Abstract
Celiac disease represents an immune-mediated intestinal injury as a result of intolerance to gluten, a protein found in wheat, rye, and barley. It affects genetically susceptible individuals with a prevalence ranging from 0.7 to 2 % in various communities. Symptoms vary from persistent and daily to subclinical, vague, and variable. They can include abdominal pain, diarrhea, bloating, as well as signs and symptoms of malabsorption, such as fatigue, nutritional deficiencies, anemia, osteoporosis, and ataxia. Other associated autoimmune phenomena include dermatitis herpetiformis, alopecia, and infertility. The majority of patients have clinical response to dietary restrictions, and persistent symptoms are most commonly secondary to gluten contamination. Capsule endoscopy has a distinct role in the diagnostic work-up for gluten enteropathy as well as in known celiac patients who demonstrate alarm or refractory symptomatology. This chapter will highlight the many benefits in the diagnosis and management of celiac disease.
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Bibliography
Green PH, Cellier C. Celiac disease. N Engl J Med. 2007;357:1731–43.
Rewers M. Epidemiology of celiac disease: what are the prevalence, incidence and progression of celiac disease? Gastroenterol. 2005;128:S47–51.
Green PHR. The many faces of celiac disease: clinical presentation of celiac disease in the adult population. Gastroenterol. 2008;128:S74–8.
Rondonotti E, de Franchis R. Diagnosing coeliac disease: is the videocapsule a suitable tool? Dig and Liver Dis. 2007;39:145–7.
Lee SK, Green PH. Endoscopy in celiac disease. Curr Opin Gastroenterol. 2005;21:589–94.
Marsh MN. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity (celiac sprue). Gastroenterology. 1992;102:330–54.
Oberhuber G, Granditsch G, Vogelsang H. The histopathology of coeliac disease: a time for standardized report scheme for pathologists. Eur J Gastroenterol Hepatol. 1999;11:1185–94.
Cameron AH, Astley R, Hallowell M, et al. Duodeno-jejunal biopsy in the investigation of children with celiac disease. Q J Med. 1962;31:125–40.
Cellier C, Green PH, Collin P, Murray J. ICCE consensus for celiac disease. Endoscopy. 2005;37(10):1055–9.
Rondonotti E, Spada C, Cave D, et al. Video capsule enteroscopy in the diagnosis of celiac disease: a multicenter study. Am J Gastroenterol. 2007;102:1624–31.
Rokkas T, Niv Y. The role of video capsule endoscopy in the diagnosis of celiac disease: a meta-analysis. Eur J Gastroenterol Hepatol. 2012;24:303–8.
Maiden L, Elliott T, McLaughlin SD, et al. A blinded pilot comparison of capsule endoscopy and small bowel histology in unresponsive celiac disease. Dig Dis Sci. 2009;54:1280–3.
Barret M, Malamut G, Rahmi G, et al. Diagnostic yield of capsule endoscopy in refractory disease. Am J Gastroenterol. 2012;107(10):1546–53.
Murray JA, Rubio-Tapia A, Van Dyke CT. Mucosal atrophy in celiac disease: extent of involvement, correlation with clinical presentation, and response to treatment. Clin Gastroenterol Hepatol. 2008;6:186–93.
Vahedi K, Mascart F, Mary JY, et al. Reliability of antitransglutaminase antibodies as predictors of gluten-free compliance in adult celiac disease. Am J Gastroenterol. 2003;98:1079–87.
Dickey W, Hughes DF, Path FRC, et al. Disappearance of endomysial antibodies in treated celiac disease does not indicate histological recovery. Am J Clin Pathol. 2002;118:458–63.
Lidums I, Teo E, Field J, Cummins AG. Capsule endoscopy: a valuable tool in the follow-up of people with celiac disease on a gluten-free diet. Clin Transl Gastroenterol. 2011;2:e4.
Cellier C, Patey N, Mauvieux L, et al. Abnormal intestinal intraepithelial lymphocytes in refractory sprue. Gastroenterology. 1998;114:471–81.
Atlas DS, Rubio-Tapia A, Van Dyke CT, et al. Capsule endoscopy in nonresponsive celiac disease. Gastrointest Endosc. 2011;74(6):1315–22.
Daum S, Wahnschaffe U, Glasenapp R, et al. Capsule endoscopy in refractory celiac disease. Endoscopy. 2007;39(5):455–8.
Tennyson CA, Green PH. The role of capsule endoscopy in patients with nonresponsive celiac disease. Gastrointest Endosc. 2011;74:1323–4.
Tennyson CA, Ciaccio EJ, Lewis SK. Video capsule endoscopy in celiac disease. Gastrointest Endosc Clin N Am. 2012;22:747–58.
Ciaccio EJ, Bhagat G, Lewis SK, Green PH. Quantitative image analysis of celiac disease. World J Gastroenterol. 2015;21(9):2577–81.
Ciaccio EJ, Bhagat G, Naiyer AJ, Hernandez L, Green PH. Quantitative assessment of the degree of villous atrophy in patients with coeliac disease. J Clin Pathol. 2008;61:1089–93.
Ciaccio EJ, Tennyson CA, Lewis CK, et al. Distinguishing patients with celiac disease by quantitative analysis of videocapsule endoscopy images. Comput Methods Prog Biomed. 2010;100(1):39–48.
Koulaozidis A, Rondonotti E, Karargyris A. Small-bowel capsule endoscopy: a ten-point contemporary review. World J Gastroenterol. 2013;19(24):3726–46.
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Soumekh, A.E., Otaki, F. (2017). The Role of Capsule Endoscopy in the Diagnosis and Management of Celiac Disease and Refractory Diarrhea. In: Hass, D. (eds) Capsule Endoscopy. Springer, Cham. https://doi.org/10.1007/978-3-319-49173-8_6
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DOI: https://doi.org/10.1007/978-3-319-49173-8_6
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