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Short Stature in Children with Cerebral Palsy

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Abstract

Growth in children is complex. Externally, growth is determined by changes in height, in weight, and in features of physical maturation such as body shape, body composition, and secondary sexual characteristics. Internally, growth is a churning interplay of many biochemical and physiological systems. Nutrition, metabolism, and hormones integrate with neuronal pathways and physiology in the developing brain, allowing adaptation to the environment and future reproductive capacity.

In children with cerebral palsy, assessment of growth has several challenges. Anthropometric measurements, for example, are difficult to obtain because of contractures and other bodily deformities. There are also limitations in our understanding of how maturational descriptors of growth such as bone age, bone mineral density, and body composition are applied to growing children with cerebral palsy compared to their healthier peers.

It is necessary for appropriate management of children with cerebral palsy to be aware of the subtleties in the use of modified measures of growth, in the selection of appropriate growth charts, and in the correct treatment intervention. A clearer understanding of the true health challenges the child with cerebral palsy faces leads to better risk assessments for surgical readiness and long-term health needs. The overarching goal is an improvement in the quality of life for these children as they grow into adulthood.

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References

  • Ali O, Shim M, Fowler I, Greenberg M, Perkins D, Oppenheim W, Cohen P (2007) Growth hormone therapy improves bone mineral density in children with cerebral palsy: a preliminary pilot study. J Clin Endocrinol Metab 92(3):932–937. Accessed 10 2017. https://doi.org/10.1210/jc.2006-0385

    Article  CAS  PubMed  Google Scholar 

  • Allen DB, Rundle AC, Graves DA, Blethen SL (1997) Risk of leukemia in children treated with growth hormone: review and reanalysis. J Pediatr 131(1 Pt 2):S32–S36

    Article  CAS  Google Scholar 

  • Araujo LA, SIlva LR (2013) Anthropometric assessment of patients with cerebral palsy: which curves are more appropriate. J Pediatr 89(3):307–314

    Article  Google Scholar 

  • Brooks J, Day S, Shevelle R, Strauss D (2011) Low weight, morbidity, and mortality in children with cerebral palsy: new clinical growth charts. Pediatrics 128(2):e299–e307

    Article  Google Scholar 

  • Chumlea WC, Guo SS, Steinbaugh ML (1994) Prediction of stature from knee height for black and white adults and children with application to mobility-impaired or handicapped persons. J Am Diet Assoc 94(12):1385–1388, 1391

    Article  CAS  Google Scholar 

  • Coniglio SJ, Stevenson RD, Rogol AD (1996) Apparent growth hormone deficiency in children with cerebral palsy. Dev Med Child Neurol 38(9):797–804

    Article  CAS  Google Scholar 

  • Davids JR, Oeffinger DJ, Bagley AM, Sison-Williamson M, Gorton G (2015) Relationship of strength, weight, age and function in ambulatory children with cerebral palsy. J Pediatr Orthop 35(5):523–529

    Article  Google Scholar 

  • Day SM (2017) Growth charts for cerebral palsy: still imperfect but gaining in value. Dev Med Child Neurol 59(9):887

    Article  Google Scholar 

  • Day SM, Strauss DJ, Vachon PJ, Rosenbloom L, Shavelle RM, Wu YW (2007) Growth patterns in a population of children and adolescents with cerebral palsy. Dev Med Child Neurol 49:167–171

    Article  Google Scholar 

  • Deceuninck J, Bernard JC, Combey A, Leroy-Coudeville S, Morel E, Loustalet E, Chaleat-Valayer E, Berthonnaud E (2013) Sagittal X-ray parameters in walking or ambulating children with cerebral palsy. Ann Phys Rehabil Med 56:123–133

    Article  CAS  Google Scholar 

  • Gilbert SR, GIlbert AC, Henderson RC (2004) Skeletal maturation in children with cerebral palsy. J Pediatr Orthop 24:292–297

    Article  Google Scholar 

  • Gollapudi K, Feeley BT, Otsuka NY (2007) Advanced skeletal maturation in ambulatory cerebral palsy patients. J Pediatr Orthop 27:295–298

    Article  Google Scholar 

  • Greulich WN, Pyle SI (1959) Radiographic atlas of skeletal development of the hand and wrist. Stanford University Press, Stanford

    Book  Google Scholar 

  • Gurka MJ, Kuperminc MN, Busby MG, Bennis JA, Grossberg RI, Houlihan CM, Stevenson RD, Henderson RC (2010) Assessment and correction of skinfold thickness equations in estimating body fat in children with cerebral palsy. Dev Med Child Neurol 52:e35–e41

    Article  Google Scholar 

  • Hamza RT, Ismail MA, Jamed AI (2011) Growth hormone deficiency in children and adolescents with cerebral palsy: relation to gross motor function and degree of spasticity. Pak J Biol Sci 14(7):433–440

    Article  CAS  Google Scholar 

  • Hayashi Y, Shiraishi T, Tani J, Aroki K, Kurashige T (1989) Pituitary reserve of growth hormone in adolescent patients with cerebral palsy and mental retardation. No To Hattatsu 21:239–244

    CAS  PubMed  Google Scholar 

  • Henderson RC, Gilbert SR, Clement ME, Abbas A, Worley G, Stevenson RD (2005) Altered skeletal maturation in moderate to severe cerebral palsy. Dev Med Child Neurol 47:229–236

    Article  Google Scholar 

  • Kong CK, Tse PW, Lee WY (1999) Bone age and linear skeletal growth of children with cerebral palsy. Dev Med Child Neurol 41:758–765

    Article  CAS  Google Scholar 

  • Krick J, Murphy-Miller P, Zeger S, Wright E (1996) Pattern of growth in children with cerebral palsy. J Am Diet Assoc 96(7):680–685

    Article  CAS  Google Scholar 

  • Kuperminc MN (2006) Longitudinal study of growth velocity and growth hormone during puberty in children with cerebral palsy and typical children. Dev Med Child Neurol 106(Suppl):38–39

    Google Scholar 

  • Kuperminc MN, Gurka MT, Houlihan CM, Henderson RC, Roemmick JN, Rogol AD, Stevenson RD (2009) Puberty, statural growth and growth hormone release in children with cerebral palsy. J Pediatr Rehabil Med 2(2):131–141

    PubMed  PubMed Central  Google Scholar 

  • Liu L, Roberts R, Moyer-Miller L, Samson-Fang L (2005) Determination of body composition in children with cerebral palsy: bIoelectrical impedance analysis and anthropometry vs dual-energy X-ray absorptiometry. J Am Diet Assoc 105(5):794–797

    Article  Google Scholar 

  • McFall J, Stewart C, Kidgell V, Postans N, Jarvis S, Freeman R, Roberts A (2015) Changes in gait which occur before and during the adolescent growth spurt in children treated by selective dorsal rhizotomy. Gait Posture 42:317–322

    Article  CAS  Google Scholar 

  • Nishi Y, Tanaka T, Takano K, Fujieda K, Igarashi Y, Hanew K, Hirano T, Yokoya S, Tachibana K, Saito T, Watanabe S (1999) Recent status in the occurrence of leukemia in growth-hormone-treated patients in Japan. GH Treatment Study Committee of the Foundation for Growth Science, Japan. J Clin Endocrinol Metab 84(6):1961–1965

    Article  CAS  Google Scholar 

  • Noble JJ, Fry NR, Lewis AP, Keevil SF, Gough M, Shortland AP (2014) Lower limb muscle volumes in bilateral spastic cerebral palsy. Brain Dev 36:294–300

    Article  Google Scholar 

  • Samson-Fang L, Fung E, Stalling VA, Conaway M, Worley G, Rosenbaum P (2002) Relationship of nutritional status to health and societal participation in children with cerebral palsy. J Pediatr 41(5):637–643

    Article  Google Scholar 

  • Shim ML, Mushang T Jr, Oppenheim WL, Cohen P (2004) Is treatment with growth hormone effective in children with cerebral palsy. Dev Med Child Neurol 46(8):561–571

    Article  Google Scholar 

  • Slaughter MH, Lohman TG, Boiteau RA (1988) Skinfold thickness equations for estimation of body fatness in children and youth. Hum Biol 60:709–723

    CAS  PubMed  Google Scholar 

  • Sperling M (ed) (2002) Pediatric endocrinology, 1 vols, 2nd edn. Saunders, Philadelphia

    Google Scholar 

  • Stanek JL, Emerson JA, Murdock FA, Petroski GF (2016) Growth characteristics in cerebral palsy subtypes: a comparative assessment. Dev Med Child Neurol 58:931–935

    Article  Google Scholar 

  • Stevenson RD (1995) Use of segmental measures to estimate stature in children with cerebral palsy. Arch Pediatr Adolesc Med 149(6):658–662

    Article  CAS  Google Scholar 

  • Stevenson RD, Roberts CD, Voglie L (1995) The effects fo non-nutritional factors on growth in cerebral palsy. Dev Med Child Neurol 37(2):124–130

    Article  CAS  Google Scholar 

  • Stevenson RD, Conaway M, Chumlea C, Rosenbaum P, Fung EB, Henderson RC, Worley G, Liptak G, O'Donnell M, Samson-Fang L, Stallings VA of the North American Growth in Cerebral Palsy Study (2006) Growth and health in children with moderate-to-severe cerebral palsy. Pediatrics 118(3):1010–1018

    Article  Google Scholar 

  • Tanner JM, Davies SWD (1985) Clinical longitudinal standards for height and height velocity for North American children. J Pediatr 107:317

    Article  CAS  Google Scholar 

  • van Eck M, Dallmeijer AJ, Voorman JM, Becher JG (2006) Skeletal maturation in children with cerebral palsy and its relationship with motor functioning. Dev Med Child Neurol 50:515–519

    Google Scholar 

  • Wright CM, REynolds L, Ingram E, Cole TJ, Brooks J (2017) Validation of US cerebral palsy growth charts using a UK cohort. Dev Med Child Neurol 59:933–938

    Article  Google Scholar 

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Correspondence to Kevin J. Sheridan .

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Sheridan, K.J. (2019). Short Stature in Children with Cerebral Palsy. In: Miller, F., Bachrach, S., Lennon, N., O'Neil, M. (eds) Cerebral Palsy. Springer, Cham. https://doi.org/10.1007/978-3-319-50592-3_73-1

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  • DOI: https://doi.org/10.1007/978-3-319-50592-3_73-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-50592-3

  • Online ISBN: 978-3-319-50592-3

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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