Abstract
The burden, cost, and complications of healthcare-associated urinary tract infections in the pediatric population are not well defined. Key risk factors for catheter-associated urinary tract infections (CAUTI) include the length of time of catheterization. The diagnosis of CAUTI is often challenging given the inherent difficulties in distinguishing bacterial colonization of urine from true infection. Surveillance utilizing Centers for Disease Control and Prevention (CDC) National Healthcare Safety Network (NHSN) criteria may not reflect clinical significance and is complicated by the potential overuse of urine culture for the evaluation of fever in critically ill patients in the intensive care unit. CAUTI prevention bundles for the pediatric population are largely derived from evidence-based adult bundles. Children with congenital abnormalities of the genitourinary tract, spina bifida with neurogenic bladder, or who have had complex surgical repairs of the urogenital system require additional methods to prevent healthcare-associated urinary tract infections.
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References
Magill SS, Edwards JR, Bamberg W, et al. Emerging infections program healthcare-associated infections and antimicrobial use prevalence survey team. Multistate point-prevalence survey of health care-associated infections. N Engl J Med. 2014;370:1198–208. https://doi.org/10.1056/NEJMoa1306801.
Weber DJ, Sickbert-Bennett EE, Gould CV, et al. Incidence of catheter-associated and non-catheter-associated urinary tract infections in a healthcare system. Infect Control Hosp Epidemiol. 2011;32:822–3. https://doi.org/10.1086/661107.
Lo E, Nicolle LE, Coffin SE, et al. Strategies to prevent catheter-associated urinary tract infections in acute care hospitals: 2014 update. Infect Control Hosp Epidemiol. 2014;35:464–79.
Davis KF, Colebaugh AM, Eithun BL, et al. Reducing catheter-associated urinary tract infections: a quality-improvement initiative. Pediatrics. 2014;134:e857–64. https://doi.org/10.1542/peds.2013-3470.
Tambyah PA, Halvorson KT, Maki DG. A prospective study of pathogenesis of catheter-associated urinary tract infections. Mayo Clin Proc. 1999;74:131–6. https://doi.org/10.4065/74.2.131.
Stamm WE. Catheter-associated urinary tract infections: epidemiology, pathogenesis, and prevention. Am J Med. 1991;91:65S–71S.
Kabbani MS, Ismail SR, Fatima A, et al. Urinary tract infection in children after cardiac surgery: incidence, causes, risk factors and outcomes in a single-center study. J Infect Public Health. 2016;9:600–10.
Lake JG, Weiner LM, Milstone AM, Saiman L, Magill SS, See I. Pathogen distribution and antimicrobial resistance among pediatric healthcare-associated infections reported to the National Healthcare Safety Network. Infect Control Hosp Epidemiol. 2011-2014;2017:1–11. https://doi.org/10.1017/ice.2017.236.
Langley JM, Hanakowski M, Leblanc JC. Unique epidemiology of nosocomial urinary tract infection in children. Am J Infect Control. 2001;29:94–8.
Davies HD, Jones EL, Sheng RY, et al. Nosocomial urinary tract infections at a pediatric hospital. Pediatr Infect Dis J. 1992;11:349.
Zimlichman E, Henderson D, Tamir O, et al. Health care-associated infections: a meta-analysis of costs and financial impact on the US health care system. JAMA Intern Med. 2013;173:2039–46. https://doi.org/10.1001/jamainternmed.2013.9763.
Dudeck MA, Edwards J, Allen-Bridson K, et al. National Healthcare Safety Network report, data summary for 2013. Device-associated module. Am J Infect Control. 2015;43:206–21. https://doi.org/10.1016/j.ajic.2014.11.014.
Patrick S, Kawai A, Kleinman K, et al. Health care-associated infections among critically ill children in the US, 2000–2012. Pediatrics. 2014;134:705–12. https://doi.org/10.1542/peds.2014-0613.
Chenoweth CE, Saint S. Urinary tract infections. Infect Dis Clin N Am. 2016;30:869–85. https://doi.org/10.1016/j.idc.2016.07.007.
Lee NG, Marchalik D, Lipsky A, Rushton HG, Pohl HG, Song X. Risk factors for catheter associated urinary tract infections in a pediatric institution. J Urol. 2016;195:1306–11. https://doi.org/10.1016/j.juro.2015.03.121.
