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Mesenchymal Stem Cell Therapy for Liver Cirrhosis Treatment: Mechanisms and Bioeffects

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Book cover Liver, Lung and Heart Regeneration

Part of the book series: Stem Cells in Clinical Applications ((SCCA))

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Abstract

Liver cirrhosis is characterized by inflammation and necrosis induced by Kupffer cells and the activation of hepatic satellite cells. In recent years, stem cell therapy has become a promising therapy for treatment. Some in vitro studies and in vivo preclinical trials have demonstrated that mesenchymal stem cells (MSCs) may improve liver cirrhosis by different mechanisms. Differentiation potential and immune modulation of MSCs are important considerations of MSC transplantation and can affect liver function improvement after transplantation. This chapter will summarize and discuss the latest MSC transplantations for liver cirrhosis treatment and some mechanisms by which MSCs exert their bioeffects on the disease.

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  1. Laboratory of Stem Cell Research and Application, University of Science, Vietnam National University, Ho Chi Minh City, Vietnam

    Nhung Hai Truong & Phuc Van Pham

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  2. Phuc Van Pham
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Correspondence to Phuc Van Pham .

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  1. Laboratory of Stem Cell Research & Application, University of Science, Vietnam National University, Ho Chi Minh City, Vietnam

    Phuc Van Pham

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Truong, N.H., Van Pham, P. (2017). Mesenchymal Stem Cell Therapy for Liver Cirrhosis Treatment: Mechanisms and Bioeffects. In: Pham, P. (eds) Liver, Lung and Heart Regeneration. Stem Cells in Clinical Applications. Springer, Cham. https://doi.org/10.1007/978-3-319-46693-4_4

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