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Non-alcoholic Fatty Liver Disease and the Effects of Bariatric Surgery

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Abstract

Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease in India and worldwide and is strongly linked to obesity and the metabolic syndrome. NAFLD is now recognized as the most common cause of cryptogenic cirrhosis [1]. The reported prevalence of NAFLD and Non-alcoholic steatohepatitis (NASH) is 10–30 % and 3–5 % respectively [2–6]. However in morbidly obese patients from bariatric surgery series the incidence of NAFLD is as high as 65–95 % and that of NASH is around 30–40 % [7–12].

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References

  1. Maheshwari A, Thuluvath PJ. Cryptogenic cirrhosis and NAFLD: are they related? Am J Gastroenterol. 2006;101(3):664–8.

    Article  PubMed  Google Scholar 

  2. Siraj P, Kohli N, Srivastava VK, Singh SK, Natu SM, Mehrotra R. Relationship of nonalcoholic fatty liver disease with anthropometric measurement among patients attending a tertiary care hospital of Northern India. Indian J Community Health. 2013;25(3):208–12.

    Google Scholar 

  3. Singh SP, Nayak S, Swain M, Rout N, Mallik RN, Agrawal O, et al. Prevalence of nonalcoholic fatty liver disease in coastal eastern India: a preliminary ultrasonographic survey. Trop Gastroenterol Off J Dig Dis Found. 2004;25(2):76–9.

    Google Scholar 

  4. Singh SP, Kar SK, Panigrahi MK, Misra B, Pattnaik K, Bhuyan P, et al. Profile of patients with incidentally detected nonalcoholic fatty liver disease (IDNAFLD) in coastal eastern India. Trop Gastroenterol Off J Dig Dis Found. 2013;34(3):144–52.

    Article  Google Scholar 

  5. Mohan V, Farooq S, Deepa M, Ravikumar R, Pitchumoni CS. Prevalence of non-alcoholic fatty liver disease in urban south Indians in relation to different grades of glucose intolerance and metabolic syndrome. Diabetes Res Clin Pract. 2009;84(1):84–91.

    Article  CAS  PubMed  Google Scholar 

  6. Amarapurkar D, Kamani P, Patel N, Gupte P, Kumar P, Agal S, et al. Prevalence of non-alcoholic fatty liver disease: population based study. Ann Hepatol. 2007;6(3):161–3.

    PubMed  Google Scholar 

  7. Dixon JB, Bhathal PS, O’Brien PE. Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology. 2001;121(1):91–100.

    Article  CAS  PubMed  Google Scholar 

  8. Beymer C, Kowdley KV, Larson A, Edmonson P, Dellinger EP, Flum DR. Prevalence and predictors of asymptomatic liver disease in patients undergoing gastric bypass surgery. Arch Surg. 2003;138(11):1240–4.

    Article  PubMed  Google Scholar 

  9. Gholam PM, Kotler DP, Flancbaum LJ. Liver pathology in morbidly obese patients undergoing Roux-en-Y gastric bypass surgery. Obes Surg. 2002;12(1):49–51.

    Article  PubMed  Google Scholar 

  10. Ong JP, Elariny H, Collantes R, Younoszai A, Chandhoke V, Reines HD, et al. Predictors of nonalcoholic steatohepatitis and advanced fibrosis in morbidly obese patients. Obes Surg. 2005;15(3):310–5.

    Article  PubMed  Google Scholar 

  11. Praveenraj P, Gomes RM, Kumar S, Karthikeyan P, Shankar A, Parthasarathi R, et al. Prevalence and predictors of non-alcoholic fatty liver disease in morbidly obese south Indian patients undergoing bariatric surgery. Obes Surg. 2015;25(11):2078–87.

    Article  PubMed  Google Scholar 

  12. Praveen Raj P, Gomes RM, Kumar S, Senthilnathan P, Karthikeyan P, Shankar A, et al. The effect of surgically induced weight loss on nonalcoholic fatty liver disease in morbidly obese Indians: “NASHOST” prospective observational trial. Surg Obes Relat Dis Off J Am Soc Bariatr Surg. 2015;11(6):1315–22.

    Article  CAS  Google Scholar 

  13. Chang Y, Ryu S, Sung E, Jang Y. Higher concentrations of alanine aminotransferase within the reference interval predict nonalcoholic fatty liver disease. Clin Chem. 2007;53(4):686–92.

    Article  CAS  PubMed  Google Scholar 

  14. Sumida Y, Nakajima A, Itoh Y. Limitations of liver biopsy and non-invasive diagnostic tests for the diagnosis of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. World J Gastroenterol. 2014;20(2):475–85.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Matsuzawa Y, Shimomura I, Nakamura T, Keno Y, Kotani K, Tokunaga K. Pathophysiology and pathogenesis of visceral fat obesity. Obes Res. 1995;3 Suppl 2:187S–94.

    Article  PubMed  Google Scholar 

  16. Yamashita S, Nakamura T, Shimomura I, Nishida M, Yoshida S, Kotani K, et al. Insulin resistance and body fat distribution. Diabetes Care. 1996;19(3):287–91.

