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Spinal Intramedullary Astrocytomas: Prognostic Factors

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Tumors of the Central Nervous System, Volume 10

Part of the book series: Tumors of the Central Nervous System ((TCNS,volume 10))

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Abstract

Intramedullary astrocytoma is one of the less common tumors of the central nervous system. The impact of prognostic factors on survival can play a major role in treatment planning and help in patient counseling; however conflicting conclusions are reported in the literature. We try to assess the importance of various patient-, tumor- and treatment- related factors on disease prognosis and patient survival. Particular attention is turned to the following: patient age, gender, history length, functional status, tumor location and extent, tumor associated cyst or syrinx presence, as well as tumor grade. Treatment strategies (resection extent and radiotherapy) are also evaluated.

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References

  • Abdel-Wahab M, Etuk B, Palermo J, Shirato H, Kresl J, Yapicier O, Walker G, Scheithauer BW, Shaw E, Lee C, Curran W, Thomas T, Markoe A (2006) Spinal cord gliomas: a multi-institutional retrospective analysis. Int J Radiat Oncol Biol Phys 64:1060–1071

    Article  PubMed  Google Scholar 

  • Benes V 3rd, Barsa P, Benes V Jr, Suchomel P (2009) Prognostic factors in intramedullary astrocytomas: a literature review. Eur Spine J 18:1397–1422

    Article  PubMed  Google Scholar 

  • Benes V 3rd, Bradac O, Ostry S, Buchvald P, Kramar F, Kaiser M, Suchomel P, Benes V Jr (2010) Intramedullary astrocytoma – A series of 15 patients and literature overview. Ceska Slov Neurol Neurochir 73:169–177

    Google Scholar 

  • Bouffet E, Pierre-Kahn A, Marchal JC, Jouvet A, Kalifa C, Choux M, Dhellemmes P, Guerin J, Tremoulet M, Mottolese C (1998) Prognostic factors in pediatric spinal cord astrocytoma. Cancer 83:2391–2399

    Article  PubMed  CAS  Google Scholar 

  • Brotchi J, Dewitte O, Levivier M, Baleriaux D, Vandesteene A, Raftopoulos C, Flament-Durand J, Noterman J (1991) A survey of 65 tumors within the spinal cord: surgical results and the importance of preoperative magnetic resonance imaging. Neurosurgery 29:651–656

    Article  PubMed  CAS  Google Scholar 

  • Constantini S, Miller DC, Allen JC, Rorke LB, Freed D, Epstein FJ (2000) Radical excision of intramedullary spinal cord tumors: surgical morbidity and long-term follow-up evaluation in 164 children and young adults. J Neurosurg 93:183–193

    Article  PubMed  CAS  Google Scholar 

  • Cristante L, Herrmann HD (1994) Surgical management of intramedullary spinal cord tumors: functional outcome and sources of morbidity. Neurosurgery 35:69–74

    Article  PubMed  CAS  Google Scholar 

  • Epstein FJ, Farmer JP, Freed D (1992) Adult intramedullary astrocytomas of the spinal cord. J Neurosurg 77:355–359

    Article  PubMed  CAS  Google Scholar 

  • Garces-Ambrossi GL, McGirt MJ, Mehta VA, Sciubba DM, Witham TF, Bydon A, Wolinksy JP, Jallo GI, Gokaslan ZL (2009) Factors associated with progression-free survival and long-term neurological outcome after resection of intramedullary spinal cord tumors: analysis of 101 consecutive cases. J Neurosurg Spine 11:591–599

    Article  PubMed  Google Scholar 

  • Garcia DM (1985) Primary spinal cord tumors treated with surgery and postoperative irradiation. Int J Radiat Oncol Biol Phys 11:1933–1939

    Article  PubMed  CAS  Google Scholar 

  • Helseth A, Mork SJ (1989) Primary intraspinal neoplasms in Norway, 1955 to 1986. A population-based survey of 467 patients. J Neurosurg 71:842–845

    Article  PubMed  CAS  Google Scholar 

  • Huddart R, Traish D, Ashley S, Moore A, Brada M (1993) Management of spinal astrocytoma with conservative surgery and radiotherapy. Br J Neurosurg 7:473–481

    Article  PubMed  CAS  Google Scholar 

  • Hulshof MC, Menten J, Dito JJ, Dreissen JJ, van den Bergh R, Gonzalez GD (1993) Treatment results in primary intraspinal gliomas. Radiother Oncol 29:294–300

    Article  PubMed  CAS  Google Scholar 

  • Innocenzi G, Raco A, Cantore G, Raimondi AJ (1996) Intramedullary astrocytomas and ependymomas in the pediatric age group: a retrospective study. Childs Nerv Syst 12:776–780

    Article  PubMed  CAS  Google Scholar 

  • Innocenzi G, Salvati M, Cervoni L, Delfini R, Cantore G (1997) Prognostic factors in intramedullary astrocytomas. Clin Neurol Neurosurg 99:1–5

    Article  PubMed  CAS  Google Scholar 

  • Jallo GI, Danish S, Velasquez L, Epstein F (2001) Intramedullary low-grade astrocytomas: long-term outcome following radical surgery. J Neurooncol 53:61–66

    Article  PubMed  CAS  Google Scholar 

  • Jyothirmayi R, Madhavan J, Nair MK, Rajan B (1997) Conservative surgery and radiotherapy in the treatment of spinal cord astrocytoma. J Neurooncol 33:205–211

    Article  PubMed  CAS  Google Scholar 

  • Karim AB, Afra D, Cornu P, Bleehan N, Schraub S, De Witte O, Darcel F, Stenning S, Pierart M, Van Glabbeke M (2002) Randomized trial on the efficacy of radiotherapy for cerebral low-grade glioma in the adult: European organization for research and treatment of cancer study 22845 with the medical research council study bro4: an interim analysis. Int J Radiat Oncol Biol Phys 52:316–324

    Article  PubMed  Google Scholar 

  • Kim MS, Chung CK, Choe G, Kim IH, Kim HJ (2001) Intramedullary spinal cord astrocytoma in adults: postoperative outcome. J Neurooncol 52:85–94

    Article  PubMed  CAS  Google Scholar 

  • Kopelson G, Linggood RM, Kleinman GM, Doucette J, Wang CC (1980) Management of intramedullary spinal cord tumors. Radiology 135:473–479

    PubMed  CAS  Google Scholar 

  • Lee HK, Chang EL, Fuller GN, Aldape KD, Atkinson GJ, Levy LB, McCutcheon IE, Maor MH (2003) The prognostic value of neurologic function in astrocytic spinal cord glioma. Neuro Oncol 5:208–213

    Article  PubMed  Google Scholar 

  • Marcus RB, Jr Million RR (1990) The incidence of myelitis after irradiation of the cervical spinal cord. Int J Radiat Oncol Biol Phys 19:3–8

    Article  PubMed  Google Scholar 

  • McGirt MJ, Goldstein IM, Chaichana KL, Tobias ME, Kothbauer KF, Jallo GI (2008) Extent of surgical resection of malignant astrocytomas of the spinal cord: outcome analysis of 35 patients. Neurosurgery 63:55–61

    Article  PubMed  Google Scholar 

  • Minehan KJ, Brown PD, Scheithauer BW, Krauss WE, Wright MP (2009) Prognosis and treatment of spinal cord astrocytoma. Int J Radiat Oncol Biol Phys 73:727–733

    Article  PubMed  Google Scholar 

  • Nakamura M, Chiba K, Ishii K, Ogawa Y, Takaishi H, Matsumoto M, Toyama Y (2006) Surgical outcomes of spinal cord astrocytomas. Spinal Cord 44:740–745

    Article  PubMed  CAS  Google Scholar 

  • O’Sullivan C, Jenkin RD, Doherty MA, Hoffman HJ, Greenberg ML (1994) Spinal cord tumors in children: long-term results of combined surgical and radiation treatment. J Neurosurg 81:507–512

    Article  PubMed  Google Scholar 

  • Przybylski GJ, Albright AL, Martinez AJ (1997) Spinal cord astrocytomas: long-term results comparing treatments in children. Childs Nerv Syst 13:375–382

    Article  PubMed  CAS  Google Scholar 

  • Raco A, Esposito V, Lenzi J, Piccirilli M, Delfini R, Cantore G (2005) Long-term follow-up of intramedullary spinal cord tumors: a series of 202 cases. Neurosurgery 56:972–981

    PubMed  Google Scholar 

  • Raco A, Piccirilli M, Landi A, Lenzi J, Delfini R, Cantore G (2010) High-grade intramedullary astrocytomas: 30 years’ experience at the Neurosurgery Department of the University of Rome “Sapienza”. J Neurosurg Spine 12:144–153

    Article  PubMed  Google Scholar 

  • Reimer R, Onofrio BM (1985) Astrocytomas of the spinal cord in children and adolescents. J Neurosurg 63:669–675

    Article  PubMed  CAS  Google Scholar 

  • Robinson CG, Prayson RA, Hahn JF, Kalfas IH, Whitfield MD, Lee SY, Suh JH (2005) Long-term survival and functional status of patients with low-grade astrocytoma of spinal cord. Int J Radiat Oncol Biol Phys 63:91–100

    Article  PubMed  Google Scholar 

  • Rodrigues GB, Waldron JN, Wong CS, Laperriere NJ (2000) A retrospective analysis of 52 cases of spinal cord glioma managed with radiation therapy. Int J Radiat Oncol Biol Phys 48:837–842

    Article  PubMed  CAS  Google Scholar 

  • Rossitch E Jr, Zeidman SM, Burger PC, Curnes JT, Harsh C, Anscher M, Oakes WJ (1990) Clinical and pathological analysis of spinal cord astrocytomas in children. Neurosurgery 27:193–196

    Article  PubMed  Google Scholar 

  • Sanai N, Berger MS (2008) Glioma extent of resection and its impact on patient outcome. Neurosurgery 62:753–766

    Article  PubMed  Google Scholar 

  • Sandler HM, Papadopoulos SM, Thornton AF Jr, Ross DA (1992) Spinal cord astrocytomas: results of therapy. Neurosurgery 30:490–493

    Article  PubMed  CAS  Google Scholar 

  • Santi M, Mena H, Wong K, Koeller K, Olsen C, Rushing EJ (2003) Spinal cord malignant astrocytomas. Clinicopathologic features in 36 cases. Cancer 98:554–561

    Article  PubMed  Google Scholar 

  • Slooff JL, Kernohan JW, MacCarty CS (1964) Primary intramedullary tumors of the spinal cord and filum terminale. WB Saunders Company, Philadelphia/London

    Google Scholar 

  • Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, Curschmann J, Janzer RC, Ludwin SK, Gorlia T, Allgeier A, Lacombe D, Cairncross JG, Eisenhauer E, Mirimanoff RO (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352:987–996

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Vladimír Beneš III .

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Beneš, V., Buchvald, P., Suchomel, P. (2013). Spinal Intramedullary Astrocytomas: Prognostic Factors. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 10. Tumors of the Central Nervous System, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5681-6_34

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  • DOI: https://doi.org/10.1007/978-94-007-5681-6_34

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