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Air Pollution in Infancy, Childhood and Young Adults

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Abstract

Children are particularly exposed to the effect of air pollution when compared to adults because of behavioural, environmental and physiological features. Exposure to air pollutants can start since foetal and early life, and the consequences on health can show up later in childhood or in adulthood with chronic or lifelong conditions. Although the effect on the respiratory tract secondary to acute and short-term exposure is known, constant exposure to background pollution can cause harmful effect on different organs and systems.

As children develop and grow, the constant action of toxins coming from airborne compounds can cause inflammation, oxidative stress and immune responses that could lead to the onset of chronic diseases and to the exacerbation of subacute conditions.

In fact, in areas particularly exposed to pollution and during those times of the season or of the year where higher peak of concentration of air pollutants is registered, the number of hospital admission and emergency department visits is higher. The burden for children and society is particularly high, but it is probably underestimated as long as the long-term consequences of childhood exposure are still unknown.

Even if the studies on children are limited, air pollution seems to have deleterious effect on birth weight and antenatal life, growth, neurological development, psychological health, immunity and infections, gastroenterological tract, cardiovascular system, metabolism, endocrinology, haematology, respiratory tract and the development of cancers of the childhood or of the adult life.

Because children can be chronically and acutely subjected to air pollution in their different phases of life and in the different places where they live, study or play—at home, at school and in extra-scholar and leisure activities—proper actions should be taken at individual and community level to reduce the chance and the level of exposure. For these reasons, doctors should always take into account the possibility of air pollution-related disease in children and must include environmental anamnesis while taking a medical history. Public health doctors should plan prevention programmes aimed to monitor the quality of the air in ambient where children live and promote project of sanitation of these same places. Policy-makers should plan intervention directed to reduce the level of pollutants emission in residential areas and close to school, playgrounds and facilities attended by children.

Individual measures, like the use of personal protection equipment, air cleaner as well as behavioural changes, remain a key factor to reduce the level of exposure in youngsters and consequently the risk of health consequences and the onset of diseases in childhood and in the adult life.

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References

  1. Doll R. Epidemiology of cancer: current perspectives. Am J Epidemiol. 1976;104(4):396–404.

    Article  CAS  PubMed  Google Scholar 

  2. Green RM. Cancer of the scrotum. Boston Med Surg J. 1910;163(20):755–9.

    Article  Google Scholar 

  3. Kim JJ, American Academy of Pediatrics Committee on Environmental H. Ambient air pollution: health hazards to children. Pediatrics. 2004;114(6):1699–707.

    Article  PubMed  Google Scholar 

  4. Kelishadi R, Poursafa P. Air pollution and non-respiratory health hazards for children. Arch Med Sci. 2010;6(4):483–95.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Goldizen FC, Sly PD, Knibbs LD. Respiratory effects of air pollution on children. Pediatr Pulmonol. 2016;51(1):94–108.

    Article  PubMed  Google Scholar 

  6. Pinault L, Crouse D, Jerrett M, Brauer M, Tjepkema M. Socioeconomic differences in nitrogen dioxide ambient air pollution exposure among children in the three largest Canadian cities. Health Rep. 2016;27(7):3–9.

    PubMed  Google Scholar 

  7. Ritz B, Wilhelm M Air pollution impact on infants and children: UCLA Institute of the Environment and Sustainability; 2013 [cited 12 Aug 2016]. Available from: http://www.environment.ucla.edu/reportcard/article1700.html.

  8. Buka I, Koranteng S, Osornio-Vargas AR. The effects of air pollution on the health of children. Paediatr Child Health. 2006;11(8):513–6.

    PubMed  PubMed Central  Google Scholar 

  9. Rudnik J, Herman S, Pisiewicz K, Roszkowska H. Long-term effects on health of air pollution in children. Z Erkr Atmungsorgane. 1983;161(2):177–91.

    CAS  PubMed  Google Scholar 

  10. Karr C. Addressing environmental contaminants in pediatric practice. Pediatr Rev. 2011;32(5):190–200.

    Article  PubMed  Google Scholar 

  11. Moya J, Bearer CF, Etzel RA. Children’s behavior and physiology and how it affects exposure to environmental contaminants. Pediatrics. 2004;113(Supplement 3):996–1006.

    PubMed  Google Scholar 

  12. Organization WH. Effects of air pollution on children’s health and development: a review of the evidence. Copenhagen: WHO; 2005.

    Google Scholar 

  13. Pedersen M. Ciliary activity and pollution. Lung. 1990;168(1):368–76.

    Article  PubMed  Google Scholar 

  14. van Roosbroeck S, Wichmann J, Janssen NA, Hoek G, van Wijnen JH, Lebret E, et al. Long-term personal exposure to traffic-related air pollution among school children, a validation study. Sci Total Environ. 2006;368(2–3):565–73.

    Article  PubMed  CAS  Google Scholar 

  15. Lee JT, Son JY, Kim H, Kim SY. Effect of air pollution on asthma-related hospital admissions for children by socioeconomic status associated with area of residence. Arch Environ Occup Health. 2006;61(3):123–30.

    Article  PubMed  Google Scholar 

  16. Chakraborty J, Zandbergen PA. Children at risk: measuring racial/ethnic disparities in potential exposure to air pollution at school and home. J Epidemiol Community Health. 2007;61(12):1074–9.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Feretti D, Ceretti E, De Donno A, Moretti M, Carducci A, Bonetta S, et al. Monitoring air pollution effects on children for supporting public health policy: the protocol of the prospective cohort MAPEC study. BMJ Open. 2014;4(9):e006096.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Demoulin-Alexikova S, Plevkova J, Mazurova L, Zatko T, Alexik M, Hanacek J, et al. Impact of air pollution on age and gender related increase in cough reflex sensitivity of healthy children in Slovakia. Front Physiol. 2016;7:54.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Spencer-Hwang R, Soret S, Ghamsary M, Rizzo N, Baum M, Juma D, et al. Gender differences in respiratory health of school children exposed to rail yard-generated air pollution: the ENRRICH study. J Environ Health. 2016;78(6):8–16.

    PubMed  PubMed Central  Google Scholar 

  20. Dong GH, Chen T, Liu MM, Wang D, Ma YN, Ren WH, et al. Gender differences and effect of air pollution on asthma in children with and without allergic predisposition: northeast Chinese children health study. PLoS One. 2011;6(7):e22470.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Newman NC, Ryan PH, Huang B, Beck AF, Sauers HS, Kahn RS. Traffic-related air pollution and asthma hospital readmission in children: a longitudinal cohort study. J Pediatr. 2014;164(6):1396–402.e1.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Atkinson RW, Ross Anderson H, Sunyer J, Ayres J, Baccini M, Vonk JM, et al. Acute effects of particulate air pollution on respiratory admissions: results from APHEA 2 project. Am J Respir Crit Care Med. 2001;164(10):1860–6.

    Article  CAS  PubMed  Google Scholar 

  23. Sun HL, Chou MC, Lue KH. The relationship of air pollution to ED visits for asthma differ between children and adults. Am J Emerg Med. 2006;24(6):709–13.

    Article  PubMed  Google Scholar 

  24. Delfino RJ, Chang J, Wu J, Ren C, Tjoa T, Nickerson B, et al. Repeated hospital encounters for asthma in children and exposure to traffic-related air pollution near the home. Ann Allergy Asthma Immunol. 2009;102(2):138–44.

    Article  PubMed  Google Scholar 

  25. Villeneuve PJ, Chen L, Rowe BH, Coates F. Outdoor air pollution and emergency department visits for asthma among children and adults: a case-crossover study in northern Alberta, Canada. Environ Health. 2007;6:40.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Liu Y, Liu J, Chen F, Bilal Haider S, Wang Q, Jiao F, et al. Coal mine air pollution and number of children hospitalizations because of respiratory tract infection: a time series analysis. J Environ Public Health. 2015;2015:649706.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  27. Bobak M, Leon DA. Air pollution and infant mortality in the Czech Republic, 1986–88. Lancet. 1992;340(8826):1010–4.

