Abstract
The neuropathology of RBD demonstrates the very strong association of alpha-synucleinopathy neurodegeneration with RBD, with complexities involving clinical synucleinopathy subtypes; prodromal stages; heterogeneous phenoconversion timelines from idiopathic RBD (iRBD) to overt neurodegeneration; distribution of synuclein pathology in the central, peripheral, and autonomic nervous systems; clinical comorbidities; antidepressant medication use; and other clinical factors. This chapter covers (1) a clinical-neuropathological study of 172 RBD cases, (2) neuropathology of iRBD cases, (3) a clinical-neuropathological study of PD and probable RBD, (4) a case report of RBD and the neuropathology of prodromal Lewy body disease, (5) two studies on how RBD is closely related to enteric neuropathology in iRBD and RBD-PD, (6) two studies on skin nerve phosphorylated α-synuclein deposits in iRBD, (7) a study on reduced intraepidermal nerve fiber density in patients with iRBD, (8) a study on α-synuclein deposition in autonomic nerve fibers in the submandibular glands in patients with iRBD, (9) a study on α-synuclein aggregates in labial glands of patients with iRBD, and (10) a study comparing the predictive value of probable RBD vs. absence of probable RBD in post-mortem histopathology-confirmed α-synucleinopathy in patients participating in a longitudinal aging and neurodegenerative disorders study.
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Schenck, C.H. (2019). Neuropathology of REM Sleep Behavior Disorder. In: Schenck, C., Högl, B., Videnovic, A. (eds) Rapid-Eye-Movement Sleep Behavior Disorder. Springer, Cham. https://doi.org/10.1007/978-3-319-90152-7_40
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DOI: https://doi.org/10.1007/978-3-319-90152-7_40
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