Skip to main content
SpringerLink
Log in
SpringerLink
Log in

Osteoblastoma of the Sacrum

  • Chapter
  • First Online:
Tumors of the Sacrum

  • 827 Accesses

Abstract

Osteoblastoma is a rare benign bone-forming tumor that accounts for approximately 1% of all bone neoplasm [1–4]. It may occur in any area of the skeleton, but it is more frequently observed in the spine (mainly in the mobile segments whereas sacrum is rarely affected) [1, 5]. Due to the rarity of the tumor and the usual delay in diagnosis, the optimal treatment of sacral osteoblastomas is controversial [1, 5–8]. Although benign, these tumors may occasionally pose a challenge in histopathologic evaluation and differential diagnosis with malignant tumors as well as in the choice of adequate surgical treatment [6, 7].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Unni KK. Benign osteoblastoma (giant osteoid osteoma). In: Unni KK, editor. Dahlin’s bone tumours: general aspects and data on 11087 cases. 5th ed. Philadelphia: Lippincott-Raven; 1996. p. 131–42.

    Google Scholar 

  2. Greenspan A, Remagen W. Differential diagnosis of tumors and tumor-like lesions of bone and joints. Philadelphia: Lippincott-Raven; 1998. p. 25–366.

    Google Scholar 

  3. Lucas DR, Unni KK, McLeod RA, O’Connor MI, Sim FH. Osteoblastoma: clinicopathologic study of 306 cases. Hum Pathol. 1994;25(2):117–34.

    Article  CAS  PubMed  Google Scholar 

  4. Campanacci L. Osteoblastoma. In: Picci P, et al., editors. Atlas of musculoskeletal tumors and tumor like lesions. Switzerland: Springer; 2014. p. 81–4.

    Chapter  Google Scholar 

  5. Campanacci M. Bone and soft tissue tumors. New York: Springer; 1993.

    Google Scholar 

  6. Ruggieri P, Huch K, Mavrogenis AF, Merlino B, Angelini A. Osteoblastoma of the sacrum: report of 18 cases and analysis of the literature. Spine. 2014;39(2):E97–E103.

    Article  PubMed  Google Scholar 

  7. Bertoni F, Bacchini P, Donati D, Martini A, Picci P, Campanacci M. Osteoblastoma-like osteosarcoma. The Rizzoli Institute experience. Mod Pathol. 1993 Nov;6(6):707–16.

    CAS  PubMed  Google Scholar 

  8. Dorfman HD, Weiss SW. Borderline osteoblastic tumors: problems in the differential diagnosis of aggressive osteoblastoma and low-grade osteosarcoma. Semin Diagn Pathol. 1984;1:215–34.

    CAS  PubMed  Google Scholar 

  9. Biagini R, Orsini U, Demitri S, et al. Osteoid osteoma and osteoblastoma of the sacrum. Orthopedics. 2001;24(11):1061–4.

    CAS  PubMed  Google Scholar 

  10. Bessou P, Lefournier V, Ramoul A, Vasdev A, Boubagra K, Crouzet G. Benign vertebral osteoblastoma. Report of 6 cases. J Neuroradiol. 1998;25(1):21–31.

    CAS  PubMed  Google Scholar 

  11. Ozaki T, Liljengvist U, Hillmann A, et al. Osteoid osteoma and osteoblastoma of the spine: experiences with 22 patients. Clin Orthop Relat Res. 2002;397:394–402.

    Article  Google Scholar 

  12. Berry M, Mankin H, Gebhardt M, Rosemberg A, Hornicek F. Osteoblastoma: a 30-year study of 99 cases. J Surg Oncol. 2008;98(3):179–83.

    Article  PubMed  Google Scholar 

  13. Poleksic ZR, Lalosevic VJ, Milinkovic ZB. Osteoblastoma of the spine. Acta Chir Iugosl. 2010;57(1):63–8.

    Article  CAS  PubMed  Google Scholar 

  14. Chakrapani SD, Grim K, Kaimaktchiev V, Anderson JC. Osteoblastoma of the spine with discordant magnetic resonance imaging and computed tomography imaging features in a child. Spine. 2008;33(25):E968–70.

