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Natural History of Hepatitis B Virus

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Abstract

Chronic HBV infection is a worldwide public health issue with an estimated 400 million persons infected. Variations in both epidemiology and genotype have been noted to affect the course and severity of sequelae of the disease; however, general comments can be made regarding the natural history of the disease. The natural history of chronic infection is generally divided into an active, higher replicative phase and a lower replicative phase. An understanding of viral activity in these phases is critical to understanding appropriate surveillance of disease activity as well as indications to begin treatment.

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Authors and Affiliations

  1. Division of Gastroenterology and Hepatology, University of Missouri, Columbia, MO, USA

    Ryan D. Heath & Veysel Tahan

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  1. Cerrahasa Medical School, Istanbul University, Istanbul, Turkey

    Resat Ozaras

  2. University of Missouri, Columbia, Missouri, USA

    Veysel Tahan

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Heath, R.D., Tahan, V. (2018). Natural History of Hepatitis B Virus. In: Ozaras, R., Tahan, V. (eds) Viral Hepatitis: Chronic Hepatitis B. Springer, Cham. https://doi.org/10.1007/978-3-319-93449-5_1

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