Skip to main content

Healthcare-Associated Urinary Tract Infections

  • Chapter
  • First Online:
Healthcare-Associated Infections in Children
  • 761 Accesses

Abstract

The burden, cost, and complications of healthcare-associated urinary tract infections in the pediatric population are not well defined. Key risk factors for catheter-associated urinary tract infections (CAUTI) include the length of time of catheterization. The diagnosis of CAUTI is often challenging given the inherent difficulties in distinguishing bacterial colonization of urine from true infection. Surveillance utilizing Centers for Disease Control and Prevention (CDC) National Healthcare Safety Network (NHSN) criteria may not reflect clinical significance and is complicated by the potential overuse of urine culture for the evaluation of fever in critically ill patients in the intensive care unit. CAUTI prevention bundles for the pediatric population are largely derived from evidence-based adult bundles. Children with congenital abnormalities of the genitourinary tract, spina bifida with neurogenic bladder, or who have had complex surgical repairs of the urogenital system require additional methods to prevent healthcare-associated urinary tract infections.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Magill SS, Edwards JR, Bamberg W, et al. Emerging infections program healthcare-associated infections and antimicrobial use prevalence survey team. Multistate point-prevalence survey of health care-associated infections. N Engl J Med. 2014;370:1198–208. https://doi.org/10.1056/NEJMoa1306801.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Weber DJ, Sickbert-Bennett EE, Gould CV, et al. Incidence of catheter-associated and non-catheter-associated urinary tract infections in a healthcare system. Infect Control Hosp Epidemiol. 2011;32:822–3. https://doi.org/10.1086/661107.

    Article  PubMed  Google Scholar 

  3. Lo E, Nicolle LE, Coffin SE, et al. Strategies to prevent catheter-associated urinary tract infections in acute care hospitals: 2014 update. Infect Control Hosp Epidemiol. 2014;35:464–79.

    Article  PubMed  Google Scholar 

  4. Davis KF, Colebaugh AM, Eithun BL, et al. Reducing catheter-associated urinary tract infections: a quality-improvement initiative. Pediatrics. 2014;134:e857–64. https://doi.org/10.1542/peds.2013-3470.

    Article  PubMed  Google Scholar 

  5. Tambyah PA, Halvorson KT, Maki DG. A prospective study of pathogenesis of catheter-associated urinary tract infections. Mayo Clin Proc. 1999;74:131–6. https://doi.org/10.4065/74.2.131.

    Article  CAS  PubMed  Google Scholar 

  6. Stamm WE. Catheter-associated urinary tract infections: epidemiology, pathogenesis, and prevention. Am J Med. 1991;91:65S–71S.

    Article  CAS  PubMed  Google Scholar 

  7. Kabbani MS, Ismail SR, Fatima A, et al. Urinary tract infection in children after cardiac surgery: incidence, causes, risk factors and outcomes in a single-center study. J Infect Public Health. 2016;9:600–10.

    Article  PubMed  Google Scholar 

  8. Lake JG, Weiner LM, Milstone AM, Saiman L, Magill SS, See I. Pathogen distribution and antimicrobial resistance among pediatric healthcare-associated infections reported to the National Healthcare Safety Network. Infect Control Hosp Epidemiol. 2011-2014;2017:1–11. https://doi.org/10.1017/ice.2017.236.

    Article  Google Scholar 

  9. Langley JM, Hanakowski M, Leblanc JC. Unique epidemiology of nosocomial urinary tract infection in children. Am J Infect Control. 2001;29:94–8.

    Article  CAS  PubMed  Google Scholar 

  10. Davies HD, Jones EL, Sheng RY, et al. Nosocomial urinary tract infections at a pediatric hospital. Pediatr Infect Dis J. 1992;11:349.

    Article  CAS  PubMed  Google Scholar 

  11. Zimlichman E, Henderson D, Tamir O, et al. Health care-associated infections: a meta-analysis of costs and financial impact on the US health care system. JAMA Intern Med. 2013;173:2039–46. https://doi.org/10.1001/jamainternmed.2013.9763.

    Article  PubMed  Google Scholar 

  12. Dudeck MA, Edwards J, Allen-Bridson K, et al. National Healthcare Safety Network report, data summary for 2013. Device-associated module. Am J Infect Control. 2015;43:206–21. https://doi.org/10.1016/j.ajic.2014.11.014.

    Article  PubMed  Google Scholar 

  13. Patrick S, Kawai A, Kleinman K, et al. Health care-associated infections among critically ill children in the US, 2000–2012. Pediatrics. 2014;134:705–12. https://doi.org/10.1542/peds.2014-0613.

    Article  PubMed  Google Scholar 

  14. Chenoweth CE, Saint S. Urinary tract infections. Infect Dis Clin N Am. 2016;30:869–85. https://doi.org/10.1016/j.idc.2016.07.007.

    Article  Google Scholar 

  15. Lee NG, Marchalik D, Lipsky A, Rushton HG, Pohl HG, Song X. Risk factors for catheter associated urinary tract infections in a pediatric institution. J Urol. 2016;195:1306–11. https://doi.org/10.1016/j.juro.2015.03.121.