    Article  PubMed  Google Scholar 

  15. Khan IS, Thakur JD, Chittiboina P, Nanda A. Large sacral osteoblastoma: a case report and review of multi-disciplinary management strategies. J La State Med Soc. 2012;164(5):251–5.

    PubMed  Google Scholar 

  16. Ruggieri P, McLeod RA, Unni KK, Sim FH. Osteoblastoma. Orthopedics. 1996;19(7):621–4.

    CAS  PubMed  Google Scholar 

  17. Dal Cin P, Sciot R, Samson I, De Wever I, Van den Berghe H. Osteoid osteoma and osteoblastoma with clonal chromosome changes. Br J Cancer. 1998;78(3):344–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Della Rocca C, Huvos AG. Osteoblastoma: varied histological presentations with a benign clinical course. An analysis of 55 cases. Am J Surg Pathol. 1996;20(7):841–50.

    Article  CAS  PubMed  Google Scholar 

  19. Sar C, Eralp L. Surgical treatment of primary tumors of the sacrum. Arch Orthop Trauma Surg. 2002;122(3):148–55.

    Article  PubMed  Google Scholar 

  20. Jambhekar NA, Desai S, Khapake D. Osteoblastoma: a study of 12 cases. Indian J Pathol Microbiol. 2006;49(4):487–90.

    CAS  PubMed  Google Scholar 

  21. Arkader A, Dormans JP. Osteoblastoma in the skeletally immature. J Pediatr Orthop. 2008;28(5):555–60.

    Article  PubMed  Google Scholar 

  22. Puri A, Agarwal MG, Shah M, Puri A, Agarwal MG, Shah M, Srinivas CH, Shukla PJ, Shrikhande SV, Jambhekar NA. Decision making in primary sacral tumors. Spine J. 2009;9(5):396–403.

    Article  PubMed  Google Scholar 

  23. Bouvet R, Vergos M, Chapuis O, André JL, Rochat G. Osteoblastomas of the coccyx. Apropos of a case. Review of the literature. J Chir (Paris). 1994;131(1):40–3.

    CAS  Google Scholar 

  24. Patel N, Sandeman DR, Cobby M, Nelson IW. Interactive image-guided surgery of the spine—use of the ISG/Elekta Viewing Wand to aid intraoperative localization of a sacral osteoblastoma. Br J Neurosurg. 1997;11(1):60–4.

    Article  CAS  PubMed  Google Scholar 

  25. Rajkumar A, Basu R, Datta NR, Dhingra S, Gupta RK. Radiation therapy for sacral osteoblastoma. Clin Oncol (R Coll Radiol). 2003;15(2):85–6.

    Article  CAS  Google Scholar 

  26. Saghieh S, Rameh C, Birjawi G, Lakkis S. Sacral osteoblastoma presenting as a L5-S1 disc herniation. Int Surg. 2005;90(5):289–92.

    PubMed  Google Scholar 

  27. Witthingham-Jones P, Hughes R, Fajinmi M, Lehovsky J, Saifuddin A. Osteoblastoma crossing the sacro-iliac joint. Skeletal Radiol. 2007;36(3):249–52.

    Article  Google Scholar 

  28. Gazzeri R, Tamorri M, Bernardi C, Alfieri A, Gazzeri G. Lumbar spinal osteoblastoma mimicking a dumbbell radicolare schwannoma. Zantralbl Neurochir. 2008;69(4):191–3.

    Article  CAS  Google Scholar 

  29. Oliveira CR, Mendonca BB, Camargo OP, et al. Classic osteoblastoma, atypical osteoblastoma, and osteosarcoma: a comparative study based on clinical, histological, and biological parameters. Clinics (Sao Paulo). 2007;62(2):167–74.

    Article  Google Scholar 

  30. Flemming DJ, Murphey MD, Carmichael BB, et al. Primary tumors of the spine. Semin Musculoskelet Radiol. 2000;4:299–320.