Kizilbash Q, Petersen N, Chen G, et al. Bacteremia and mortality with urinary catheter-associated bacteriuria. Infect Control Hosp Epidemiol. 2013;34:1153–9. https://doi.org/10.1086/673456.
AAP Subcommittee on Urinary Tract Infection, Steering Committee on Quality Improvement and Management. Clinical Practice Guideline. Urinary tract infection: clinical practice guideline for the diagnosis and management of the initial UTI in febrile infants and children 2–24 months. Pediatrics. 2011;128:595–610.
Hooton TM, Bradley SF, Cardenas DD, et al. Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults: 2009 international clinical practice guidelines from the Infectious Diseases Society of America. Clin Infect Dis. 2010;50:625–63. https://doi.org/10.1086/650482.
Al-Qas Hanna F, Sambirska O, Iyer S, Szpunar S, Fakih MG. Clinician practice and the National Healthcare Safety Network definition for the diagnosis of catheter-associated urinary tract infection. Am J Infect Control. 2013;41:1173–7. https://doi.org/10.1016/j.ajic.2013.05.024.
O’Grady NP, Barie PS, Bartlett JG, et al. Guidelines for evaluation of new fever in critically ill adult patients: 2008 update from the American College of Critical Care Medicine and the Infectious Diseases Society of America. Crit Care Med. 2008;36:1330–49. https://doi.org/10.1097/CCM.0b013e318169eda9.
Tedja R, Wentink J, O’Horo JC, Thompson R, Sampathkumar P. Catheter-associated urinary tract infections in intensive care unit patients. Infect Control Hosp Epidemiol. 2015;36:1330–4. https://doi.org/10.1017/ice.2015/172.
Laupland KB, Shahpori R, Kirkpatrick AW, Ross T, Gregson DB, Stelfox HT. Occurrence and outcome of fever in critically ill adults. Crit Care Med. 2008;36:1531–5. https://doi.org/10.1097/CCM.0b013e318170efd3.
Mullin KM, Kovacs CS, Fatica C, et al. A multifaceted approach to reduction of catheter-associated urinary tract infections in the intensive care unit with an emphasis on “stewardship of culturing”. Infect Control Hosp Epidemiol. 2017;38:186–8. https://doi.org/10.1017/ice.2016.266.
Carlson AL, Munigala S, Russo AJ, et al. Inpatient urine cultures are frequently performed without urinalysis or microscopy: findings from a large academic medical center. Infect Control Hosp Epidemiol. 2017;38:455–60. https://doi.org/10.1017/ice.2016.311.
CDC NHSN Website. https://www.cdc.gov/nhsn/index.html. Accessed 21 Jan 2018.
The Joint Commission National Patient Safety Goals. https://www.jointcommission.org/standards_information/npsgs.aspx. Accessed 21 Jan 2018.
Fakih MG, Gould CV, Trautner BW, et al. Beyond infection: device utilization ratio as a performance measure for urinary catheter harm. Infect Control Hosp Epidemiol. 2016;37:327–33. https://doi.org/10.1017/ice.2015.287.
Bardossy AC, Jayaprakash R, Alangaden AC, et al. Impact and limitations of the 2015 national health and safety network case definition on catheter-associated urinary tract infection rates. Infect Control Hosp Epidemiol. 2017;38:239–41. https://doi.org/10.1017/ice.2016.278.
Livorsi DJ, Perencevich EN. CAUTI surveillance: opportunity or opportunity cost? Infect Control Hosp Epidemiol. 2015;36:1335–6. https://doi.org/10.1017/ice.2015.174.
Wright MO, Kharasch M, Beaumont JL, Peterson LR, Robicsek A. Reporting catheter-associated urinary tract infections: denominator matters. Infect Control Hosp Epidemiol. 2011;32:635–40. https://doi.org/10.1086/660765.
Sen AI, Balzer K, Mangino D, et al. Electronic surveillance for catheter-associated urinary tract infections at a university-affiliated children’s hospital. Am J Infect Control. 2016;44:599–601. https://doi.org/10.1016/j.ajic.2015.12.006.
Gould CV, Umscheid CA, Agarwal RK, et al. Guideline for prevention of catheter-associated urinary tract infections 2009. Infect Control Hosp Epidemiol 2010;31:319–326. https://www.cdc.gov/infectioncontrol/pdf/guidelines/cauti-guidelines.pdf. Accessed 28 Jan 2018.
APIC Implementation Guides: Guide to preventing catheter-associated urinary tract infections. http://www.apic.org/implementationguides. Accessed 21 Jan 2018.
Saint S, Greene MT, Krein SL, et al. A program to prevent catheter-associated urinary tract infection in acute care. N Engl J Med. 2016;374:2111–9. https://doi.org/10.1056/NEJMoa1504906.
Solutions for Patient Safety Website: http://www.solutionsforpatientsafety.org/. Accessed 21 Jan 2018.
Brilli RJ, McClead RE Jr, Crandall WV, et al. A comprehensive patient safety program can significantly reduce preventable harm, associated costs, and hospital mortality. J Pediatr. 2013;163:1638–45. https://doi.org/10.1016/j.jpeds.2013.06.031.
Esteban E, Ferrer R, Urrea M, et al. The importance of a quality improvement intervention to reduce nosocomial infections in a PICU. Pediatr Crit Care Med. 2013;14:525–32. https://doi.org/10.1097/PCC.0b013e31828a87cc.
Zavalkoff S, Korah N, Quach C. Presence of a physician safety champion is associated with a reduction in urinary catheter utilization in the pediatric Intensive care unit. Plos One. 10:e0144222. https://doi.org/10.1371/journal.pone.0144222.
Siddiq DM, Darouiche RO. New strategies to prevent catheter-associated urinary tract infections. Nat Rev Urol. 2012;9:305–14. https://doi.org/10.1038/nrurol.2012.68.
Meddings J, Rogers MAM, Macy M, Saint S. Systematic review and meta-analysis: reminder systems to reduce catheter-associated urinary tract infections and urinary catheter use in hospitalized patients. Clin Infect Dis. 2010;51:550–60. https://doi.org/10.1086/655133.
Maki DG, Tambyah PA. Engineering out the risk for infection with urinary catheters. Emerg Infect Dis. 2001;7:342–7.
Warren JW, Tenney JH, Hoopes JM, Muncie HL, Anthony WC. A prospective microbiologic study of bacteriuria in patients with chronic indwelling urethral catheters. J Infect Dis. 1982;146:719–23.
Nicolle LE. Urinary catheter-associated infections. Infect Dis Clin N Am. 2012;26:13–27. https://doi.org/10.1016/j.idc.2011.09.009.
Newman DK, Willson MM. Review of intermittent catheterization and current best practices. Urol Nurs. 2011;31:12–48.
Madden-Fuentes RJ, McNamara ER, Lloyd JC, et al. Variation in definitions of urinary tract infections in spina bifida patients: a systemic review. Pediatrics. 2013;132:132–9. https://doi.org/10.1542/peds.2013-0557.
Zegers B, Uiterwaal C, Kimpen J, et al. Antibiotic prophylaxis for urinary tract infections in children with spina bifida on intermittent catheterization. J Urol. 2011;186:2365–71. https://doi.org/10.1016/j.juro.2011.07.108.
Berkowitz J, North AC, Tripp R, Gearhart JP, Lakshmana Y. Mitrofanoff continent catheterizable conduits: top down or bottom up? J Pediatr Urol. 2009;5:122–5. https://doi.org/10.1016/j.jpurol.2008.11.003.
Clark T, Pope JC, Adams MC, Wells N, Brock JW. Factors that influence outcomes of the Mitrofanoff and Malone antegrade continence enema reconstructive procedures in children. J Urol. 2002;168:1537–40. https://doi.org/10.1097/01.ju.0000028619.08733.7f.
Bertschy C, Bawab F, Liard A, Valioulis I, Mitrofanoff P. Enterocystoplasty complications in children: a study of 30 cases. Eur J Pediatr Surg. 2000;10:30–4.
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Nyquist, AC. (2019). Healthcare-Associated Urinary Tract Infections. In: McNeil, J., Campbell, J., Crews, J. (eds) Healthcare-Associated Infections in Children. Springer, Cham. https://doi.org/10.1007/978-3-319-98122-2_13
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