    Article  PubMed  Google Scholar 

  16. Kizilbash Q, Petersen N, Chen G, et al. Bacteremia and mortality with urinary catheter-associated bacteriuria. Infect Control Hosp Epidemiol. 2013;34:1153–9. https://doi.org/10.1086/673456.

    Article  PubMed  Google Scholar 

  17. AAP Subcommittee on Urinary Tract Infection, Steering Committee on Quality Improvement and Management. Clinical Practice Guideline. Urinary tract infection: clinical practice guideline for the diagnosis and management of the initial UTI in febrile infants and children 2–24 months. Pediatrics. 2011;128:595–610.

    Article  Google Scholar 

  18. Hooton TM, Bradley SF, Cardenas DD, et al. Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults: 2009 international clinical practice guidelines from the Infectious Diseases Society of America. Clin Infect Dis. 2010;50:625–63. https://doi.org/10.1086/650482.

    Article  PubMed  Google Scholar 

  19. Al-Qas Hanna F, Sambirska O, Iyer S, Szpunar S, Fakih MG. Clinician practice and the National Healthcare Safety Network definition for the diagnosis of catheter-associated urinary tract infection. Am J Infect Control. 2013;41:1173–7. https://doi.org/10.1016/j.ajic.2013.05.024.

    Article  PubMed  Google Scholar 

  20. O’Grady NP, Barie PS, Bartlett JG, et al. Guidelines for evaluation of new fever in critically ill adult patients: 2008 update from the American College of Critical Care Medicine and the Infectious Diseases Society of America. Crit Care Med. 2008;36:1330–49. https://doi.org/10.1097/CCM.0b013e318169eda9.

    Article  PubMed  Google Scholar 

  21. Tedja R, Wentink J, O’Horo JC, Thompson R, Sampathkumar P. Catheter-associated urinary tract infections in intensive care unit patients. Infect Control Hosp Epidemiol. 2015;36:1330–4. https://doi.org/10.1017/ice.2015/172.

    Article  PubMed  Google Scholar 

  22. Laupland KB, Shahpori R, Kirkpatrick AW, Ross T, Gregson DB, Stelfox HT. Occurrence and outcome of fever in critically ill adults. Crit Care Med. 2008;36:1531–5. https://doi.org/10.1097/CCM.0b013e318170efd3.

    Article  PubMed  Google Scholar 

  23. Mullin KM, Kovacs CS, Fatica C, et al. A multifaceted approach to reduction of catheter-associated urinary tract infections in the intensive care unit with an emphasis on “stewardship of culturing”. Infect Control Hosp Epidemiol. 2017;38:186–8. https://doi.org/10.1017/ice.2016.266.

    Article  PubMed  Google Scholar 

  24. Carlson AL, Munigala S, Russo AJ, et al. Inpatient urine cultures are frequently performed without urinalysis or microscopy: findings from a large academic medical center. Infect Control Hosp Epidemiol. 2017;38:455–60. https://doi.org/10.1017/ice.2016.311.

    Article  PubMed  PubMed Central  Google Scholar 

  25. CDC NHSN Website. https://www.cdc.gov/nhsn/index.html. Accessed 21 Jan 2018.

  26. The Joint Commission National Patient Safety Goals. https://www.jointcommission.org/standards_information/npsgs.aspx. Accessed 21 Jan 2018.

  27. Fakih MG, Gould CV, Trautner BW, et al. Beyond infection: device utilization ratio as a performance measure for urinary catheter harm. Infect Control Hosp Epidemiol. 2016;37:327–33. https://doi.org/10.1017/ice.2015.287.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Bardossy AC, Jayaprakash R, Alangaden AC, et al. Impact and limitations of the 2015 national health and safety network case definition on catheter-associated urinary tract infection rates. Infect Control Hosp Epidemiol. 2017;38:239–41. https://doi.org/10.1017/ice.2016.278.

    Article  PubMed  Google Scholar 

  29. Livorsi DJ, Perencevich EN. CAUTI surveillance: opportunity or opportunity cost? Infect Control Hosp Epidemiol. 2015;36:1335–6. https://doi.org/10.1017/ice.2015.174.

    Article  PubMed  Google Scholar 

  30. Wright MO, Kharasch M, Beaumont JL, Peterson LR, Robicsek A. Reporting catheter-associated urinary tract infections: denominator matters. Infect Control Hosp Epidemiol. 2011;32:635–40. https://doi.org/10.1086/660765.

    Article  PubMed  Google Scholar 

  31. Sen AI, Balzer K, Mangino D, et al. Electronic surveillance for catheter-associated urinary tract infections at a university-affiliated children’s hospital. Am J Infect Control. 2016;44:599–601. https://doi.org/10.1016/j.ajic.2015.12.006.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Gould CV, Umscheid CA, Agarwal RK, et al. Guideline for prevention of catheter-associated urinary tract infections 2009. Infect Control Hosp Epidemiol 2010;31:319–326. https://www.cdc.gov/infectioncontrol/pdf/guidelines/cauti-guidelines.pdf. Accessed 28 Jan 2018.