    Article  CAS  PubMed  Google Scholar 

  28. Saldiva PH, Lichtenfels A, Paiva P, Barone I, Martins M, Massad E, et al. Association between air pollution and mortality due to respiratory diseases in children in São Paulo, Brazil: a preliminary report. Environ Res. 1994;65(2):218–25.

    Article  CAS  PubMed  Google Scholar 

  29. Conceicao G, Miraglia S, Kishi HS, Saldiva P, Singer JM. Air pollution and child mortality: a time-series study in São Paulo, Brazil. Environ Health Perspect. 2001;109(Suppl 3):347.

    CAS  PubMed  PubMed Central  Google Scholar 

  30. Gouveia N, Fletcher T. Time series analysis of air pollution and mortality: effects by cause, age and socioeconomic status. J Epidemiol Community Health. 2000;54(10):750–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Landrigan PJ, Schechter CB, Lipton JM, Fahs MC, Schwartz J. Environmental pollutants and disease in American children: estimates of morbidity, mortality, and costs for lead poisoning, asthma, cancer, and developmental disabilities. Environ Health Perspect. 2002;110(7):721.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Smith KR, Mehta S. The burden of disease from indoor air pollution in developing countries: comparison of estimates. Int J Hyg Environ Health. 2003;206(4):279–89.

    Article  CAS  PubMed  Google Scholar 

  33. Aarnio M, Winter T, Kujala U, Kaprio J. Associations of health related behaviour, social relationships, and health status with persistent physical activity and inactivity: a study of Finnish adolescent twins. Br J Sports Med. 2002;36(5):360–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. O’Lenick CR, Winquist A, Mulholland JA, Friberg MD, Chang HH, Kramer MR, et al. Assessment of neighbourhood-level socioeconomic status as a modifier of air pollution-asthma associations among children in Atlanta. J Epidemiol Community Health. 2016;71(2):129–36.

    Article  PubMed  Google Scholar 

  35. Bener A, Kamal M, Shanks NJ. Impact of asthma and air pollution on school attendance of primary school children: are they at increased risk of school absenteeism? J Asthma. 2007;44(4):249–52.

    Article  PubMed  Google Scholar 

  36. Romieu I, Lugo MC, Velasco SR, Sanchez S, Meneses F, Hernandez M. Air pollution and school absenteeism among children in Mexico City. Am J Epidemiol. 1992;136(12):1524–31.

    Article  CAS  PubMed  Google Scholar 

  37. Romieu I, Samet JM, Smith KR, Bruce N. Outdoor air pollution and acute respiratory infections among children in developing countries. J Occup Environ Med. 2002;44(7):640–9.

    Article  PubMed  Google Scholar 

  38. Mishra V. Indoor air pollution from biomass combustion and acute respiratory illness in preschool age children in Zimbabwe. Int J Epidemiol. 2003;32(5):847–53.

    Article  PubMed  Google Scholar 

  39. Khalequzzaman M, Kamijima M, Sakai K, Chowdhury NA, Hamajima N, Nakajima T. Indoor air pollution and its impact on children under five years old in Bangladesh. Indoor Air. 2007;17(4):297–304.

    Article  CAS  PubMed  Google Scholar 

  40. Nandasena S, Wickremasinghe AR, Sathiakumar N. Indoor air pollution and respiratory health of children in the developing world. World J Clin Pediatr. 2013;2(2):6–15.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Dionisio KL, Howie S, Fornace KM, Chimah O, Adegbola RA, Ezzati M. Measuring the exposure of infants and children to indoor air pollution from biomass fuels in the Gambia. Indoor Air. 2008;18(4):317–27.

    Article  CAS  PubMed  Google Scholar 

  42. Baumgartner J, Schauer JJ, Ezzati M, Lu L, Cheng C, Patz J, et al. Patterns and predictors of personal exposure to indoor air pollution from biomass combustion among women and children in rural China. Indoor Air. 2011;21(6):479–88.

    Article  CAS  PubMed  Google Scholar 

  43. Emmelin A, Wall S. Indoor air pollution: a poverty-related cause of mortality among the children of the world. Chest. 2007;132(5):1615–23.

    Article  CAS  PubMed  Google Scholar 

  44. Knopik VS, Marceau K, Palmer RH, Smith TF, Heath AC. Maternal smoking during pregnancy and offspring birth weight: a genetically-informed approach comparing multiple raters. Behav Genet. 2016;46(3):353–64.

    Article  PubMed  Google Scholar 

  45. Campbell AM. The effect of excessive cigaret smoking on maternal health. Am J Obstet Gynecol. 1936;31(3):502–8.

    Article  Google Scholar 

  46. Huang JV, Leung GM, Schooling CM. The association of air pollution with birthweight and gestational age: evidence from Hong Kong’s ‘children of 1997’ birth cohort. J Public Health (Oxf). 2016:1–9.

    Google Scholar 

  47. Mortimer K, Neugebauer R, Lurmann F, Alcorn S, Balmes J, Tager I. Air pollution and pulmonary function in asthmatic children: effects of prenatal and lifetime exposures. Epidemiology. 2008;19(4):550–7. discussion 61-2

    Article  PubMed  Google Scholar 

  48. Yang CY, Tseng YT, Chang CC. Effects of air pollution on birth weight among children born between 1995 and 1997 in Kaohsiung, Taiwan. J Toxicol Environ Health A. 2003;66(9):807–16.

    Article  CAS  PubMed  Google Scholar 

  49. Ritz B, Yu F, Chapa G, Fruin S. Effect of air pollution on preterm birth among children born in Southern California between 1989 and 1993. Epidemiology. 2000;11(5):502–11.

    Article  CAS  PubMed  Google Scholar 

  50. Rey-Ares L, Irazola VE, Althabe F, Sobrino E, Mazzoni A, Seron P, et al. Lower respiratory tract illness in children younger than five years of age and adverse pregnancy outcomes related to household air pollution in Bariloche (Argentina) and Temuco (Chile). Indoor Air. 2015;26(6):964–75.

    Article  CAS  Google Scholar 

  51. Gilliland F, Avol E, Kinney P, Jerrett M, Dvonch T, Lurmann F, et al. Air pollution exposure assessment for epidemiologic studies of pregnant women and children: lessons learned from the centers for Children’s environmental health and disease prevention research. Environ Health Perspect. 2005;113(10):1447–54.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Röösli M. Non-cancer effects of chemical agents on children’s health. Prog Biophys Mol Biol. 2011;107(3):315–22.

    Article  PubMed  CAS  Google Scholar 

  53. Kalkbrenner AE, Daniels JL, Chen J-C, Poole C, Emch M, Morrissey J. Perinatal exposure to hazardous air pollutants and autism spectrum disorders at age 8. Epidemiology. 2010;21(5):631.

    Article  PubMed  PubMed Central  Google Scholar 

  54. von Ehrenstein OS, Aralis H, Cockburn M, Ritz B. In utero exposure to toxic air pollutants and risk of childhood autism. Epidemiology. 2014;25(6):851.

    Article  Google Scholar 

  55. Netriova Y, Brezina M, Hruskovic I, Kacenakova M. Growth in children living in areas with air pollution. Cesk Pediatr. 1990;45(8):456–8.

    CAS  PubMed  Google Scholar 

  56. Schlipkoter HW, Rosicky B, Dolgner R, Pelech L. Growth and bone maturation in children from two regions of the F.R.G. Differing in the degree of air pollution: results of the 1974 and 1984 surveys. J Hyg Epidemiol Microbiol Immunol. 1986;30(4):353–8.