    Article  CAS  PubMed  Google Scholar 

  31. Shaikh MI, Saifuddin A, Pringle J, Natali C, Sherazi Z. Spinal osteoblastoma: CT and MR imaging with pathological correlation. Skeletal Radiol. 1999;28:33–40.

    Article  CAS  PubMed  Google Scholar 

  32. Hosalkar HS, Garg S, Moroz L, et al. The diagnostic accuracy of MRI versus CT imaging for osteoid osteoma in children. Clin Orthop Relat Res. 2005;433:171–7.

    Article  Google Scholar 

  33. Davies M, Cassar-Pullicino VN, Davies AM, et al. The diagnostic accuracy of MR imaging in osteoid osteoma. Skeletal Radiol. 2002;31:559–69.

    Article  PubMed  Google Scholar 

  34. Cheung FM, Wu WC, Lam CK, et al. Diagnostic criteria for pseudomalignant osteoblastoma. Histopathology. 1997;31:196–200.

    Article  CAS  PubMed  Google Scholar 

  35. Mirra JM, Kendrick RA, Kendrick RE. Pseudomalignant osteoblastoma versus arrested osteosarcoma: a case report. Cancer. 1976;37:2005–14.

    Article  CAS  PubMed  Google Scholar 

  36. Schajowicz F, Lemos C. Malignant osteoblastoma. J Bone Joint Surg Br. 1976;58:202–11.

    CAS  PubMed  Google Scholar 

  37. Mayer L. Malignant degeneration of so-called benign osteoblastoma. Bull Hosp Jt Dis. 1967;28:4–13.

    CAS  Google Scholar 

  38. Seki T, Fukuda H, Ishii Y, Hanaoka H, Yatabe S. Malignant transformation of benign osteoblastoma. A case report. J Bone Joint Surg Am. 1975;57:424–6.

    Article  CAS  PubMed  Google Scholar 

  39. Merryweather R, Middlemiss JH, Sanerkin NG. Malignant transformation of osteoblastoma. J Bone Joint Surg Br. 1980;62:381–4.

    CAS  PubMed  Google Scholar 

  40. Bertoni F, Unni KK, McLeod RA, Dahlin DC. Osteosarcoma resembling osteoblastoma. Cancer. 1985;55(2):416–26.

    Article  CAS  PubMed  Google Scholar 

  41. Hosono A, Yamaguchi U, Makimoto A, Endo M, Watanabe A, Shimoda T, Kaya M, Matsumura T, Sonobe H, Kusumi T, Yamaguchi T, Hasegawa T. Utility of immunohistochemical analysis for cyclo-oxygenase 2 in the differential diagnosis of osteoblastoma and osteosarcoma. J Clin Pathol. 2007;60(4):410–4.

    Article  CAS  PubMed  Google Scholar 

  42. Kawaguchi Y, Hasegawa T, Oka S, et al. Mechanism of intramedullary high intensity area on T2 weighted magnetic resonance imaging in osteoid osteoma: a possible role of COX-2 expression. Pathol Int. 2001;51:933–7.

    Article  CAS  PubMed  Google Scholar 

  43. Mungo DV, Zhang X, O’Keefe RJ, et al. COX-1 and COX-2 expression in osteoid osteomas. J Orthop Res. 2002;20:159–62.

    Article  CAS  PubMed  Google Scholar 

  44. Tsujii M, DuBois RN. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell. 1995;83:493–501.

    Article  CAS  PubMed  Google Scholar 

  45. Harrop JS, Schmidt MH, Boriani S, Shaffrey CI. Aggressive “benign” primary spine neoplasm: osteoblastoma, aneurismal bone cyst, and giant cell tumor. Spine. 2009;34(22 Suppl):S39–47.

    Article  PubMed  Google Scholar 

  46. Berberoglu S, Oguz A, Aribal E, et al. Osteoblastoma response to radiotherapy and chemotherapy. Med Pediatr Oncol. 1997;28:305–9.