    Article  Google Scholar 

  33. APIC Implementation Guides: Guide to preventing catheter-associated urinary tract infections. http://www.apic.org/implementationguides. Accessed 21 Jan 2018.

  34. Saint S, Greene MT, Krein SL, et al. A program to prevent catheter-associated urinary tract infection in acute care. N Engl J Med. 2016;374:2111–9. https://doi.org/10.1056/NEJMoa1504906.

    Article  CAS  PubMed  Google Scholar 

  35. Solutions for Patient Safety Website: http://www.solutionsforpatientsafety.org/. Accessed 21 Jan 2018.

  36. Brilli RJ, McClead RE Jr, Crandall WV, et al. A comprehensive patient safety program can significantly reduce preventable harm, associated costs, and hospital mortality. J Pediatr. 2013;163:1638–45. https://doi.org/10.1016/j.jpeds.2013.06.031.

    Article  PubMed  Google Scholar 

  37. Esteban E, Ferrer R, Urrea M, et al. The importance of a quality improvement intervention to reduce nosocomial infections in a PICU. Pediatr Crit Care Med. 2013;14:525–32. https://doi.org/10.1097/PCC.0b013e31828a87cc.

    Article  PubMed  Google Scholar 

  38. Zavalkoff S, Korah N, Quach C. Presence of a physician safety champion is associated with a reduction in urinary catheter utilization in the pediatric Intensive care unit. Plos One. 10:e0144222. https://doi.org/10.1371/journal.pone.0144222.

  39. Siddiq DM, Darouiche RO. New strategies to prevent catheter-associated urinary tract infections. Nat Rev Urol. 2012;9:305–14. https://doi.org/10.1038/nrurol.2012.68.

    Article  CAS  PubMed  Google Scholar 

  40. Meddings J, Rogers MAM, Macy M, Saint S. Systematic review and meta-analysis: reminder systems to reduce catheter-associated urinary tract infections and urinary catheter use in hospitalized patients. Clin Infect Dis. 2010;51:550–60. https://doi.org/10.1086/655133.

    Article  PubMed  Google Scholar 

  41. Maki DG, Tambyah PA. Engineering out the risk for infection with urinary catheters. Emerg Infect Dis. 2001;7:342–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Warren JW, Tenney JH, Hoopes JM, Muncie HL, Anthony WC. A prospective microbiologic study of bacteriuria in patients with chronic indwelling urethral catheters. J Infect Dis. 1982;146:719–23.

    Article  CAS  PubMed  Google Scholar 

  43. Nicolle LE. Urinary catheter-associated infections. Infect Dis Clin N Am. 2012;26:13–27. https://doi.org/10.1016/j.idc.2011.09.009.

    Article  Google Scholar 

  44. Newman DK, Willson MM. Review of intermittent catheterization and current best practices. Urol Nurs. 2011;31:12–48.

    Article  PubMed  Google Scholar 

  45. Madden-Fuentes RJ, McNamara ER, Lloyd JC, et al. Variation in definitions of urinary tract infections in spina bifida patients: a systemic review. Pediatrics. 2013;132:132–9. https://doi.org/10.1542/peds.2013-0557.

    Article  PubMed  Google Scholar 

  46. Zegers B, Uiterwaal C, Kimpen J, et al. Antibiotic prophylaxis for urinary tract infections in children with spina bifida on intermittent catheterization. J Urol. 2011;186:2365–71. https://doi.org/10.1016/j.juro.2011.07.108.

    Article  PubMed  Google Scholar 

  47. Berkowitz J, North AC, Tripp R, Gearhart JP, Lakshmana Y. Mitrofanoff continent catheterizable conduits: top down or bottom up? J Pediatr Urol. 2009;5:122–5. https://doi.org/10.1016/j.jpurol.2008.11.003.

    Article  CAS  PubMed  Google Scholar 

  48. Clark T, Pope JC, Adams MC, Wells N, Brock JW. Factors that influence outcomes of the Mitrofanoff and Malone antegrade continence enema reconstructive procedures in children. J Urol. 2002;168:1537–40. https://doi.org/10.1097/01.ju.0000028619.08733.7f.

    Article  PubMed  Google Scholar 

  49. Bertschy C, Bawab F, Liard A, Valioulis I, Mitrofanoff P. Enterocystoplasty complications in children: a study of 30 cases. Eur J Pediatr Surg. 2000;10:30–4.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ann-Christine Nyquist .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Nyquist, AC. (2019). Healthcare-Associated Urinary Tract Infections. In: McNeil, J., Campbell, J., Crews, J. (eds) Healthcare-Associated Infections in Children. Springer, Cham. https://doi.org/10.1007/978-3-319-98122-2_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-98122-2_13

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-98121-5

  • Online ISBN: 978-3-319-98122-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics