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Efflux-Mediated Antimicrobial Resistance in Bacteria pp 261–279Cite as

Antimicrobial Drug Efflux Pumps in Salmonella

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Abstract

Salmonella species are causative organisms of salmonellosis, and the prevalence of multidrug-resistant Salmonella has increased dramatically. These multidrug-resistant isolates have been found in both humans and animals and thus pose a major public health concern. Drug resistance in Salmonella has been shown to be largely attributable to multiple target gene mutations and to active efflux by pumps. At least ten drug efflux system genes in the genome of this organism have been experimentally identified to date, and some efflux pump genes encoded in plasmids have been also identified. This chapter describes the drug resistance and virulence roles of efflux pumps and their regulation in Salmonella.

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Acknowledgments

The author acknowledges funding from the Japan Agency for Medical Research and Development; the Japan Science and Technology Agency; the Japan Society for the Promotion of Science; the Ministry of Education, Culture, Sports, Science and Technology, Japan; and the Cabinet Office, Government of Japan.

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  1. Institute of Scientific and Industrial Research, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan

    Kunihiko Nishino

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Correspondence to Kunihiko Nishino .

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  1. Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada

    Xian-Zhi Li

  2. U.S. Food and Drug Administration, Laurel, Maryland, USA

    Christopher A. Elkins

  3. University of Oklahoma, Norman, Oklahoma, USA

    Helen I. Zgurskaya

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Nishino, K. (2016). Antimicrobial Drug Efflux Pumps in Salmonella . In: Li, XZ., Elkins, C., Zgurskaya, H. (eds) Efflux-Mediated Antimicrobial Resistance in Bacteria. Adis, Cham. https://doi.org/10.1007/978-3-319-39658-3_10

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