    CAS  PubMed  Google Scholar 

  47. Marsh BW, Bonfiglio M, Brady LP, et al. Benign osteoblastoma: range of manifestations. J Bone Joint Surg Am. 1975;57:1–9.

    Article  CAS  PubMed  Google Scholar 

  48. Mavrogenis AF, Rossi G, Rimondi E, Papagelopoulos PJ, Ruggieri P. Embolization of bone tumors. Orthopedics. 2011;34(4):303–10.

    Article  PubMed  Google Scholar 

  49. Gottfried ON, Schmidt MH, Stevens EA. Embolization of sacral tumors. Neurosurg Focus. 2003;15(2):E4.

    Article  PubMed  Google Scholar 

  50. Kollender Y, Meller I, Bickels J, Flusser G, Issakov J, Merimsky O, Marouani N, Nirkin A, Weinbroum AA. Role of adjuvant cryosurgery in intralesional treatment of sacral tumors. Cancer. 2003;97(11):2830–8. doi:10.1002/cncr.11383.

    Article  PubMed  Google Scholar 

  51. Nader R, Alford BT, Nauta HJ, Crow W, van Sonnenberg E, Hadjepavlou AG. Preoperative embolization and intraoperative cryocoagulation as adjuncts in resection of hypervascular lesions of the thoracolumbar spine. J Neurosurg. 2002;97(3 Suppl):294–300.

    PubMed  Google Scholar 

  52. Ruggieri P, Angelini A, Ussia G, Montalti M, Mercuri M. Surgical margins and local control in resection of sacral chordomas. Clin Orthop Relat Res. 2010;468(11):2939–47.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Rosenthal DI, Hornicek FJ, Torriani M, et al. Osteoid osteoma: percutaneous treatment with radiofrequency energy. Radiology. 2003;229:171–5.

    Article  PubMed  Google Scholar 

  54. Frassica FJ, Waltrip RL, Sponseller PD, et al. Clinicopathologic features and treatment of osteoid osteoma and osteoblastoma in children and adolescents. Orthop Clin North Am. 1996;27:559–74.

    CAS  PubMed  Google Scholar 

  55. DiCaprio MR, Bellapianta JM. Use of radiofrequency ablation in the treatment of bone tumors. Tech Orthop. 2007;22(2):99–109.

    Article  Google Scholar 

  56. Jackson RP. Recurrent osteoblastoma: a review. Clin Orthop Relat Res. 1978;131:229–33.

    Google Scholar 

  57. Jackson RP, Reckling FW, Mants FA. Osteoid osteoma and osteoblastoma. Similar histologic lesions with different natural histories. Clin Orthop Relat Res. 1977;128:303–13.

    Google Scholar 

  58. Boriani S, Amendola L, Bandiera S, et al. Staging and treatment of osteoblastoma in the mobile spine: a review of 51 cases. Eur Spine J. 2012;21(10):2003–10.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Conflict-of-Interest Statement

No benefits have been or will be received from a commercial party related directly or indirectly to the subject matter of this article.

Author information

Authors and Affiliations

  1. Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

    Andrea Angelini M.D., Ph.D. & Pietro Ruggieri M.D., Ph.D.

Authors
  1. Andrea Angelini M.D., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pietro Ruggieri M.D., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Pietro Ruggieri M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Padova, Italy

    Pietro Ruggieri

  2. Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Padova, Italy

    Andrea Angelini

  3. Department of Pathology, Istituto Ortopedico Rizzoli, Bologna, Italy

    Daniel Vanel

  4. Laboratory of Experimental Oncology, Musculoskeletal Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy

    Piero Picci

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Cite this chapter

Angelini, A., Ruggieri, P. (2017). Osteoblastoma of the Sacrum. In: Ruggieri, P., Angelini, A., Vanel, D., Picci, P. (eds) Tumors of the Sacrum. Springer, Cham. https://doi.org/10.1007/978-3-319-51202-0_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-51202-0_9

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-51200-6

  • Online ISBN: 978-3-319-51202-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation