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Experimental Models for Drug Evaluation in Noise-Induced Hearing Loss and Age-Related Hearing Impairment

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Drug Discovery and Evaluation: Pharmacological Assays

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Abstract

The contribution of noise and aging to hearing loss are distinct, yet interrelated. Noise-induced hearing loss (NIHL) is one of the leading – preventable – causes of hearing loss worldwide. NIHL is usually characterized by an elevation in the hearing threshold, and the area of damage is most pronounced one-half octave above the frequency of noise exposure. A significant body of evidence suggests that NIHL damage results from noise-induced free radical production (Oishi and Schacht 2011). Age is an independent risk factor for acquired hearing loss, although its effects may be difficult to distinguish from those of noise exposure in the clinical setting. The mechanism underlying age-related hearing loss (presbycusis) is heavily influenced by an individual’s genetic susceptibility, and there is thus dramatic variation. Four-way cross animal models allow a longitudinal examination of these factors in relation to age and hearing loss.

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Authors and Affiliations

  1. Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI, USA

    Amrita Ray & Michael J. Brenner

  2. Department of Biological Chemistry, Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI, USA

    Jochen Schacht

Authors
  1. Amrita Ray
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  2. Jochen Schacht
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  3. Michael J. Brenner
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Corresponding author

Correspondence to Michael J. Brenner .

Editor information

Editors and Affiliations

  1. Dieburg, Germany

    Franz J. Hock

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© 2014 Springer-Verlag Berlin Heidelberg

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Ray, A., Schacht, J., Brenner, M.J. (2014). Experimental Models for Drug Evaluation in Noise-Induced Hearing Loss and Age-Related Hearing Impairment. In: Hock, F. (eds) Drug Discovery and Evaluation: Pharmacological Assays. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27728-3_139-1

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  • DOI: https://doi.org/10.1007/978-3-642-27728-3_139-1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27728-3

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