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Vitamin D in Chronic Kidney Disease pp 465–491Cite as

Natural Vitamin D in Chronic Kidney Disease

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Abstract

Vitamin D plays an essential role on bone and mineral metabolism. Its deficiency leads to bone demineralization, osteomalacia, skeletal fractures and skeletal deformation. The lack of vitamin D is also associated with an increased risk of developing arterial hypertension, cardiovascular diseases, diabetes, immune diseases, neurological disorders, malignancies, and other diseases. The supplementation of natural vitamin D usually corrects vitamin-deficiency-related mineral and bone disorders, however, the scientific evidences demonstrating any beneficial effect of natural vitamin D on non-classical target organs in the general population as well as in renal insufficient subjects are still inconsistent and await confirmation by large randomized clinical trials. Moreover, chronic kidney disease (CKD) beside its altered mineral and bone metabolism (MBD) is associated with low 25(OH)D (calcidiol), and low 1,25OH2D3 (calcitriol) levels as well as vitamin D resistance. However, the major health care organizations worldwide have been unable to define a unique and consensual desirable circulating 25(OH)D values for the health population and for the CKD population. The aim of this chapter is to provide an update review of the sources and pharmacological characteristics of natural vitamin D compounds, their most important clinical uses and results obtained in CKD patients.

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References

  1. Meguid El Nahas A, Bello AK. Chronic kidney disease: the global challenge. Lancet. 2005;365:331–40.

    Article  CAS  PubMed  Google Scholar 

  2. Moe S, Drueke T, Cunningham J, et al. Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int. 2006;69:1945–53.

    Article  CAS  PubMed  Google Scholar 

  3. Kandula P, Dobre M, Schold JD, Schreiber Jr MJ, Mehrotra R, Navaneethan SD. Vitamin D supplementation in chronic kidney disease: a systematic review and meta-analysis of observational studies and randomized controlled trials. Clin J Am Soc Nephrol. 2011;6:50–62.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Bhan I, Burnett-Bowie SA, Ye J, Tonelli M, Thadhani R. Clinical measures identify vitamin D deficiency in dialysis. Clin J Am Soc Nephrol. 2010;5:460–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. LaClair RE, Hellman RN, Karp SL, et al. Prevalence of calcidiol deficiency in CKD: a cross-sectional study across latitudes in the United States. Am J Kidney Dis. 2005;45:1026–33.

    Article  CAS  PubMed  Google Scholar 

  6. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911–30.

    Article  CAS  PubMed  Google Scholar 

  7. Ross AC, Manson JE, Abrams SA, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011;96:53–8.

    Article  CAS  PubMed  Google Scholar 

  8. Watts NB, Bilezikian JP, Camacho PM, et al. American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the diagnosis and treatment of postmenopausal osteoporosis. Endocr Pract: Off J Am Coll Endocrinol Am Assoc Clin Endocrinol. 2010;16 Suppl 3:1–37.

    Article  Google Scholar 

  9. National KF. K/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease. Am J Kidney Dis. 2003;42:S1–201.

    Google Scholar 

  10. KDIGO. KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD). Kidney Int. 2009;(Suppl 113):S1–130.

    Google Scholar 

  11. Ravani P, Malberti F, Tripepi G, et al. Vitamin D levels and patient outcome in chronic kidney disease. Kidney Int. 2009;75:88–95.

    Article  CAS  PubMed  Google Scholar 

  12. Blunt JW, DeLuca HF, Schnoes HK. 25-hydroxycholecalciferol. A biologically active metabolite of vitamin D3. Biochemistry. 1968;7:3317–22.

    Article  CAS  PubMed  Google Scholar 

  13. Blunt JW, Tanaka Y, DeLuca HF. Biological activity of 25-hydroxycholecalciferol, a metabolite of vitamin D3. Proc Natl Acad Sci U S A. 1968;61:1503–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Haussler M, Whitfield G, Haussler C, et al. The nuclear vitamin D receptor: biological and molecular regulatory properties reealed. J Bone Min Res. 1998;13:325–49.

    Article  CAS  Google Scholar 

  15. Holick MF. Vitamin D, deficiency. N Engl J Med. 2007;357:266–81.

    Article  CAS  PubMed  Google Scholar 

  16. Schlingmann KP, Kaufmann M, Weber S, et al. Mutations in CYP24A1 and idiopathic infantile hypercalcemia. N Engl J Med. 2011;365:410–21.

    Article  CAS  PubMed  Google Scholar 

  17. Dusso A, Lopez-Hilker S, Rapp N, Slatopolsky E. Extra-renal production of calcitriol in chronic renal failure. Kidney Int. 1988;34:368–75.

    Article  CAS  PubMed  Google Scholar 

  18. Holick MF. Optimal vitamin D status for the prevention and treatment of osteoporosis. Drugs Aging. 2007;24:1017–29.

    Article  CAS  PubMed  Google Scholar 

  19. Souberbielle JC, Body JJ, Lappe JM, et al. Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: recommendations for clinical practice. Autoimmun Rev. 2010;9:709–15.

    Article  CAS  PubMed  Google Scholar 

  20. Avenell A, Mak JC, O’Connell D. Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men. Cochrane Database Syst Rev. 2014;4, CD000227.

    PubMed  Google Scholar 

  21. Holick MF. Vitamin D: a D-Lightful health perspective. Nutr Rev. 2008;66:S182–94.

    Article  PubMed  Google Scholar 

  22. Holick MF, Uskokovic M, Henley JW, MacLaughlin J, Holick SA, Potts Jr JT. The photoproduction of 1 alpha,25-dihydroxyvitamin D3 in skin: an approach to the therapy of vitamin-D-resistant syndromes. N Engl J Med. 1980;303:349–54.

    Article  CAS  PubMed  Google Scholar 

  23. Yuste C, Quiroga B, Garcia de Vinuesa S, et al. The effect of some medications given to CKD patients on vitamin D levels. Nefrologia. 2015;35:150–6.

    Article  PubMed  Google Scholar 

  24. Uhlin F, Magnusson P, Larsson TE, Fernstrom A. In the backwater of convective dialysis: decreased 25-hydroxyvitamin D levels following the switch to online hemodiafiltration. Clin Nephrol. 2015;83:315–21.

    Article  CAS  PubMed  Google Scholar 

  25. Holick MF, Biancuzzo RM, Chen TC, et al. Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. J Clin Endocrinol Metab. 2008;93:677–81.

    Article  CAS  PubMed  Google Scholar 

  26. Powe CE, Evans MK, Wenger J, et al. Vitamin D-binding protein and vitamin D status of black Americans and white Americans. N Engl J Med. 2013;369:1991–2000.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Armas LA, Hollis BW, Heaney RP. Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab. 2004;89:5387–91.

    Article  CAS  PubMed  Google Scholar 

  28. Lehmann U, Hirche F, Stangl GI, Hinz K, Westphal S, Dierkes J. Bioavailability of vitamin D(2) and D(3) in healthy volunteers, a randomized placebo-controlled trial. J Clin Endocrinol Metab. 2013;98:4339–45.

    Article  CAS  PubMed  Google Scholar 

  29. Logan VF, Gray AR, Peddie MC, Harper MJ, Houghton LA. Long-term vitamin D3 supplementation is more effective than vitamin D2 in maintaining serum 25-hydroxyvitamin D status over the winter months. Br J Nutr. 2013;109:1082–8.

    Article  CAS  PubMed  Google Scholar 

  30. Tripkovic L, Lambert H, Hart K, et al. Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. Am J Clin Nutr. 2012;95:1357–64.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Ross C, Manson JE, Abrams S, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 1999;96:53–8.

    Article  CAS  Google Scholar 

  32. Binkley N, Gemar D, Engelke J, et al. Evaluation of ergocalciferol or cholecalciferol dosing, 1,600 IU daily or 50,000 IU monthly in older adults. J Clin Endocrinol Metab. 2011;96:981–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Ish-Shalom S, Segal E, Salganik T, Raz B, Bromberg IL, Vieth R. Comparison of daily, weekly, and monthly vitamin D3 in ethanol dosing protocols for two months in elderly hip fracture patients. J Clin Endocrinol Metab. 2008;93:3430–5.

    Article  CAS  PubMed  Google Scholar 

  34. Heaney RP. Vitamin D, in health and disease. Clin J Am Soc Nephrol. 2008;3:1535–41.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Cashman KD, Seamans KM, Lucey AJ, et al. Relative effectiveness of oral 25-hydroxyvitamin D3 and vitamin D3 in raising wintertime serum 25-hydroxyvitamin D in older adults. Am J Clin Nutr. 2012;95:1350–6.

    Article  CAS  PubMed  Google Scholar 

  36. Brandenburg VM, Kruger T. Calcifediol – more than the stepchild of CKD-MBD therapy? Curr Vasc Pharmacol. 2014;12:286–93.

    Article  CAS  PubMed  Google Scholar 

  37. Phillips KM, Horst RL, Koszewski NJ, Simon RR. Vitamin D4 in mushrooms. PLoS One. 2012;7, e40702.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Rickers H, Christiansen C, Christensen P, Christensen M, Rodbro P. Serum concentrations of vitamin D metabolites in different degrees of impaired renal function. Estimation of renal and extrarenal secretion rate of 24,25-dihydroxyvitamin D. Nephron. 1985;39:267–71.

    Article  CAS  PubMed  Google Scholar 

  39. Urena-Torres P, Metzger M, Haymann JP, et al. Association of kidney function, vitamin D deficiency, and circulating markers of mineral and bone disorders in CKD. Am J Kidney Dis. 2011;58:544–53.

    Article  CAS  PubMed  Google Scholar 

  40. Del Valle E, Negri AL, Aguirre C, Fradinger E, Zanchetta JR. Prevalence of 25(OH) vitamin D insufficiency and deficiency in chronic kidney disease stage 5 patients on hemodialysis. Hemodial Int. 2007;11:315–21.

    Article  PubMed  Google Scholar 

  41. Jacob AI, Sallman A, Santiz Z, Hollis BW. Defective photoproduction of cholecalciferol in normal and uremic humans. J Nutr. 1984;114:1313–9.

    CAS  PubMed  Google Scholar 

  42. Abdelbaqi-Salhab M, Shalhub S, Morgan MB. A current review of the cutaneous manifestations of renal disease. J Cutan Pathol. 2003;30:527–38.

    Article  PubMed  Google Scholar 

  43. Vaziri ND, Hollander D, Hung EK, Vo M, Dadufalza L. Impaired intestinal absorption of vitamin D3 in azotemic rats. Am J Clin Nutr. 1983;37:403–6.

    CAS  PubMed  Google Scholar 

  44. Gonzalez EA, Sachdeva A, Oliver DA, Martin KJ. Vitamin D insufficiency and deficiency in chronic kidney disease. A single center observational study. Am J Nephrol. 2004;24:503–10.

    Article  CAS  PubMed  Google Scholar 

  45. Sato KA, Gray RW, Lemann Jr J. Urinary excretion of 25-hydroxyvitamin D in health and the nephrotic syndrome. J Lab Clin Med. 1982;99:325–30.

    CAS  PubMed  Google Scholar 

  46. Mawer EB, Taylor CM, Backhouse J, Lumb GA, Stanbury SW. Failure of formation of 1,25-dihydroxycholecalciferol in chronic renal insufficiency. Lancet. 1973;1:626–8.

    Article  CAS  PubMed  Google Scholar 

  47. Ishimura E, Nishizawa Y, Inaba M, et al. Serum levels of 1,25-dihydroxyvitamin D, 24,25-dihydroxyvitamin D, and 25-hydroxyvitamin D in nondialyzed patients with chronic renal failure. Kidney Int. 1999;55:1019–27.

    Article  CAS  PubMed  Google Scholar 

  48. Nigwekar SU, Bhan I, Thadhani R. Ergocalciferol and cholecalciferol in CKD. Am J Kidney Dis. 2012;60:139–56.

    Article  CAS  PubMed  Google Scholar 

  49. Gutierrez O, Isakova T, Rhee E, et al. Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease. J Am Soc Nephrol. 2005;16:2205–15.

    Article  CAS  PubMed  Google Scholar 

  50. Hsu CH, Vanholder R, Patel S, De Smet RR, Sandra P, Ringoir SM. Subfractions in uremic plasma ultrafiltrate inhibit calcitriol metabolism. Kidney Int. 1991;40:868–73.

