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Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment

  • Book
  • © 1997

Overview

Editors:
  1. Nick D. Hadjiliadis

    1. Laboratory of Inorganic and General Chemistry, Department of Chemistry, University of Ioannina, Ioannina, Greece

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Part of the book series: NATO Science Partnership Subseries: 2 (ASEN2, volume 26)

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Table of contents (39 chapters)

  1. Front Matter

    Pages i-xxiv
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  2. Metal Carcinogenesis

    1. Zinc Finger-DNA Interaction: Effect of Metal Replacement, Free Radical Generation and DNA Damage and its Relevance to Carcinogenesis

      • B. Sarkar
      Pages 1-14

    2. Pathways in the Chromium(VI)-Mediated Formation of DNA Lesions: A Review

      • A. Kortenkamp, M. Casadevall, P. Da Cruz Fresco, R. O. J. Shayer
      Pages 15-34

    3. Approaches to the Biological Monitoring of Chromium(VI) Exposed Individuals

      • A. Kortenkamp
      Pages 35-53

    4. The Mechanisms of Metal Carcinogenicity

      • Diane M. Stearns, Karen E. Wetterhahn
      Pages 55-72

    5. The Oxidative Damage Hypothesis of Metal-Induced Genotoxicity and Carcinogenesis

      • K. S. Kasprzak
      Pages 73-92

    6. Effects of Calcium, Magnesium, Zinc, and Iron on Nickel Carcinogenesis: Inhibition Versus Enhancement

      • K. S. Kasprzak
      Pages 93-106

    7. Modeling the Metal Binding Sites in Core Histones: Interactions of Carcinogenic Ni(II) with the -CAIH- Motif of Histone H3

      • W. Bal, K. S. Kasprzak
      Pages 107-121

    8. Perinatal Effects of Metals and Cancer in Offspring

      • M. A. Sipowicz, B. A. Diwan, D. Ramljak, G. S. Buzard, W. Yu, M. P. Waalkes et al.
      Pages 123-138

  4. Biological Role of Aluminium

    1. Aluminium(III) Speciation and Biological Effects

      • P. Zatta, P. Zambenedetti
      Pages 231-240

    2. Interaction of Al(III) with Biomolecules: Bioinorganic Chemistry and Biological Implication

      • Tamas Kiss, Andrea Lakatos, Erzsebet Kiss, R. Bruce Martin
      Pages 241-251

    3. Complexes of Aluminium(III) with Biologically Important Ligands

      • A. L. Petrou, M. Kollia, A.-I. Scourti, M. Chrycikopoulou, T. Mavromoystakos, E. Theodoropoulou et al.
      Pages 253-263

  6. Metal Transport

    1. Li+ Transport Properties in Perfused Neuronal Cells by 7Li NMR Spectroscopy

      • M. M. C. A. Castro, J. Nikolakopoulos, C. Zachariah, D. M. de Freitas, C. F. G. C. Geraldes, R. Ramasamy
      Pages 311-321

    2. Active Efflux Mechanisms for Cellular Resistance

      • A. Garnier-Suillerot
      Pages 323-347
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Keywords

About this book

Environmental pollution is one of the main problems to confront humanity, with the heavy metals occupying a leading role among the most pernicious pollutants. The metals cause cancer and other sicknesses. Their cytotoxic, mutagenic and carcinogenic potentials are not fully understood, and any thorough investigation demands the combined efforts of scientists drawn from many different disciplines. But the effects of heavy metals are not all negative: some, like cis-DDP, and some ruthenium and tin complexes, have antitumour activity.
The idea underlying the present work is therefore to present a multidisciplinary perspective on heavy metals in the environment, affording a better understanding of their action on human organisms and health, aiming to make them less polluting and more environmentally friendly.

Editors and Affiliations

  • Laboratory of Inorganic and General Chemistry, Department of Chemistry, University of Ioannina, Ioannina, Greece

    Nick D. Hadjiliadis

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