Skip to main content

Parkinson Symptoms in Dementia with Lewy Bodies

  • Chapter
  • First Online:

Abstract

Parkinsonism in dementia with Lewy bodies (DLB) is reviewed. Frequencies of tremor, wearing off, and dyskinesia seem to be lower than those of PD. This may in part due to older age of onset in DLB compared to PD. In addition, the presence of dementia and hallucination may make use of higher doses of levodopa difficult. This may result in lower frequencies of wearing off and dyskinesia. However, not many studies were done to compare parkinsonism in DLB and PD. We do not know how much of DLB patients are suffering from gait disturbance, retropulsion, freezing, falls, camptocormia, Pisa syndrome, drop head, drooling, dysphagia, small voice, micrographia, wearing off, dyskinesia, and so on. Among the non-motor spheres, data on autonomic disturbances, pain, olfaction, fatigue impulse control disorders, and dopamine dysregulation syndromes are spares. Further studies are necessary.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. McKeith IG, Dickson DW, Lowe J, et al. Consortium on DLB. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology. 2005;65:1863–72.

    Article  CAS  PubMed  Google Scholar 

  2. Matsui Y, Tanizaki Y, Arima H, et al. Incidence and survival of dementia in a general population of Japanese elderly: the Hisayama study. J Neurol Neurosurg Psychiatry. 2009;80:366–70.

    Article  CAS  PubMed  Google Scholar 

  3. Ikejima C, Hisanaga A, Meguro K, et al. Multicentre population-based dementia prevalence survey in Japan: a preliminary report. Psychogeriatrics. 2012;12:120–3.

    Article  PubMed  Google Scholar 

  4. Wada-Isoe K, Uemura Y, Nakashita S, et al. Prevalence of dementia and mild cognitive impairment in the rural island town of Ama-cho, Japan. Dement Geriatr Cogn Dis Extra. 2012;2:190–9.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Tola-Arribas MA, Yugueros MI, Garea MJ, et al. Prevalence of dementia and subtypes in Valladolid, northwestern Spain: the DEMINVALL study. PLoS One. 2013;8:e77688.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Farina E, Baglio F, Caffarra P, et al. Frequency and clinical features of Lewy body dementia in Italian memory clinics. Acta Biomed. 2009;80:57–64.

    PubMed  Google Scholar 

  7. Aarsland D, Rongve A, Nore SP, et al. Frequency and case identification of dementia with Lewy bodies using the revised consensus criteria. Dement Geriatr Cogn Disord. 2008;26:445–52.

    Article  PubMed  Google Scholar 

  8. Kobayashi K, Nakano H, Akiyama N, et al. Pure psychiatric presentation of the Lewy body disease is depression-an analysis of 60 cases verified with myocardial meta-iodobenzylguanidine study. Int J Geriatr Psychiatry. 2014. doi:10.1002/gps.4214.

    PubMed  Google Scholar 

  9. Hughes AJ, Daniel SE, Kilford L, et al. Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry. 1992;55:181–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Jankovic J, Schwartz KS, Ondo W. Re-emergent tremor of Parkinson’s disease. J Neurol Neurosurg Psychiatry. 1999;67:646–50.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Schäbitz WR, Glatz K, Schuhan C, et al. Severe forward flexion of the trunk in Parkinson’s disease: focal myopathy of the paraspinal muscles mimicking camptocormia. Mov Disord. 2003;18:408–14.

    Article  PubMed  Google Scholar 

  12. Azher SN, Jankovic J. Camptocormia: pathogenesis, classification, and response to therapy. Neurology. 2005;65:355–9.

    Article  PubMed  Google Scholar 

  13. Galati S, Möller JC, Städler C. Ropinirole-induced Pisa syndrome in Parkinson disease. Clin Neuropharmacol. 2014;37:58–9.

    Article  CAS  PubMed  Google Scholar 

  14. Chen W, Xiao Q, Shao M, et al. Prevalence of wearing-off and dyskinesia among the patients with Parkinson’s disease on levodopa therapy: a multi-center registry survey in mainland China. Transl Neurodegener. 2014;3:26.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Burn DJ, Rowan EN, Minett T, et al. Extrapyramidal features in Parkinson’s disease with and without dementia and dementia with Lewy bodies: a cross-sectional comparative study. Mov Disord. 2003;18:884–9.

