Skip to main content

Restricted Fetal Oxygen Supply: A Cause of Intrauterine Growth Retardation?

  • Conference paper

Abstract

This chapter focuses on the interaction between oxygen and/or substrate delivery and fetal growth. It begins with a brief review of experimental data dealing with chronic reductions in oxygen and substrate delivery. This information is then used to examine the premise that fetal growth is regulated by delivery of substrate and/or oxygen. The chapter concludes with discussion of a potential mechanism which may regulate the interaction.

This work was supported in part by the Harry W. Chandler Memorial Research Fund

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Alexander G, Hales JRS, Stevens D, Donnelly JB (1987) Effects of acute and prolonged exposure to heat on regional blood flows in pregnant sheep. J Dev Physiol 9: 1–15

    PubMed  CAS  Google Scholar 

  • Bell AW, Wilkening RB, Meschia G (1987) Some aspects of placental function in chronically heat stressed ewes. J Dev Physiol 9: 17–29

    PubMed  CAS  Google Scholar 

  • Charlton V, Johengen M (1987) Fetal intravenous nutritional supplementation ameliorates the development of embolization-induced growth retardation in sheep. Pediatr Res 22: 55–61

    Article  PubMed  CAS  Google Scholar 

  • Clapp JF (1989) Utero-placental blood flow and fetal growth. In: Sharp F, Fraser RB, Milner RDG (eds) Fetal growth. The Royal College of Obstetricians and Gynaecologists, London, p 235

    Google Scholar 

  • Clapp JF, Szeto HH, Larrow R, Hewitt J, Mann LI (1981) Fetal metabolic response to experimental placental vascular damage. Am J Obstet Gynecol 140: 446–451

    PubMed  Google Scholar 

  • Clapp JF, McLaughlin MK, Larrow R, Farnham J, Mann LI (1982 a) The uterine hemodynamic response to repetitive unilateral vascular embolization in the pregnant ewe. Am J Obstet Gynecol 82: 30%I –318

    Google Scholar 

  • Clapp JF, Auletta FJ, Farnham J, Larrow R, Mann LI (1982b) The ovine fetoplacental endocrine response to placental damage. Am J Obstet Gynecol 144: 47–54

    PubMed  CAS  Google Scholar 

  • Clark KE, Mack CE (1987) A new model of growth retardation — fetal growth is blood flow dependent. Proceedings of teh Society of Gynecol Invest (abstr no 137)

    Google Scholar 

  • Gilbert RD, Cummings LA, Juchau MR, Longo LD (1979) Placental diffusing capacity and fetal development in exercising or hypoxic guinea pigs. J Appl Physiol 46: 828–834

    PubMed  CAS  Google Scholar 

  • Jacobs R, Robinson JS, Owens JA, Falconer J, Webster MED (1988 a) The effect of prolonged hypobaric hypoxia on growth of fetal sheep. J Dev Physiol 10: 97–112

    PubMed  CAS  Google Scholar 

  • Jacobs R, Owens JA, Falconer J, Webster MED, Robinson JS (1988b) Changes to metabolite concentration in fetal sheep subjected to prolonged hypobaric hypoxia. J Dev Physiol 10: 113–121

    Google Scholar 

  • Jones CT (1985) Reprogramming of metabolic development by restriction of fetal growth. Biochem Soc Trans 13: 89–91

    PubMed  CAS  Google Scholar 

  • Jones CT, Lafeber HN, Price DA, Parer JT (1987) Studies on the growth of the fetal guinea pig. Effects of a reduction in uterine blood flow on plasma sulphation-promoting activity and on the concentration of insulin-like growth factors-I and -II. J Dev Physiol 9: 181–201

    PubMed  CAS  Google Scholar 

  • Kitanaka T, Gilbert RD, Longo LD (1989 a) Maternal responses to long-term hypoxemia in sheep. Am J Physiol 256: R1340–1347

    Google Scholar 

  • Kitanaka T, Alonso JG, Gilbert RD, Clemons GK, Longo LD (1989b) Fetal responses to long-term hypoxemia in sheep. Am J Physiol 256: R1348–1354

    PubMed  CAS  Google Scholar 

  • Lichty JA, Ting RY, Burns PD, Dyar E (1957) Studies of babies born at high altitude. I. Relation of altitude to birth weight. Am Med Assoc J Dis Child 93: 666–678

    CAS  Google Scholar 

  • Mellor D (1983) Nutritional and placental determinants of foetal growth rate in sheep and consequences for the newborn lamb. Br Vet J 139: 307–324

    PubMed  CAS  Google Scholar 

  • Morriss FH, Rosenfeld CR, Crandell SS, Adcock EW (1980) Effects of fasting on uterine blood flow and substrate uptake in sheep. J Nutr 110: 2433–2443

    PubMed  CAS  Google Scholar 

  • Owens JA, Falconer J, Robinson JS (1986) Effect of restriction of placental growth on umbilical and uterine blood flows. Am J Physiol 250: R427–434

    PubMed  CAS  Google Scholar 

  • Robinson JS, Falconer J, Owens JA (1985) Intrauterine growth retardation: clinical and experimental. Acta Paediatr Scand Suppl 319: 135–142

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Clapp, J.F. (1992). Restricted Fetal Oxygen Supply: A Cause of Intrauterine Growth Retardation?. In: Künzel, W., Kirschbaum, M. (eds) OXYGEN: Basis of the Regulation of Vital Functions in the Fetus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77469-0_29

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-77469-0_29

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77471-3

  • Online ISBN: 978-3-642-77469-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics