Abstract
Our laboratory pioneered the patient-derived orthotopic xenograft (PDOX) nude-mouse model with the technique of surgical orthotopic implantation (SOI) of intact cancer tissue. PDOX models from patients with colon, pancreatic, breast, ovarian, lung, mesothelioma, and stomach cancer were established in the early 1990s, resulting in primary and metastatic tumor growth very similar to that of the donor patient. This chapter reviews the properties of the models, which provide the basis for mouse models of metastatic cancer that most closely resemble the clinical pattern.
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Hoffman, R.M. (2017). The First Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Cancer: Cancer of the Colon, Pancreas, Lung, Breast, Ovary, and Mesothelioma. In: Hoffman, R. (eds) Patient-Derived Mouse Models of Cancer . Molecular and Translational Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-57424-0_7
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DOI: https://doi.org/10.1007/978-3-319-57424-0_7
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