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Heart Rate Variability (HRV) and Sympathetic Nerve Activity

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Clinical Assessment of the Autonomic Nervous System

Abstract

The available epidemiological and clinical data implicate increased sympathetic nervous system activity in increased cardiovascular morbidity and mortality and show that it has strong predictive power for mortality and cardiovascular events. Analysis of heart rate variability (HRV) has been widely used as a noninvasive assessment tool for autonomic nervous system function, and results show that reduced and/or abnormal HRV is associated with an increased risk of mortality in cardiac patients such as patients after acute myocardial infarction and patients with congestive heart failure. However, most indices derived from HRV primarily reflect vagal function. In contrast, few indices have been suggested as markers of sympathetic nervous system activity. This chapter reviews characteristics of HRV that have been proposed as potential markers of cardiac sympathetic activity, such as (in the frequency domain) low-frequency (LF) power, short-term scaling exponent, and non-Gaussianity index. While there is no widely accepted and well-tested HRV-based index of cardiac sympathetic activity, we discuss the key issues for the assessment of cardiac sympathetic activity based on HRV analysis.

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Authors and Affiliations

  1. Division of Bioengineering, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka, 560-8531, Japan

    Ken Kiyono

  2. Department of Medical Education, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Aichi, Japan

    Junichiro Hayano

  3. Division of Cardiology, Department of Internal Medicine, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan

    Eiichi Watanabe

  4. Educational Physiology Laboratory, Graduate School of Education, University of Tokyo, Tokyo, Japan

    Yoshiharu Yamamoto

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  1. Ken Kiyono
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  2. Junichiro Hayano
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  3. Eiichi Watanabe
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  4. Yoshiharu Yamamoto
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Correspondence to Ken Kiyono .

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Editors and Affiliations

  1. Department of Phyisiology, Aichi Medical University, Nagakute, Aichi, Japan

    Satoshi Iwase

  2. Nagoya City University, Graduate School of Medical Science, Nagoya, Japan

    Junichiro Hayano

  3. Department of Neurology, Kanto Central Hospital, Tokyo, Tokyo, Japan

    Satoshi Orimo

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Kiyono, K., Hayano, J., Watanabe, E., Yamamoto, Y. (2017). Heart Rate Variability (HRV) and Sympathetic Nerve Activity. In: Iwase, S., Hayano, J., Orimo, S. (eds) Clinical Assessment of the Autonomic Nervous System. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56012-8_9

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