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Corynebacterium glutamicum pp 149–172Cite as

Biorefinery Applications of Corynebacterium glutamicum

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Part of the book series: Microbiology Monographs ((MICROMONO,volume 23))

Abstract

The biorefinery concept is an emerging concept for conducting industrial processes to manufacture a range of commodity chemicals, fuels, and energy from biomass-based feedstock. The current interest in implementing a biorefinery industry is largely derived by a combination of rising petroleum prices as well as the need to reduce greenhouse gas emissions and atmospheric CO2 levels to mitigate global warming. To date, Corynebacterium glutamicum-based technology has not been considered as the primary manufacturing platform for sustainable chemicals. Indeed, despite a long history of use for the industrial production of amino acids, C. glutamicum, as compared to Escherichia coli or Saccharomyces cerevisiae, has been scarcely studied and engineered to fit the needs of the lignocellulosic biorefinery. However, progress over the last decade in the understanding of its molecular physiology and metabolic engineering makes this microorganism an attractive option as a biorefinery biocatalyst. In addition, the development of a novel bioprocess using growth-arrested cells of C. glutamicum under oxygen deprivation constitutes a promise for biorefinery research and development. In this chapter, recent studies on the development of C. glutamicum as a commodity chemicals producer are reviewed and the key challenges that remain to overcome in order to deliver the full potential of this microbe to produce commodity chemicals are outlined.

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References

  • Akashi K, Ikeda S, Shibai H, Kobayashi K, Hirose Y (1978) Determination of redox potential levels critical for cell respiration and suitable for L-leucine production. Biotechnol Bioeng 20:27–41

    Article  PubMed  CAS  Google Scholar 

  • Akinterinwa O, Khankal R, Cirino PC (2008) Metabolic engineering for bioproduction of sugar alcohols. Curr Opin Biotechnol 19:461–467

    Article  PubMed  CAS  Google Scholar 

  • Alper H, Stephanopoulos G (2009) Engineering for biofuels: exploiting innate microbial capacity or importing biosynthetic potential? Nat Rev Microbiol 7:715–723

    Article  PubMed  CAS  Google Scholar 

  • Anderson AJ, Dawes EA (1990) Occurrence, metabolism, metabolic role, and industrial uses of bacterial polyhydroxyalkanoates. Microbiol Rev 54:450–472

    PubMed  CAS  Google Scholar 

  • Aristidou A, Penttilä M (2000) Metabolic engineering applications to renewable resource utilization. Curr Opin Biotechnol 11:187–198

    Article  PubMed  CAS  Google Scholar 

  • Atsumi S, Hanai T, Liao JC (2008) Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels. Nature 451:86–89

    Article  PubMed  CAS  Google Scholar 

  • Barrett E, Stanton C, Zelder O, Fitzgerald G, Ross RP (2004) Heterologous expression of lactose- and galactose-utilizing pathways from lactic acid bacteria in Corynebacterium glutamicum for production of lysine in whey. Appl Environ Microbiol 70:2861–2866

    Article  PubMed  CAS  Google Scholar 

  • Blombach B, Schreiner ME, Holátko J, Bartek T, Oldiges M, Eikmanns BJ (2007) L-valine production with pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum. Appl Environ Microbiol 73:2079–2084

    Article  PubMed  CAS  Google Scholar 

  • Blombach B, Riester T, Wieschalka S, Ziert C, Youn JW, Wendisch VF, Eikmanns BJ (2011) Corynebacterium glutamicum tailored for efficient isobutanol production. Appl Environ Microbiol 77:3300–3310

    Article  PubMed  CAS  Google Scholar 

  • Bozell JJ, Petersen GR (2010) Technology development for the production of biobased products from biorefinery carbohydrates―the US Department of Energy’s “Top 10” revisited. Green Chem 12:539–554

    Article  CAS  Google Scholar 

  • Buschke N, Schröder H, Wittmann C (2011) Metabolic engineering of Corynebacterium glutamicum for production of 1,5-diaminopentane from hemicellulose. Biotechnol J 6:306

    Article  PubMed  CAS  Google Scholar 

  • Cirino PC, Chin JW, Ingram LO (2006) Engineering Escherichia coli for xylitol production from glucose-xylose mixtures. Biotechnol Bioeng 95:1167–1176

    Article  PubMed  CAS  Google Scholar 

  • Collins M, Cummins C (1986) Genus Corynebacterium. In: Sneath PHA, Mair NS, Sharpe ME, Holt JG (Eds) Bergey's manual of systematic bacteriology, vol 2. Williams & Wilkins, Baltimore, pp 1266–1276.

