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Multimodal Simple Analgesia

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Analgesia in Major Abdominal Surgery

Abstract

Multimodal analgesia relies on the principle of administering different types of analgesic medications, which through an additive or synergistic effect can improve post-operative pain control. A multimodal analgesic approach allows a reduction in systemic opioid requirements and their associated adverse effects, with the ultimate goal of facilitating early feeding and postoperative mobilization in patients undergoing abdominal surgery. A multimodal analgesia protocol should be procedure-specific and include non-opioid analgesics administered regularly, with systemic opioids to treat moderate-severe breakthrough pain, and regional anaesthesia techniques for certain surgical procedures.

This chapter reviews the pathophysiology of surgical pain after abdominal surgery and it describes the most common simple analgesic agents used in multimodal analgesic protocols to provide optimal analgesia for patients undergoing abdominal surgery.

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References

  1. Gan TJ, Habib AS, Miller TE, White W, Apfelbaum JL. Incidence, patient satisfaction, and perceptions of post-surgical pain: results from a US national survey. Curr Med Res Opin. 2014;30(1):149–60.

    Article  Google Scholar 

  2. Gritsenko K, Khelemsky Y, Kaye AD, Vadivelu N, Urman RD. Multimodal therapy in perioperative analgesia. Best Pract Res Clin Anaesthesiol. 2014;28(1):59–79.

    Article  Google Scholar 

  3. PROcedure SPECific postoperative pain menagemenT (PROSPECT) [PROcedure SPEC postoperative pain managemenT]. Available at: http://www.postoppain.org/.

  4. Wheeler M, Oderda GM, Ashburn MA, Lipman AG. Adverse events associated with postoperative opioid analgesia: a systematic review. J Pain. 2002;3(3):159–80.

    Article  Google Scholar 

  5. Le-Wendling L, Nin O, Capdevila X. Cancer recurrence and regional anesthesia: the theories, the data, and the future in outcomes. Pain Med. 2016;17(4):756–75.

    PubMed  Google Scholar 

  6. Gustafsson UO, Scott MJ, Schwenk W, Demartines N, Roulin D, Francis N, et al. Guidelines for perioperative care in elective colonic surgery: Enhanced Recovery After Surgery (ERAS®) Society recommendations. World J Surg. 2013;37(2):259–84.

    Article  CAS  Google Scholar 

  7. Ong CK, Lirk P, Seymour RA, Jenkins BJ. The efficacy of preemptive analgesia for acute postoperative pain management: a meta-analysis. Anesth Analg. 2005;100(3):757–73.

    Article  Google Scholar 

  8. Kandel ER. Principles of neural science. 5th ed. New York: McGraw-Hill; 2013.

    Google Scholar 

  9. Millan MJ. The induction of pain: an integrative review. Prog Neurobiol. 1999;57(1):1–164.

    Article  CAS  Google Scholar 

  10. Marret E, Rolin M, Beaussier M, Bonnet F. Meta-analysis of intravenous lidocaine and postoperative recovery after abdominal surgery. Br J Surg. 2008;95(11):1331–8.

    Article  CAS  Google Scholar 

  11. Fishman S, Ballantyne J, Rathmell JP, Bonica JJ. Bonica’s management of pain. 4th ed. Baltimore, MD: Lippincott, Williams & Wilkins; 2010.

    Google Scholar 

  12. Dahl JB, Moiniche S. Relief of postoperative pain by local anaesthetic infiltration: efficacy for major abdominal and orthopedic surgery. Pain. 2009;143(1–2):7–11.

    Article  Google Scholar 

  13. Moiniche S, Jorgensen H, Wetterslev J, Dahl JB. Local anesthetic infiltration for postoperative pain relief after laparoscopy: a qualitative and quantitative systematic review of intraperitoneal, port-site infiltration and mesosalpinx block. Anesth Analg. 2000;90(4):899–912.

    Article  CAS  Google Scholar 

  14. Beaussier M, El’Ayoubi H, Schiffer E, Rollin M, Parc Y, Mazoit JX, et al. Continuous preperitoneal infusion of ropivacaine provides effective analgesia and accelerates recovery after colorectal surgery: a randomized, double-blind, placebo-controlled study. Anesthesiology. 2007;107(3):461–8.

