Abstract
In 1951 William Dameshek speculated that under certain conditions hematopoietic cells (precursors of erythrocytes, granulocytes, and platelets), as well as fibroblasts, proliferated “en masse” within the bone marrow in response to a myelostimulatory factor. This factor, said Dameshek, appeared also to activate dormant embryonal hematopoietic tissue in the liver and spleen. These processes resulted in a spectrum of clinicopathologic entities which Dameshek frred to as the myeloproliferative syndromes. The concept of myeloproliferative syndrome, which was well grounded in studies of hematopathology by earlier workers, has gained widespread acceptance, although more recent knowledge about hematopoiesis has necessitated certain modifications to the original hypothesis.
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Further Reading
Polycythemia Vera
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Iland, H.J., Laszlo, J. (1986). Myeloproliferative Disorders: Polycythemia Vera, Essential Thrombocythemia, and Idiopathic Myelofibrosis/Agnogenic Myeloid Metaplasia. In: Hoogstraten, B. (eds) Hematologic Malignancies. UICC Current Treatment of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82734-1_3
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DOI: https://doi.org/10.1007/978-3-642-82734-1_3
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