    Article  PubMed  Google Scholar 

  16. Jankovic J, Kapadia AS. Functional decline in Parkinson disease. Arch Neurol. 2001;58:1611–5.

    Article  CAS  PubMed  Google Scholar 

  17. Burn DJ, Rowan EN, Allan LM, et al. Motor subtype and cognitive decline in Parkinson’s disease, Parkinson’s disease with dementia, and dementia with Lewy bodies. J Neurol Neurosurg Psychiatry. 2006;77:585–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Schrag A, Quinn N. Dyskinesias and motor fluctuations in Parkinson’s disease. A community-based study. Brain. 2000;123:2297–305.

    Article  PubMed  Google Scholar 

  19. Braak H, Del Tredici K, Rüb U, et al. Staging of brain pathology related to sporadic Parkinson’s disease. Neurobiol Aging. 2003;24:197–211.

    Article  PubMed  Google Scholar 

  20. Schenck CH, Bundlie SR, Mahowald MW. Delayed emergence of a Parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder. Neurology. 1996;46:388–93.

    Article  CAS  PubMed  Google Scholar 

  21. Ferman TJ, Boeve BF, Smith GE, et al. Inclusion of RBD improves the diagnostic classification of dementia with Lewy bodies. Neurology. 2011;77:875–82.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Murray ME, Ferman TJ, Boeve BF, et al. MRI and pathology of REM sleep behavior disorder in dementia with Lewy bodies. Neurology. 2013;81:1681–9.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Boeve BF, Silber MH, Saper CB, et al. Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease. Brain. 2007;130:2770–88.

    Article  CAS  PubMed  Google Scholar 

  24. Olsen EJ, Boeve BF, Silber MH. Rapid eye movement sleep behavior disorder: demographic, clinical and laboratory findings in 93 cases. Brain. 2000;123:331–9.

    Article  Google Scholar 

  25. Gagnon JF, Postuma RB, Mazza S, et al. Rapid-eye-movement sleep behaviour disorder and neurodegenerative diseases. Lancet Neurol. 2006;5:424–32.

    Article  PubMed  Google Scholar 

  26. Högl B, Kiechl S, Willeit J, et al. Restless legs syndrome: a community-based study of prevalence, severity, and risk factors. Neurology. 2005;64:1920–4.

    Article  PubMed  Google Scholar 

  27. Tan EK, Seah A, See SJ, et al. Restless legs syndrome in an Asian population: a study in Singapore. Mov Disord. 2001;16:577–9.

    Article  CAS  PubMed  Google Scholar 

  28. Nomura T, Inoue Y, Miyake M, et al. Prevalence and clinical characteristics of restless legs syndrome in Japanese patients with Parkinson’s disease. Mov Disord. 2006;21:380–4.

    Article  PubMed  Google Scholar 

  29. Paulus W, Trenkwalder C. Less is more: pathophysiology of dopaminergic- therapy-related augmentation in restless legs syndrome. Lancet Neurol. 2006;5:878–86.

    Article  CAS  PubMed  Google Scholar 

  30. Schmidauer C, Sojer M, Seppi K, et al. Transcranial ultrasound shows nigral hypoechogenicity in restless legs syndrome. Ann Neurol. 2005;58:630–4.

    Article  PubMed  Google Scholar 

  31. Trenkwalder C, Hening WA, Montagna P, et al. Treatment of restless legs syndrome: an evidence-based review and implications for clinical practice. Mov Disord. 2008;23:2267–302.

    Article  PubMed  Google Scholar 

  32. Guarnieri B, Adorni F, Musicco M, et al. Prevalence of sleep disturbances in mild cognitive impairment and dementing disorders: a multicenter Italian clinical cross-sectional study on 431 patients. Dement Geriatr Cogn Disord. 2012;33:50–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Verbaan D, van Rooden SM, Visser M, et al. Nighttime sleep problems and daytime sleepiness in Parkinson’s disease. Mov Disord. 2008;23:35–41.