    Article  CAS  Google Scholar 

  15. Jouve P, Bazin JE, Petit A, Minville V, Gerard A, Buc E, et al. Epidural versus continuous preperitoneal analgesia during fast-track open colorectal surgery: a randomized controlled trial. Anesthesiology. 2013;118(3):622–30.

    Article  Google Scholar 

  16. Bertoglio S, Fabiani F, Negri PD, Corcione A, Merlo DF, Cafiero F, et al. The postoperative analgesic efficacy of preperitoneal continuous wound infusion compared to epidural continuous infusion with local anesthetics after colorectal cancer surgery: a randomized controlled multicenter study. Anesth Analg. 2012;115(6):1442–50.

    Article  CAS  Google Scholar 

  17. Cohen SM. Extended pain relief trial utilizing infiltration of Exparel®, a long-acting multivesicular liposome formulation of bupivacaine: a Phase IV health economic trial in adult patients undergoing open colectomy. J Pain Res. 2012;5:567–72.

    Article  CAS  Google Scholar 

  18. Candiotti KA, Sands LR, Lee E, Bergese SD, Harzman AE, Marcet J, et al. Liposome bupivacaine for postsurgical analgesia in adult patients undergoing laparoscopic colectomy: results from prospective Phase IV sequential cohort studies assessing health economic outcomes. Curr Ther Res Clin Exp. 2014;76:1–6.

    Article  CAS  Google Scholar 

  19. Kahokehr A, Sammour T, Zargar Shoshtari K, Taylor M, Hill AG. Intraperitoneal local anesthetic improves recovery after colon resection: a double-blinded randomized controlled trial. Ann Surg. 2011;254(1):28–38.

    Article  Google Scholar 

  20. Kahokehr A, Sammour T, Srinivasa S, Hill AG. Systematic review and meta-analysis of intraperitoneal local anaesthetic for pain reduction after laparoscopic gastric procedures. Br J Surg. 2011;98(1):29–36.

    Article  CAS  Google Scholar 

  21. Stuhldreher JM, Adamina M, Konopacka A, Brady K, Delaney CP. Effect of local anesthetics on postoperative pain and opioid consumption in laparoscopic colorectal surgery. Surg Endosc. 2012;26(6):1617–23.

    Article  Google Scholar 

  22. Bucciero M, Ingelmo PM, Fumagalli R, Noll E, Garbagnati A, Somaini M, et al. Intraperitoneal ropivacaine nebulization for pain management after laparoscopic cholecystectomy: a comparison with intraperitoneal instillation. Anesth Analg. 2011;113(5):1266–71.

    Article  CAS  Google Scholar 

  23. Ingelmo PM, Bucciero M, Somaini M, Sahillioglu E, Garbagnati A, Charton A, et al. Intraperitoneal nebulization of ropivacaine for pain control after laparoscopic cholecystectomy: a double-blind, randomized, placebo-controlled trial. Br J Anaesth. 2013;110(5):800–6.

    Article  CAS  Google Scholar 

  24. Scalia Catenacci S, Lovisari F, Peng S, Allegri M, Somaini M, Ghislanzoni L, et al. Postoperative analgesia after laparoscopic ovarian cyst resection: double-blind multicenter randomized control trial comparing intraperitoneal nebulization and peritoneal instillation of ropivacaine. J Minim Invasive Gynecol. 2015;22(5):759–66.

    Article  Google Scholar 

  25. Somaini M, Brambillasca P, Ingelmo PM, Lovisari F, Catenacci SS, Rossini V, et al. Effects of peritoneal ropivacaine nebulization for pain control after laparoscopic gynecologic surgery. J Minim Invasive Gynecol. 2014;21(5):863–9.

    Article  Google Scholar 

  26. Bugada D, Scalia Catenacci S, Lovisari F, Bronco A, Sahillioglu E, Minardi C, et al. Intraperitoneal nebulization of local anesthetics for postoperative analgesia: theory, practice and future trends. Abstracts and highlight papers of the 31st annual European Society of Regional Anaesthesia (ESRA) Congress 2012. Reg Anesth Pain Med. 2012;37(5):E161–3.

    Google Scholar 

  27. De Oliveira GS Jr, Castro-Alves LJ, Nader A, Kendall MC, McCarthy RJ. Transversus abdominis plane block to ameliorate postoperative pain outcomes after laparoscopic surgery: a meta-analysis of randomized controlled trials. Anesth Analg. 2014;118(2):454–63.