    CAS  PubMed  Google Scholar 

  57. Thielebeule U, Pelech L, Grosser PJ, Horn K. Body height and bone age of school children in areas of different air pollution concentrations. (a repeat study conducted in Bitterfeld and Berlin, capital of the GDR). Z Gesamte Hyg. 1980;26(10):771–4.

    CAS  PubMed  Google Scholar 

  58. Liu C, Fuertes E, Flexeder C, Hofbauer LC, Berdel D, Hoffmann B, et al. Associations between ambient air pollution and bone turnover markers in 10-year old children: results from the GINIplus and LISAplus studies. Int J Hyg Environ Health. 2015;218(1):58–65.

    Article  CAS  PubMed  Google Scholar 

  59. Calderon-Garciduenas L, Mora-Tiscareno A, Francolira M, Torres-Jardon R, Pena-Cruz B, Palacios-Lopez C, et al. Exposure to urban air pollution and bone health in clinically healthy six-year-old children. Arh Hig Rada Toksikol. 2013;64(1):23–34.

    Article  CAS  PubMed  Google Scholar 

  60. Holick MF. Environmental factors that influence the cutaneous production of vitamin D. Am J Clin Nutr. 1995;61(3):638S–45S.

    Article  CAS  PubMed  Google Scholar 

  61. Ando M, Tadano M, Yamamoto S, Tamura K, Asanuma S, Watanabe T, et al. Health effects of fluoride pollution caused by coal burning. Sci Total Environ. 2001;271(1):107–16.

    Article  CAS  PubMed  Google Scholar 

  62. Qin X, Wang S, Yu M, Zhang L, Li X, Zuo Z, et al. Child skeletal fluorosis from indoor burning of coal in southwestern China. J Environ Public Health. 2009;2009:7.

    Article  CAS  Google Scholar 

  63. Goyer RA. Toxic and essential metal interactions. Annu Rev. Nutr. 1997;17(1):37–50.

    Article  CAS  PubMed  Google Scholar 

  64. Berglund M, Åkesson A, Bjellerup P, Vahter M. Metal–bone interactions. Toxicol Lett. 2000;112:219–25.

    Article  PubMed  Google Scholar 

  65. Järup L, Åkesson A. Current status of cadmium as an environmental health problem. Toxicol Appl Pharmacol. 2009;238(3):201–8.

    Article  PubMed  CAS  Google Scholar 

  66. Ejaz S, Camer GA, Anwar K, Ashraf M. Monitoring impacts of air pollution: PIXE analysis and histopathological modalities in evaluating relative risks of elemental contamination. Ecotoxicology. 2014;23(3):357–69.

    Article  CAS  PubMed  Google Scholar 

  67. Chiu YH, Hsu HH, Coull BA, Bellinger DC, Kloog I, Schwartz J, et al. Prenatal particulate air pollution and neurodevelopment in urban children: examining sensitive windows and sex-specific associations. Environ Int. 2016;87:56–65.

    Article  CAS  PubMed  Google Scholar 

  68. Sunyer J. The neurological effects of air pollution in children. Eur Respir J. 2008;32(3):535–7.

    Article  CAS  PubMed  Google Scholar 

  69. Calderon-Garciduenas L, Cross JV, Franco-Lira M, Aragon-Flores M, Kavanaugh M, Torres-Jardon R, et al. Brain immune interactions and air pollution: macrophage inhibitory factor (MIF), prion cellular protein (PrP(C)), interleukin-6 (IL-6), interleukin 1 receptor antagonist (IL-1Ra), and interleukin-2 (IL-2) in cerebrospinal fluid and MIF in serum differentiate urban children exposed to severe vs. low air pollution. Front Neurosci. 2013;7:183.

    Article  PubMed  PubMed Central  Google Scholar 

  70. Calderon-Garciduenas L, Mora-Tiscareno A, Styner M, Gomez-Garza G, Zhu H, Torres-Jardon R, et al. White matter hyperintensities, systemic inflammation, brain growth, and cognitive functions in children exposed to air pollution. J Alzheimers Dis. 2012;31(1):183–91.

    CAS  PubMed  Google Scholar 

  71. Calderon-Garciduenas L, Leray E, Heydarpour P, Torres-Jardon R, Reis J. Air pollution, a rising environmental risk factor for cognition, neuroinflammation and neurodegeneration: the clinical impact on children and beyond. Rev Neurol. 2016;172(1):69–80.

    Article  CAS  PubMed  Google Scholar 

  72. Calderon-Garciduenas L, Vojdani A, Blaurock-Busch E, Busch Y, Friedle A, Franco-Lira M, et al. Air pollution and children: neural and tight junction antibodies and combustion metals, the role of barrier breakdown and brain immunity in neurodegeneration. J Alzheimers Dis. 2015;43(3):1039–58.

    CAS  PubMed  Google Scholar 

  73. Clark C, Martin R, Van Kempen E, Alfred T, Head J, Davies HW, et al. Exposure-effect relations between aircraft and road traffic noise exposure at school and reading comprehension the RANCH project. Am J Epidemiol. 2006;163(1):27–37.

    Article  PubMed  Google Scholar 

  74. Sunyer J, Esnaola M, Alvarez-Pedrerol M, Forns J, Rivas I, Lopez-Vicente M, et al. Association between traffic-related air pollution in schools and cognitive development in primary school children: a prospective cohort study. PLoS Med. 2015;12(3):e1001792.

    Article  PubMed  PubMed Central  Google Scholar 

  75. Suglia SF, Gryparis A, Wright R, Schwartz J, Wright R. Association of black carbon with cognition among children in a prospective birth cohort study. Am J Epidemiol. 2008;167(3):280–6.

    Article  PubMed  Google Scholar 

  76. Mirowsky J, Ross CE. Life change: an abandoned explanation. In:Social causes of psychological distress. Piscataway, NJ: Transaction Publishers; 2003. p. 159–65.

    Google Scholar 

  77. Evans GW, Colome SD, Shearer DF. Psychological reactions to air pollution. Environ Res. 1988;45(1):1–15.

    Article  CAS  PubMed  Google Scholar 

  78. Lundberg A. Psychiatric aspects of air pollution. Otolaryngol Head Neck Surg. 1996;114(2):227–31.

    Article  CAS  PubMed  Google Scholar 

  79. Power MC, Kioumourtzoglou M-A, Hart JE, Okereke OI, Laden F, Weisskopf MG. The relation between past exposure to fine particulate air pollution and prevalent anxiety: observational cohort study. BMJ. 2015;350:h1111.

    Article  PubMed  PubMed Central  Google Scholar 

  80. Oudin A, Braback L, Astrom DO, Stromgren M, Forsberg B. Association between neighbourhood air pollution concentrations and dispensed medication for psychiatric disorders in a large longitudinal cohort of Swedish children and adolescents. BMJ Open. 2016;6(6):e010004.

    Article  PubMed  PubMed Central  Google Scholar 

  81. Volk HE, Hertz-Picciotto I, Delwiche L, Lurmann F, McConnell R. Residential proximity to freeways and autism in the CHARGE study. Environ Health Perspect. 2011;119(6):873.

    Article  PubMed  Google Scholar 

  82. Newman NC, Ryan P, LeMasters G, Levin L, Bernstein D, Hershey GKK, et al. Traffic-related air pollution exposure in the first year of life and behavioral scores at 7 years of age. Environ Health Perspect. 2013;121(6):731.

    Article  PubMed  PubMed Central  Google Scholar 

  83. Perera FP, Wang S, Vishnevetsky J, Zhang B, Cole KJ, Tang D, et al. Polycyclic aromatic hydrocarbons-aromatic DNA adducts in cord blood and behavior scores in New York city children. Environ Health Perspect. 2011;119(8):1176.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  84. Saxon A, Diaz-Sanchez D. Air pollution and allergy: you are what you breathe. Nat Immunol. 2005;6(3):223–6.