    Article  CAS  PubMed  Google Scholar 

  51. Kawashima H, Kraut JA, Kurokawa K. Metabolic acidosis suppresses 25-hydroxyvitamin in D3-1alpha-hydroxylase in the rat kidney. Distinct site and mechanism of action. J Clin Invest. 1982;70:135–40.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Takahashi S, Yamamoto T, Moriwaki Y, Tsutsumi Z, Yamakita J, Higashino K. Decreased serum concentrations of 1,25(OH)2-vitamin D3 in patients with gout. Adv Exp Med Biol. 1998;431:57–60.

    Article  CAS  PubMed  Google Scholar 

  53. Zehnder D, Bland R, Williams MC, et al. Extrarenal expression of 25-hydroxyvitamin d(3)-1 alpha-hydroxylase. J Clin Endocrinol Metab. 2001;86:888–94.

    CAS  PubMed  Google Scholar 

  54. Nykjaer A, Dragun D, Walther D, et al. An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. Cell. 1999;96:507–15.

    Article  CAS  PubMed  Google Scholar 

  55. Takemoto F, Shinki T, Yokoyama K, et al. Gene expression of vitamin D hydroxylase and megalin in the remnant kidney of nephrectomized rats. Kidney Int. 2003;64:414–20.

    Article  CAS  PubMed  Google Scholar 

  56. Shimada T, Kakitani M, Yamazaki Y, et al. Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J Clin Invest. 2004;113:561–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Fukuda N, Tanaka H, Tominaga Y, Fukagawa M, Kurokawa K, Seino Y. Decreased 1,25-dihydroxyvitamin D3 receptor density is associated with a more severe form of parathyroid hyperplasia in chronic uremic patients. J Clin Invest. 1993;92:1436–43.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. Hsu CH, Patel SR. Altered vitamin D metabolism and receptor interaction with the target genes in renal failure: calcitriol receptor interaction with its target gene in renal failure. Curr Opin Nephrol Hypertens. 1995;4:302–6.

    Article  CAS  PubMed  Google Scholar 

  59. Patel SR, Ke HQ, Vanholder R, Koenig RJ, Hsu CH. Inhibition of calcitriol receptor binding to vitamin D response elements by uremic toxins. J Clin Invest. 1995;96:50–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  60. London GM, Guerin AP, Verbeke FH, et al. Mineral metabolism and arterial functions in end-stage renal disease: potential role of 25-hydroxyvitamin D deficiency. J Am Soc Nephrol. 2007;18:613–20.

    Article  CAS  PubMed  Google Scholar 

  61. Mendel CM. The free hormone hypothesis: a physiologically based mathematical model. Endocr Rev. 1989;10:232–74.

    Article  CAS  PubMed  Google Scholar 

  62. Bhan I, Powe CE, Berg AH, et al. Bioavailable vitamin D is more tightly linked to mineral metabolism than total vitamin D in incident hemodialysis patients. Kidney Int. 2012;82:84–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  63. Coen G, Mantella D, Manni M, et al. 25-hydroxyvitamin D levels and bone histomorphometry in hemodialysis renal osteodystrophy. Kidney Int. 2005;68:1840–8.

    Article  CAS  PubMed  Google Scholar 

  64. Ambrus C, Almasi C, Berta K, et al. Vitamin D insufficiency and bone fractures in patients on maintenance hemodialysis. Int Urol Nephrol. 2011;43:475–82.

    Article  CAS  PubMed  Google Scholar 

  65. Mucsi I, Almasi C, Deak G, et al. Serum 25(OH)-vitamin D levels and bone metabolism in patients on maintenance hemodialysis. Clin Nephrol. 2005;64:288–94.

    Article  CAS  PubMed  Google Scholar 

  66. Elder GJ, Mackun K. 25-hydroxyvitamin D deficiency and diabetes predict reduced BMD in patients with chronic kidney disease. J Bone Miner Res. 2006;21:1778–84.

    Article  CAS  PubMed  Google Scholar 

  67. Ghazali A, Fardellone P, Pruna A, et al. Is low plasma 25-(OH)vitamin D a major risk factor for hyperparathyroidism and Looser’s zones independent of calcitriol? Kidney Int. 1999;55:2169–77.

    Article  CAS  PubMed  Google Scholar 

  68. Stanbury SW. Azotaemic renal osteodystrophy. Br Med Bull. 1957;13:57–60.

    CAS  PubMed  Google Scholar 

  69. Fournier A, Bordier P, Gueris J, et al. Comparison of 1 alpha-hydroxycholecalciferol and 25-hydroxycholecalciferol in the treatment of renal osteodystrophy: greater effect of 25-hydroxycholecalciferol on bone mineralization. Kidney Int. 1979;15:196–204.

    Article  CAS  PubMed  Google Scholar 

  70. Blair D, Byham-Gray L, Lewis E, McCaffrey S. Prevalence of vitamin D [25(OH)D] deficiency and effects of supplementation with ergocalciferol (vitamin D2) in stage 5 chronic kidney disease patients. J Ren Nutr. 2008;18:375–82.

    Article  PubMed  Google Scholar 

  71. Jean G, Souberbielle JC, Chazot C. Monthly cholecalciferol administration in haemodialysis patients: a simple and efficient strategy for vitamin D supplementation. Nephrol Dial Transplant. 2009;24:3799–805.

    Article  CAS  PubMed  Google Scholar 

  72. Kooienga L, Fried L, Scragg R, Kendrick J, Smits G, Chonchol M. The effect of combined calcium and vitamin D3 supplementation on serum intact parathyroid hormone in moderate CKD. Am J Kidney Dis. 2009;53:408–16.

    Article  CAS  PubMed  Google Scholar 

  73. Stubbs JR, Idiculla A, Slusser J, Menard R, Quarles LD. Cholecalciferol supplementation alters calcitriol-responsive monocyte proteins and decreases inflammatory cytokines in ESRD. J Am Soc Nephrol. 2010;21:353–61.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. Albalate M, de la Piedra C, Ortiz A, et al. Risk in dosing regimens for 25-OH vitamin D supplementation in chronic haemodialysis patients. Nephron Clin Pract. 2012;121:c112–9.

    Article  CAS  PubMed  Google Scholar 

  75. Buccianti G, Bianchi ML, Valenti G, Lorenz M, Cresseri D. Effects of calcifediol treatment on the progression of renal osteodystrophy during continuous ambulatory peritoneal dialysis. Nephron. 1990;56:353–6.

    Article  CAS  PubMed  Google Scholar 

  76. Daroux M, Shenouda M, Bacri JL, Lemaitre V, Vanhille P, Bataille P. Vitamin D2 versus vitamin D3 supplementation in hemodialysis patients: a comparative pilot study. J Nephrol. 2013;26:152–7.

    Article  CAS  PubMed  Google Scholar 

  77. Matias PJ, Jorge C, Ferreira C, et al. Cholecalciferol supplementation in hemodialysis patients: effects on mineral metabolism, inflammation, and cardiac dimension parameters. Clin J Am Soc Nephrol. 2010;5:905–11.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  78. Delanaye P, Weekers L, Warling X, et al. Cholecalciferol in haemodialysis patients: a randomized, double-blind, proof-of-concept and safety study. Nephrol Dial Transplant. 2013;28:1779–86.

    Article  PubMed  Google Scholar 

  79. Massart A, Debelle FD, Racape J, et al. Biochemical parameters after cholecalciferol repletion in hemodialysis: results from the VitaDial randomized trial. Am J Kidney Dis. 2014;64:696–705.

    Article  CAS  PubMed  Google Scholar 

  80. Wasse H, Huang R, Long Q, Singapuri S, Raggi P, Tangpricha V. Efficacy and safety of a short course of very-high-dose cholecalciferol in hemodialysis. Am J Clin Nutr. 2012;95:522–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  81. Palmer SC, McGregor DO, Macaskill P, Craig JC, Elder GJ, Strippoli GF. Meta-analysis: vitamin D compounds in chronic kidney disease. Ann Intern Med. 2007;147:840–53.

    Article  PubMed  Google Scholar 

  82. Chandra P, Binongo JN, Ziegler TR, et al. Cholecalciferol (vitamin D3) therapy and vitamin D insufficiency in patients with chronic kidney disease: a randomized controlled pilot study. Endocr Pract: Off J Am Coll Endocrinol Am Assoc Clin Endocrinol. 2008;14:10–7.

    Article  Google Scholar 

  83. Dogan E, Erkoc R, Sayarlioglu H, Soyoral Y, Dulger H. Effect of depot oral cholecalciferol treatment on secondary hyperparathyroidism in stage 3 and stage 4 chronic kidney diseases patients. Ren Fail. 2008;30:407–10.

    Article  CAS  PubMed  Google Scholar 

  84. Oksa A, Spustova V, Krivosikova Z, et al. Effects of long-term cholecalciferol supplementation on mineral metabolism and calciotropic hormones in chronic kidney disease. Kidney Blood Press Res. 2008;31:322–9.

    Article  CAS  PubMed  Google Scholar 

  85. Wissing KM, Broeders N, Moreno-Reyes R, Gervy C, Stallenberg B, Abramowicz D. A controlled study of vitamin D3 to prevent bone loss in renal-transplant patients receiving low doses of steroids. Transplantation. 2005;79:108–15.

    Article  CAS  PubMed  Google Scholar 

  86. Mann MC, Hobbs AJ, Hemmelgarn BR, Roberts DJ, Ahmed SB, Rabi DM. Effect of oral vitamin D analogs on mortality and cardiovascular outcomes among adults with chronic kidney disease: a meta-analysis. Clin Kidney J. 2015;8:41–8.

    Article  PubMed  Google Scholar 

  87. Alvarez JA, Law J, Coakley KE, et al. High-dose cholecalciferol reduces parathyroid hormone in patients with early chronic kidney disease: a pilot, randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2012;96:672–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  88. Hewitt NA, O’Connor AA, O’Shaughnessy DV, Elder GJ. Effects of cholecalciferol on functional, biochemical, vascular, and quality of life outcomes in hemodialysis patients. Clin J Am Soc Nephrol. 2013;8:1143–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  89. Marckmann P, Agerskov H, Thineshkumar S, et al. Randomized controlled trial of cholecalciferol supplementation in chronic kidney disease patients with hypovitaminosis D. Nephrol Dial Transplant. 2012;27:3523–31.

    Article  CAS  PubMed  Google Scholar 

  90. Mose FH, Vase H, Larsen T, et al. Cardiovascular effects of cholecalciferol treatment in dialysis patients – a randomized controlled trial. BMC Nephrol. 2014;15:50.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  91. Harter HR, Birge SJ, Martin KJ, Klahr S, Karl IE. Effects of vitamin D metabolites on protein catabolism of muscle from uremic rats. Kidney Int. 1983;23:465–72.

    Article  CAS  PubMed  Google Scholar 

  92. Pointon JJ, Francis MJ, Smith R. Effect of vitamin D deficiency on sarcoplasmic reticulum function and troponin C concentration of rabbit skeletal muscle. Clin Sci (Lond). 1979;57:257–63.

    Article  CAS  Google Scholar 

  93. Francis MJ, Pointon JJ, Smith R, Mercola DA. Decreased troponin C concentrations in vitamin D-deficient rabbit skeletal muscle [proceedings]. Biochem Soc Trans. 1978;6:1273–4.

    Article  CAS  PubMed  Google Scholar 

  94. Gilsanz V, Kremer A, Mo AO, Wren TA, Kremer R. Vitamin D status and its relation to muscle mass and muscle fat in young women. J Clin Endocrinol Metab. 2010;95:1595–601.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  95. Kremer R, Campbell PP, Reinhardt T, Gilsanz V. Vitamin D status and its relationship to body fat, final height, and peak bone mass in young women. J Clin Endocrinol Metab. 2009;94:67–73.

    Article  CAS  PubMed  Google Scholar 

  96. Morino K, Petersen KF, Sono S, et al. Regulation of mitochondrial biogenesis by lipoprotein lipase in muscle of insulin-resistant offspring of parents with type 2 diabetes. Diabetes. 2012;61:877–87.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  97. Stockton KA, Mengersen K, Paratz JD, Kandiah D, Bennell KL. Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis. Osteoporos Int. 2011;22:859–71.

    CAS  PubMed  Google Scholar 

  98. Bischoff-Ferrari HA, Borchers M, Gudat F, Durmuller U, Stahelin HB, Dick W. Vitamin D receptor expression in human muscle tissue decreases with age. J Bone Miner Res. 2004;19:265–9.