    Article  Google Scholar 

  28. Keller DS, Ermlich BO, Schiltz N, Champagne BJ, Reynolds HL Jr, Stein SL, et al. The effect of transversus abdominis plane blocks on postoperative pain in laparoscopic colorectal surgery: a prospective, randomized, double-blind trial. Dis Colon Rectum. 2014;57(11):1290–7.

    Article  Google Scholar 

  29. Hubner M, Blanc C, Roulin D, Winiker M, Gander S, Demartines N. Randomized clinical trial on epidural versus patient-controlled analgesia for laparoscopic colorectal surgery within an enhanced recovery pathway. Ann Surg. 2015;261(4):648–53.

    Article  Google Scholar 

  30. Levy BF, Scott MJ, Fawcett W, Fry C, Rockall TA. Randomized clinical trial of epidural, spinal or patient-controlled analgesia for patients undergoing laparoscopic colorectal surgery. Br J Surg. 2011;98(8):1068–78.

    Article  CAS  Google Scholar 

  31. Levy BF, Scott MJ, Fawcett WJ, Rockall TA. 23-Hour-stay laparoscopic colectomy. Dis Colon Rectum. 2009;52(7):1239–43.

    Article  CAS  Google Scholar 

  32. Dahl JB, Nielsen RV, Wetterslev J, Nikolajsen L, Hamunen K, Kontinen VK, et al. Post-operative analgesic effects of paracetamol, NSAIDs, glucocorticoids, gabapentinoids and their combinations: a topical review. Acta Anaesthesiol Scand. 2014;58(10):1165–81.

    Article  CAS  Google Scholar 

  33. Marret E, Kurdi O, Zufferey P, Bonnet F. Effects of nonsteroidal antiinflammatory drugs on patient-controlled analgesia morphine side effects: meta-analysis of randomized controlled trials. Anesthesiology. 2005;102(6):1249–60.

    Article  CAS  Google Scholar 

  34. De Oliveira GS Jr, Agarwal D, Benzon HT. Perioperative single dose ketorolac to prevent postoperative pain: a meta-analysis of randomized trials. Anesth Analg. 2012;114(2):424–33.

    Article  Google Scholar 

  35. Brown CR, Moodie JE, Wild VM, Bynum LJ. Comparison of intravenous ketorolac tromethamine and morphine sulfate in the treatment of postoperative pain. Pharmacotherapy. 1990;10(6, Pt 2):116S–21S.

    CAS  PubMed  Google Scholar 

  36. Peirce RJ, Fragen RJ, Pemberton DM. Intravenous ketorolac tromethamine versus morphine sulfate in the treatment of immediate postoperative pain. Pharmacotherapy. 1990;10(6, Pt 2):111S–5S.

    CAS  PubMed  Google Scholar 

  37. Smith LA, Carroll D, Edwards JE, Moore RA, McQuay HJ. Single-dose ketorolac and pethidine in acute postoperative pain: systematic review with meta-analysis. Br J Anaesth. 2000;84(1):48–58.

    Article  CAS  Google Scholar 

  38. Gillis JC, Brogden RN. Ketorolac. A reappraisal of its pharmacodynamic and pharmacokinetic properties and therapeutic use in pain management. Drugs. 1997;53:139–88.

    Article  CAS  Google Scholar 

  39. Tramer MR, Williams JE, Carroll D, Wiffen PJ, Moore RA, McQuay HJ. Comparing analgesic efficacy of non-steroidal anti-inflammatory drugs given by different routes in acute and chronic pain: a qualitative systematic review. Acta Anaesthesiol Scand. 1998;42(1):71–9.

    Article  CAS  Google Scholar 

  40. McDaid C, Maund E, Rice S, Wright K, Jenkins B, Woolacott N. Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs (NSAIDs) for the reduction of morphine-related side effects after major surgery: a systematic review. Health Technol Assess. 2010;14(17):1–153.

    Article  CAS  Google Scholar 

  41. Elia N, Lysakowski C, Tramer MR. Does multimodal analgesia with acetaminophen, nonsteroidal antiinflammatory drugs, or selective cyclooxygenase-2 inhibitors and patient-controlled analgesia morphine offer advantages over morphine alone? Meta-analyses of randomized trials. Anesthesiology. 2005;103(6):1296–304.

    Article  CAS  Google Scholar 

  42. Nussmeier NA, Whelton AA, Brown MT, Joshi GP, Langford RM, Singla NK, et al. Safety and efficacy of the cyclooxygenase-2 inhibitors parecoxib and valdecoxib after noncardiac surgery. Anesthesiology. 2006;104(3):518–26.

    Article  CAS  Google Scholar 

  43. Gorissen KJ, Benning D, Berghmans T, Snoeijs MG, Sosef MN, Hulsewe KW, et al. Risk of anastomotic leakage with non-steroidal anti-inflammatory drugs in colorectal surgery. Br J Surg. 2012;99(5):721–7.

    Article  CAS  Google Scholar 

  44. Bhangu A, Singh P, Fitzgerald JE, Slesser A, Tekkis P. Postoperative nonsteroidal anti-inflammatory drugs and risk of anastomotic leak: meta-analysis of clinical and experimental studies. World J Surg. 2014;38(9):2247–57.

    Article  Google Scholar 

  45. Burton TP, Mittal A, Soop M. Nonsteroidal anti-inflammatory drugs and anastomotic dehiscence in bowel surgery: systematic review and meta-analysis of randomized, controlled trials. Dis Colon Rectum. 2013;56(1):126–34.

    Article  Google Scholar 

  46. Graham GG, Scott KF. Mechanism of action of paracetamol. Am J Ther. 2005;12(1):46–55.

    Article  Google Scholar 

  47. Prescott LF. Paracetamol overdosage. Pharmacological considerations and clinical management. Drugs. 1983;25(3):290–314.

    Article  CAS  Google Scholar 

  48. Remy C, Marret E, Bonnet F. Effects of acetaminophen on morphine side-effects and consumption after major surgery: meta-analysis of randomized controlled trials. Br J Anaesth. 2005;94(4):505–13.

    Article  CAS  Google Scholar 

  49. Apfel CC, Turan A, Souza K, Pergolizzi J, Hornuss C. Intravenous acetaminophen reduces postoperative nausea and vomiting: a systematic review and meta-analysis. Pain. 2013;154(5):677–89.

    Article  CAS  Google Scholar 

  50. Apfel CCSK, Portillo J, Dalal P, Bergese SD. Patient satisfaction with intravenous acetaminophen: a pooled analysis of five randomized, placebo controlled studies in the acute postoperative setting. J Healthc Qual. 2015;37(3):155–62.

    Article  Google Scholar 

  51. Swenson BR, Gottschalk A, Wells LT, Rowlingson JC, Thompson PW, Barclay M, et al. Intravenous lidocaine is as effective as epidural bupivacaine in reducing ileus duration, hospital stay, and pain after open colon resection: a randomized clinical trial. Reg Anesth Pain Med. 2010;35:370–6.

    Article  CAS  Google Scholar 

  52. Vigneault L, Turgeon AF, Cote D, Lauzier F, Zarychanski R, Moore L, et al. Perioperative intravenous lidocaine infusion for postoperative pain control: a meta-analysis of randomized controlled trials. Can J Anaesth. 2011;58(1):22–37.

    Article  Google Scholar 

  53. Lirk P, Berger R, Hollmann MW, Fiegl H. Lidocaine time- and dose-dependently demethylates deoxyribonucleic acid in breast cancer cell lines in vitro. Br J Anaesth. 2012;109(2):200–7.

    Article  CAS  Google Scholar 

  54. Sridhar P, Sistla SC, Ali SM, Karthikeyan VS, Badhe AS, Ananthanarayanan PH. Effect of intravenous lignocaine on perioperative stress response and post-surgical ileus in elective open abdominal surgeries: a double-blind randomized controlled trial. ANZ J Surg. 2015;85(6):425–9.

    Article  Google Scholar 

  55. McCartney CJ, Sinha A, Katz J. A qualitative systematic review of the role of N-methyl-d-aspartate receptor antagonists in preventive analgesia. Anesth Analg. 2004;98(5):1385–400.

    Article  CAS  Google Scholar 

  56. Bell RF, Dahl JB, Moore RA, Kalso E. Perioperative ketamine for acute postoperative pain. Cochrane Database Syst Rev. 2006;(1):CD004603.

    Google Scholar 

  57. Elia N, Tramer MR. Ketamine and postoperative pain: a quantitative systematic review of randomised trials. Pain. 2005;113(1–2):61–70.

    Article  CAS  Google Scholar 

  58. Carstensen M, Moller AM. Adding ketamine to morphine for intravenous patient-controlled analgesia for acute postoperative pain: a qualitative review of randomized trials. Br J Anaesth. 2010;104(4):401–6.

    Article  CAS  Google Scholar 

  59. Fu ES, Miguel R, Scharf JE. Preemptive ketamine decreases postoperative narcotic requirements in patients undergoing abdominal surgery. Anesth Analg. 1997;84(5):1086–90.

    Article  CAS  Google Scholar 

  60. Fawcett WJ, Baldini G. Optimal analgesia during major open and laparoscopic abdominal surgery. Anesthesiol Clin. 2015;33(1):65–78.

    Article  Google Scholar 

  61. Tiippana EM, Hamunen K, Kontinen VK, Kalso E. Do surgical patients benefit from perioperative gabapentin/pregabalin? A systematic review of efficacy and safety. Anesth Analg. 2007;104(6):1545–56.

    Article  CAS  Google Scholar 

  62. Hurley RW, Cohen SP, Williams KA, Rowlingson AJ, Wu CL. The analgesic effects of perioperative gabapentin on postoperative pain: a meta-analysis. Reg Anesth Pain Med. 2006;31(3):237–47.

    CAS  PubMed  Google Scholar 

  63. Gilron I. Review article: The role of anticonvulsant drugs in postoperative pain management: a bench-to-bedside perspective. Can J Anaesth. 2006;53:562–71.

    Article  Google Scholar 

  64. Zhang J, Ho KY, Wang Y. Efficacy of pregabalin in acute postoperative pain: a meta-analysis. Br J Anaesth. 2011;106(4):454–62.

    Article  CAS  Google Scholar 

  65. Ramaswamy S, Wilson JA, Colvin L. Non-opioid-based adjuvant analgesia in perioperative care. Contin Educ Anaesth Crit Care Pain. 2013;13:152–7.

    Article  Google Scholar 

  66. Blaudszun G, Lysakowski C, Elia N, Tramer MR. Effect of perioperative systemic alpha2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials. Anesthesiology. 2012;116(6):1312–22.

    Article  CAS  Google Scholar 

  67. De Oliveira GS Jr, Almeida MD, Benzon HT, McCarthy RJ. Perioperative single dose systemic dexamethasone for postoperative pain: a meta-analysis of randomized controlled trials. Anesthesiology. 2011;115(3):575–88.

    Article  Google Scholar 

  68. Waldron NH, Jones CA, Gan TJ, Allen TK, Habib AS. Impact of perioperative dexamethasone on postoperative analgesia and side-effects: systematic review and meta-analysis. Br J Anaesth. 2013;110(2):191–200.

    Article  CAS  Google Scholar 

  69. Vignali A, Di Palo S, Orsenigo E, Ghirardelli L, Radaelli G, Staudacher C. Effect of prednisolone on local and systemic response in laparoscopic vs. open colon surgery: a randomized, double-blind, placebo-controlled trial. Dis Colon Rectum. 2009;52(6):1080–8.

    Article  Google Scholar 

  70. Katz J, Clarke H, Seltzer Z. Review article: Preventive analgesia: quo vadimus? Anesth Analg. 2011;113(5):1242–53.

    Article  Google Scholar 

  71. Taylor BK, Brennan TJ. Preemptive analgesia: moving beyond conventional strategies and confusing terminology. J Pain. 2000;1:77–84.

    Article  Google Scholar 

  72. Katz J, McCartney CJ. Current status of preemptive analgesia. Curr Opin Anaesthesiol. 2002;15(4):435–41.

    Article  Google Scholar 

  73. Moiniche S, Kehlet H, Dahl JB. A qualitative and quantitative systematic review of preemptive analgesia for postoperative pain relief: the role of timing of analgesia. Anesthesiology. 2002;96(3):725–41.

    Article  Google Scholar 

  74. Richebe P, Rivat C, Liu SS. Perioperative or postoperative nerve block for preventive analgesia: should we care about the timing of our regional anesthesia? Anesth Analg. 2013;116(5):969–70.

    Article  Google Scholar 

  75. Barreveld A, Witte J, Chahal H, Durieux ME, Strichartz G. Preventive analgesia by local anesthetics: the reduction of postoperative pain by peripheral nerve blocks and intravenous drugs. Anesth Analg. 2013;116(5):1141–61.

    Article  CAS  Google Scholar 

  76. Andreae MH, Andreae DA. Local anaesthetics and regional anaesthesia for preventing chronic pain after surgery. Cochrane Database Syst Rev. 2012;(10):CD007105.

    Google Scholar 

  77. Joshi GP, Schug SA, Kehlet H. Procedure-specific pain management and outcome strategies. Best Pract Res Clin Anaesthesiol. 2014;28(2):191–201.

    Article  Google Scholar 

  78. Challapalli V, Tremont-Lukats IW, McNicol ED, Lau J, Carr DB. Systemic administration of local anesthetic agents to relieve neuropathic pain. Cochrane Database Syst Rev. 2005;(4):CD003345.

    Google Scholar 

  79. Shavit Y, Lewis JW, Terman GW, Gale RP, Liebeskind JC. Opioid peptides mediate the suppressive effect of stress on natural killer cell cytotoxicity. Science. 1984;223(4632):188–90.

    Article  CAS  Google Scholar 

  80. Singleton PA, Moss J. Effect of perioperative opioids on cancer recurrence: a hypothesis. Future Oncol. 2010;6(8):1237–42.

    Article  CAS  Google Scholar 

  81. Exadaktylos AK, Buggy DJ, Moriarty DC, Mascha E, Sessler DI. Can anesthetic technique for primary breast cancer surgery affect recurrence or metastasis? Anesthesiology. 2006;105(4):660–4.

    Article  Google Scholar 

  82. Gach K, Wyrebska A, Fichna J, Janecka A. The role of morphine in regulation of cancer cell growth. Naunyn Schmiedebergs Arch Pharmacol. 2011;384(3):221–30.

    Article  CAS  Google Scholar 

  83. Doornebal CW, Vrijland K, Hau CS, Coffelt SB, Ciampricotti M, Jonkers J, et al. Morphine does not facilitate breast cancer progression in two preclinical mouse models for human invasive lobular and HER2(+) breast cancer. Pain. 2015;156(8):1424–32.

    Article  CAS  Google Scholar 

  84. Cha YI, DuBois RN. NSAIDs and cancer prevention: targets downstream of COX-2. Annu Rev Med. 2007;58:239–52.

    Article  CAS  Google Scholar 

  85. Forget P, Collet V, Lavand’homme P, De Kock M. Does analgesia and condition influence immunity after surgery? Effects of fentanyl, ketamine and clonidine on natural killer activity at different ages. Eur J Anaesthesiol. 2010;27(3):233–40.

    Article  Google Scholar 

  86. Forget P, Vandenhende J, Berliere M, Machiels JP, Nussbaum B, Legrand C, et al. Do intraoperative analgesics influence breast cancer recurrence after mastectomy? A retrospective analysis. Anesth Analg. 2010;110(6):1630–5.

    Article  CAS  Google Scholar 

  87. Monk TG, Weldon BC, Garvan CW, Dede DE, van der Aa MT, Heilman KM, et al. Predictors of cognitive dysfunction after major noncardiac surgery. Anesthesiology. 2008;108(1):18–30.

    Article  Google Scholar 

  88. Deiner S, Silverstein JH. Postoperative delirium and cognitive dysfunction. Br J Anaesth. 2009;103(Suppl 1):i41–6.

    Article  Google Scholar 

  89. Bruce AJ, Ritchie CW, Blizard R, Lai R, Raven P. The incidence of delirium associated with orthopedic surgery: a meta-analytic review. Int Psychogeriatr. 2007;19(2):197–214.

    Article  Google Scholar 

  90. Steinmetz J, Christensen KB, Lund T, Lohse N, Rasmussen LS, Group I. Long-term consequences of postoperative cognitive dysfunction. Anesthesiology. 2009;110(3):548–55.

    Article  Google Scholar 

  91. Aubrun F, Marmion F. The elderly patient and postoperative pain treatment. Best Pract Res Clin Anaesthesiol. 2007;21(1):109–27.

    Article  Google Scholar 

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Michelagnoli, G., Baldini, G. (2018). Multimodal Simple Analgesia. In: Krige, A., Scott, M. (eds) Analgesia in Major Abdominal Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-94482-1_2

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