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Efflux-Mediated Antimicrobial Resistance in Bacteria pp 45–71Cite as

Small Multidrug Resistance Efflux Pumps

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Abstract

Small multidrug resistance (SMR) transporters confer resistance to a variety of quaternary cation compound antimicrobials. These secondary active transporters are the smallest known transporters and have been demonstrated to function within the membrane. The focus of this chapter explores and updates SMR family diversity and reviews current structural and functional knowledge of these members. This chapter also provides an update of known SMR pump-mediated resistance to antimicrobial substrates (including naturally synthesized quaternary cation compounds) and their clinical significance.

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Authors and Affiliations

  1. Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada

    Denice C. Bay

  2. Department of Biological Sciences, University of Calgary, Calgary, AB, Canada

    Raymond J. Turner

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  1. Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada

    Xian-Zhi Li

  2. U.S. Food and Drug Administration, Laurel, Maryland, USA

    Christopher A. Elkins

  3. University of Oklahoma, Norman, Oklahoma, USA

    Helen I. Zgurskaya

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Bay, D.C., Turner, R.J. (2016). Small Multidrug Resistance Efflux Pumps. In: Li, XZ., Elkins, C., Zgurskaya, H. (eds) Efflux-Mediated Antimicrobial Resistance in Bacteria. Adis, Cham. https://doi.org/10.1007/978-3-319-39658-3_3

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