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Perioperative Assessment of the Maxillofacial Surgery Patient pp 145–160Cite as

Peri-Operative Pain Management in Maxillofacial Surgery

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Abstract

Oral and maxillofacial surgery procedures are known to cause acute postoperative pain. Effective management of acute postoperative pain is critically important for physiological and psychological stability. The goal of effective postoperative pain management is to reduce or eliminate pain and discomfort with a minimum of side effects. Inadequate management of acute postoperative pain is a potential source of complications and a significant cause of decreased quality of life. Preemptive and perioperative medication administration and multimodal postoperative therapy have been shown to be effective in postoperative acute pain management following oral and maxillofacial surgery procedures.

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Notes

  1. 1.

    500-mg dosing of acetaminophen is no longer available.

References

  1. American Society of Anesthesiologists Task Force on Acute Pain Management. Practice guidelines for acute pain management in the perioperative setting: an updated report by the American Society of Anesthesiologists Task Force on acute pain management. Anesthesiology. 2012;116(2):248–73. https://doi.org/10.1097/ALN.0b013e31823c1030.

    Article  Google Scholar 

  2. Lago-Méndez L, Diniz-Freitas M, Senra-Rivera C, Gude-Sampedro F, Gándara Rey JM, García-García A. Relationships between surgical difficulty and postoperative pain in lower third molar extractions. J Oral Maxillofac Surg. 2007;65(5):979.

    Article  PubMed  Google Scholar 

  3. Garcia A, Gude Sampedro F, Gandara Rey J, Gallas Torreira M. Trismus and pain after removal of impacted lower third molars. J Oral Maxillofac Surg. 1997;55(11):1223.

    Article  Google Scholar 

  4. Bentley MW, Stas JM, Johnson JM, Viet BC, Garrett N. Effects of preincisional ketamine treatment on natural killer cell activity and postoperative pain management after oral maxillofacial surgery. AANA J. 2005;73(6):427–36.

    PubMed  Google Scholar 

  5. Niemi L, Tuominen M, Pitkänen M, Rosenberg PH. Comparison of parenteral diclofenac and ketoprofen for postoperative pain relief after maxillofacial surgery. Acta Anaesthesiol Scand. 1995;39(1):96–9.

    Article  CAS  PubMed  Google Scholar 

  6. Phillips C, Blakey G 3rd, Jaskolka M. Recovery after orthognathic surgery: short-term health-related quality of life outcomes. J Oral Maxillofac Surg. 2008;66(10):2110–5. https://doi.org/10.1016/j.joms.2008.06.080.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Phillips C, Blakey G 3rd. Short-term recovery after orthognathic surgery: a medical daily diary approach. Int J Oral Maxillofac Surg. 2008;37(10):892–6. https://doi.org/10.1016/j.ijom.2008.07.005.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Bryce G, Bomfim DI, Bassi GS. Pre- and post-operative management of dental implant placement. Part 1: management of post-operative pain. Br Dent J. 2014;217(3):123–7. https://doi.org/10.1038/sj.bdj.2014.650.

    Article  CAS  PubMed  Google Scholar 

  9. Nolan R, Kemmoona M, Polyzois I, Claffey N. The influence of prophylactic antibiotic administration on post-operative morbidity in dental implant surgery. A prospective double blind randomized controlled clinical trial. Clin Oral Implants Res. 2014;25(2):252–9. https://doi.org/10.1111/clr.12124.

    Article  PubMed  Google Scholar 

  10. Pani SC, AlGarni B, AlZain LM, AlQahtani NS. Assessment of the impact of stress and anxiety on pain perception in patients undergoing surgery for placement of their first dental implant. Oral Health Dent Manag. 2014;13(2):464–8.

    PubMed  Google Scholar 

  11. Carr DB, Goudas LC. Acute pain. Lancet. 1999;353(9169):2051–8.

    Article  CAS  PubMed  Google Scholar 

  12. Leykin Y, Pellis T, Ambrosio C. Highlights in postoperative pain treatment. Expert Rev Neurother. 2007;7(5):533–45.

    Article  CAS  PubMed  Google Scholar 

  13. Chou R, Gordon DB, de Leon-Casasola OA, et al. Management of Postoperative Pain: a clinical practice guideline from the American pain society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists' committee on regional anesthesia, executive committee, and administrative council. J Pain. 2016;17(2):131–57. https://doi.org/10.1016/j.jpain.2015.12.008.

    Article  PubMed  Google Scholar 

  14. Glowacki D. Effective pain management and improvements in patients' outcomes and satisfaction. Crit Care Nurse. 2015;35(3):33–41. https://doi.org/10.4037/ccn2015440.

    Article  PubMed  Google Scholar 

  15. Vadivelu N, Mitra S, Narayan D. Recent advances in postoperative pain management. Yale J Biol Med. 2010;83(1):11–25.

    CAS  PubMed  PubMed Central  Google Scholar 

  16. Ip HY, Abrishami A, Peng PW, Wong J, Chung F. Predictors of postoperative pain and analgesic consumption: a qualitative systematic review. Anesthesiology. 2009;111:657–77. https://doi.org/10.1097/ALN.0b013e3181aae87a.

    Article  PubMed  Google Scholar 

  17. Nishizawa D, Fukuda K, Kasai S, Al e. Genome-wide association study identifies a potent locus associated with human opioid sensitivity. Mol Psychiatry. 2014;19(1):55–62. https://doi.org/10.1038/mp.2012.164.

    Article  CAS  PubMed  Google Scholar 

  18. Yoshida K, Nishizawa D, Ichinomiya T, Ichinohe T, Hayashida M, Fukuda K, Ikeda K. Prediction formulas for individual opioid analgesic requirements based on genetic polymorphism analyses. PLoS One. 2015;10(1):e0116885. https://doi.org/10.1371/journal.pone.0116885.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  19. Fukuda K, Hayashida M, Ide S, Saita N, Kokita Y, Kasai S, Nishizawa D, Ogai Y, Hasegawa J, Nagashima M, Tagami M, Komatsu H, Sora I, Koga H, Kaneko Y, Ikeda K. Association between OPRM1 gene polymorphisms and fentanyl sensitivity in patients undergoing painful cosmetic surgery. Pain. 2009;147(1–3):194–201. https://doi.org/10.1016/j.pain.2009.09.004.

    Article  CAS  PubMed  Google Scholar 

  20. Kelly DJ, Ahmad M, Brull SJ. Preemptive analgesia I: physiological pathways and pharmacological modalities. Can J Anaesth. 2001;48(10):1000–10.

    Article  CAS  PubMed  Google Scholar 

  21. Woolf CJ, Chong MS. Preemptive analgesia—treating postoperative pain by preventing the establishment of central sensitization. Anesth Analg. 1993;77:362.

    Article  CAS  PubMed  Google Scholar 

  22. Campbell WI, Kendrick RW, Ramsay-Baggs P, McCaughey W. The effect of pre-operative administration of bupivacaine compared with its postoperative use. Anaesthesia. 1997;52(12):1212–6.

    Article  CAS  PubMed  Google Scholar 

  23. Campbell WI, Kendrick RW. Pre-emptive analgesia using local anaesthesia: a study in bilaterally symmetrical surgery. Br J Anaesth. 1997;79:657–9.

    Article  CAS  PubMed  Google Scholar 

  24. Campbell WI, Kendrick RW, Fee JP. Balanced pre-emptive analgesia: does it work? A double-blind, controlled study in bilaterally symmetrical oral surgery. Br J Anaesth. 1998;81:727.

    Article  CAS  PubMed  Google Scholar 

  25. Bridgman JB, Gillgrass TG, Zacharias M. The absence of any pre-emptive analgesic effect for non-steroidal anti-inflammatory drugs. Br J Oral Maxillofac Surg. 1996;34:428.

    Article  CAS  PubMed  Google Scholar 

  26. Lebrun T, Van Elstraete AC, Sandefo I, et al. Lack of a pre-emptive effect of low-dose ketamine on postoperative pain following oral surgery. Can J Anaesth. 2006;53:146.

    Article  PubMed  Google Scholar 

  27. Melzack R, Wall PD. Pain mechanisms: a new theory. Science. 1965;150:971.

    Article  CAS  PubMed  Google Scholar 

  28. Kissin I. Preemptive analgesia. Anesthesiology. 2000;93:1138.

    Article  CAS  PubMed  Google Scholar 

  29. Eriksson L, Tegelberg A. Analgesic efficacy and clinical acceptability of adjunct pre-emptive intravenous tramadol in midazolam sedation for third molar surgery. Oral Maxillofac Surg. 2012;17:193.

    Article  PubMed  Google Scholar 

  30. Eriksson LB, Tegelberg Å. Safety of adjunct pre-emptive intravenous tramadol with midazolam sedation for third molar surgery. Oral Maxillofac Surg. 2015;19(4):353–9. https://doi.org/10.1007/s10006-015-0502-9.

    Article  PubMed  Google Scholar 

  31. Pandit MK, Godhi S, Lall AB. Preoperative intravenous tramadol versus diclofenac for preventing postoperative pain after third molar surgery: a comparative study. J Maxillofac Oral Surg. 2011;10(4):306–9. https://doi.org/10.1007/s12663-011-0250-9.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Shah AV, Arun Kumar KV, Rai KK, Rajesh Kumar BP. Comparative evaluation of pre-emptive analgesic efficacy of intramuscular ketorolac versus tramadol following third molar surgery. J Maxillofac Oral Surg. 2013;12(2):197–202. https://doi.org/10.1007/s12663-012-0420-4.

    Article  PubMed  Google Scholar 

  33. Shah AV, Arun Kumar KV, Rai KK, Rajesh Kumar BP. Comparative evaluation of pre-emptive analgesic efficacy of intramuscular ketorolac versus tramadol following third molar surgery. J Maxillofac Oral Surg. 2013;12(2):197–202. https://doi.org/10.1007/s12663-012-0420-4.

    Article  PubMed  Google Scholar 

  34. Gopalraju P, Lalitha RM, Prasad K, Ranganath K. Comparative study of intravenous tramadol versus ketorolac for preventing postoperative pain after third molar surgery--a prospective randomized study. J Craniomaxillofac Surg. 2014;42(5):629–33. https://doi.org/10.1016/j.jcms.2013.09.004.

    Article  PubMed  Google Scholar 

  35. Lustenberger FD, Grätz KW, Mutzbauer TS. Efficacy of ibuprofen versus lornoxicam after third molar surgery: a randomized, double-blind, crossover pilot study. Oral Maxillofac Surg. 2011;15(1):57–62. https://doi.org/10.1007/s10006-010-0255-4.

    Article  PubMed  Google Scholar 

  36. Lau SL, Chow RL, Yeung RW, Samman N. Pre-emptive ibuprofen arginate in third molar surgery: a double-blind randomized controlled crossover clinical trial. Aust Dent J. 2009;54(4):355–60. https://doi.org/10.1111/j.1834-7819.2009.01162.x.

  37. Morse Z, Tump A, Kevelham E. Ibuprofen as a pre-emptive analgesic is as effective as rofecoxib for mandibular third molar surgery. Odontology. 2006;94(1):59–63.

    Article  CAS  PubMed  Google Scholar 

  38. Costa FW, Soares EC, Esses DF, Silva PG, Bezerra TP, Scarparo HC, Ribeiro TR, Fonteles CS. A split-mouth, randomized, triple-blind, placebo-controlled study to analyze the pre-emptive effect of etoricoxib 120 mg on inflammatory events following removal of unerupted mandibular third molars. Int J Oral Maxillofac Surg. 2015;44(9):1166–74. https://doi.org/10.1016/j.ijom.2015.06.012.

    Article  CAS  PubMed  Google Scholar 

  39. Al-Sukhun J, Al-Sukhun S, Penttila H, et al. Preemptive analgesic effect of low doses of celecoxib is superior to low doses of traditional nonsteroidal anti-inflammatory drugs. J Craniofac Surg. 2012;23:526.

    Article  PubMed  Google Scholar 

  40. Cillo JE Jr, Dattilo DJ. Pre-emptive analgesia with pregabalin and celecoxib decreases postsurgical pain following maxillomandibular advancement surgery: a randomized controlled clinical trial. J Oral Maxillofac Surg. 2014;72(10):1909–14. https://doi.org/10.1016/j.joms.2014.05.014.

    Article  PubMed  Google Scholar 

  41. Gopalraju P, Lalitha RM, Prasad K, Ranganath K. Comparative study of intravenous tramadol versus ketorolac for preventing postoperative pain after third molar surgery--a prospective randomized study. J Craniomaxillofac Surg. 2014;42(5):629–33. https://doi.org/10.1016/j.jcms.2013.09.004.

    Article  PubMed  Google Scholar 

  42. Pozos-Guillen A, Martinez-Rider R, Aguirre-Banuelos P, Perez-Urizar J. Pre-emptive analgesic effect of tramadol after mandibular third molar extraction: a pilot study. J Oral Maxillofac Surg. 2007;65(7):1315–20.

    Article  PubMed  Google Scholar 

  43. da Costa Arajo FA, de Santana ST, de Morais HH, Laureano Filho JR, de Oliveira E Silva ED, Vasconcellos RJ. Comparative analysis of preemptive analgesic effect of tramadol chlorhydrate and nimesulide following third molar surgery. J Craniomaxillofac Surg. 2012;40(8):e346–9. https://doi.org/10.1016/j.jcms.2012.01.018.

    Article  Google Scholar 

  44. Isiordia-Espinoza MA, Sanchez-Prieto M, Tobas F, Reyes-Garcia JG, Granados-Soto V. Pre-emptive analgesia with the combination of tramadol plus meloxicam for third molar surgery: a pilot study. Br J Oral Maxillofac Surg. 2012;50(7):673–7. https://doi.org/10.1016/j.bjoms.2011.12.003.

    Article  PubMed  Google Scholar 

  45. Sener M, Ozgur Pektas Z, Yilmaz I, Turkoz A, Uckan S, Donmez A, Arslan G. Comparison of preemptive analgesic effects of a single dose of nonopioid analgesics for pain management after ambulatory surgery: a prospective, randomized, single-blind study in Turkish patients. Curr Ther Res Clin Exp. 2005;66(6):541–51. https://doi.org/10.1016/j.curtheres.2005.12.001.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Ahiskalioglu A, Ance A, Aksoy M, Yalcin E, Ahiskalioglu EO, Kilinc A. Effects of a single-dose of pre-Emptive Pregabalin on postoperative pain and opioid consumption after double-jaw surgery: a randomized controlled trial. J Oral Maxillofac Surg. 2016;74(1):53.e1–7. https://doi.org/10.1016/j.joms.2015.09.008.

    Article  Google Scholar 

  47. Moore RA, Derry S, Aldington D, Wiffen PJ. Single dose oral analgesics for acute postoperative pain in adults-an overview of Cochrane reviews. Cochrane Database Syst Rev. 2015;(9):CD008659. https://doi.org/10.1002/14651858.CD008659.pub3.

  48. Dionne RA. Additive analgesic effects of oxycodone and ibuprofen in the oral surgery model. J Oral Maxillofac Surg. 1999;57(6):673–8.

    Article  CAS  PubMed  Google Scholar 

  49. Mehlisch DR, Sollecito WA, Helfrick LF. Multicenter clinical trial of ibuprofen and acetaminophen in the treatment of postoperative dental pain. J Am Dent Assoc. 1990;121:257.

    Article  CAS  PubMed  Google Scholar 

  50. Kehlet H, Dahl JB. The value of “multimodal” or “balanced analgesia” in postoperative pain treatment. Anesth Analg. 1993;77:1048.

    Article  CAS  PubMed  Google Scholar 

  51. Ma CSJ, Lin D. Patient controlled analgesia: drug options infusion schedules and other considerations. Hosp Formul. 1991;26:198.

    CAS  PubMed  Google Scholar 

  52. Miller RD. Anesthesia. New York, NY: Churchill Livingstone; 1990.

    Google Scholar 

  53. Geha H, Nimeskern N, Beziat JL. Patient-controlled analgesia in orthognathic surgery: evaluation of the relationship to anxiety and anxiolytics. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108(3):e33–6. https://doi.org/10.1016/j.tripleo.2009.05.027.

    Article  CAS  PubMed  Google Scholar 

  54. Precious DS, Multari J, Finley GA, McGrath P. A comparison of patient-controlled and fixed schedule analgesia after orthognathic surgery. J Oral Maxillofac Surg. 1997;55(1):33–9.

    Article  CAS  PubMed  Google Scholar 

  55. Hepso HU, Lokken P, Bjornson J, Godan HC. Double-blind crossover study of the effect of acetylsalicylic acid on bleeding and post-operative course after bilateral oral surgery. J Clin Pharmacol. 1976;10:217–25.

    Article  Google Scholar 

  56. Skelbred J, Lokken P. Acetylsalicylic acid vs. paracetamol, effects on post-operative course. Eur J Clin Pharmacol. 1977;12:257–69.

    Article  Google Scholar 

  57. Moore PA, Crout RJ, Jackson DL, Schneider LG, Graves RW, Bakos L. Tramadol hydrochloride: analgesic efficacy compared with codeine, aspirin with codeine, and placebo after dental extraction. J Clin Pharmacol. 1998;38(6):554–60.

    Article  CAS  PubMed  Google Scholar 

  58. Moore PA, Nahouraii HS, Zovko JG, Wisniewski SR. Dental therapeutic practice patterns in the U.S. II. Analgesics, corticosteroids, and antibiotics. Gen Dent. 2006;54(3):201–7.

    PubMed  Google Scholar 

  59. Aznar-Arasa L, Harutunian K, Figueiredo R, Valmaseda-Castellon E, Gay-Escoda C. Effect of preoperative ibuprofen on pain and swelling after lower third molar removal: a randomized controlled trial. Int J Oral Maxillofac Surg. 2012;41(8):1005–9. https://doi.org/10.1016/j.ijom.2011.12.028.

    Article  CAS  PubMed  Google Scholar 

  60. Bailey E, Worthington HV, van Wijk A, Yates JM, Coulthard P, Afzal Z. Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth. Cochrane Database Syst Rev. 2013;(12):CD004624. https://doi.org/10.1002/14651858.CD004624.pub2.

  61. Bailey E, Worthington H, Coulthard P. Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth, a Cochrane systematic review. Br Dent J. 2014;216(8):451–5. https://doi.org/10.1038/sj.bdj.2014.330.

    Article  CAS  PubMed  Google Scholar 

  62. Ferraiolo DM, Veitz-Keenan A. Ibuprofen is superior to paracetamol for pain relief following third molar removal. Evid Based Dent. 2014;15(4):106–7. https://doi.org/10.1038/sj.ebd.6401059.

    Article  PubMed  Google Scholar 

  63. Au AH, Choi SW, Cheung CW, Leung YY. The efficacy and clinical safety of various analgesic combinations for post-operative pain after third molar surgery: a systematic review and meta-analysis. PLoS One. 2015;10(6):e0127611. https://doi.org/10.1371/journal.pone.0127611.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  64. Litkowski LJ, Christensen SE, Adamson DN, Van Dyke T, Han SH, Newman KB. Analgesic efficacy and tolerability of oxycodone 5 mg/ibuprofen 400 mg compared with those of oxycodone 5 mg/acetaminophen 325 mg and hydrocodone 7.5 mg/acetaminophen 500 mg in patients with moderate to severe postoperative pain: a randomized, double-blind, placebo-controlled, single-dose, parallel-group study in a dental pain model. Clin Ther. 2005;27(4):418–29.

    Article  CAS  PubMed  Google Scholar 

  65. Derry CJ, Derry S, Moore RA. Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain. Cochrane Database Syst Rev. 2013;24(6):CD010210. https://doi.org/10.1002/14651858.CD010210.pub2.

    Google Scholar 

  66. Moore PA, Hersh EV. Combining ibuprofen and acetaminophen for acute pain management after third-molar extractions: translating clinical research to dental practice. J Am Dent Assoc. 2013;144(8):898–908.

    Article  CAS  PubMed  Google Scholar 

  67. Sisk AL, Grover BJ. A comparison of preoperative and postoperative naproxen sodium for suppression of postoperative pain. J Oral Maxillofac Surg. 1990;48(7):674–8.

    Article  CAS  PubMed  Google Scholar 

  68. Kiersch TA, Halladay SC, Koschik M. A double-blind, randomized study of naproxen sodium, ibuprofen, and placebo in postoperative dental pain. Clin Ther. 1993;15(5):845–54.

    CAS  PubMed  Google Scholar 

  69. Kara IM, Polat S, Inci MF, Gamay C. Analgesic and anti-inflammatory effects of oxaprozin and naproxen sodium after removal of impacted lower third molars: a randomized, double-blind, placebo-controlled crossover study. J Oral Maxillofac Surg. 2010;68(5):1018–24. https://doi.org/10.1016/j.joms.2009.09.094.

    Article  PubMed  Google Scholar 

  70. Fricke J, Halladay SC, Bynum L, Francisco CA. Pain relief after dental impaction surgery using ketorolac, hydrocodone plus acetaminophen, or placebo. Clin Ther. 1993;15(3):500–9.

    CAS  PubMed  Google Scholar 

  71. Gutta R, Koehn CR, James LE. Does ketorolac have a preemptive analgesic effect? A randomized, double-blind, control study. J Oral Maxillofac Surg. 2013;71(12):2029–34. https://doi.org/10.1016/j.joms.2013.06.220.

    Article  PubMed  Google Scholar 

  72. Niebler G, Dayno J. Effect size comparison of ketorolac nasal spray and commonly prescribed oral combination opioids for pain relief after third molar extraction surgery. Postgrad Med. 2016;128(1):12–7. https://doi.org/10.1080/00325481.2016.1126185.

    Article  PubMed  Google Scholar 

  73. Garibaldi JA, Elder MF. Evaluation of ketorolac (Toradol) with varying amounts of codeine for postoperative extraction pain control. Int J Oral Maxillofac Surg. 2002;31(3):276–80.

    Article  CAS  PubMed  Google Scholar 

  74. Aoki T, Ota Y, Mori Y, Otsuru M, Ota M, Kaneko A. Analgesic efficacy of celecoxib in patients after oral surgery: special reference to time to onset of analgesia and duration of analgesic effect. Oral Maxillofac Surg. 2016;20(3):265–71. https://doi.org/10.1007/s10006-016-0565-2.

    Article  PubMed  Google Scholar 

  75. Yamashita Y, Sano N, Shimohira D, Danjo A, Goto M. A parallel-group comparison study of celecoxib with loxoprofen sodium in third mandibular molar extraction patients. Int J Oral Maxillofac Surg. 2014;43(12):1509–13. https://doi.org/10.1016/j.ijom.2014.09.002.

    Article  CAS  PubMed  Google Scholar 

  76. Moghaddamnia AA, Nosrati K, Mehdizadeh M, Milani S, Aghvami M. A comparative study of the effect of prednisolone and Celecoxib on MMO (maximum mouth opening) and pain following removal of impacted mandibular third molars. J Maxillofac Oral Surg. 2013;12(2):184–7. https://doi.org/10.1007/s12663-012-0401-7.

    PubMed  Google Scholar 

  77. Saito K, Kaneko A, Machii K, Ohta H, Ohkura M, Suzuki M. Efficacy and safety of additional 200-mg dose of celecoxib in adult patients with postoperative pain following extraction of impacted third mandibular molar: a multicenter, randomized, double-blind, placebo-controlled, phase II study in Japan. Clin Ther. 2012;34(2):314–28. https://doi.org/10.1016/j.clinthera.2012.01.004.

    Article  CAS  PubMed  Google Scholar 

  78. Pilatti GL, Andr_e dos Santos F, Bianchi A, et al. The use of celecoxib and dexamethasone for the prevention and control of postoperative pain after periodontal surgery. J Periodontol. 2006;77:1809.

    Article  CAS  PubMed  Google Scholar 

  79. Ong KS, Tan JM. Preoperative intravenous tramadol versus ketorolac for preventing postoperative pain after third molar surgery. Int J Oral Maxillofac Surg. 2004;33(3):274–8.

    Article  CAS  PubMed  Google Scholar 

  80. Claseman TS, Foley WL, Davis RD, Morrison JW, Palmore CA, Murchison DF. A clinical evaluation of the analgesic efficacy of preoperative administration of ketorolac and dexamethasone following surgical removal of third molars. Anesth Prog. 1998;45(3):110–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  81. Ong KS, Seymour RA, Chen FG, Ho VC. Preoperative ketorolac has a preemptive effect for postoperative third molar surgical pain. Int J Oral Maxillofac Surg. 2004;33(8):771–6.

    Article  CAS  PubMed  Google Scholar 

  82. Christensen K, Daniels S, Bandy D, Ernst CC, Hamilton DA, Mermelstein FH, Wang J, Carr DB. A double-blind placebo-controlled comparison of a novel formulation of intravenous diclofenac and ketorolac for postoperative third molar extraction pain. Anesth Prog. 2011;58(2):73–81. https://doi.org/10.2344/0003-3006-58.2.73.

    Article  PubMed  PubMed Central  Google Scholar 

  83. Gopalraju P, Lalitha RM, Prasad K, Ranganath K. Comparative study of intravenous tramadol versus ketorolac for preventing postoperative pain after third molar surgery--a prospective randomized study. J Craniomaxillofac Surg. 2014;42(5):629–33. https://doi.org/10.1016/j.jcms.2013.09.004.

    Article  PubMed  Google Scholar 

  84. Chin KR, Sundram H, Marcotte P. Bleeding risk with ketorolac after lumbar microdiscectomy. J Spinal Disord Tech. 2007;20(2):123–6.

    Article  PubMed  Google Scholar 

  85. Gan TJ, Candiotti K, Turan A, Buvanendran A, Philip BK, Viscusi ER, Soghomonyan S, Bergese SD, Intravenous Ibuprofen Surgical Surveillance Trial Investigational Sites. The shortened infusion time of intravenous ibuprofen, part 2: a multicenter, open-label, surgical surveillance trial to evaluate safety. Clin Ther. 2015;37(2):368–75. https://doi.org/10.1016/j.clinthera.2014.12.006.

    Article  CAS  PubMed  Google Scholar 

  86. Gwirtz KH, Kim HC, Nagy DJ, Young JV, Byers RS, Kovach DA, Li W. Intravenous ketorolac and subarachnoid opioid analgesia in the management of acute postoperative pain. Reg Anesth. 1995;20(5):395–401.

    CAS  PubMed  Google Scholar 

  87. Houck CS, Wilder RT, McDermott JS, Sethna NF, Berde CB. Safety of intravenous ketorolac therapy in children and cost savings with a unit dosing system. J Pediatr. 1996;129(2):292–6.

    Article  CAS  PubMed  Google Scholar 

  88. Bergese SD, Candiotti K, Ayad SS, Soghomonyan S, Gan TJ, Intravenous Ibuprofen Surveillance Trial Investigational Sites. The shortened infusion time of intravenous ibuprofen part 1: a multicenter, open-label, surveillance trial to evaluate safety and efficacy. Clin Ther. 2015;37(2):360–7. https://doi.org/10.1016/j.clinthera.2014.12.004.

    Article  CAS  PubMed  Google Scholar 

  89. Moller PL, Juhl GI, Payen-Champenois C, Skoglund LA. Intravenous acetaminophen (paracetamol): comparable analgesic efficacy, but better local safety than its prodrug, propacetamol, for postoperative pain after third molar surgery. Anesth Analg. 2005;101(1):90–6.

    Article  CAS  PubMed  Google Scholar 

  90. Southworth S, Peters J, Rock A, Pavliv L. A multicenter, randomized, double-blind, placebo-controlled trial of intravenous ibuprofen 400 and 800 mg every 6 hours in the management of postoperative pain. Clin Ther. 2009;31(9):1922–35. https://doi.org/10.1016/j.clinthera.2009.08.026.

    Article  CAS  PubMed  Google Scholar 

  91. Marquez-Lara A, Hutchinson ID, Nuñez F Jr, Smith TL, Miller AN. Nonsteroidal anti-inflammatory drugs and bone-healing: a systematic review of research quality. JBJS Rev;4(3), 2016. pii: 01874474–201603000-00005. doi:https://doi.org/10.2106/JBJS.RVW.O.00055.

  92. Mutlu I, Abubaker AO, Laskin DM. Narcotic prescribing habits and other methods of pain control by oral and maxillofacial surgeons after impacted third molar removal. J Oral Maxillofac Surg. 2013;71:1500.

    Article  PubMed  Google Scholar 

  93. Rosenberg M, Carroll F, Negus S. Effects of monoamine reuptake inhibitors in assays of acute pain-stimulated and pain-depressed behavior in rats. J Pain. 2013;14(3):246–59. https://doi.org/10.1016/j.jpain.2012.11.006.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  94. Scott RF. A double-blind comparison of nalbuphine and meperidine hydrochloride as intravenous analgesics in combination with diazepam for oral surgery outpatients. J Oral Maxillofac Surg. 1987;45(6):473–6.

    Article  CAS  PubMed  Google Scholar 

  95. Isiordia-Espinoza MA, de Jesús Pozos-Guillén A, Aragon-Martinez OH. Analgesic efficacy and safety of single-dose tramadol and non-steroidal anti-inflammatory drugs in operations on the third molars: a systematic review and meta-analysis. Br J Oral Maxillofac Surg. 2014;52(9):775–83. https://doi.org/10.1016/j.bjoms.2014.05.005.

    Article  PubMed  Google Scholar 

  96. Isiordia-Espinoza MA, Pozos-Guillen A, Martinez-Rider R, Perez-Urizar J. Comparison of the analgesic efficacy of oral ketorolac versus intramuscular tramadol after third molar surgery: a parallel, double-blind, randomized, placebo-controlled clinical trial. Med Oral Patol Oral Cir Bucal. 2016;21(5):e637–43.

    PubMed  PubMed Central  Google Scholar 

  97. Ong CK, Lirk P, Tan JM, Sow BW. The analgesic efficacy of intravenous versus oral tramadol for preventing postoperative pain after third molar surgery. J Oral Maxillofac Surg. 2005;63(8):1162–8.

    Article  PubMed  Google Scholar 

  98. Perez-Urizar J, MartÃnez-Rider R, Torres-Roque I, Garrocho-Rangel A, Pozos-Guillen A. Analgesic efficacy of lysine clonixinate plus tramadol versus tramadol in multiple doses following impacted third molar surgery. Int J Oral Maxillofac Surg. 2014;43(3):348–54. https://doi.org/10.1016/j.ijom.2013.08.003.

    Article  CAS  PubMed  Google Scholar 

  99. Collins M, Young I, Sweeney P, Fenn GC, Stratford ME, Wilson A, Harris M. The effect of tramadol on dento-alveolar surgical pain. Br J Oral Maxillofac Surg. 1997;35(1):54–8.

    Article  CAS  PubMed  Google Scholar 

  100. Hassan SS, Ahmed A, Rai M, Kalappa TM. Analgesic efficacy of tramadol and butorphanol in mandibular third molar surgery: a comparative study. J Contemp Dent Pract. 2012;13(3):364–70.

    PubMed  Google Scholar 

  101. Gönül O, Satilmiş T, Ciftci A, Sipahi A, Garip H, Göker K. Comparison of the effects of topical ketamine and tramadol on postoperative pain after mandibular molar extraction. J Oral Maxillofac Surg. 2015;73(11):2103–7. https://doi.org/10.1016/j.joms.2015.05.012.

    Article  PubMed  Google Scholar 

  102. Pozos AJ, MartÃnez R, Aguirre P, Pérez J. Tramadol administered in a combination of routes for reducing pain after removal of an impacted mandibular third molar. J Oral Maxillofac Surg. 2007;65(8):1633–9.

    Article  PubMed  Google Scholar 

  103. Medve RA, Wang J, Karim R. Tramadol and acetaminophen tablets for dental pain. Anesth Prog. 2001;48(3):79–81.

    CAS  PubMed  PubMed Central  Google Scholar 

  104. Fricke JR Jr, Karim R, Jordan D, Rosenthal N. A double-blind, single-dose comparison of the analgesic efficacy of tramadol/acetaminophen combination tablets, hydrocodone/acetaminophen combination tablets, and placebo after oral surgery. Clin Ther Jun. 2002;24(6):953–68.

    Article  CAS  Google Scholar 

  105. Ziccardi VB, Desjardins PJ, Daly-DeJoy E, Seng GF. Single-dose vicoprofen compared with acetaminophen with codeine and placebo in patients with acute postoperative pain after third molar extractions. J Oral Maxillofac Surg. 2000;58(6):622–8.

    Article  CAS  PubMed  Google Scholar 

  106. Forbes JA, Bates JA, Edquist IA, Burchfield WH, Smith FG, Schwartz MK, Kit V, Hyatt J, Bell WE, Beaver WT. Evaluation of two opioid-acetaminophen combinations and placebo in postoperative oral surgery pain. Pharmacotherapy. 1994;14(2):139–46.

    CAS  PubMed  Google Scholar 

  107. Yagoubian B, Akkara J, Afzali P, Alfi DM, Olson L, Conell-Price J, Yeh J, Eisig SB, Flood P. Nicotine nasal spray as an adjuvant analgesic for third molar surgery. J Oral Maxillofac Surg. 2011;69(5):1316–9. https://doi.org/10.1016/j.joms.2010.07.025.

    Article  PubMed  Google Scholar 

  108. Freda NM, Keenan AV. Moderate evidence to recommend submucosal injection of dexamethasone in reducing post-operative oedema and pain after third molar extraction. Evid Based Dent. 2016;17(2):58–9. https://doi.org/10.1038/sj.ebd.6401174.

    Article  PubMed  Google Scholar 

  109. Eshghpour M, Mortazavi H, Mohammadzadeh Rezaei N, Nejat A. Effectiveness of green tea mouthwash in postoperative pain control following surgical removal of impacted third molars: double blind randomized clinical trial. Daru. 2013;21(1):59. https://doi.org/10.1186/2008-2231-21-59.

    Article  PubMed  PubMed Central  Google Scholar 

  110. Olmedo-Gaya MV, Manzano-Moreno FJ, Galvez-Mateos R, González-Rodriguez MP, Talero-Sevilla C, Vallecillo-Capilla M. Oral pregabalin for postoperative pain relief after third molar extraction: a randomized controlled clinical trial. Clin Oral Investig. 2016;20(7):1819–26. https://doi.org/10.1007/s00784-015-1657-3.

    Article  PubMed  Google Scholar 

  111. Hill CM, Balkenohl M, Thomas DW, Walker R, Mathé H, Murray G. Pregabalin in patients with postoperative dental pain. Eur J Pain. 2001;5(2):119–24.

    Article  CAS  PubMed  Google Scholar 

  112. Cheung CW, Choi WS, Leung YY, Lui F, Ng JK, Hei-Ho AM, Irwin MG. A double-blind randomized crossover study to evaluate the timing of pregabalin for third molar surgery under local anesthesia. J Oral Maxillofac Surg. 2012;70(1):25–30. https://doi.org/10.1016/j.joms.2011.03.056.

    Article  PubMed  Google Scholar 

  113. Brkovic B, Gardasevic M, Roganovic J, Jovic N, Todorovic L, Stojic D. Lidocaine+clonidine for maxillary infiltration anaesthesia: parameters of anaesthesia and vascular effects. Int J Oral Maxillofac Surg. 2008;37(2):149–55.

    Article  CAS  PubMed  Google Scholar 

  114. Brkovic B, Todorovic L, Stojic D. Comparison of clonidine and epinephrine in lidocaine anaesthesia for lower third molar surgery. Int J Oral Maxillofac Surg. 2005;34(4):401–6.

    Article  CAS  PubMed  Google Scholar 

  115. Patil PM, Patil SP. Is clonidine an adequate alternative to epinephrine as a vasoconstrictor in patients with hypertension? J Oral Maxillofac Surg. 2012;70(2):257–62. https://doi.org/10.1016/j.joms.2011.07.011.

    Article  PubMed  Google Scholar 

  116. Tuffin JR, Cunliffe DR, Shaw SR. Do local analgesics injected at the time of third molar removal under general anaesthesia reduce significantly post-operative analgesic requirements? A double-blind controlled trial. Br J Oral Maxillofac Surg. 1989;27(1):27–32.

    Article  CAS  PubMed  Google Scholar 

  117. Gordon SM, Dionne RA, Brahim J, Jabir F, Dubner R. Blockade of peripheral neuronal barrage reduces postoperative pain. Pain. 1997;70:209–15.

    Article  CAS  PubMed  Google Scholar 

  118. Nayyar MS, Yates C. Bupivacaine as pre-emptive analgesia in third molar surgery: randomised controlled trial. Br J Oral Maxillofac Surg. 2006;44(6):501–3.

    Article  PubMed  Google Scholar 

  119. Hersh EV, Moore PA. Comment on controlling dental post-operative pain and the intraoral local delivery of drugs. Curr Med Res Opin. 2015;31(12):2185–7. https://doi.org/10.1185/03007995.2015.1109504.

    Article  CAS  PubMed  Google Scholar 

  120. Tordoff SG, Brossy M, Rowbotham DJ, James JN, James R, Raphael JH. The effect of pre-incisional infiltration with lignocaine on postoperative pain after molar teeth extraction under general anaesthesia. Anaesthesia. 1996;51:585–7.

    Article  CAS  PubMed  Google Scholar 

  121. Singh K, Phillips FM, Kuo E, Campbell M. A prospective, randomized, double-blind study of the efficacy of postoperative continuous local anesthetic infusion at the iliac crest bone graft site after posterior spinal arthrodesis: a minimum of 4-year follow-up. Spine (Phila Pa 1976). 2007;32(25):2790–6. https://doi.org/10.1097/BRS.0b013e31815b7650.

    Article  Google Scholar 

  122. Puri R, Moskovich R, Gusmorino P, Shott S. Bupivacaine for postoperative pain relief at the iliac crest bone graft harvest site. Am J Orthop (Belle Mead NJ). 2000;29(6):443–6.

    CAS  Google Scholar 

  123. Hahn M, Dover MS, Whear NM, Moule I. Local bupivacaine infusion following bone graft harvest from the iliac crest. Int J Oral Maxillofac Surg. 1996;25(5):400–1.

    Article  CAS  PubMed  Google Scholar 

  124. Saikrishna D, Sujit S, Sheetal KR. Use of a modified epidural catheter for analgesia after iliac crest bone procurement. J Maxillofac Oral Surg. 2009;8(3):254–6. https://doi.org/10.1007/s12663-009-0062-3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  125. Sbitany H, Koltz PF, Waldman J, Girotto JA. Continuous bupivacaine infusion in iliac bone graft donor sites to minimize pain and hospitalization. Cleft Palate Craniofac J. 2010;47(3):293–6. https://doi.org/10.1597/09-049.1.

    Article  PubMed  Google Scholar 

  126. O'Neill KR, Lockney DT, Bible JE, Crosby CG, Devin CJ. Bupivacaine for pain reduction after iliac crest bone graft harvest. Orthopedics. 2014;37(5):e428–34. https://doi.org/10.3928/01477447-20140430-52.

    Article  PubMed  Google Scholar 

  127. Hoard MA, Bill TJ, Campbell RL. Reduction in morbidity after iliac crest bone harvesting: the concept of preemptive analgesia. J Craniofac Surg. 1998;9(5):448–51.

    Article  CAS  PubMed  Google Scholar 

  128. Barkhuysen R, Meijer GJ, Soehardi A, Merkx MA, Borstlap WA, Bergà SJ, Bronkhorst EM, Hoppenreijs TJ. The effect of a single dose of bupivacaine on donor site pain after anterior iliac crest bone harvesting. Int J Oral Maxillofac Surg. 2010;39(3):260–5. https://doi.org/10.1016/j.ijom.2009.10.015.

    Article  CAS  PubMed  Google Scholar 

  129. Gamli M, Dalgic A, Ornek D, Horasanli E, Kilci O, Un C, Dikmen B. Evaluation of the efficacy of bupivacaine soaked in Gelfoam(®) at the iliac crest bone graft site. Rev Bras Anestesiol. 2012;62(6):811–8. https://doi.org/10.1016/S0034-7094(12)70181-2.

    Article  CAS  PubMed  Google Scholar 

  130. Kukidome H, Matsuura N, Kasahara M, Ichinohe T. Continuous postoperative pain control using a multiple-hole catheter after iliac bone grafting: comparison between ropivacaine and levobupivacaine. Int J Oral Maxillofac Surg. 2016;45(4):454–9. https://doi.org/10.1016/j.ijom.2015.09.010.

    Article  CAS  PubMed  Google Scholar 

  131. Modi M, Rastogi S, Kumar A. Buprenorphine with bupivacaine for intraoral nerve blocks to provide postoperative analgesia in outpatients after minor oral surgery. J Oral Maxillofac Surg. 2009;67(12):2571–6. https://doi.org/10.1016/j.joms.2009.07.014.

    Article  PubMed  Google Scholar 

  132. Bernard JM, Macaire P. Dose-range effects of clonidine added to lidocaine for brachial plexus block. Anesthesiology. 1997;87:277.

    Article  CAS  PubMed  Google Scholar 

  133. Moore UJ, Seymour RA, Gilroy J, Rawlins MD. The efficacy of locally applied morphine in post-operative pain after bilateral third molar surgery. Br J Clin Pharmacol. 1994;37(3):227–30.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  134. Dionne RA, Gordon SM, Tahara M, et al. Analgesic efficacy and pharmacokinetics of ketoprofen administered into a surgical site. J Clin Pharmacol. 1999;39:131.

    Article  CAS  PubMed  Google Scholar 

  135. Strumper D, Durieux ME. Antidepressants as long-acting local anesthetics. Reg Anesth Pain Med. 2004;29:277.

    Article  CAS  PubMed  Google Scholar 

  136. Bazin JE, Massoni C, Bruelle P. The addition of opioids to local anaesthetics in brachial plexus block: the comparative effects of morphine, buprenorphine and sufentanil. Anesthesia. 1997;52:858.

    Article  CAS  Google Scholar 

  137. Kapral S, Gollmann G, Waltl B, et al. Tramadol added to mepivacaine prolongs the duration of an axillary brachial plexus blockade. Anesth Analg. 1999;88:853.

    Article  CAS  PubMed  Google Scholar 

  138. Robaux S, Blunt C, Viel E, et al. Tramadol added to 1.5% mepivacaine for axillary brachial plexus block improves postoperative analgesia dose-dependently. Anesth Analg. 2004;98:1172.

    Article  CAS  PubMed  Google Scholar 

  139. Yue Y, Collaku A, Brown J, Buchanan WL, Reed K, Cooper SA, Otto J. Efficacy and speed of onset of pain relief of fast-dissolving paracetamol on postsurgical dental pain: two randomized, single-dose, double-blind, placebo-controlled clinical studies. Clin Ther. 2013;35(9):1306–20. https://doi.org/10.1016/j.clinthera.2013.07.422.

    Article  CAS  PubMed  Google Scholar 

  140. Moeller C, Pawlowski J, Pappas AL, Fargo K, Welch K. The safety and efficacy of intravenous ketorolac in patients undergoing primary endoscopic sinus surgery: a randomized, double-blinded clinical trial. Int Forum Allergy Rhinol. 2012;2(4):342–7. https://doi.org/10.1002/alr.21028.

    Article  PubMed  Google Scholar 

  141. Van Aken H, Thys L, Veekman L, Buerkle H. Assessing analgesia in single and repeated administrations of propacetamol for postoperative pain: comparison with morphine after dental surgery. Anesth Analg. 2004;98(1):159–65.

    Article  PubMed  CAS  Google Scholar 

  142. Juhl GI, Norholt SE, Tonnesen E, Hiesse-Provost O, Jensen TS. Analgesic efficacy and safety of intravenous paracetamol (acetaminophen) administered as a 2-g starting dose following third molar surgery. Eur J Pain. 2006;10(4):371–7.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Oral and Maxillofacial Surgery, Drexel University College of Medicine, Allegheny General Hospital, Allegheny Health Network, Pittsburgh, PA, USA

    Joseph E. Cillo Jr. D.M.D., M.P.H., Ph.D., F.A.C.S.

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Correspondence to Joseph E. Cillo Jr. D.M.D., M.P.H., Ph.D., F.A.C.S. .

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  1. University of Connecticut, Farmington, Connecticut, USA

    Elie M. Ferneini

  2. Indianapolis, Indiana, USA

    Jeffrey D. Bennett

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Cillo, J.E. (2018). Peri-Operative Pain Management in Maxillofacial Surgery. In: Ferneini, E., Bennett, J. (eds) Perioperative Assessment of the Maxillofacial Surgery Patient. Springer, Cham. https://doi.org/10.1007/978-3-319-58868-1_11

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