    Article  CAS  PubMed  Google Scholar 

  85. Hadnagy W, Stiller-Winkler R, Idel H. Immunological alterations in sera of persons living in areas with different air pollution. Toxicol Lett. 1996;88(1):147–53.

    Article  CAS  PubMed  Google Scholar 

  86. Zhang J, Smith KR. Household air pollution from coal and biomass fuels in China: measurements, health impacts, and interventions. Environ Health Perspect. 2007;115(6):848–55.

    Article  PubMed  Google Scholar 

  87. Lin H-H, Ezzati M, Murray M. Tobacco smoke, indoor air pollution and tuberculosis: a systematic review and meta-analysis. PLoS Med. 2007;4(1):e20.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  88. Houtmeyers E, Gosselink R, Gayan-Ramirez G, Decramer M. Regulation of mucociliary clearance in health and disease. Eur Respir J. 1999;13(5):1177–88.

    Article  CAS  PubMed  Google Scholar 

  89. Rovers MM, de Kok IM, Schilder AG. Risk factors for otitis media: an international perspective. Int J Pediatr Otorhinolaryngol. 2006;70(7):1251–6.

    Article  PubMed  Google Scholar 

  90. Heinrich J, Raghuyamshi VS. Air pollution and otitis media: a review of evidence from epidemiologic studies. Curr Allergy Asthma Rep. 2004;4(4):302–9.

    Article  PubMed  Google Scholar 

  91. Patel MA, Mener DJ, Garcia-Esquinas E, Navas-Acien A, Agrawal Y, Lin SY. Tobacco smoke exposure and eustachian tube disorders in US children and adolescents. PLoS One. 2016;11(10):e0163926.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  92. Gulya AJ. Environmental tobacco smoke and otitis media. Otolaryngol Head Neck Surg. 1994;111(1):6–8.

    Article  CAS  PubMed  Google Scholar 

  93. Brook I. The impact of smoking on oral and nasopharyngeal bacterial flora. J Dent Res. 2011;90(6):704–10.

    Article  CAS  PubMed  Google Scholar 

  94. Bukharin OV, Deriabin DG, Nemtseva NV. Staphylococcal contamination of the upper respiratory tract mucosa in children exposed to air pollution. Gig Sanit. 1996;(6):6–8.

    Google Scholar 

  95. Nandi S, Kumar R, Ray P, Vohra H, Ganguly NK. Group a streptococcal sore throat in a periurban population of northern India: a one-year prospective study. Bull World Health Organ. 2001;79(6):528–33.

    CAS  PubMed  PubMed Central  Google Scholar 

  96. Orazzo F, Nespoli L, Ito K, Tassinari D, Giardina D, Funis M, et al. Air pollution, aeroallergens, and emergency room visits for acute respiratory diseases and gastroenteric disorders among young children in six Italian cities. Environ Health Perspect. 2009;117(11):1780–5.

    CAS  PubMed  PubMed Central  Google Scholar 

  97. Savilov ED, Shcherbakova EB. Acute intestinal infections in children in areas with industrial environmental air pollution. Gig Sanit. 2003;(4):6–8.

    Google Scholar 

  98. Herbarth O, Franck U, Krumbiegel P, Rehwagen M, Rolle-Kampczyk U, Weiss H. Noninvasive assessment of liver detoxification capacity of children, observed in children from heavily polluted industrial and clean control areas, together with assessments of air pollution and chloro-organic body burden. Environ Toxicol. 2004;19(2):103–8.

    Article  CAS  PubMed  Google Scholar 

  99. Liu C, Fuertes E, Tiesler CM, Birk M, Babisch W, Bauer CP, et al. The associations between traffic-related air pollution and noise with blood pressure in children: results from the GINIplus and LISAplus studies. Int J Hyg Environ Health. 2014;217(4–5):499–505.

    Article  CAS  PubMed  Google Scholar 

  100. Dong GH, Qian ZM, Trevathan E, Zeng XW, Vaughn MG, Wang J, et al. Air pollution associated hypertension and increased blood pressure may be reduced by breastfeeding in Chinese children: the seven northeastern cities Chinese Children’s study. Int J Cardiol. 2014;176(3):956–61.

    Article  PubMed  Google Scholar 

  101. Pieters N, Koppen G, Van Poppel M, De Prins S, Cox B, Dons E, et al. Blood pressure and same-day exposure to air pollution at school: associations with nano-sized to coarse PM in children. Environ Health Perspect. 2015;123(7):737–42.

    PubMed  PubMed Central  Google Scholar 

  102. Iannuzzi A, Verga MC, Renis M, Schiavo A, Salvatore V, Santoriello C, et al. Air pollution and carotid arterial stiffness in children. Cardiol Young. 2010;20(2):186–90.

    Article  PubMed  Google Scholar 

  103. Calderón-Garcidueñas L, Vincent R, Mora-Tiscareño A, Franco-Lira M, Henríquez-Roldán C, Barragán-Mejía G, et al. Elevated plasma endothelin-1 and pulmonary arterial pressure in children exposed to air pollution. Environ Health Perspect. 2007;115(8):1248–53.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  104. Poursafa P, Kelishadi R, Lahijanzadeh A, Modaresi M, Javanmard SH, Assari R, et al. The relationship of air pollution and surrogate markers of endothelial dysfunction in a population-based sample of children. BMC Public Health. 2011;11(1):1.

    Article  Google Scholar 

  105. Kelishadi R, Hashemi M, Javanmard SH, Mansourian M, Afshani M, Poursafa P, et al. Effect of particulate air pollution and passive smoking on surrogate biomarkers of endothelial dysfunction in healthy children. Paediatr Int Child Health. 2014;34(3):165–9.

    Article  PubMed  Google Scholar 

  106. Dong GH, Wang J, Zeng XW, Chen L, Qin XD, Zhou Y, et al. Interactions between air pollution and obesity on blood pressure and hypertension in chinese children. Epidemiology. 2015;26(5):740–7.

    Article  PubMed  Google Scholar 

  107. Atkinson RW, Carey IM, Kent AJ, van Staa TP, Anderson HR, Cook DG. Long-term exposure to outdoor air pollution and incidence of cardiovascular diseases. Epidemiology. 2013;24(1):44–53.

    Article  PubMed  Google Scholar 

  108. Poursafa P, Kelishadi R, Haghjooy-Javanmard S, Rafiei L, Keramatian K. Synergistic effects of genetic polymorphism and air pollution on markers of endothelial dysfunction in children. J Res Med Sci. 2012;17(8):718–23.

    CAS  PubMed  PubMed Central  Google Scholar 

  109. Hashemi M, Afshani MR, Mansourian M, Poursafa P, Kelishadi R. Association of particulate air pollution and secondhand smoke on endothelium-dependent brachial artery dilation in healthy children. J Res Med Sci. 2012;17(4):317–21.

    PubMed  PubMed Central  Google Scholar 

  110. Watanabe N. Urinary 17-KS and 17-OHCS as markers of endocrine disruption by air pollution in primary school children. Environ Health Prev Med. 2000;4(4):221–3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  111. Thiering E, Cyrys J, Kratzsch J, Meisinger C, Hoffmann B, Berdel D, et al. Long-term exposure to traffic-related air pollution and insulin resistance in children: results from the GINIplus and LISAplus birth cohorts. Diabetologia. 2013;56(8):1696–704.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  112. Hathout EH, Beeson WL, Ischander M, Rao R, Mace JW. Air pollution and type 1 diabetes in children. Pediatr Diabetes. 2006;7(2):81–7.

    Article  PubMed  Google Scholar 

  113. Tamayo T, Rathmann W, Stahl-Pehe A, Landwehr S, Sugiri D, Kramer U, et al. No adverse effect of outdoor air pollution on HbA1c in children and young adults with type 1 diabetes. Int J Hyg Environ Health. 2016;219(4–5):349–55.

    Article  CAS  PubMed  Google Scholar 

  114. Jerrett M, McConnell R, Wolch J, Chang R, Lam C, Dunton G, et al. Traffic-related air pollution and obesity formation in children: a longitudinal, multilevel analysis. Environ Health. 2014;13:49.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  115. Grün F, Blumberg B. Endocrine disrupters as obesogens. Mol Cell Endocrinol. 2009;304(1):19–29.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  116. Dong GH, Qian Z, Liu MM, Wang D, Ren WH, Fu Q, et al. Obesity enhanced respiratory health effects of ambient air pollution in Chinese children: the seven northeastern cities study. Int J Obes. 2013;37(1):94–100.

    Article  CAS  Google Scholar 

  117. Roels H, Bruaux P, Buchet JP, Claeys-Thoreau F, Lauwerys R, Lafontaine A, et al. Impact of air pollution by lead on the heme biosynthetic pathway in school-age children. Arch Environ Health. 1976;31(6):310–6.

    Article  CAS  PubMed  Google Scholar 

  118. Poursafa P, Kelishadi R, Amini A, Amini A, Amin MM, Lahijanzadeh M, et al. Association of air pollution and hematologic parameters in children and adolescents. J Pediatr. 2011;87(4):350–6.

    Article  Google Scholar 

  119. Landrigan PJ, Baker EL, Feldman RG, Cox DH, Eden KV, Orenstein WA, et al. Increased lead absorption with anemia and slowed nerve conduction in children near a lead smelter. J Pediatr. 1976;89(6):904–10.

    Article  CAS  PubMed  Google Scholar 

  120. Pönkä A. Lead in the ambient air and blood of children in Helsinki. Sci Total Environ. 1998;219(1):1–5.

    Article  PubMed  Google Scholar 

  121. Nikolić M, Nikić D, Stanković A. Effects of air pollution on red blood cells in children. Pol J Environ Stud. 2008;17(28):267.

    Google Scholar 

  122. Weng H-H, Tsai S-S, Chen C-C, Chiu H-F, Wu T-N, Yang C-Y. Childhood leukemia development and correlation with traffic air pollution in Taiwan using nitrogen dioxide as an air pollutant marker. J Toxicol Environ Health. 2008;71(7):434–8.

    Article  CAS  Google Scholar 

  123. Pearson RL, Wachtel H, Ebi KL. Distance-weighted traffic density in proximity to a home is a risk factor for leukemia and other childhood cancers. J Air Waste Manage Assoc. 2000;50(2):175–80.

    Article  CAS  Google Scholar 

  124. Crosignani P, Tittarelli A, Borgini A, Codazzi T, Rovelli A, Porro E, et al. Childhood leukemia and road traffic: a population-based case-control study. Int J Cancer. 2004;108(4):596–9.

    Article  CAS  PubMed  Google Scholar 

  125. Tzivian L. Outdoor air pollution and asthma in children. J Asthma. 2011;48(5):470–81.

    Article  PubMed  Google Scholar 

  126. Rodriguez-Villamizar LA, Magico A, Osornio-Vargas A, Rowe BH. The effects of outdoor air pollution on the respiratory health of Canadian children: a systematic review of epidemiological studies. Can Respir J. 2015;22(5):282–92.

    Article  PubMed  PubMed Central  Google Scholar 

  127. Chen Z, Salam MT, Eckel SP, Breton CV, Gilliland FD. Chronic effects of air pollution on respiratory health in Southern California children: findings from the Southern California Children’s health study. J Thorac Dis. 2015;7(1):46–58.

    PubMed  PubMed Central  Google Scholar 

  128. Salvi S. Health effects of ambient air pollution in children. Paediatr Respir Rev. 2007;8(4):275–80.

    Article  PubMed  Google Scholar 

  129. Ward DJ, Ayres JG. Particulate air pollution and panel studies in children: a systematic review. Occup Environ Med. 2004;61(4):e13.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  130. Gehring U, Gruzieva O, Agius RM, Beelen R, Custovic A, Cyrys J, et al. Air pollution exposure and lung function in children: the ESCAPE project. Environ Health Perspect. 2013;121(11–12):1357–64.

    PubMed  PubMed Central  Google Scholar 

  131. Dherani M, Pope D, Mascarenhas M, Smith KR, Weber M, Bruce N. Indoor air pollution from unprocessed solid fuel use and pneumonia risk in children aged under five years: a systematic review and meta-analysis. Bull World Health Organ. 2008;86(5):390–8C.

    Article  PubMed  PubMed Central  Google Scholar 

  132. Kim BJ, Hong SJ. Ambient air pollution and allergic diseases in children. Korean J Pediatr. 2012;55(6):185–92.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  133. Esposito S, Tenconi R, Lelii M, Preti V, Nazzari E, Consolo S, et al. Possible molecular mechanisms linking air pollution and asthma in children. BMC Pulm Med. 2014;14:31.

    Article  PubMed  PubMed Central  Google Scholar 

  134. Gasana J, Dillikar D, Mendy A, Forno E, Ramos VE. Motor vehicle air pollution and asthma in children: a meta-analysis. Environ Res. 2012;117:36–45.

    Article  CAS  PubMed  Google Scholar 

  135. Chen CH, Chan CC, Chen BY, Cheng TJ, Leon GY. Effects of particulate air pollution and ozone on lung function in non-asthmatic children. Environ Res. 2015;137:40–8.

    Article  CAS  PubMed  Google Scholar 

  136. Wong EY, Gohlke J, Griffith WC, Farrow S, Faustman EM. Assessing the health benefits of air pollution reduction for children. Environ Health Perspect. 2004;112(2):226–32.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  137. Dockery DW, Cunningham J, Damokosh AI, Neas LM, Spengler JD, Koutrakis P, et al. Health effects of acid aerosols on north American children: respiratory symptoms. Environ Health Perspect. 1996;104(5):500–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  138. Patel MM, Chillrud SN, Deepti K, Ross JM, Kinney PL. Traffic-related air pollutants and exhaled markers of airway inflammation and oxidative stress in new York City adolescents. Environ Res. 2013;121:71–8.

    Article  CAS  PubMed  Google Scholar 

  139. Lenney W. The burden of pediatric asthma. Pediatr Pulmonol. 1997;24(S15):13–6.

    Article  Google Scholar 

  140. Ierodiakonou D, Zanobetti A, Coull BA, Melly S, Postma DS, Boezen HM, et al. Ambient air pollution, lung function, and airway responsiveness in asthmatic children. J Allergy Clin Immunol. 2016;137(2):390–9.

    Article  CAS  PubMed  Google Scholar 

  141. Klumper C, Kramer U, Lehmann I, von Berg A, Berdel D, Herberth G, et al. Air pollution and cytokine responsiveness in asthmatic and non-asthmatic children. Environ Res. 2015;138:381–90.

    Article  PubMed  CAS  Google Scholar 

  142. Renzetti G, Silvestre G, D'Amario C, Bottini E, Gloria-Bottini F, Bottini N, et al. Less air pollution leads to rapid reduction of airway inflammation and improved airway function in asthmatic children. Pediatrics. 2009;123(3):1051–8.

    Article  PubMed  Google Scholar 

  143. To T, Zhu J, Larsen K, Simatovic J, Feldman L, Ryckman K, et al. Progression from asthma to chronic obstructive pulmonary disease (COPD): is air pollution a risk factor? Am J Respir Crit Care Med. 2016;194(4):429–38.

    Article  CAS  PubMed  Google Scholar 

  144. Hasunuma H, Sato T, Iwata T, Kohno Y, Nitta H, Odajima H, et al. Association between traffic-related air pollution and asthma in preschool children in a national Japanese nested case-control study. BMJ Open. 2016;6(2):–e010410.

    Google Scholar 

  145. Patel MM, Quinn JW, Jung KH, Hoepner L, Diaz D, Perzanowski M, et al. Traffic density and stationary sources of air pollution associated with wheeze, asthma, and immunoglobulin E from birth to age 5 years among New York City children. Environ Res. 2011;111(8):1222–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  146. Jerrett M, Shankardass K, Berhane K, Gauderman WJ, Kunzli N, Avol E, et al. Traffic-related air pollution and asthma onset in children: a prospective cohort study with individual exposure measurement. Environ Health Perspect. 2008;116(10):1433–8.

    Article  PubMed  PubMed Central  Google Scholar 

  147. Shima M, Nitta Y, Adachi M. Traffic-related air pollution and respiratory symptoms in children living along trunk roads in Chiba prefecture, Japan. J Epidemiol. 2003;13(2):108–19.

    Article  PubMed  Google Scholar 

  148. Sonnenschein-van der Voort AM, de Kluizenaar Y, Jaddoe VW, Gabriele C, Raat H, Moll HA, et al. Air pollution, fetal and infant tobacco smoke exposure, and wheezing in preschool children: a population-based prospective birth cohort. Environ Health. 2012;11:91.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  149. Nishimura KK, Galanter JM, Roth LA, Oh SS, Thakur N, Nguyen EA, et al. Early-life air pollution and asthma risk in minority children. The GALA II and SAGE II studies. Am J Respir Crit Care Med. 2013;188(3):309–18.

    Article  PubMed  PubMed Central  Google Scholar 

  150. Wendt JK, Symanski E, Stock TH, Chan W, Du XL. Association of short-term increases in ambient air pollution and timing of initial asthma diagnosis among Medicaid-enrolled children in a metropolitan area. Environ Res. 2014;131:50–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  151. Shima M, Nitta Y, Ando M, Adachi M. Effects of air pollution on the prevalence and incidence of asthma in children. Arch Environ Health. 2002;57(6):529–35.

    Article  CAS  PubMed  Google Scholar 

  152. Esposito S, Galeone C, Lelii M, Longhi B, Ascolese B, Senatore L, et al. Impact of air pollution on respiratory diseases in children with recurrent wheezing or asthma. BMC Pulm Med. 2014;14:130.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  153. Breysse PN, Diette GB, Matsui EC, Butz AM, Hansel NN, McCormack MC. Indoor air pollution and asthma in children. Proc Am Thorac Soc. 2010;7(2):102–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  154. Sarnat SE, Raysoni AU, Li WW, Holguin F, Johnson BA, Flores Luevano S, et al. Air pollution and acute respiratory response in a panel of asthmatic children along the U.S.-Mexico border. Environ Health Perspect. 2012;120(3):437–44.

    Article  CAS  PubMed  Google Scholar 

  155. Tétreault L-F, Doucet M, Gamache P, Fournier M, Brand A, Kosatsky T, et al. Severe and moderate asthma exacerbations in asthmatic children and exposure to ambient air pollutants. Int J Environ Res Public Health. 2016;13(8):771.

    Article  PubMed Central  CAS  Google Scholar 

  156. Sandstrom T, Kelly FJ. Traffic-related air pollution, genetics and asthma development in children. Thorax. 2009;64(2):98–9.

    Article  PubMed  Google Scholar 

  157. Mann JK, Balmes JR, Bruckner TA, Mortimer KM, Margolis HG, Pratt B, et al. Short-term effects of air pollution on wheeze in asthmatic children in Fresno, California. Environ Health Perspect. 2010;118(10):1497–502.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  158. McConnell R, Berhane K, Gilliland F, Molitor J, Thomas D, Lurmann F, et al. Prospective study of air pollution and bronchitic symptoms in children with asthma. Am J Respir Crit Care Med. 2003;168(7):790–7.

    Article  PubMed  Google Scholar 

  159. YoussefAgha AH, Jayawardene WP, Lohrmann DK, El Afandi GS. Air pollution indicators predict outbreaks of asthma exacerbations among elementary school children: integration of daily environmental and school health surveillance systems in Pennsylvania. J Environ Monit. 2012;14(12):3202–10.

    Article  CAS  PubMed  Google Scholar 

  160. Schildcrout JS, Sheppard L, Lumley T, Slaughter JC, Koenig JQ, Shapiro GG. Ambient air pollution and asthma exacerbations in children: an eight-city analysis. Am J Epidemiol. 2006;164(6):505–17.

    Article  PubMed  Google Scholar 

  161. Liu L, Poon R, Chen L, Frescura AM, Montuschi P, Ciabattoni G, et al. Acute effects of air pollution on pulmonary function, airway inflammation, and oxidative stress in asthmatic children. Environ Health Perspect. 2009;117(4):668–74.

    Article  CAS  PubMed  Google Scholar 

  162. Lee SL, Wong WH, Lau YL. Association between air pollution and asthma admission among children in Hong Kong. Clin Exp Allergy. 2006;36(9):1138–46.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  163. Escamilla-Nunez MC, Barraza-Villarreal A, Hernandez-Cadena L, Moreno-Macias H, Ramirez-Aguilar M, Sienra-Monge JJ, et al. Traffic-related air pollution and respiratory symptoms among asthmatic children, resident in Mexico City: the EVA cohort study. Respir Res. 2008;9:74.

    Article  PubMed  PubMed Central  Google Scholar 

  164. Yeh KW, Chang CJ, Huang JL. The association of seasonal variations of asthma hospitalization with air pollution among children in Taiwan. Asian Pac J Allergy Immunol. 2011;29(1):34–41.

    PubMed  Google Scholar 

  165. Just J, Segala C, Sahraoui F, Priol G, Grimfeld A, Neukirch F. Short-term health effects of particulate and photochemical air pollution in asthmatic children. Eur Respir J. 2002;20(4):899–906.

    Article  CAS  PubMed  Google Scholar 

  166. Jalaludin B, Khalaj B, Sheppeard V, Morgan G. Air pollution and ED visits for asthma in Australian children: a case-crossover analysis. Int Arch Occup Environ Health. 2008;81(8):967–74.

    Article  CAS  PubMed  Google Scholar 

  167. Migliaretti G, Cavallo F. Urban air pollution and asthma in children. Pediatr Pulmonol. 2004;38(3):198–203.

    Article  PubMed  Google Scholar 

  168. Slaughter JC, Lumley T, Sheppard L, Koenig JQ, Shapiro GG. Effects of ambient air pollution on symptom severity and medication use in children with asthma. Ann Allergy Asthma Immunol. 2003;91(4):346–53.

    Article  CAS  PubMed  Google Scholar 

  169. Penard-Morand C, Raherison C, Charpin D, Kopferschmitt C, Lavaud F, Caillaud D, et al. Long-term exposure to close-proximity air pollution and asthma and allergies in urban children. Eur Respir J. 2010;36(1):33–40.

    Article  CAS  PubMed  Google Scholar 

  170. Lewis TC, Robins TG, Mentz GB, Zhang X, Mukherjee B, Lin X, et al. Air pollution and respiratory symptoms among children with asthma: vulnerability by corticosteroid use and residence area. Sci Total Environ. 2013;448:48–55.

    Article  CAS  PubMed  Google Scholar 

  171. Chauhan A, Inskip HM, Linaker CH, Smith S, Schreiber J, Johnston SL, et al. Personal exposure to nitrogen dioxide (NO 2) and the severity of virus-induced asthma in children. Lancet. 2003;361(9373):1939–44.

    Article  CAS  PubMed  Google Scholar 

  172. Puranik S, Forno E, Bush A, Celedón JC. Predicting severe asthma exacerbations in children. Am J Respir Crit Care Med. 2016;195(7):854–9.

    Article  Google Scholar 

  173. Wisniewski JA, McLaughlin AP, Stenger PJ, Patrie J, Brown MA, El-Dahr JM, et al. A comparison of seasonal trends in asthma exacerbations among children from geographic regions with different climates. Allergy Asthma Proc. 2016;37(6):475–81.

    Article  PubMed  PubMed Central  Google Scholar 

  174. Rey-Ares L, Irazola V, Althabe F, Sobrino E, Mazzoni A, Serón P, et al. Lower tract respiratory infection in children younger than 5 years of age and adverse pregnancy outcomes related to household air pollution in Bariloche (Argentina) and Temuco (Chile). Indoor Air. 2016;26(6):964–75.

    Article  CAS  PubMed  Google Scholar 

  175. Zhu YD, Wei JR, Huang L, Wang SH, Tian HM, Guo XB. Comparison of respiratory diseases and symptoms among school-age children in areas with different levels of air pollution. Beijing Da Xue Xue Bao. 2015;47(3):395–9.

    CAS  PubMed  Google Scholar 

  176. Upadhyay AK, Singh A, Kumar K, Singh A. Impact of indoor air pollution from the use of solid fuels on the incidence of life threatening respiratory illnesses in children in India. BMC Public Health. 2015;15:300.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  177. Darrow LA, Klein M, Flanders WD, Mulholland JA, Tolbert PE, Strickland MJ. Air pollution and acute respiratory infections among children 0-4 years of age: an 18-year time-series study. Am J Epidemiol. 2014;180(10):968–77.

    Article  PubMed  PubMed Central  Google Scholar 

  178. Ramesh Bhat Y, Manjunath N, Sanjay D, Dhanya Y. Association of indoor air pollution with acute lower respiratory tract infections in children under 5 years of age. Paediatr Int Child Health. 2012;32(3):132–5.

    Article  CAS  PubMed  Google Scholar 

  179. Brauer M, Hoek G, Van Vliet P, Meliefste K, Fischer PH, Wijga A, et al. Air pollution from traffic and the development of respiratory infections and asthmatic and allergic symptoms in children. Am J Respir Crit Care Med. 2002;166(8):1092–8.

    Article  PubMed  Google Scholar 

  180. Cliff J. Indoor air pollution and acute respiratory infections in children. Lancet. 1992;339(8790):396–8.

    Article  Google Scholar 

  181. McCarthy CE, Duffney PF, Thatcher TH, Phipps RP, Sime PJ. Dung biomass smoke attenuates innate immune responses to a viral mimetic and influenza a virus in human small airway epithelial cells. In:B15. Health effects of indoor/outdoor pollution in childhood. New York: American Thoracic Society; 2016. p. A2874.

    Google Scholar 

  182. Hou W, Xu X, Lei Y, Cao J, Zhang Y, Chen L, et al. The role of the PM2. 5-associated metals in pathogenesis of child Mycoplasma Pneumoniae infections: a systematic review. Environ Sci Pollut Res. 2016;23(11):10604–14.

    Article  CAS  Google Scholar 

  183. Smith GS, Van Den Eeden SK, Garcia C, Shan J, Baxter R, Herring AH, et al. Air pollution and pulmonary tuberculosis: a nested case-control study among members of a northern California health plan. Environ Health Perspect. 2016;124(6):761.

    Article  PubMed  PubMed Central  Google Scholar 

  184. Mishra VK, Retherford RD, Smith KR. Biomass cooking fuels and prevalence of tuberculosis in India. Int J Infect Dis. 1999;3(3):119–29.

    Article  CAS  PubMed  Google Scholar 

  185. Bates JM, Mahaffy DJ. Relationships of reported allergy symptoms, relative humidity and airborne biologicals in thirteen Florida classrooms. Proc Indoor Air. 1996;96:551–6.

    Google Scholar 

  186. Gravesen S, Larsen L, Gyntelberg F, Skov P. Demonstration of microorganisms and dust in schools and offices. Allergy. 1986;41(7):520–5.

    Article  CAS  PubMed  Google Scholar 

  187. Daisey JM, Angell WJ, Apte MG. Indoor air quality, ventilation and health symptoms in schools: an analysis of existing information. Indoor Air. 2003;13(1):53–64.

    Article  CAS  PubMed  Google Scholar 

  188. Calogero C, Sly P. 1 developmental physiology: lung function during growth and development from birth to old age. Eur Respir Monogr. 2010;47:1.

    Google Scholar 

  189. Schultz ES, Gruzieva O, Bellander T, Bottai M, Hallberg J, Kull I, et al. Traffic-related air pollution and lung function in children at 8 years of age: a birth cohort study. Am J Respir Crit Care Med. 2012;186(12):1286–91.

    Article  PubMed  Google Scholar 

  190. Roy A, Chapman RS, Hu W, Wei F, Liu X, Zhang J. Indoor air pollution and lung function growth among children in four Chinese cities. Indoor Air. 2012;22(1):3–11.

    Article  CAS  PubMed  Google Scholar 

  191. Gao Y, Chan EY, Li LP, He QQ, Wong TW. Chronic effects of ambient air pollution on lung function among Chinese children. Arch Dis Child. 2013;98(2):128–35.

    Article  PubMed  Google Scholar 

  192. Eenhuizen E, Gehring U, Wijga AH, Smit HA, Fischer PH, Brauer M, et al. Traffic-related air pollution is related to interrupter resistance in 4-year-old children. Eur Respir J. 2013;41(6):1257–63.

    Article  PubMed  Google Scholar 

  193. Altug H, Gaga EO, Dogeroglu T, Ozden O, Ornektekin S, Brunekreef B, et al. Effects of air pollution on lung function and symptoms of asthma, rhinitis and eczema in primary school children. Environ Sci Pollut Res Int. 2013;20(9):6455–67.

    Article  CAS  PubMed  Google Scholar 

  194. Martins PC, Valente J, Papoila AL, Caires I, Araujo-Martins J, Mata P, et al. Airways changes related to air pollution exposure in wheezing children. Eur Respir J. 2012;39(2):246–53.

    Article  CAS  PubMed  Google Scholar 

  195. Correia-Deur JE, Claudio L, Imazawa AT, Eluf-Neto J. Variations in peak expiratory flow measurements associated to air pollution and allergic sensitization in children in Sao Paulo, Brazil. Am J Ind Med. 2012;55(12):1087–98.

    Article  CAS  PubMed  Google Scholar 

  196. Wiwatanadate P, Trakultivakorn M. Air pollution-related peak expiratory flow rates among asthmatic children in Chiang Mai, Thailand. Inhal Toxicol. 2010;22(4):301–8.

    Article  CAS  PubMed  Google Scholar 

  197. Linares B, Guizar JM, Amador N, Garcia A, Miranda V, Perez JR, et al. Impact of air pollution on pulmonary function and respiratory symptoms in children. Longitudinal repeated-measures study. BMC Pulm Med. 2010;10:62.

    Article  PubMed  PubMed Central  Google Scholar 

  198. Cara AC, Degryse J, van den Akker M, Dinant GJ, Manolovici C, Buntinx F. Impact of early childhood air pollution on respiratory status of school children. Eur J Gen Pract. 2010;16(3):133–8.

    Article  PubMed  Google Scholar 

  199. Fuentes-Leonarte V, Ballester F, Tenias JM. Sources of indoor air pollution and respiratory health in preschool children. J Environ Public Health. 2009;2009:727516.

    Article  PubMed  CAS  Google Scholar 

  200. Delfino RJ, Staimer N, Tjoa T, Gillen D, Kleinman MT, Sioutas C, et al. Personal and ambient air pollution exposures and lung function decrements in children with asthma. Environ Health Perspect. 2008;116(4):550–8.

    Article  PubMed  Google Scholar 

  201. Kasamatsu J, Shima M, Yamazaki S, Tamura K, Sun G. Effects of winter air pollution on pulmonary function of school children in Shenyang, China. Int J Hyg Environ Health. 2006;209(5):435–44.

    Article  PubMed  Google Scholar 

  202. Timonen KL, Pekkanen J, Tiittanen P, Salonen RO. Effects of air pollution on changes in lung function induced by exercise in children with chronic respiratory symptoms. Occup Environ Med. 2002;59(2):129–34.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  203. Gauderman WJ, Gilliland GF, Vora H, Avol E, Stram D, McConnell R, et al. Association between air pollution and lung function growth in southern California children: results from a second cohort. Am J Respir Crit Care Med. 2002;166(1):76–84.

    Article  PubMed  Google Scholar 

  204. Mannino DM, Siegel M, Husten C, Rose D, Etzel R. Environmental tobacco smoke exposure and health effects in children: results from the 1991 National Health Interview Survey. Tob Control. 1996;5(1):13–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  205. Deng Q, Lu C, Yu Y, Li Y, Sundell J, Norback D. Early life exposure to traffic-related air pollution and allergic rhinitis in preschool children. Respir Med. 2016;121:67–73.

    Article  PubMed  Google Scholar 

  206. Calderon-Garciduenas L, Franco-Lira M, Henriquez-Roldan C, Osnaya N, Gonzalez-Maciel A, Reynoso-Robles R, et al. Urban air pollution: influences on olfactory function and pathology in exposed children and young adults. Exp Toxicol Pathol. 2010;62(1):91–102.

    Article  PubMed  Google Scholar 

  207. Smith WH. Air pollution and forests: interactions between air contaminants and forest ecosystems. Berlin: Springer; 2012.

    Google Scholar 

  208. Behrendt H, Becker W, Fritzsche C, Sliwa-Tomczok W, Tomczok J, Friedrichs K, et al. Air pollution and allergy: experimental studies on modulation of allergen release from pollen by air pollutants. Int Arch Allergy Immunol. 1997;113(1–3):69–74.

    Article  CAS  PubMed  Google Scholar 

  209. Majd A, Chehregani A, Moin M, Gholami M, Kohno S, Nabe T, et al. The effects of air pollution on structures, proteins and allergenicity of pollen grains. Aerobiologia. 2004;20(2):111–8.

    Article  Google Scholar 

  210. Bartra J, Mullol J, Del Cuvillo A, Davila I, Ferrer M, Jauregui I, et al. Air pollution and allergens. J Investig Allergol Clin Immunol. 2007;17(Suppl 2):3–8.

    PubMed  Google Scholar 

  211. Morgenstern V, Zutavern A, Cyrys J, Brockow I, Koletzko S, Kramer U, et al. Atopic diseases, allergic sensitization, and exposure to traffic-related air pollution in children. Am J Respir Crit Care Med. 2008;177(12):1331–7.

    Article  PubMed  Google Scholar 

  212. D’Amato G. Urban air pollution and plant-derived respiratory allergy. Clin Exp Allergy. 2000;30(5):628–36.

    Article  PubMed  Google Scholar 

  213. Janssen NA, Brunekreef B, van Vliet P, Aarts F, Meliefste K, Harssema H, et al. The relationship between air pollution from heavy traffic and allergic sensitization, bronchial hyperresponsiveness, and respiratory symptoms in Dutch schoolchildren. Environ Health Perspect. 2003;111(12):1512.

    Article  PubMed  PubMed Central  Google Scholar 

  214. D’amato G, Liccardi G, D’amato M, Cazzola M. The role of outdoor air pollution and climatic changes on the rising trends in respiratory allergy. Respir Med. 2001;95(7):606–11.

    Article  PubMed  Google Scholar 

  215. D’Amato G, Liccardi G, D’amato M, Cazzola M. Outdoor air pollution, climatic changes and allergic bronchial asthma. Eur Respir J. 2002;20(3):763–76.

    Article  PubMed  CAS  Google Scholar 

  216. Gruzieva O, Bellander T, Eneroth K, Kull I, Melen E, Nordling E, et al. Traffic-related air pollution and development of allergic sensitization in children during the first 8 years of life. J Allergy Clin Immunol. 2012;129(1):240–6.

    Article  CAS  PubMed  Google Scholar 

  217. Kramer U, Koch T, Ranft U, Ring J, Behrendt H. Traffic-related air pollution is associated with atopy in children living in urban areas. Epidemiology. 2000;11(1):64–70.

    Article  CAS  PubMed  Google Scholar 

  218. Boffetta P, Tredaniel J, Greco A. Risk of childhood cancer and adult lung cancer after childhood exposure to passive smoke: a meta-analysis. Environ Health Perspect. 2000;108(1):73–82.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  219. Reynolds P, Von Behren J, Gunier RB, Goldberg DE, Hertz A, Smith DF. Childhood cancer incidence rates and hazardous air pollutants in California: an exploratory analysis. Environ Health Perspect. 2003;111(4):663–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  220. Raaschou-Nielsen O, Hertel O, Thomsen BL, Olsen JH. Air pollution from traffic at the residence of children with cancer. Am J Epidemiol. 2001;153(5):433–43.

    Article  CAS  PubMed  Google Scholar 

  221. Raaschou-Nielsen O, Hertel O, Thomsen BL, Olsen JH. Traffic-related air pollution at the place of residence and risk of cancer among children. Ugeskr Laeger. 2002;164(17):2283–7.

    PubMed  Google Scholar 

  222. Ruchirawat M, Settachan D, Navasumrit P, Tuntawiroon J, Autrup H. Assessment of potential cancer risk in children exposed to urban air pollution in Bangkok, Thailand. Toxicol Lett. 2007;168(3):200–9.

    Article  CAS  PubMed  Google Scholar 

  223. Lewtas J. Complex mixtures of air pollutants: characterizing the cancer risk of polycyclic organic matter. Environ Health Perspect. 1993;100:211.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  224. Calderon-Garciduenas L, Mora-Tiscareno A, Franco-Lira M, Zhu H, Lu Z, Solorio E, et al. Decreases in short term memory, IQ, and altered brain metabolic ratios in urban apolipoprotein epsilon4 children exposed to air pollution. J Alzheimers Dis. 2015;45(3):757–70.

    CAS  PubMed  Google Scholar 

  225. Calderon-Garciduenas L, Mora-Tiscareno A, Fordham LA, Chung CJ, Valencia-Salazar G, Flores-Gomez S, et al. Lung radiology and pulmonary function of children chronically exposed to air pollution. Environ Health Perspect. 2006;114(9):1432–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  226. Scotland A. Third-hand smoke. 2011.

    Google Scholar 

  227. Merritt TA, Mazela J, Adamczak A, Merritt T. The impact of second-hand tobacco smoke exposure on pregnancy outcomes, infant health, and the threat of third-hand smoke exposure to our environment and to our children. Przeglad lekarski. 2012;69(10):717–720.

    Google Scholar 

  228. Ueta I, Saito Y, Teraoka K, Miura T, Jinno K. Determination of volatile organic compounds for a systematic evaluation of third-hand smoking. Anal Sci. 2010;26(5):569–74.

    Article  CAS  PubMed  Google Scholar 

  229. Bayer-Oglesby L, Grize L, Gassner M, Takken-Sahli K, Sennhauser FH, Neu U, et al. Decline of ambient air pollution levels and improved respiratory health in Swiss children. Environ Health Perspect. 2005;113(11):1632–7.

    Article  PubMed  PubMed Central  Google Scholar 

  230. Barnes BR, Mathee A, Krieger L, Shafritz L, Favin M, Sherburne L. Testing selected behaviors to reduce indoor air pollution exposure in young children. Health Educ Res. 2004;19(5):543–50.

    Article  CAS  PubMed  Google Scholar 

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Capello, F., Pili, G. (2018). Air Pollution in Infancy, Childhood and Young Adults. In: Capello, F., Gaddi, A. (eds) Clinical Handbook of Air Pollution-Related Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-62731-1_10

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