    Article  CAS  PubMed  Google Scholar 

  17. Polyzos SA, Kountouras J, Zavos C. Nonalcoholic fatty liver disease: the pathogenetic roles of insulin resistance and adipocytokines. Curr Mol Med. 2009;9(3):299–314.

    Article  CAS  PubMed  Google Scholar 

  18. Day CP, James OF. Steatohepatitis: a tale of two “hits”? Gastroenterology. 1998;114(4):842–5.

    Article  CAS  PubMed  Google Scholar 

  19. Teli MR, James OF, Burt AD, Bennett MK, Day CP. The natural history of nonalcoholic fatty liver: a follow-up study. Hepatology. 1995;22(6):1714–9.

    Article  CAS  PubMed  Google Scholar 

  20. Sjöström L, Lindroos A-K, Peltonen M, Torgerson J, Bouchard C, Carlsson B, et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med. 2004;351(26):2683–93.

    Article  PubMed  Google Scholar 

  21. Mottin CC, Moretto M, Padoin AV, Kupski C, Swarowsky AM, Glock L, et al. Histological behavior of hepatic steatosis in morbidly obese patients after weight loss induced by bariatric surgery. Obes Surg. 2005;15(6):788–93.

    Article  PubMed  Google Scholar 

  22. Clark JM, Alkhuraishi ARA, Solga SF, Alli P, Diehl AM, Magnuson TH. Roux-en-Y gastric bypass improves liver histology in patients with non-alcoholic fatty liver disease. Obes Res. 2005;13(7):1180–6.

    Article  PubMed  Google Scholar 

  23. Mattar SG, Velcu LM, Rabinovitz M, Demetris AJ, Krasinskas AM, Barinas-Mitchell E, et al. Surgically-induced weight loss significantly improves nonalcoholic fatty liver disease and the metabolic syndrome. Ann Surg. 2005;242(4):610–7; discussion 618–20.

    PubMed  PubMed Central  Google Scholar 

  24. De Almeida SR, Rocha PRS, Sanches MD, Leite VHR, da Silva RAP, Diniz MTC, et al. Roux-en-Y gastric bypass improves the nonalcoholic steatohepatitis (NASH) of morbid obesity. Obes Surg. 2006;16(3):270–8.

    Article  PubMed  Google Scholar 

  25. Furuya CK, de Oliveira CPMS, de Mello ES, Faintuch J, Raskovski A, Matsuda M, et al. Effects of bariatric surgery on nonalcoholic fatty liver disease: preliminary findings after 2 years. J Gastroenterol Hepatol. 2007;22(4):510–4.

    Article  CAS  PubMed  Google Scholar 

  26. Weiner RA. Surgical treatment of non-alcoholic steatohepatitis and non-alcoholic fatty liver disease. Dig Dis Basel Switz. 2010;28(1):274–9.

    Article  CAS  Google Scholar 

  27. Barker KB, Palekar NA, Bowers SP, Goldberg JE, Pulcini JP, Harrison SA. Non-alcoholic steatohepatitis: effect of Roux-en-Y gastric bypass surgery. Am J Gastroenterol. 2006;101(2):368–73.

    Article  PubMed  Google Scholar 

  28. Silverman EM, Sapala JA, Appelman HD. Regression of hepatic steatosis in morbidly obese persons after gastric bypass. Am J Clin Pathol. 1995;104(1):23–31.

    Article  CAS  PubMed  Google Scholar 

  29. Csendes A, Smok G, Burgos AM. Histological findings in the liver before and after gastric bypass. Obes Surg. 2006;16(5):607–11.

    Article  PubMed  Google Scholar 

  30. Liu X, Lazenby AJ, Clements RH, Jhala N, Abrams GA. Resolution of nonalcoholic steatohepatits after gastric bypass surgery. Obes Surg. 2007;17(4):486–92.

    Article  PubMed  Google Scholar 

  31. Moretto M, Kupski C, da Silva VD, Padoin AV, Mottin CC. Effect of bariatric surgery on liver fibrosis. Obes Surg. 2012;22(7):1044–9.

    Article  PubMed  Google Scholar 

  32. Klein S, Mittendorfer B, Eagon JC, Patterson B, Grant L, Feirt N, et al. Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. Gastroenterology. 2006;130(6):1564–72.

    Article  CAS  PubMed  Google Scholar 

  33. Tai C-M, Huang C-K, Hwang J-C, Chiang H, Chang C-Y, Lee C-T, et al. Improvement of nonalcoholic fatty liver disease after bariatric surgery in morbidly obese Chinese patients. Obes Surg. 2012;22(7):1016–21.

    Article  PubMed  Google Scholar 

  34. Stratopoulos C, Papakonstantinou A, Terzis I, Spiliadi C, Dimitriades G, Komesidou V, et al. Changes in liver histology accompanying massive weight loss after gastroplasty for morbid obesity. Obes Surg. 2005;15(8):1154–60.

    Article  PubMed  Google Scholar 

  35. Dixon JB, Bhathal PS, Hughes NR, O’Brien PE. Nonalcoholic fatty liver disease: improvement in liver histological analysis with weight loss. Hepatology. 2004;39(6):1647–54.

    Article  PubMed  Google Scholar 

  36. Mathurin P, Hollebecque A, Arnalsteen L, Buob D, Leteurtre E, Caiazzo R, et al. Prospective study of the long-term effects of bariatric surgery on liver injury in patients without advanced disease. Gastroenterology. 2009;137(2):532–40.

    Article  CAS  PubMed  Google Scholar 

  37. Ranløv I, Hardt F. Regression of liver steatosis following gastroplasty or gastric bypass for morbid obesity. Digestion. 1990;47(4):208–14.

    Article  PubMed  Google Scholar 

  38. Luyckx FH, Desaive C, Thiry A, Dewé W, Scheen AJ, Gielen JE, et al. Liver abnormalities in severely obese subjects: effect of drastic weight loss after gastroplasty. Int J Obes Relat Metab Disord J Int Assoc Study Obes. 1998;22(3):222–6.

    Article  CAS  Google Scholar 

  39. Dixon JB, Bhathal PS, O’Brien PE. Weight loss and non-alcoholic fatty liver disease: falls in gamma-glutamyl transferase concentrations are associated with histologic improvement. Obes Surg. 2006;16(10):1278–86.

    Article  PubMed  Google Scholar 

  40. Jaskiewicz K, Raczynska S, Rzepko R, Sledziński Z. Nonalcoholic fatty liver disease treated by gastroplasty. Dig Dis Sci. 2006;51(1):21–6.

    Article  CAS  PubMed  Google Scholar 

  41. Keshishian A, Zahriya K, Willes EB. Duodenal switch has no detrimental effects on hepatic function and improves hepatic steatohepatitis after 6 months. Obes Surg. 2005;15(10):1418–23.

    Article  PubMed  Google Scholar 

  42. Kral JG, Thung SN, Biron S, Hould F-S, Lebel S, Marceau S, et al. Effects of surgical treatment of the metabolic syndrome on liver fibrosis and cirrhosis. Surgery. 2004;135(1):48–58.

    Article  PubMed  Google Scholar 

  43. Caiazzo R, Lassailly G, Leteurtre E, Baud G, Verkindt H, Raverdy V, et al. Roux-en-Y gastric bypass versus adjustable gastric banding to reduce nonalcoholic fatty liver disease: a 5-year controlled longitudinal study. Ann Surg. 2014;260(5):893–8; discussion 898–9.

    Article  PubMed  Google Scholar 

  44. Hafeez S, Ahmed MH. Bariatric surgery as potential treatment for nonalcoholic fatty liver disease: a future treatment by choice or by chance? J Obes. 2013;2013:839275.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Takata MC, Campos GM, Ciovica R, Rabl C, Rogers SJ, Cello JP, et al. Laparoscopic bariatric surgery improves candidacy in morbidly obese patients awaiting transplantation. Surg Obes Relat Dis Off J Am Soc Bariatr Surg. 2008;4(2):159–64; discussion 164–5.

    Article  Google Scholar 

  46. Shimizu H, Phuong V, Maia M, Kroh M, Chand B, Schauer PR, et al. Bariatric surgery in patients with liver cirrhosis. Surg Obes Relat Dis Off J Am Soc Bariatr Surg. 2013;9(1):1–6.

    Article  Google Scholar 

  47. Dallal RM, Mattar SG, Lord JL, Watson AR, Cottam DR, Eid GM, et al. Results of laparoscopic gastric bypass in patients with cirrhosis. Obes Surg. 2004;14(1):47–53.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Bariatric Division, Upper Gastrointestinal Surgery and Minimal Access Surgery Unit, GEM Hospital and Research Centre, Coimbatore, India

    Rachel Maria Gomes MS, FMAS & Praveen Raj Palanivelu MS, DNB, DNB (SGE), FALS, FMAS

Authors
  1. Rachel Maria Gomes MS, FMAS
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  2. Praveen Raj Palanivelu MS, DNB, DNB (SGE), FALS, FMAS
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Correspondence to Rachel Maria Gomes MS, FMAS .

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Editors and Affiliations

  1. Bariatric Division, Upper Gastrointestinal Surgery and Minimal Access Surgery Unit, GEM Hospital and Research Centre, Coimbatore, Tamil Nadu, India

    Saravana Kumar

  2. Bariatric Division, Upper Gastrointestinal Surgery and Minimal Access Surgery Unit, GEM Hospital and Research Centre, Coimbatore, Tamil Nadu, India

    Rachel Maria Gomes

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Gomes, R.M., Palanivelu, P.R. (2017). Non-alcoholic Fatty Liver Disease and the Effects of Bariatric Surgery. In: Kumar, S., Gomes, R. (eds) Bariatric Surgical Practice Guide. Springer, Singapore. https://doi.org/10.1007/978-981-10-2705-5_16

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  • DOI: https://doi.org/10.1007/978-981-10-2705-5_16

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