    Google Scholar 

  • Dien BS, Cotta MA, Jeffries TW (2003) Bacteria engineered for fuel ethanol production: current status. Appl Microbiol Biotechnol 63:258–266

    Article  PubMed  CAS  Google Scholar 

  • Dominguez H, Nezondet C, Lindley ND, Cocaign M (1993) Modified carbon flux during oxygen limited growth of Corynebacterium glutamicum and the consequences for amino acid overproduction. Biotech Lett 15:449–454

    Article  CAS  Google Scholar 

  • Dominguez-Faus R, Powers SE, Burken JG, Alvarez PJ (2009) The water footprint of biofuels: a drink or drive issue? Environ Sci Technol 43:3005–3010

    Article  PubMed  CAS  Google Scholar 

  • Eggeling L, Bott M (2005) Handbook of Corynebacterium glutamicum. CRC, Boca Raton, FL

    Google Scholar 

  • Elander RT, Dale BE, Holtzapple M, Ladisch MR, Lee YY, Mitchinson C, Saddler JN, Wyman CE (2009) Summary of findings from the Biomass Refining Consortium for Applied Fundamentals and Innovation (CAFI): corn stover pretreatment. Cellulose 16:649–659

    Article  CAS  Google Scholar 

  • Geddes CC, Mullinnix MT, Nieves IU, Peterson JJ, Hoffman RW, York SW, Yomano LP, Miller EN, Shanmugam KT, Ingram LO (2011) Simplified process for ethanol production from sugarcane bagasse using hydrolysate-resistant Escherichia coli strain MM160. Bioresour Technol 102:2702–2711

    Article  PubMed  CAS  Google Scholar 

  • Gielen D (2008) Energy Technology Perspectives. Paris, International Energy Agency

    Google Scholar 

  • Hamana K, Matsuzaki S (1992) Polyamines as a chemotaxonomic marker in bacterial systematics. Crit Rev Microbiol 18:261–283

    Article  PubMed  CAS  Google Scholar 

  • Hansen AC, Kyritsis DC, Lee CF (2010) Characteristics of biofuels and renewable fuel standards. Blackwell, Oxford

    Google Scholar 

  • Hazelwood LA, Daran JM, van Maris AJ, Pronk JT, Dickinson JR (2008) The Ehrlich pathway for fusel alcohol production: a century of research on Saccharomyces cerevisiae metabolism. Appl Environ Microbiol 74:2259–2266

    Article  PubMed  CAS  Google Scholar 

  • Ikeda M (2003) Amino acid production processes. Adv Biochem Eng Biotechnol 79:1–35

    PubMed  CAS  Google Scholar 

  • Ikeda M, Nakagawa S (2003) The Corynebacterium glutamicum genome: features and impacts on biotechnological processes. Appl Microbiol Biotechnol 62:99–109

    Article  PubMed  CAS  Google Scholar 

  • Inui M, Kawaguchi H, Murakami S, Vertès AA, Yukawa H (2004a) Metabolic engineering of Corynebacterium glutamicum for fuel ethanol production under oxygen-deprivation conditions. J Mol Microbiol Biotechnol 8:243–254

    Article  PubMed  Google Scholar 

  • Inui M, Murakami S, Okino S, Kawaguchi H, Vertès AA, Yukawa H (2004b) Metabolic analysis of Corynebacterium glutamicum during lactate and succinate productions under oxygen deprivation conditions. J Mol Microbiol Biotechnol 7:182–196

    Article  PubMed  CAS  Google Scholar 

  • Inui M, Suda M, Okino S, Nonaka H, Puskas LG, Vertès AA, Yukawa H (2007) Transcriptional profiling of Corynebacterium glutamicum metabolism during organic acid production under oxygen deprivation conditions. Microbiology 153:2491–2504

    Article  PubMed  CAS  Google Scholar 

  • Inui M, Vertès AA, Yukawa H (2010) Advanced fermentation technologies. In: Vertès AA, Qureshi N, Blaschek HP, Yukawa H (eds) Biomass to biofuels: strategies for global industries. Wiley, New Jersey, pp 311–330