    Article  CAS  PubMed  Google Scholar 

  99. Bischoff-Ferrari HA, Dawson-Hughes B, Willett WC, et al. Effect of vitamin D on falls: a meta-analysis. JAMA. 2004;291:1999–2006.

    Article  CAS  PubMed  Google Scholar 

  100. Clyne N, Jogestrand T, Lins LE, Pehrsson SK. Progressive decline in renal function induces a gradual decrease in total hemoglobin and exercise capacity. Nephron. 1994;67:322–6.

    Article  CAS  PubMed  Google Scholar 

  101. Gordon PL, Doyle JW, Johansen KL. Association of 1,25-dihydroxyvitamin D levels with physical performance and thigh muscle cross-sectional area in chronic kidney disease stage 3 and 4. J Ren Nutr. 2012;22:423–33.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  102. Li J, Zhang Z, Wang D, Wang Y, Li Y, Wu G. TGF-beta 1/Smads signaling stimulates renal interstitial fibrosis in experimental AAN. J Recept Signal Transduct Res. 2009;29:280–5.

    Article  PubMed  CAS  Google Scholar 

  103. Zhang Y, Kong J, Deb DK, Chang A, Li YC. Vitamin D receptor attenuates renal fibrosis by suppressing the renin-angiotensin system. J Am Soc Nephrol. 2010;21:966–73.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  104. Hirata M, Katsumata K, Endo K, Fukushima N, Ohkawa H, Fukagawa M. In subtotally nephrectomized rats 22-oxacalcitriol suppresses parathyroid hormone with less risk of cardiovascular calcification or deterioration of residual renal function than 1,25(OH)2 vitamin D3. Nephrol Dial Transplant. 2003;18:1770–6.

    Article  CAS  PubMed  Google Scholar 

  105. Makibayashi K, Tatematsu M, Hirata M, et al. A vitamin D analog ameliorates glomerular injury on rat glomerulonephritis. Am J Pathol. 2001;158:1733–41.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  106. Zhang X, Zanello LP. Vitamin D receptor-dependent 1 alpha,25(OH)2 vitamin D3-induced anti-apoptotic PI3K/AKT signaling in osteoblasts. J Bone Miner Res. 2008;23:1238–48.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  107. Zhang Z, Sun L, Wang Y, et al. Renoprotective role of the vitamin D receptor in diabetic nephropathy. Kidney Int. 2008;73:163–71.

    Article  CAS  PubMed  Google Scholar 

  108. Li YC. Vitamin D, regulation of the renin-angiotensin system. J Cell Biochem. 2003;88:327–31.

    Article  CAS  PubMed  Google Scholar 

  109. Rostand SG. Vitamin D, blood pressure, and African Americans: toward a unifying hypothesis. Clin J Am Soc Nephrol. 2010;5:1697–703.

    Article  CAS  PubMed  Google Scholar 

  110. Hsia J, Heiss G, Ren H, et al. Calcium/vitamin D supplementation and cardiovascular events. Circulation. 2007;115:846–54.

    Article  CAS  PubMed  Google Scholar 

  111. Thadhani R, Appelbaum E, Pritchett Y, et al. Vitamin D therapy and cardiac structure and function in patients with chronic kidney disease: the PRIMO randomized controlled trial. JAMA. 2012;307:674–84.

    Article  CAS  PubMed  Google Scholar 

  112. Wang AY, Fang F, Chan J, et al. Effect of paricalcitol on left ventricular mass and function in CKD – the OPERA trial. J Am Soc Nephrol. 2014;25:175–86.

    Article  CAS  PubMed  Google Scholar 

  113. Liu PT, Stenger S, Li H, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science. 2006;311:1770–3.

    Article  CAS  PubMed  Google Scholar 

  114. Yamshchikov AV, Desai NS, Blumberg HM, Ziegler TR, Tangpricha V. Vitamin D for treatment and prevention of infectious diseases: a systematic review of randomized controlled trials. Endocr Pract: Off J Am Coll Endocrinol Am Assoc Clin Endocrinol. 2009;15:438–49.

    Article  Google Scholar 

  115. Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr. 2010;91:1255–60.

    Article  CAS  PubMed  Google Scholar 

  116. Abu-Mouch S, Fireman Z, Jarchovsky J, Zeina AR, Assy N. Vitamin D supplementation improves sustained virologic response in chronic hepatitis C (genotype 1)-naive patients. World J Gastroenterol: WJG. 2011;17:5184–90.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  117. Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA. 2006;296:2832–8.

    Article  CAS  PubMed  Google Scholar 

  118. Krishnan AV, Feldman D. Mechanisms of the anti-cancer and anti-inflammatory actions of vitamin D. Annu Rev Pharmacol Toxicol. 2011;51:311–36.

    Article  CAS  PubMed  Google Scholar 

  119. Wactawski-Wende J, Kotchen JM, Anderson GL, et al. Calcium plus vitamin D supplementation and the risk of colorectal cancer. N Engl J Med. 2006;354:684–96.

    Article  CAS  PubMed  Google Scholar 

  120. Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr. 2007;85:1586–91.

    CAS  PubMed  Google Scholar 

  121. Pittas AG, Dawson-Hughes B. Vitamin D and diabetes. J Steroid Biochem Mol Biol. 2010;121:425–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  122. Hypponen E, Laara E, Reunanen A, Jarvelin MR, Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet. 2001;358:1500–3.

    Article  CAS  PubMed  Google Scholar 

  123. Zipitis CS, Akobeng AK. Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis. Arch Dis Child. 2008;93:512–7.

    Article  CAS  PubMed  Google Scholar 

  124. Jacobus CH, Holick MF, Shao Q, et al. Hypervitaminosis D associated with drinking milk. N Engl J Med. 1992;326:1173–7.

    Article  CAS  PubMed  Google Scholar 

  125. Kara C, Gunindi F, Ustyol A, Aydin M. Vitamin D intoxication due to an erroneously manufactured dietary supplement in seven children. Pediatrics. 2014;133:e240–4.

    Article  PubMed  Google Scholar 

  126. Gallagher JC, Sai A, Templin 2nd T, Smith L. Dose response to vitamin D supplementation in postmenopausal women: a randomized trial. Ann Intern Med. 2012;156:425–37.

    Article  PubMed  Google Scholar 

  127. Gallagher JC, Smith LM, Yalamanchili V. Incidence of hypercalciuria and hypercalcemia during vitamin D and calcium supplementation in older women. Menopause. 2014;21:1173–80.

    Article  PubMed  PubMed Central  Google Scholar 

  128. Jean G, Souberbielle JC, Lechevallier S, Chazot C. Kinetics of serum 25-hydroxyvitamin D in haemodialysis patients treated with monthly oral cholecalciferol. Clin Kidney J. 2015;8:388–92.

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Division of Nephrology, Miulli General Hospital, Acquaviva delle Fonti, Italy

    Carlo Basile MD

  2. Department of Cardiology and Center for Rare Diseases (ZSEA), RWTH University Hospital, Aachen, Germany

    Vincent Brandenburg

  3. Ramsay-Générale de Santé, Service de Néphrologie et Dialyse, Clinique du Landy, Saint Ouen, France

    Pablo A. Ureña Torres MD, PhD

  4. Department of Renal Physiology, Necker Hospital, University of Paris V, René Descartes, Paris, France

    Pablo A. Ureña Torres MD, PhD

Authors
  1. Carlo Basile MD
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  2. Vincent Brandenburg
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  3. Pablo A. Ureña Torres MD, PhD
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Correspondence to Carlo Basile MD .

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Editors and Affiliations

  1. Ramsay-Générale de Santé, Clinique du Landy, Saint Ouen, France

    Pablo A. Ureña Torres

  2. San Paolo Hospital, DiSS University of Milan, Milan, Italy

    Mario Cozzolino

  3. VU University Medical Center, Amsterdam, The Netherlands

    Marc G. Vervloet

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Basile, C., Brandenburg, V., Ureña Torres, P.A. (2016). Natural Vitamin D in Chronic Kidney Disease. In: Ureña Torres, P., Cozzolino, M., Vervloet, M. (eds) Vitamin D in Chronic Kidney Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-32507-1_28

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  • DOI: https://doi.org/10.1007/978-3-319-32507-1_28

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