    Article  PubMed  Google Scholar 

  34. Paus S, Brecht HM, Köster J, et al. Sleep attacks, daytime sleepiness, and dopamine agonists in Parkinson’s disease. Mov Disord. 2003;18:659–67.

    Article  PubMed  Google Scholar 

  35. Borroni B, Agosti C, Padovani A. Behavioral and psychological symptoms in dementia with Lewy-bodies (DLB): frequency and relationship with disease severity and motor impairment. Arch Gerontol Geriatr. 2008;46:101–6.

    Article  CAS  PubMed  Google Scholar 

  36. Hynninen MJ, Breitve MH, Rongve A, et al. The frequency and correlates of anxiety in patients with first-time diagnosed mild dementia. Int Psychogeriatr. 2012;24:1771–8.

    Article  PubMed  Google Scholar 

  37. Pluck GC, Brown RG. Apathy in Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2002;73:636–42.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Starkstein SE, Merello M, Jorge R, et al. The syndromal validity and nosological position of apathy in Parkinson’s disease. Mov Disord. 2009;24:1211–6.

    Article  PubMed  Google Scholar 

  39. Boesveldt S, Verbaan D, Knol DL, et al. A comparative study of odor identification and odor discrimination deficits in Parkinson’s disease. Mov Disord. 2008;23:1984–90.

    Article  PubMed  Google Scholar 

  40. Berendse HW, Roos DS, Raijmakers P, et al. Motor and non-motor correlates of olfactory dysfunction in Parkinson’s disease. J Neurol Sci. 2011;310:21–4.

    Article  PubMed  Google Scholar 

  41. Baba T, Kikuchi A, Hirayama K, et al. Severe olfactory dysfunction is a prodromal symptom of dementia associated with Parkinson’s disease: a 3 year longitudinal study. Brain. 2012;135:161–9.

    Article  PubMed  Google Scholar 

  42. Olichney JM, Murphy C, Hofstetter CR, et al. Anosmia is very common in the Lewy body variant of Alzheimer’s disease. J Neurol Neurosurg Psychiatry. 2005;76:1342–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Rana AQ, Saeed U, Sufian Masroor M, et al. A cross-sectional study investigating clinical predictors and physical experiences of pain in Parkinson’s disease. Funct Neurol. 2013;28:297–304.

    PubMed  Google Scholar 

  44. Kassubek J, Chaudhuri KR, Zesiewicz T, et al. Rotigotine transdermal system and evaluation of pain in patients with Parkinson’s disease: a post hoc analysis of the RECOVER study. BMC Neurol. 2014;14:42.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Cury RG, Galhardoni R, Fonoff ET, et al. Effects of deep brain stimulation on pain and other nonmotor symptoms in Parkinson disease. Neurology. 2014;83:1403–9.

    Article  PubMed  Google Scholar 

  46. Friedman JH, Brown RG, Comella C, et al. Fatigue in Parkinson’s disease: a review. Mov Disord. 2007;22:297–308.

    Article  PubMed  Google Scholar 

  47. Miwa H, Kondo T. Increased writing activity in Parkinson’s disease: a punding-like behavior? Parkinsonism Relat Disord. 2005;11:323–5.

    Article  PubMed  Google Scholar 

  48. Weintraub D, Siderowf AD, Potenza MN, et al. Association of dopamine agonist use with impulse control disorders in Parkinson disease. Arch Neurol. 2006;63:969–73.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Voon V, Hassan K, Zurowski M, et al. Prevalence of repetitive and reward-seeking behaviors in Parkinson disease. Neurology. 2006;67:1254–7.

    Article  CAS  PubMed  Google Scholar 

  50. Aarsland D, Andersen K, Larsen JP, et al. Prevalence and characteristics of dementia in Parkinson disease: an 8-year prospective study. Arch Neurol. 2003;60:387–92.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yoshikuni Mizuno .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer Japan KK

About this chapter

Cite this chapter

Mizuno, Y. (2017). Parkinson Symptoms in Dementia with Lewy Bodies. In: Kosaka, K. (eds) Dementia with Lewy Bodies. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55948-1_8

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-55948-1_8

  • Published:

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-55946-7

  • Online ISBN: 978-4-431-55948-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics