Hidradenoma, Clear Cell (Eccrine Acrospiroma)

Synonyms

Adenoma of the clear cell type; Clear cell hidradenoma; Clear cell myoepithelioma; Cystic hidradenoma; Eccrine acrospiroma; Eccrine poroma; Eccrine sweat gland adenoma; Nodular cell hidradenoma; Porosyringoma

Definition

A solid cystic cutaneous nodule arising from the duct and secretory coil of eccrine sweat glands.

Etiology

Clear cell hidradenomas may be due to impaired drainage of eccrine sweat glands within the dermis.

Clinical Presentation

Flesh colored, solid or cystic intradermal nodules, typically 5–30 mm, covered by intact skin. Pressure applied to the lesion may produce tenderness in 20% of patients. They present in middle age and frequently occur on the head, but can occur anywhere on the body (Shields and Shields 1999; Albert and Jakobie 2008; Rabady et al. 2008).

Diagnostics

Excisional biopsy provides definitive diagnosis. Histopathologically, clear cell hidradenoma demonstrates a well circumscribed dermal lesion composed of lobules of epithelial cells in a...