EE, Coulam CB, Wilcox AJ, Jeyendran RS. Y-chromosome microdeletions and recurrent pregnancy loss. Fertil Steril. 2006;85:441–5.

    Article  CAS  Google Scholar 

  23. Ghorbian S, Saliminejad K, Sadeghi MR, Javadi G. The association between Y chromosome microdeletion and recurrent pregnancy loss. Iran Red Crescent Med J. 2012;14(6):358–62.

    CAS  PubMed  PubMed Central  Google Scholar 

  24. Sakkas D, Alvarez JG. Sperm DNA fragmentation: mechanisms of origin, impact on reproductive outcome, and analysis. Fertil Steril. 2010;93:1027–36.

    Article  CAS  Google Scholar 

  25. Kleinhaus K, Perrin M, Friedlander Y, et al. Paternal age and spontaneous abortion. Obstet Gynecol. 2006;108:369–77.

    Article  CAS  Google Scholar 

  26. Kavitha P, Malini SS. Positive association of sperm dysfunction in the pathogenesis of recurrent pregnancy loss. J Clin Diagn Res. 2014;8(11):OC07–10.

    Google Scholar 

  27. Panton JA, Kilpatrick DC. Anti-cardiolipin antibodies in sexual partners of recurrent aborters. Hum Reprod. 1997;12(3):464–7.

    Article  CAS  Google Scholar 

  28. Hedin LW, Janson PO. Domestic violence during pregnancy: the prevalence of physical injuries, substance use, abortions and miscarriage. Acta Obstet Gynecol Scand. 2000;79:625–30.

    CAS  PubMed  Google Scholar 

  29. Kilpatrick DC, Bevan BH, Liston WA. Association between mannan binding protein deficiency and recurrent miscarriage. Hum Reprod. 1995;10:2501–5.

    Article  CAS  Google Scholar 

  30. WHO laboratory manual for the examination and processing of human semen. 5th ed. 2010.

    Google Scholar 

  31. Gopalkrishnan K, Padwal D, Balaiah V. Efficiency of routine semen analysis to predict functional and structural integrity of human spermatozoa. Indian J Exp Biol. 1995;33(9):652–4.

    CAS  PubMed  Google Scholar 

  32. Fernández JL, Muriel L, Goyanes V, Segrelles E, Gosálvez J, MaríaEnciso M, LaFromboise M, Jonge CD. Simple determination of human sperm DNA fragmentation with an improved sperm chromatin dispersion test. Fertil Steril. 2005;84:833–42.

    Article  Google Scholar 

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Correspondence to Ritu Khatuja .

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Khatuja, R., Chawla, L. (2018). Male Factor in Recurrent Pregnancy Loss. In: Mehta, S., Gupta, B. (eds) Recurrent Pregnancy Loss. Springer, Singapore. https://doi.org/10.1007/978-981-10-7338-0_11

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  • DOI: https://doi.org/10.1007/978-981-10-7338-0_11

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-7337-3

  • Online ISBN: 978-981-10-7338-0

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