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Respiratory Outcomes in Preterm Infants pp 31–43Cite as

Why Do Former Preterm Infants Wheeze? Clues from the Laboratory

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Part of the book series: Respiratory Medicine ((RM))

Abstract

Increased airway reactivity is a major challenge in former preterm infants across the spectrum of gestational ages. It is, therefore, imperative that underlying mechanisms be addressed, and this is probably best done in neonatal animal models. Available evidence points to multiple anatomic and neural contributors to longer lasting airway hyperreactivity elicited by neonatal lung injury, especially hyperoxic exposure. Future studies need to address the interplay of exposure to supplemental oxygen with antenatal and postnatal inflammation as well as the pressure effects elicited by various ventilatory modes to which the immature lung and airway are exposed.

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Author information

Authors and Affiliations

  1. Case Western Reserve University School of Medicine, Cleveland, OH, USA

    Richard J. Martin MD & Thomas M. Raffay

  2. Rainbow Babies & Children’s Hospital, Cleveland, OH, USA

    Richard J. Martin MD & Thomas M. Raffay

Authors
  1. Richard J. Martin MD
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  2. Thomas M. Raffay
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Correspondence to Richard J. Martin MD .

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Editors and Affiliations

  1. Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA

    Anna Maria Hibbs

  2. Department of Pediatrics, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA

    Marianne S. Muhlebach

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Martin, R.J., Raffay, T.M. (2017). Why Do Former Preterm Infants Wheeze? Clues from the Laboratory. In: Hibbs, A., Muhlebach , M. (eds) Respiratory Outcomes in Preterm Infants. Respiratory Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-48835-6_3

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  • DOI: https://doi.org/10.1007/978-3-319-48835-6_3

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