Abstract
Commonly utilized treatments for primary, secondary, and recurrent cancers of the liver include resection, radiofrequency ablation, percutaneous ethanol injection, transarterial chemoembolization, selective internal radiation therapy, and stereotactic body radiation therapy. Image-guided brachyablation represents another solution for treatment of these lesions with good outcomes. With computed tomography, ultrasound, or MRI guidance, interstitial catheters can be introduced percutaneously into the targeted lesions, allowing the subsequent delivery of ablative doses with sparing of other portions of the liver. In this chapter, we provide a brief overview of the evidence behind interstitial liver brachytherapy and outline a method for performing image-guided brachyablation for liver tumors.
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Chung YE, Kim M-J, Park YN, et al. Varying appearances of cholangiocarcinoma: radiologic-pathologic correlation. Radiographics. 2009;29(3):683–700.
Ricke J, Wust P, Stohlmann A, et al. CT-guided interstitial brachytherapy of liver malignancies alone or in combination with thermal ablation: phase I-II results of a novel technique. Int J Radiat Oncol Biol Phys. 2004;58(5):1496–505.
Ricke J, Wust P, Wieners G, et al. Liver malignancies: CT-guided interstitial brachytherapy in patients with unfavorable lesions for thermal ablation. J Vasc Interv Radiol. 2004;15(11):1279–86.
Pech M, Wieners G, Kryza R, et al. CT-guided brachytherapy (CTGB) versus interstitial laser ablation (ILT) of colorectal liver metastases: an intraindividual matched-pair analysis. Strahlenther Onkol. 2008;184(6):302–6.
Ricke J, Mohnike K, Pech M, et al. Local response and impact on survival after local ablation of liver metastases from colorectal carcinoma by computed tomography-guided high-dose-rate brachytherapy. Int J Radiat Oncol Biol Phys. 2010;78(2):479–85.
Collettini F, Poellinger A, Schnapauff D, et al. CT-guided high-dose-rate brachytherapy of metachronous ovarian cancer metastasis to the liver: initial experience. Anticancer Res. 2011;31(8):2597–602.
Wieners G, Mohnike K, Peters N, et al. Treatment of hepatic metastases of breast cancer with CT-guided interstitial brachytherapy—a phase II-study. Radiother Oncol. 2011;100(2):314–9. doi:10.1016/j.radonc.2011.03.005.
Collettini F, Golenia M, Schnapauff D, et al. Percutaneous computed tomography-guided high-dose-rate brachytherapy ablation of breast cancer liver metastases: initial experience with 80 lesions. J Vasc Interv Radiol. 2012;23(5):618–26.
Geisel D, Denecke T, Collettini F, et al. Treatment of hepatic metastases from gastric or gastroesophageal adenocarcinoma with computed tomography-guided high-dose-rate brachytherapy (CT-HDRBT). Anticancer Res. 2012;32(12):5453–8.
Collettini F, Singh A, Schnapauff D, et al. Computed-tomography-guided high-dose-rate brachytherapy (CT-HDRBT) ablation of metastases adjacent to the liver hilum. Eur J Radiol. 2013;82(10):e509–14.
Tselis N, Chatzikonstantinou G, Kolotas C, Milickovic N, Baltas D, Zamboglou N. Computed tomography-guided interstitial high dose rate brachytherapy for centrally located liver tumours: a single institution study. Eur Radiol. 2013;23(8):2264–70.
Sharma DN, Thulkar S, Sharma S, et al. High-dose-rate interstitial brachytherapy for liver metastases: first study from India. J Contemp Brachytherapy. 2013;5(2):70–5.
Geisel D, Collettini F, Denecke T, et al. Treatment for liver metastasis from renal cell carcinoma with computed-tomography-guided high-dose-rate brachytherapy (CT-HDRBT): a case series. World J Urol. 2013;31(6):1525–30.
Collettini F, Lutter A, Schnapauff D, et al. Unresectable colorectal liver metastases: percutaneous ablation using CT-guided high-dose-rate brachytherapy (CT-HDBRT). RöFo. 2014;186(6):606–12.
Wieners G, Schippers AC, Collettini F, et al. CT-guided high-dose-rate brachytherapy in the interdisciplinary treatment of patients with liver metastases of pancreatic cancer. Hepatobiliary Pancreat Dis Int. 2015;14(5):530–8.
Collettini F, Schnapauff D, Poellinger A, et al. Hepatocellular carcinoma: computed-tomography-guided high-dose-rate brachytherapy (CT-HDRBT) ablation of large (5-7 cm) and very large (>7 cm) tumours. Eur Radiol. 2012;22(5):1101–9.
Collettini F, Schreiber N, Schnapauff D, et al. CT-guided high-dose-rate brachytherapy of unresectable hepatocellular carcinoma. Strahlenther Onkol. 2015;191(5):405–12.
Schnapauff D, Collettini F, Hartwig K, et al. CT-guided brachytherapy as salvage therapy for intrahepatic recurrence of HCC after surgical resection. Anticancer Res. 2015;35(1):319–23.
Denecke T, Stelter L, Schnapauff D, et al. CT-guided interstitial brachytherapy of hepatocellular carcinoma before liver transplantation: an equivalent alternative to transarterial chemoembolization? Eur Radiol. 2015;25(9):2608–16.
Schnapauff D, Denecke T, Grieser C, et al. Computed tomography-guided interstitial HDR brachytherapy (CT-HDRBT) of the liver in patients with irresectable intrahepatic cholangiocarcinoma. Cardiovasc Intervent Radiol. 2012;35(3):581–7.
Kamphues C, Seehofer D, Collettini F, et al. Preliminary experience with CT-guided high-dose rate brachytherapy as an alternative treatment for hepatic recurrence of cholangiocarcinoma. HPB (Oxford). 2012;14(12):791–7.
Mukewar S, Gupta A, Baron TH, et al. Endoscopically inserted nasobiliary catheters for high dose-rate brachytherapy as part of neoadjuvant therapy for perihilar cholangiocarcinoma. Endoscopy. 2015;47(10):878–83.
Seidensticker M, Seidensticker R, Damm R, et al. Prospective randomized trial of enoxaparin, pentoxifylline and ursodeoxycholic acid for prevention of radiation-induced liver toxicity. PLoS One. 2014;9(11):e112731.
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Patel, S., Ricke, J., Kamrava, M. (2017). Image-Guided BrachyAblation (IGBA) for Liver Metastases and Primary Liver Cancers. In: Mayadev, J., Benedict, S., Kamrava, M. (eds) Handbook of Image-Guided Brachytherapy. Springer, Cham. https://doi.org/10.1007/978-3-319-44827-5_17
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DOI: https://doi.org/10.1007/978-3-319-44827-5_17
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