    Chapter  Google Scholar 

  • Jo SJ, Matsumoto K, Leong CR, Ooi T, Taguchi S (2007) Improvement of poly(3-hydroxybutyrate) [P(3HB)] production in Corynebacterium glutamicum by codon optimization, point mutation and gene dosage of P(3HB) biosynthetic genes. J Biosci Bioeng 104:457–463

    Article  PubMed  CAS  Google Scholar 

  • John RP, Nampoothiri KM, Pandey A (2007) Fermentative production of lactic acid from biomass: an overview on process developments and future perspectives. Appl Microbiol Biotechnol 74:524–534

    Article  PubMed  CAS  Google Scholar 

  • Jojima T, Omumasaba CA, Inui M, Yukawa H (2010) Sugar transporters in efficient utilization of mixed sugar substrates: current knowledge and outlook. Appl Microbiol Biotechnol 85:471–480

    Article  PubMed  CAS  Google Scholar 

  • Jordan N, Boody G, Broussard W, Glover JD, Keeney D, McCown BH, McIsaac G, Muller M, Murray H, Neal J, Pansing C, Turner RE, Warner K, Wyse D (2007) Environment. Sustainable development of the agricultural bio-economy. Science 316:1570–1571

    Article  PubMed  CAS  Google Scholar 

  • Kalinowski J, Bathe B, Bartels D, Bischoff N, Bott M, Burkovski A, Dusch N, Eggeling L, Eikmanns BJ, Gaigalat L, Goesmann A, Hartmann M, Huthmacher K, Krämer R, Linke B, McHardy AC, Meyer F, Möckel B, Pfefferle W, Puhler A, Rey DA, Ruckert C, Rupp O, Sahm H, Wendisch VF, Wiegräbe I, Tauch A (2003) The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins. J Biotechnol 104:5–25

    Article  PubMed  CAS  Google Scholar 

  • Kamm B, Kamm M (2004) Principles of biorefineries. Appl Microbiol Biotechnol 64:137–145

    Article  PubMed  CAS  Google Scholar 

  • Kamm B, Kamm M (2007) Biorefineries–multi product processes. Adv Biochem Eng Biotechnol 105:175–204

    PubMed  CAS  Google Scholar 

  • Katzen R, Schell DJ (2006) Lignocellulosic feedstock biorefinery: history and plant development for biomass hydrolysis. In: Kamm B, Gruber PR, Kamm M (eds) Biorefineries: industrial processes and products, vol 2. Wiley-VCH, Weinheim, pp 129–138

    Google Scholar 

  • Kawaguchi H, Vertès AA, Okino S, Inui M, Yukawa H (2006) Engineering of a xylose metabolic pathway in Corynebacterium glutamicum. Appl Environ Microbiol 72:3418–3428

    Article  PubMed  CAS  Google Scholar 

  • Kawaguchi H, Sasaki M, Vertès AA, Inui M, Yukawa H (2008) Engineering of an L-arabinose metabolic pathway in Corynebacterium glutamicum. Appl Microbiol Biotechnol 77:1053–1062

    Article  PubMed  CAS  Google Scholar 

  • Kawaguchi H, Sasaki M, Vertès AA, Inui M, Yukawa H (2009) Identification and functional analysis of the gene cluster for L-arabinose utilization in Corynebacterium glutamicum. Appl Environ Microbiol 75:3419–3429

    Article  PubMed  CAS  Google Scholar 

  • Kind S, Jeong WK, Schröder H, Wittmann C (2010a) Systems-wide metabolic pathway engineering in Corynebacterium glutamicum for bio-based production of diaminopentane. Metab Eng 12:341–351

    Article  PubMed  CAS  Google Scholar 

  • Kind S, Jeong WK, Schröder H, Zelder O, Wittmann C (2010b) Identification and elimination of the competing N-acetyldiaminopentane pathway for improved production of diaminopentane by Corynebacterium glutamicum. Appl Environ Microbiol 76:5175–5180

    Article  PubMed  CAS  Google Scholar 

  • Klinke HB, Thomsen AB, Ahring BK (2004) Inhibition of ethanol-producing yeast and bacteria by degradation products produced during pre-treatment of biomass. Appl Microbiol Biotechnol 66:10–26

    Article  PubMed  CAS  Google Scholar 

  • Kotrba P, Inui M, Yukawa H (2001) The ptsI gene encoding enzyme I of the phosphotransferase system of Corynebacterium glutamicum. Biochem Biophys Res Commun 289:1307–1313

    Article  PubMed  CAS  Google Scholar 

  • Kotrba P, Inui M, Yukawa H (2003) A single V317A or V317M substitution in Enzyme II of a newly identified beta-glucoside phosphotransferase and utilization system of Corynebacterium glutamicum R extends its specificity towards cellobiose. Microbiology 149:1569–1580

    Article  PubMed  CAS  Google Scholar 

  • Krause FS, Blombach B, Eikmanns BJ (2010) Metabolic engineering of Corynebacterium glutamicum for 2-ketoisovalerate production. Appl Environ Microbiol 76:8053–8061

    Article  PubMed  CAS  Google Scholar 

  • Leuchtenberger W, Huthmacher K, Drauz K (2005) Biotechnological production of amino acids and derivatives: current status and prospects. Appl Microbiol Biotechnol 69:1–8

    Article  PubMed  CAS  Google Scholar 

  • Liu S (2010) Conversion of biomass to ethanol by other organisms. In: Vertès AA, Qureshi N, Blaschek HP, Yukawa H (eds) Biomass to biofuels: strategies for global industries. Wiley, New Jersey, pp 293–310

    Chapter  Google Scholar 

  • Liu H, Xu Y, Zheng Z, Liu D (2010) 1,3-Propanediol and its copolymers: research, development and industrialization. Biotechnol J 5:1137–1148

    Article  PubMed  CAS  Google Scholar 

  • Madison LL, Huisman GW (1999) Metabolic engineering of poly(3-hydroxyalkanoates): from DNA to plastic. Microbiol Mol Biol Rev 63:21–53

    PubMed  CAS  Google Scholar 

  • McKinlay JB, Vieille C, Zeikus JG (2007) Prospects for a bio-based succinate industry. Appl Microbiol Biotechnol 76:727–740

    Article  PubMed  CAS  Google Scholar 

  • Miller EN, Turner PC, Jarboe LR, Ingram LO (2010) Genetic changes that increase 5-hydroxymethyl furfural resistance in ethanol-producing Escherichia coli LY180. Biotechnol Lett 32:661–667

    Article  PubMed  CAS  Google Scholar 

  • Mimitsuka T, Sawai H, Hatsu M, Yamada K (2007) Metabolic engineering of Corynebacterium glutamicum for cadaverine fermentation. Biosci Biotechnol Biochem 71:2130–2135

    Article  PubMed  CAS  Google Scholar 

  • Nigam P, Singh D (1995) Processes for fermentative production of xylitol – a sugar substitute. Process Biochem 30:117–124

    CAS  Google Scholar 

  • Nishimura T, Vertès AA, Shinoda Y, Inui M, Yukawa H (2007) Anaerobic growth of Corynebacterium glutamicum using nitrate as a terminal electron acceptor. Appl Microbiol Biotechnol 75:889–897

    Article  PubMed  CAS  Google Scholar 

  • Okino S, Inui M, Yukawa H (2005) Production of organic acids by Corynebacterium glutamicum under oxygen deprivation. Appl Microbiol Biotechnol 68:475–480

    Article  PubMed  CAS  Google Scholar 

  • Okino S, Noburyu R, Suda M, Jojima T, Inui M, Yukawa H (2008a) An efficient succinic acid production process in a metabolically engineered Corynebacterium glutamicum strain. Appl Microbiol Biotechnol 81:459–464

    Article  PubMed  CAS  Google Scholar 

  • Okino S, Suda M, Fujikura K, Inui M, Yukawa H (2008b) Production of D-lactic acid by Corynebacterium glutamicum under oxygen deprivation. Appl Microbiol Biotechnol 78:449–454

    Article  PubMed  CAS  Google Scholar 

  • Perlack RD, Wright LL, Turhollow AF, Graham RL, Stokes BJ, Erbach DC (2005) Biomass as feedstock for a biorefinery and bioproducts industry: the technical feasibility of a billion-ton annual supply. Oak Ridge National Lab report

    Google Scholar 

  • Petersson A, Almeida JR, Modig T, Karhumaa K, Hähn-Hagerdal B, Gorwa-Grauslund MF, Lidén G (2006) A 5-hydroxymethyl furfural reducing enzyme encoded by the Saccharomyces cerevisiae ADH6 gene conveys HMF tolerance. Yeast 23:455–464

    Article  PubMed  CAS  Google Scholar 

  • Pienkos PT, Zhang M (2009) Role of pretreatment and conditioning processes on toxicity of lignocellulosic biomass hydrolysates. Cellulose 16:743–762

    Article  CAS  Google Scholar 

  • Ragauskas AJ, Williams CK, Davison BH, Britovsek G, Cairney J, Eckert CA, Frederick WJ Jr, Hallett JP, Leak DJ, Liotta CL, Mielenz JR, Murphy R, Templer R, Tschaplinski T (2006) The path forward for biofuels and biomaterials. Science 311:484–489

    Article  PubMed  CAS  Google Scholar 

  • Rittmann D, Lindner SN, Wendisch VF (2008) Engineering of a glycerol utilization pathway for amino acid production by Corynebacterium glutamicum. Appl Environ Microbiol 74:6216–6222

    Article  PubMed  CAS  Google Scholar 

  • Sakai S, Tsuchida Y, Nakamoto H, Okino S, Ichihashi O, Kawaguchi H, Watanabe T, Inui M, Yukawa H (2007) Effect of lignocellulose-derived inhibitors on growth of and ethanol production by growth-arrested Corynebacterium glutamicum R. Appl Environ Microbiol 73:2349–2353

    Article  PubMed  CAS  Google Scholar 

  • Sasaki M, Jojima T, Inui M, Yukawa H (2008) Simultaneous utilization of D-cellobiose, D-glucose, and D-xylose by recombinant Corynebacterium glutamicum under oxygen-deprived conditions. Appl Microbiol Biotechnol 81:691–699

    Article  PubMed  CAS  Google Scholar 

  • Sasaki M, Jojima T, Kawaguchi H, Inui M, Yukawa H (2009) Engineering of pentose transport in Corynebacterium glutamicum to improve simultaneous utilization of mixed sugars. Appl Microbiol Biotechnol 85:105–115

    Article  PubMed  CAS  Google Scholar 

  • Sasaki M, Jojima T, Inoue T, Yukawa H (2010) Xylitol production by recombinant Corynebacterium glutamicum under oxygen deprivation. Appl Microbiol Biotechnol 86:1057–1066

    Article  PubMed  CAS  Google Scholar 

  • Scharlemann JP, Laurance WF (2008) How green are biofuels? Science 319:43–44

    Article  PubMed  CAS  Google Scholar 

  • Schmidt FR (2005) Optimization and scale up of industrial fermentation processes. Appl Microbiol Biotechnol 68:425–435

    Article  PubMed  CAS  Google Scholar 

  • Schneider J, Wendisch VF (2010) Putrescine production by engineered Corynebacterium glutamicum. Appl Microbiol Biotechnol 88:859–868

    Article  PubMed  CAS  Google Scholar 

  • Schneider J, Niermann K, Wendisch VF (2011) Production of the amino acids l-glutamate, l-lysine, l-ornithine and l-arginine from arabinose by recombinant Corynebacterium glutamicum. J Biotechnol 154(2–3):191–198

    Article  PubMed  CAS  Google Scholar 

  • Smith KM, Cho KM, Liao JC (2010) Engineering Corynebacterium glutamicum for isobutanol production. Appl Microbiol Biotechnol 87:1045–1055

    Article  PubMed  CAS  Google Scholar 

  • Steinbüchel A, Lütke-Eversloh T (2003) Metabolic engineering and pathway construction for biotechnological production of relevant polyhydroxyalkanoates in microorganisms. Biochem Eng J 16:81–96

    Article  Google Scholar 

  • Suzuki N, Inui M, Yukawa H (2008) Random genome deletion methods applicable to prokaryotes. Appl Microbiol Biotechnol 79:519–526

    Article  PubMed  CAS  Google Scholar 

  • Takeno S, Ohnishi J, Komatsu T, Masaki T, Sen K, Ikeda M (2007) Anaerobic growth and potential for amino acid production by nitrate respiration in Corynebacterium glutamicum. Appl Microbiol Biotechnol 75:1173–1182

    Article  PubMed  CAS  Google Scholar 

  • Tateno T, Okada Y, Tsuchidate T, Tanaka T, Fukuda H, Kondo A (2009) Direct production of cadaverine from soluble starch using Corynebacterium glutamicum coexpressing α-amylase and lysine decarboxylase. Appl Microbiol Biotechnol 82:115–121

    Article  PubMed  CAS  Google Scholar 

  • Terasawa M, Yukawa H (1993) Industrial production of biochemicals by native immobilization. In: Tanaka A, Tosa T, Kobayashi T (eds) Industrial application of immobilized biocatalysts. Marcel Dekker, New York, pp 25–36

    Google Scholar 

  • Terasawa M, Yukawa H, Takayama Y (1985) Production of L-aspartic acid from Brevibacterium by the cell re-using process. Process Biochem 20:124–128

    CAS  Google Scholar 

  • Tilman D, Socolow R, Foley JA, Hill J, Larson E, Lynd L, Pacala S, Reilly J, Searchinger T, Somerville C, Williams R (2009) Energy. Beneficial biofuels–the food, energy, and environment trilemma. Science 325:270–271

    Article  PubMed  CAS  Google Scholar 

  • Tsuji H (2005) Poly(lactide) stereocomplexes: formation, structure, properties, degradation, and applications. Macromol Biosci 5:569–597

    Article  PubMed  CAS  Google Scholar 

  • Vertès AA (2010) Axes of development in chemical and process engineering for converting biomass to energy. In: Vertès AA, Qureshi N, Blaschek HP, Yukawa H (eds) Biomass to biofuels: strategies for global industries. Wiley, New Jersey, pp 491–521

    Chapter  Google Scholar 

  • Vertès AA, Inui M, Yukawa H (2005) Manipulating corynebacteria, from individual genes to chromosomes. Appl Environ Microbiol 71:7633–7642

    Article  PubMed  Google Scholar 

  • Vertès AA, Inui M, Yukawa H (2006) Implementing biofuels on a global scale. Nat Biotechnol 24:761–764

    Article  PubMed  Google Scholar 

  • Vertès AA, Inui M, Yukawa H (2007) Alternative technologies for biotechnological fuel ethanol manufacturing. J Chem Technol Biotechnol 82:693–697

    Article  Google Scholar 

  • Vertès AA, Inui M, Yukawa H (2008) Technological options for biological fuel ethanol. J Mol Microbiol Biotechnol 15:16–30

    Article  PubMed  Google Scholar 

  • Wang F, Lee SY (1998) High cell density culture of metabolically engineered Escherichia coli for the production of poly(3-hydroxybutyrate) in a defined medium. Biotechnol Bioeng 58:325–328

    Article  PubMed  CAS  Google Scholar 

  • Yamamoto S, Sakai M, Inui M, Yukawa H (2011) Diversity of metabolic shift in response to oxygen deprivation in Corynebacterium glutamicum and its close relatives. Appl Microbiol Biotechnol 90:1051–1061

    Article  PubMed  CAS  Google Scholar 

  • Yang S, Land ML, Klingeman DM, Pelletier DA, Lu TY, Martin SL, Guo HB, Smith JC, Brown SD (2010) Paradigm for industrial strain improvement identifies sodium acetate tolerance loci in Zymomonas mobilis and Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 107:10395–10400

    Article  PubMed  CAS  Google Scholar 

  • Yukawa H, Terasawa M (1986) L-isoleucine production by ethanol utilizing micro-organism. Process Biochem 21:196–199

    CAS  Google Scholar 

  • Yukawa H, Omumasaba CA, Nonaka H, Kos P, Okai N, Suzuki N, Suda M, Tsuge Y, Watanabe J, Ikeda Y, Vertès AA, Inui M (2007) Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R. Microbiology 153:1042–1058

    Article  PubMed  CAS  Google Scholar 

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  1. Research Institute of Innovative Technology for the Earth (RITE), 9-2, Kizugawadai, Kizugawa, Kyoto, 619-0292, Japan

    Toru Jojima, Masayuki Inui & Hideaki Yukawa

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  1. Toru Jojima
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  2. Masayuki Inui
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  3. Hideaki Yukawa
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Correspondence to Hideaki Yukawa .

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  1. Technology for the Earth (RITE), Microbiology Research Group, Research Institute of Innovative, Kizu-cho 9-2, Soraku-gun, Kyoto, 619-0292, Japan

    Hideaki Yukawa

  2. Technology for the Earth (RITE), Research Institute of Innovative, Kizugawadai, Kizu-cho 9-2, Soraku-gun, Kyoto, 619-0292, Japan

    Masayuki Inui

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Jojima, T., Inui, M., Yukawa, H. (2013). Biorefinery Applications of Corynebacterium glutamicum . In: Yukawa, H., Inui, M. (eds) Corynebacterium glutamicum. Microbiology Monographs, vol 23. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-29857-8_5

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