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Intracerebral Hemorrhage and Cerebral Amyloid Angiopathy

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Stroke Genetics

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Abstract

Intracerebral hemorrhage (ICH) is the acute manifestation of a chronic progressive disease of the cerebral vessels [1]. Rarely, the underlying vessel disease can be a vascular malformation. However, for patients over the age of 55 years, the overwhelming majority of ICH cases occur in the presence of cerebral small vessel disease [2]. ICH is routinely classified according to the region of the brain in which it occurs: the thalamus, basal ganglia, brainstem, cerebellum (“deep” or “nonlobar” ICH), or at the junction of the cortical gray matter and subcortical white matter (“lobar” ICH). Pathological studies demonstrate that ICH location frequently correlates with different underlying small vessel diseases. For example, while chronic hypertension has long been recognized as the leading cause of deep ICH, cerebral amyloid angiopathy (CAA) has been recognized as a leading cause of lobar (ICH) [3–7].

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Authors and Affiliations

  1. Department of Neurology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 6818, Boston, MA, 02114, USA

    Alessandro Biffi M.D.

  2. Center for Human Genetics Research, Massachusetts General Hospital, 185 Cambridge Street, CPZN 6818, Boston, MA, 02114, USA

    Alessandro Biffi M.D. & Jonathan Rosand M.D., M.Sc.

  3. Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA

    Alessandro Biffi M.D. & Jonathan Rosand M.D., M.Sc.

  4. Division of Neurocritical Care and Emergency Neurology, Massachusetts General Hospital (MGH), Boston, MA, USA

    Jonathan Rosand M.D., M.Sc.

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  1. Alessandro Biffi M.D.
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  2. Jonathan Rosand M.D., M.Sc.
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Correspondence to Alessandro Biffi M.D. .

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Editors and Affiliations

  1. Department of Neurology, Institute of Cardiovascular Research Royal Holloway College, University of London Imperial College London Healthcare NHS Trust, London, United Kingdom

    Pankaj Sharma

  2. Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA

    James F. Meschia

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Biffi, A., Rosand, J. (2017). Intracerebral Hemorrhage and Cerebral Amyloid Angiopathy. In: Sharma, P., Meschia, J. (eds) Stroke Genetics. Springer, Cham. https://doi.org/10.1007/978-3-319-56210-0_5

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